High IDL causes

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Intermediate Density Lipoprotein Microchapters


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High IDL

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Case #1

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ogheneochuko Ajari, MB.BS, MS [2]


Disorders that would increase or cause high IDL may be due to defects or deficiency in the lipoprotein particle, endocrine causes, familial and metabolic causes.


Life Threatening Causes

Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.

There are no life threatening causes of high IDL.

Common Causes

Causes by Organ System

Cardiovascular Hypocalcemia, Reaven X syndrome
Chemical/Poisoning No underlying causes
Dental No underlying causes
Dermatologic No underlying causes
Drug Side Effect No underlying causes
Ear Nose Throat No underlying causes
Endocrine Diabetes mellitus type 2, diabetic nephropathy, hyperparathyroidism, hypocalcemia, Reaven X syndrome
Environmental No underlying causes
Gastroenterologic Glycogen storage disease type 1a
Genetic Apolipoprotein E deficiency, decreased hepatic triglyceride lipase, familial alphalipoprotein deficiency, glycogen storage disease type 1a, Reaven X syndrome
Hematologic No underlying causes
Iatrogenic No underlying causes
Infectious Disease No underlying causes
Musculoskeletal/Orthopedic No underlying causes
Neurologic No underlying causes
Nutritional/Metabolic Glycogen storage disease type 1a, hypocalcemia, Reaven X syndrome
Obstetric/Gynecologic No underlying causes
Oncologic No underlying causes
Ophthalmologic Diabetes mellitus type 2
Overdose/Toxicity No underlying causes
Psychiatric No underlying causes
Pulmonary No underlying causes
Renal/Electrolyte Chronic renal failure, diabetes mellitus type 2, diabetic nephropathy, hypocalcemia
Rheumatology/Immunology/Allergy Reaven syndrome X
Sexual No underlying causes
Trauma No underlying causes
Urologic No underlying causes
Miscellaneous No underlying causes

Causes in Alphabetical Order


  1. Nishizawa Y, Shoji T, Tabata T, Inoue T, Morii H (1999). "Effects of lipid-lowering drugs on intermediate-density lipoprotein in uremic patients". Kidney Int Suppl. 71: S134–6. PMID 10412757.
  2. 2.0 2.1 2.2 Nishizawa Y, Shoji T, Kawagishi T, Morii H (1997). "Atherosclerosis in uremia: possible roles of hyperparathyroidism and intermediate density lipoprotein accumulation". Kidney Int Suppl. 62: S90–2. PMID 9350691.
  3. Oi K, Hirano T, Sakai S, Kawaguchi Y, Hosoya T (1999). "Role of hepatic lipase in intermediate-density lipoprotein and small, dense low-density lipoprotein formation in hemodialysis patients". Kidney Int Suppl. 71: S227–8. PMID 10412783.
  4. Durrington PN (1993). "Diabetes, hypertension and hyperlipidaemia". Postgrad Med J. 69 Suppl 1: S18–25, discussion S25-9. PMID 8497453.
  5. Shoji T, Emoto M, Kawagishi T, Kimoto E, Yamada A, Tabata T; et al. (2001). "Atherogenic lipoprotein changes in diabetic nephropathy". Atherosclerosis. 156 (2): 425–33. PMID 11395040.
  6. Geberhiwot T, Alger S, McKiernan P, Packard C, Caslake M, Elias E; et al. (2007). "Serum lipid and lipoprotein profile of patients with glycogen storage disease types I, III and IX". J Inherit Metab Dis. 30 (3): 406. doi:10.1007/s10545-007-0485-2. PMID 17407002.
  7. Levy E, Thibault LA, Roy CC, Bendayan M, Lepage G, Letarte J (1988). "Circulating lipids and lipoproteins in glycogen storage disease type I with nocturnal intragastric feeding". J Lipid Res. 29 (2): 215–26. PMID 3130454.

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