Familial adenomatous polyposis screening
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Sadaf Sharfaei M.D.[2], Mohamad Alkateb, MBBCh [3]
Overview
Screening for familial adenomatous polyposis by genetic testing and/or colonoscopy is recommended among patients with history of multiple colonic adenomas and family history of familial adenomatous polyposis.
Screening
Screening for familial adenomatous polyposis is recommended in the following patients:[1][2]
- Positive family history of FAP in the first degree relative
- It must be started at the age of the youngest family member's polyps or symptoms
Screening for familial adenomatous polyposis for individuals at high risk may be done by:
- Sigmoidoscopy every 2 years beginning at age of 10 years
- Colonoscopy every year following finding an adenoma
- Endoscopy concomitant with colonoscopy
- Side viewing endoscopy beginning at age 15 years to evaluate ampulla
- Genetic testing[3]
References
- ↑ King, John E.; Dozois, Roger R.; Lindor, Noralane M.; Ahlquist, David A. (2000). "Care of Patients and Their Families With Familial Adenomatous Polyposis". Mayo Clinic Proceedings. 75 (1): 57–67. doi:10.4065/75.1.57. ISSN 0025-6196.
- ↑ Kennedy, Raelene D.; Potter, D. Dean; Moir, Christopher R.; El-Youssef, Mounif (2014). "The natural history of familial adenomatous polyposis syndrome: A 24year review of a single center experience in screening, diagnosis, and outcomes". Journal of Pediatric Surgery. 49 (1): 82–86. doi:10.1016/j.jpedsurg.2013.09.033. ISSN 0022-3468.
- ↑ Roy, Hemant K.; Khandekar, Janardan D. (2012). "APC Gene Testing for Familial Adenomatosis Polyposis". JAMA. 308 (5): 514. doi:10.1001/jama.2012.9516. ISSN 0098-7484.