5-Lipoxygenase activating protein
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| arachidonate 5-lipoxygenase-activating protein | |
|---|---|
| Identifiers | |
| Symbol | ALOX5AP |
| Entrez | 241 |
| HUGO | 436 |
| OMIM | 603700 |
| RefSeq | NM_001629 |
| UniProt | P20292 |
| Other data | |
| Locus | Chr. 13 q12 |
5-Lipoxygenase activating protein, or FLAP, is an enzyme necessary for the activation of 5-lipoxygenase and therefore for the production of leukotrienes.[1] It is bound to the nuclear membrane.
Pathology
Gene polymorphisms in FLAP are suspected of playing a role in Alzheimer's disease.[2]
References
- ↑ Peters-Golden M, Brock TG (2003). "5-lipoxygenase and FLAP". Prostaglandins Leukot Essent Fatty Acids. 69 (2–3): 99–109. PMID 12895592.
- ↑ Manev H, Manev R (2006). "5-Lipoxygenase (ALOX5) and FLAP (ALOX5AP) gene polymorphisms as factors in vascular pathology and Alzheimer's disease". Med Hypotheses. 66 (3): 501–3. PMID 16278051.
External links
- 5-lipoxygenase-activating+protein at the US National Library of Medicine Medical Subject Headings (MeSH)
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