Acute lymphoblastic leukemia history and symptoms
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2] Carlos A Lopez, M.D. [3]
Overview
Symptoms of acute lymphoblastic leukemia include generalized weakness and fatigue, frequent or unexplained fever and infections, weight loss and/or loss of appetite, excessive bruising, bleeding from wounds, nosebleeds, petechiae, bone pain, joint pains and dyspnea.
History
Patients with acute lymphoblastic leukemia may have a positive history of:[1][2][3][4][5]
Symptoms
Common symptoms
Common symptoms of acute lymphoblastic leukemia include the following:[6][7][8][9][4]
- Generalized weakness and fatigue
- Anemia
- Frequent or unexplained fever and infections
- Weight loss
- Anorexia
- Excessive bleeding from minor wounds
- Bone pain
- Dyspnea
- Excessive bruising
- Petechiae
Less common symptoms
- Epistaxis[10]
- Arthralgia (caused by the spread of "blast" cells to the surface of the bone or into the joint from the marrow cavity)[11]
References
- ↑ Bakhshi S, Padmanjali KS, Arya LS (June 2008). "Infections in childhood acute lymphoblastic leukemia: an analysis of 222 febrile neutropenic episodes". Pediatr Hematol Oncol. 25 (5): 385–92. doi:10.1080/08880010802106564. PMID 18569840.
- ↑ Sutor AH, Mall V, Thomas KB (1999). "Bleeding and thrombosis in children with acute lymphoblastic leukaemia, treated according to the ALL-BFM-90 protocol". Klin Padiatr. 211 (4): 201–4. doi:10.1055/s-2008-1043788. PMID 10472550.
- ↑ Steele M, Narendran A (October 2012). "Mechanisms of defective erythropoiesis and anemia in pediatric acute lymphoblastic leukemia (ALL)". Ann. Hematol. 91 (10): 1513–8. doi:10.1007/s00277-012-1475-5. PMID 22543829.
- ↑ 4.0 4.1 Terwilliger T, Abdul-Hay M (June 2017). "Acute lymphoblastic leukemia: a comprehensive review and 2017 update". Blood Cancer J. 7 (6): e577. doi:10.1038/bcj.2017.53. PMC 5520400. PMID 28665419.
- ↑ Shephard EA, Neal RD, Rose PW, Walter FM, Hamilton W (March 2016). "Symptoms of adult chronic and acute leukaemia before diagnosis: large primary care case-control studies using electronic records". Br J Gen Pract. 66 (644): e182–8. doi:10.3399/bjgp16X683989. PMC 4758497. PMID 26917658.
- ↑ Clarke RT, Van den Bruel A, Bankhead C, Mitchell CD, Phillips B, Thompson MJ (October 2016). "Clinical presentation of childhood leukaemia: a systematic review and meta-analysis". Arch. Dis. Child. 101 (10): 894–901. doi:10.1136/archdischild-2016-311251. PMID 27647842.
- ↑ Vesterby A, Myhre Jensen O (September 1985). "Aseptic bone/bone marrow necrosis in leukaemia". Scand J Haematol. 35 (3): 354–7. PMID 4059858.
- ↑ Sinigaglia R, Gigante C, Bisinella G, Varotto S, Zanesco L, Turra S (2008). "Musculoskeletal manifestations in pediatric acute leukemia". J Pediatr Orthop. 28 (1): 20–8. doi:10.1097/BPO.0b13e31815ff350. PMID 18157042.
- ↑ Pui CH (January 2009). "Acute lymphoblastic leukemia: introduction". Semin. Hematol. 46 (1): 1–2. doi:10.1053/j.seminhematol.2008.09.011. PMC 2638983. PMID 19100362.
- ↑ Aboud, H.; Treleaven, J.; Carter, R.; O'Brien, M.; Powels, R. (1991). "An adult with common acute lymphoblastic leukaemia (C-ALL) presenting with skin infiltration". British Journal of Dermatology. 124 (1): 84–85. doi:10.1111/j.1365-2133.1991.tb03287.x. ISSN 0007-0963.
- ↑ Brix N, Rosthøj S, Herlin T, Hasle H (2015). "Arthritis as presenting manifestation of acute lymphoblastic leukaemia in children". Arch Dis Child. 100 (9): 821–5. doi:10.1136/archdischild-2014-307751. PMID 26216831.