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major histocompatibility complex (human), class I, A80
Alleles A*8001
Structure (See HLA-A)
Symbol(s) HLA-A
EBI-HLA A*8001
Locus chr.6 6p21.31

HLA-A80 (A80) is the least common HLA-A group. The serotype identifies the more common HLA-A*8001 gene product. A80 is almost exclusively found in africa and recent immigrants groups from West Africa


A80 and A10 serotype recognition of Some HLA A*3601 allele-group gene products[1]
A*80 A80 A10 Sample
allele % % size (N)
8001 36 10 505

HLA-A80 typing is poor. Most typing is done with SSP-PCR. Most of 8001 are detected with "Blank" serotype.

Distribution and References

HLA A*8001 frequencies
ref. Population (%)
[2] Bamileke (Cameroon) 1.9
Botswana 1.8
[3] Fulani (Burkino Faso) 1.0
[2] Bete(Cameroon) 0.6
Bubi(Eq. Guinea) 0.5
  1. derived from IMGT/HLA
  2. 2.0 2.1 Torimiro JN, Carr JK, Wolfe ND; et al. (2006). "HLA class I diversity among rural rainforest inhabitants in Cameroon: identification of A*2612-B*4407 haplotype". Tissue Antigens. 67 (1): 30–7. doi:10.1111/j.1399-0039.2005.00527.x. PMID 16451198.
  3. Modiano D, Luoni G, Petrarca V; et al. (2001). "HLA class I in three West African ethnic groups: genetic distances from sub-Saharan and Caucasoid populations". Tissue Antigens. 57 (2): 128–37. PMID 11260507.

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