Fibromuscular dysplasia natural history, complications and prognosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohsen Basiri M.D.

Overview

Current knowledge about natural history, the efficacy of medical therapies, complications and prognosis of FMD, are really restricted; however the natural history of FMD is benign, and the long-term prognosis of patients with FMD is good, and its existence alone is not an indication for preventive intervention or surgery.

Renal or cervival artery dissection and Intracranial aneurysms rupture and SAH are the most common complications of FMD.

Natural History, Complications, and Prognosis

Natural History

Current knowledge about natural history, the efficacy of medical therapies, complications and prognosis of FMD, are really restricted; however the natural history of FMD is benign.

There are numerous top research priorities in determination of the natural history of FMD in the asymptomatic and symptomatic patient, progression, vascular events, complications, and many unanswered aspects of FMD.

Complications

• Common complications of FMD include:
  • Renal or cervival artery dissection
  • Intracranial aneurysms rupture and SAH
  • Carotid-cavernous fistula
  • Vertebral arteriovenous fistula

Cervical artery dissection is a classical complication of cervicocranial FMD In the US FMD registry, about 20% of patients suffered from carotid arteries dissection.

Prognosis

• The long-term prognosis of patients with the cervico-cranial FMD is good, and its existence alone is not an indication for preventive surgery.