Bezold-Jarisch reflex pathophysiology
Template:Bezold-Jarisch reflex
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor-In-Chief: Cafer Zorkun, M.D., Ph.D. [2]; Rim Halaby, M.D. [3]; Mugilan Poongkunran M.B.B.S [4]
Overview
Pathophysiology
Bezold-Jarisch reflex is the occurrence of bradycardia and hypotension through a pathway involving cardiac receptors,medullary centers and vagal afferent nerves.[1] Bezold-Jarisch reflex originates from inhibitory mechanoreceptors that are located in the left ventricle, particularly in the inferoposterior wall. The stimulation of these receptors occurs in the context of stretching and contraction of a poorly filled ventricle. Once stimulated, these mechanoreceptors stimulateparasympathetic pathways and inhibits the sympathetic pathways. The result of this reflex is a constellation of bradycardia,vasodilation and hypotension in addition to increase renin and vasopressin release.[2]
Below is an image that illustrates the physiology of Bezold-Jarisch reflex.
References
- ↑ Aviado DM, Guevara Aviado D (2001). "The Bezold-Jarisch reflex. A historical perspective of cardiopulmonary reflexes". Ann N Y Acad Sci. 940: 48–58. PMID 11458703.
- ↑ Mark AL (1983). "The Bezold-Jarisch reflex revisited: clinical implications of inhibitory reflexes originating in the heart". J Am Coll Cardiol. 1 (1): 90–102. PMID 6826948.