High chylomicron remnant causes
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mugilan Poongkunran M.B.B.S [2]
Overview
High chylomicron remnants level can either be due to genetic conditions as in type I and type V hyperlipoproteinemia or can be secondary to conditions such as chronic renal failure, hypothyroidism, and diabetes mellitus.
Causes
Life Threatening Causes
Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.
Common Causes
- Alcoholism
- Chronic renal failure
- Diabetes mellitus
- Hypothyroidism
- Oral contraceptives
- Pregnancy
- Thiazide diuretics
Causes by Organ System
| Cardiovascular | No underlying causes |
| Chemical/Poisoning | No underlying causes |
| Dental | No underlying causes |
| Dermatologic | No underlying causes |
| Drug Side Effect | Antiretroviral therapy, atypical antipsychotics, glucocorticoids, heparin, isotretinoin, oral contraceptives, tamoxifen, thiazide diuretics |
| Ear Nose Throat | No underlying causes |
| Endocrine | Diabetes mellitus, hypothyroidism |
| Environmental | No underlying causes |
| Gastroenterologic | Acute pancreatitis, alcoholic liver disease, cirrhosis, hepatitis, hereditary hemochromatosis, non-alcoholic steatohepatitis (NASH), Wilson's disease |
| Genetic | Familial hypertriglyceridemia, fructose-1-phosphate aldolase deficiency, galactosemia, glycogen storage disease type I, glycogen storage disease type IV, lipoprotein lipase deficiency, mixed hyperlipoproteinemia, type 1C hyperlipoproteinemia, tyrosinemia type 1 |
| Hematologic | No underlying causes |
| Iatrogenic | Dialysis |
| Infectious Disease | No underlying causes |
| Musculoskeletal/Orthopedic | No underlying causes |
| Neurologic | No underlying causes |
| Nutritional/Metabolic | Familial hypertriglyceridemia, glycogen storage disease type I, glycogen storage disease type IV, high carbohydrate diet, high saturated fat diet, isolated low HDL, lipoprotein lipase deficiency |
| Obstetric/Gynecologic | Pregnancy |
| Oncologic | No underlying causes |
| Ophthalmologic | No underlying causes |
| Overdose/Toxicity | No underlying causes |
| Psychiatric | No underlying causes |
| Pulmonary | No underlying causes |
| Renal/Electrolyte | Acute renal failure, chronic renal failure, nephrotic syndrome |
| Rheumatology/Immunology/Allergy | Autoimmune hyperchylomicronemia [1] |
| Sexual | No underlying causes |
| Trauma | No underlying causes |
| Urologic | No underlying causes |
| Miscellaneous | Alcoholism |
Causes by Alphabetical Order
References
- ↑ 1.0 1.1 Yoshimura, T.; Ito, M.; Sakoda, Y.; Kobori, S.; Okamura, H. (1998). "Rare case of autoimmune hyperchylomicronemia during pregnancy". Eur J Obstet Gynecol Reprod Biol. 76 (1): 49–51. PMID 9481547. Unknown parameter
|month=ignored (help) - ↑ Weintraub M, Burstein A, Rassin T, Liron M, Ringel Y, Cabili S; et al. (1992). "Severe defect in clearing postprandial chylomicron remnants in dialysis patients". Kidney Int. 42 (5): 1247–52. PMID 1453610.
- ↑ Ito M, Takamatsu J, Matsuo T, Kameoka K, Kubota S, Fukata S; et al. (2003). "Serum concentrations of remnant-like particles in hypothyroid patients before and after thyroxine replacement". Clin Endocrinol (Oxf). 58 (5): 621–6. PMID 12699445.
- ↑ Benjó AM, Maranhão RC, Coimbra SR, Andrade AC, Favarato D, Molina MS; et al. (2006). "Accumulation of chylomicron remnants and impaired vascular reactivity occur in subjects with isolated low HDL cholesterol: effects of niacin treatment". Atherosclerosis. 187 (1): 116–22. doi:10.1016/j.atherosclerosis.2005.08.025. PMID 16458316.
- ↑ Brasaemle DL, Cornely-Moss K, Bensadoun A (1993). "Hepatic lipase treatment of chylomicron remnants increases exposure of apolipoprotein E." J Lipid Res. 34 (3): 455–65. PMID 8468529.