Acute promyelocytic leukemia causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Shyam Patel [2] Associate Editor(s)-in-Chief: Sogand Goudarzi, MD [3]; Grammar Reviewer: Natalie Harpenau, B.S.[4]


The cause of acute promyelocytic leukemia is sporadic rather than hereditary. It is caused by a reciprocal translocation between chromosomes 15 and 17, which creates a novel protein known as PML-RARA, leading to a differentiation block. In general, the causes of acute leukemia of myeloid origin include chemicals, radiation, cytotoxic chemotherapeutic agents, and specific mutations.

Acute promyelocytic leukemia causes


  1. 1.0 1.1 1.2 1.3 1.4 Greim H, Kaden DA, Larson RA, Palermo CM, Rice JM, Ross D; et al. (2014). "The bone marrow niche, stem cells, and leukemia: impact of drugs, chemicals, and the environment". Ann N Y Acad Sci. 1310: 7–31. doi:10.1111/nyas.12362. PMC 4002179. PMID 24495159.
  2. Zhang, L.; Samad, A.; Pombo-de-Oliveira, M.S.; Scelo, G.; Smith, M.T.; Feusner, J.; Wiemels, J.L.; Metayer, C. (2015). "Global characteristics of childhood acute promyelocytic leukemia". Blood Reviews. 29 (2): 101–125. doi:10.1016/j.blre.2014.09.013. ISSN 0268-960X.
  3. Casorelli, Ida; Bossa, Cecilia; Bignami, Margherita (2012). "DNA Damage and Repair in Human Cancer: Molecular Mechanisms and Contribution to Therapy-Related Leukemias". International Journal of Environmental Research and Public Health. 9 (8): 2636–2657. doi:10.3390/ijerph9082636. ISSN 1660-4601.
  4. Valentini, Caterina Giovanna; Fianchi, Luana; Voso, Maria Teresa; Caira, Morena; Leone, Giuseppe; Pagano, Livio (2011). "INCIDENCE OF ACUTE MYELOID LEUKEMIA AFTER BREAST CANCER". Mediterranean Journal of Hematology and Infectious Diseases. 3 (1): e2011069. doi:10.4084/mjhid.2011.069. ISSN 2035-3006.
  5. Felix, Carolyn A. (2001). "Leukemias related to treatment with DNA topoisomerase II inhibitors". Medical and Pediatric Oncology. 36 (5): 525–535. doi:10.1002/mpo.1125. ISSN 0098-1532.
  6. Pendleton, MaryJean; Lindsey, R. Hunter; Felix, Carolyn A.; Grimwade, David; Osheroff, Neil (2014). "Topoisomerase II and leukemia". Annals of the New York Academy of Sciences. 1310 (1): 98–110. doi:10.1111/nyas.12358. ISSN 0077-8923.
  7. Larsson, Connie A.; Cote, Gilbert; Quintás-Cardama, Alfonso (2013). "The Changing Mutational Landscape of Acute Myeloid Leukemia and Myelodysplastic Syndrome". Molecular Cancer Research. 11 (8): 815–827. doi:10.1158/1541-7786.MCR-12-0695. ISSN 1541-7786.
  8. DiNardo, C. D.; Cortes, J. E. (2016). "Mutations in AML: prognostic and therapeutic implications". Hematology. 2016 (1): 348–355. doi:10.1182/asheducation-2016.1.348. ISSN 1520-4391.
  9. Mazzarella, Luca; Riva, Laura; Luzi, Lucilla; Ronchini, Chiara; Pelicci, Pier Giuseppe (2014). "The Genomic and Epigenomic Landscapes of AML". Seminars in Hematology. 51 (4): 259–272. doi:10.1053/j.seminhematol.2014.08.007. ISSN 0037-1963.
  10. Cazzola M, Rossi M, Malcovati L (January 2013). "Biologic and clinical significance of somatic mutations of SF3B1 in myeloid and lymphoid neoplasms". Blood. 121 (2): 260–9. doi:10.1182/blood-2012-09-399725. PMC 3790951. PMID 23160465.
  11. 11.0 11.1 Patel SA (2018). "Enasidenib-Induced Differentiation Syndrome in IDH2-Mutant Acute Myeloid Leukemia". JAMA Oncol. doi:10.1001/jamaoncol.2017.4724. PMID 29346477.

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