Celiac disease diagnostic criteria
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Aditya Ganti M.B.B.S. [2]
Overview
The diagnosis of celiac disease is made when at least four of the following five or three out of four (if the HLA genotype is not performed) diagnostic criteria are met: typical symptoms (chronic diarrhea, chronic abdominal pain, malabsorption, bloating, constipation, failure to thrive/weight loss, anorexia, vomiting, GERD), serum positivity for Ig A autoantibodies at high titer, HLA-DQ2 or HLA-DQ8 genotypes, celiac enteropathy on small intestinal biopsy, and response to gluten-free diet.
Diagnostic criteria
The diagnosis of celiac disease is made when at least four of the following five or three out of four (if the HLA genotype is not performed) diagnostic criteria are met:[1][2]
- Typical symptoms (chronic diarrhea, chronic abdominal pain, malabsorption, bloating, constipation (more commonly in children), failure to thrive/weight loss, anorexia, vomiting, GERD)
- Serum positivity for IgA autoantibodies at high titer
- HLA-DQ2 or HLA-DQ8 genotypes
- Celiac enteropathy at the small intestinal biopsy
- Response to gluten-free diet
| ♦ Diagnostic criteria met ♦ Symptomatic patients ♦ High risk population | |||||||||||||||||||||||||||||||||
| Serology | |||||||||||||||||||||||||||||||||
| Positive | Negative | ||||||||||||||||||||||||||||||||
| Biopsy | Celiac disease is ruled out consider other diagnosis | ||||||||||||||||||||||||||||||||
| Positive | Negative | ||||||||||||||||||||||||||||||||
| Celiac disease | Reevaluate HLA DQ2 and DQ8 other diagnosis | ||||||||||||||||||||||||||||||||
References
- ↑ Rubio-Tapia A, Hill ID, Kelly CP, Calderwood AH, Murray JA. "ACG clinical guidelines: diagnosis and management of celiac disease". Am. J. Gastroenterol. doi:10.1038/ajg.2013.79. PMC 3706994. PMID 23609613.
- ↑ "Revised criteria for diagnosis of coeliac disease. Report of Working Group of European Society of Paediatric Gastroenterology and Nutrition". Arch. Dis. Child. 65 (8): 909–11. 1990. PMC 1792502. PMID 2205160.