Cryoglobulinemia natural history, complications and prognosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Feham Tariq, MD [2]

Complications

The complications of cryoglobulinemia are as follows:

• Rapidly progressive neuropathy
• Heart failure
• Digital ischemia threatening amputation
• Diffuse alveolar hemorrhage resulting in hemoptysis
• Respiratory failure
• Stroke
• End stage renal disease

Prognosis

Patients having severe manifestations of the disease such as pulmonary vasculitis, end-stage renal disease, cardiac vasculitis and central nervous system vasculitis have generally poor prognosis of the disease. The prognosis of cryoglobulinemia depends on the organ system involved and varies accordingly.

Organ system involved	Survival rate
Glomerulonephritis	79%
Pulmonary vasculitis	22%
Central nervous system vasculitis	66%
Gastrointestinal vasculitis	67%
Cardiac vasculitis	100%

References

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