Atypical small acinar proliferation
Steven C. Campbell, M.D., Ph.D.
In urologic pathology, atypical small acinar proliferation, abbreviated ASAP, is a collection of small prostatic glands, on prostate biopsy, whose significance is uncertain and cannot be determined to be benign or malignant.
ASAP, generally, is not considered a pre-malignancy, or a carcinoma in situ; it is an expression of diagnostic uncertainty, and analogous to the diagnosis of ASCUS (atypical squamous cells of undetermined significance) on the Pap test.
Association with adenocarcinoma
On a subsequent biopsy, given the diagnosis of ASAP, the chance of finding prostate adenocarcinoma is approximately 40%; this is higher than if there is high-grade prostatic intraepithelial neoplasia (HGPIN).
ASAP is considered an indication for re-biopsy.
- ↑ Flury SC, Galgano MT, Mills SE, Smolkin ME, Theodorescu D (2007). "Atypical small acinar proliferation: biopsy artefact or distinct pathological entity". BJU International. 99 (4): 780–5. Unknown parameter
- ↑ Leite KR, Camara-Lopes LH, Cury J, Dall'oglio MF, Sañudo A, Srougi M (2008). "Prostate cancer detection at rebiopsy after an initial benign diagnosis: results using sextant extended prostate biopsy". Clinics. 63 (3): 339–42. PMID 18568243. Unknown parameter
- ↑ Bostwick DG, Meiers I (2006). "Atypical small acinar proliferation in the prostate: clinical significance in 2006". Arch. Pathol. Lab. Med. 130 (7): 952–7. PMID 16831049. Unknown parameter