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'''Editor-in-Chief:''' [User:Casey Glass, M.D.|Casey Glass, M.D.] [mailto:cglass@wfubmc.edu]
[[Image:Ultrasound range diagram.png|thumb|200px|right|Approximate frequency ranges corresponding to ultrasound, with rough guide of some applications]]
[[Image:Baby in ultrasound.jpg|thumb|right|A fetus in its mother's womb, viewed in a sonogram (brightness scan)]]


{{EH}}
{{SI}}
'''Editor(s)-in-Chief:''' [[C. Michael Gibson]], M.S.,M.D. [mailto:charlesmichaelgibson@gmail.com] Phone:617-632-7753; [[User:Casey Glass, M.D.|Casey Glass, M.D.]] [mailto:cglass@wfubmc.edu]


==Overview==
'''Ultrasound''' is cyclic [[sound]] pressure with a [[frequency]] greater than the upper limit of [[human]] [[hearing (sense)|hearing]]. Although this limit varies from person to person, it is approximately 20 [[Hertz|kilohertz]] (20,000 hertz) in healthy, young adults and thus, 20 kHz serves as a useful lower limit in describing ultrasound. Ultrasound is manually produced in many different fields, typically to penetrate a medium and measure the reflection signature or supply focused energy. The reflection signature can reveal details about the inner structure of the medium. The most well known application of this technique is its use in sonography to produce pictures of fetuses in the human womb. There are a vast number of other applications as well.
'''Ultrasound''' is cyclic [[sound]] pressure with a [[frequency]] greater than the upper limit of [[human]] [[hearing (sense)|hearing]]. Although this limit varies from person to person, it is approximately 20 [[Hertz|kilohertz]] (20,000 hertz) in healthy, young adults and thus, 20 kHz serves as a useful lower limit in describing ultrasound. Ultrasound is manually produced in many different fields, typically to penetrate a medium and measure the reflection signature or supply focused energy. The reflection signature can reveal details about the inner structure of the medium. The most well known application of this technique is its use in sonography to produce pictures of fetuses in the human womb. There are a vast number of other applications as well.
[[Image:Ultrasound range diagram.png|thumb|300px|right|Approximate frequency ranges corresponding to ultrasound, with rough guide of some applications]]
[[Image:Baby in ultrasound.jpg|thumb|right|A fetus in its mother's womb, viewed in a sonogram (brightness scan)]]


==Ability to hear ultrasound==
==Ability to hear ultrasound==
The upper frequency limit in humans (approximately 20 kHz) is caused by the [[middle ear]], which acts as a [[low-pass filter]].  If ultrasound is fed directly into the skull bone and reaches the [[cochlea]] without passing through the middle ear, much higher frequencies can be heard.  This effect is discussed in [[ultrasonic hearing]].  Carefully-designed scientific studies have been performed and confirmed what they call the [[hypersonic effect]] - that even without consciously hearing it, high-frequency sound can have a measurable effect on the mind.
The upper frequency limit in humans (approximately 20 kHz) is caused by the [[middle ear]], which acts as a [[low-pass filter]].  If ultrasound is fed directly into the skull bone and reaches the [[cochlea]] without passing through the middle ear, much higher frequencies can be heard.  This effect is discussed in [[ultrasonic hearing]].  Carefully-designed scientific studies have been performed and confirmed what they call the [[hypersonic effect]] - that even without consciously hearing it, high-frequency sound can have a measurable effect on the mind.


It is a fact in [[psychoacoustics]] that children can hear some high-pitched sounds that older adults cannot hear, because in humans the upper limit pitch of hearing tends to become lower with age.<ref>Takeda S et al (1992)</ref> <ref>{{cite web |url=http://dx.doi.org/10.1007/BF00243505 | title=Age variation in the upper limit of hearing}}European Journal of Applied Physiology 65(5), 403-408</ref>  A [[cell phone]] company has used this to create ring signals supposedly only able to be heard by younger humans<ref>[http://www.nytimes.com/2006/06/12/technology/12ring.html?ex=1307764800&en=2a80d150770df0df&ei=5090&partner=rssuserland&emc=rss%3Cbr%20/%3E "A Ring Tone Meant to Fall on Deaf Ears"] (New York Times article)</ref>; but many older people claim to be able to hear it, which is likely given the considerable variation of age-related deterioration in the upper hearing threshold.
It is a fact in [[psychoacoustics]] that children can hear some high-pitched sounds that older adults cannot hear, because in humans the upper limit pitch of hearing tends to become lower with age.<ref>Takeda S et al (1992)</ref> <ref>{{cite web |url=http://dx.doi.org/10.1007/BF00243505 | title=Age variation in the upper limit of hearing}}European Journal of Applied Physiology 65(5), 403-408</ref>  A cell phone company has used this to create ring signals supposedly only able to be heard by younger humans<ref>[http://www.nytimes.com/2006/06/12/technology/12ring.html?ex=1307764800&en=2a80d150770df0df&ei=5090&partner=rssuserland&emc=rss%3Cbr%20/%3E "A Ring Tone Meant to Fall on Deaf Ears"] (New York Times article)</ref>; but many older people claim to be able to hear it, which is likely given the considerable variation of age-related deterioration in the upper hearing threshold.


Some animals &ndash; such as [[dog]]s, [[cats]], [[dolphins]], [[bat]]s, and [[mouse|mice]] &ndash; have an upper frequency limit that is greater than that of the human [[ear]] and thus can hear ultrasound.
Some animals &ndash; such as dogs, cats, dolphins, bats, and mice have an upper frequency limit that is greater than that of the human [[ear]] and thus can hear ultrasound.


==Diagnostic sonography==
==Diagnostic sonography==
[[Image:Embryo at 14 weeks profile.JPG|thumb|right|Sonogram of a fetus at 14 weeks (Profile)]]
 
[[Image:3dultrasound.png|thumb|right|A fetus, aged 29 weeks, in a "[[4D Ultrasound|3D ultrasound]]"]]
{{main|Medical ultrasonography}}
{{main|Medical ultrasonography}}
'''Medical sonography''' ('''ultrasonography''') is an ultrasound-based diagnostic [[medical imaging]] technique used to visualize muscles, tendons, and many internal organs, their size, structure and any pathological [[lesion]]s with real time tomographic images.  It is also used to visualize a fetus during routine and emergency [[prenatal care]].  Ultrasound scans are performed by medical health care professionals called [[sonographer]]s.  [[Obstetric ultrasonography|Obstetric sonography]] is commonly used during [[pregnancy]].
'''Medical sonography''' ('''ultrasonography''') is an ultrasound-based diagnostic [[medical imaging]] technique used to visualize muscles, tendons, and many internal organs, their size, structure and any pathological [[lesion]]s with real time tomographic images.  It is also used to visualize a fetus during routine and emergency [[prenatal care]].  Ultrasound scans are performed by medical health care professionals called [[sonographer]]s.  [[Obstetric ultrasonography|Obstetric sonography]] is commonly used during [[pregnancy]].
Ultrasound has  been used to image the human body for at least 50 years.  It is  one of the most widely used diagnostic tools in  modern medicine.  The technology is relatively inexpensive and portable, especially when compared with modalities such as [[magnetic resonance imaging]](MRI) and [[computed tomography]] (CT).
Ultrasound has  been used to image the human body for at least 50 years.  It is  one of the most widely used diagnostic tools in  modern medicine.  The technology is relatively inexpensive and portable, especially when compared with modalities such as [[magnetic resonance imaging]](MRI) and [[computed tomography]] (CT).
As currently applied in the medical environment, ultrasound poses no known risks to the patient.<ref>[http://radiographics.rsnajnls.org/cgi/content/abstract/23/4/1019?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=3d+ultrasound&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&sortspec=relevance&resourcetype=HWCIT]</ref>
As currently applied in the medical environment, ultrasound poses no known risks to the patient.<ref>[http://radiographics.rsnajnls.org/cgi/content/abstract/23/4/1019?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=3d+ultrasound&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&sortspec=relevance&resourcetype=HWCIT]</ref>
[[Image:Embryo at 14 weeks profile.JPG|thumb|right|Sonogram of a fetus at 14 weeks (Profile)]]
[[Sonography]] is generally described as a "safe test" because it does not use ionizing radiation, which imposes hazards, such as cancer production and chromosome breakage.  However, ultrasonic energy has two potential physiological effects: it enhances inflammatory response; and it can heat soft tissue.<ref>[http://www.electrotherapy.org/electro/ultrasound/therapeutic_ultrasound.htm Watson, T. (2006). "Therapeutic Ultrasound".] (see [http://www.electrotherapy.org/electro/downloads/Therapeutic%20Ultrasound.pdf here] for a pdf version with the author and date information)</ref>  Ultrasound energy produces a mechanical pressure wave through soft tissue.  This pressure wave may cause microscopic bubbles in living tissues, and distortion of the cell membrane, influencing ion fluxes and intracellular activity.  When ultrasound enters the body, it causes molecular friction and heats the tissues slightly.  This effect is very minor as normal tissue perfusion dissipates heat.  With  high intensity, it can also cause small pockets of gas in body fluids or tissues to expand and contract/collapse in a phenomenon called cavitation (this is not known to occur at diagnostic power levels used by modern diagnostic ultrasound units).  The long-term effects of tissue heating and cavitation are not known.<ref>http://www.fda.gov/cdrh/radhealth/products/ultrasound-imaging.html</ref> There are several studies that indicate the harmful side effects on animal fetuses associated with the use of sonography on pregnant mammals.  A noteworthy study in 2006 suggests exposure to ultrasound can affect fetal brain development in mice.  This misplacement of brain cells during their development is linked to disorders ranging "from mental retardation and childhood epilepsy to developmental dyslexia, autism spectrum disorders and schizophrenia,'' the researchers said.  
[[Sonography]] is generally described as a "safe test" because it does not use ionizing radiation, which imposes hazards, such as cancer production and chromosome breakage.  However, ultrasonic energy has two potential physiological effects: it enhances inflammatory response; and it can heat soft tissue.<ref>[http://www.electrotherapy.org/electro/ultrasound/therapeutic_ultrasound.htm Watson, T. (2006). "Therapeutic Ultrasound".] (see [http://www.electrotherapy.org/electro/downloads/Therapeutic%20Ultrasound.pdf here] for a pdf version with the author and date information)</ref>  Ultrasound energy produces a mechanical pressure wave through soft tissue.  This pressure wave may cause microscopic bubbles in living tissues, and distortion of the cell membrane, influencing ion fluxes and intracellular activity.  When ultrasound enters the body, it causes molecular friction and heats the tissues slightly.  This effect is very minor as normal tissue perfusion dissipates heat.  With  high intensity, it can also cause small pockets of gas in body fluids or tissues to expand and contract/collapse in a phenomenon called cavitation (this is not known to occur at diagnostic power levels used by modern diagnostic ultrasound units).  The long-term effects of tissue heating and cavitation are not known.<ref>http://www.fda.gov/cdrh/radhealth/products/ultrasound-imaging.html</ref> There are several studies that indicate the harmful side effects on animal fetuses associated with the use of sonography on pregnant mammals.  A noteworthy study in 2006 suggests exposure to ultrasound can affect fetal brain development in mice.  This misplacement of brain cells during their development is linked to disorders ranging "from mental retardation and childhood epilepsy to developmental dyslexia, autism spectrum disorders and schizophrenia,'' the researchers said.  
<ref>http://www.livescience.com/health/060807_ap_baby_ultrasound.html</ref>
<ref>http://www.livescience.com/health/060807_ap_baby_ultrasound.html</ref>
[[Image:3dultrasound.png|thumb|right|A fetus, aged 29 weeks, in a "[[4D Ultrasound|3D ultrasound]]"]]
There is no link made yet between the test results on animals, such as mice, and the possible outcome to humans. Widespread clinical use of diagnostic ultrasound testing on humans has not been done for ethical reasons.  The possibility exists that biological effects may be identified in the future, currently most doctors feel that based on available information the benefits to patients outweigh the risks.<ref>http://www.aium.org/patient/aboutExam/safety.asp</ref>
There is no link made yet between the test results on animals, such as mice, and the possible outcome to humans. Widespread clinical use of diagnostic ultrasound testing on humans has not been done for ethical reasons.  The possibility exists that biological effects may be identified in the future, currently most doctors feel that based on available information the benefits to patients outweigh the risks.<ref>http://www.aium.org/patient/aboutExam/safety.asp</ref>
Obstetric ultrasound can be used to identify many conditions that would be harmful to the mother and the baby.  For this reason many health care professionals consider that the risk of leaving these conditions undiagnosed is much greater than the very small risk, if any, associated with undergoing the scan.  According to Cochrane review, routine ultrasound in early pregnancy (less than 24 weeks) appears to enable better gestational age assessment, earlier detection of multiple pregnancies and earlier detection of clinically unsuspected fetal malformation at a time when termination of pregnancy is possible.<ref>{{cite web |url=http://www.cochrane.org/reviews/en/ab000182.html | title=Ultrasound for fetal assessment in early pregnancy}}</ref>
Obstetric ultrasound can be used to identify many conditions that would be harmful to the mother and the baby.  For this reason many health care professionals consider that the risk of leaving these conditions undiagnosed is much greater than the very small risk, if any, associated with undergoing the scan.  According to Cochrane review, routine ultrasound in early pregnancy (less than 24 weeks) appears to enable better gestational age assessment, earlier detection of multiple pregnancies and earlier detection of clinically unsuspected fetal malformation at a time when termination of pregnancy is possible.<ref>{{cite web |url=http://www.cochrane.org/reviews/en/ab000182.html | title=Ultrasound for fetal assessment in early pregnancy}}</ref>
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A study on rodent fetus brains that are exposed to ultrasound showed signs of damage.  Speculation on human fetuses can be in a range of no significant complications to a variety of mental and brain disorders.  The study shows that rodent brain cells failed to grow to their proper position and remained scattered in incorrect parts of the brain.  The conditions of this experiment are different from typical fetal scanning because of the long dwell times.  [National Institute of Neurological Disorders; Proceedings of the National Academy of Sciences].  Care should be taken to use low power settings and avoid pulsed wave scanning of the fetal brain unless specifically indicated in high risk pregnancies.
A study on rodent fetus brains that are exposed to ultrasound showed signs of damage.  Speculation on human fetuses can be in a range of no significant complications to a variety of mental and brain disorders.  The study shows that rodent brain cells failed to grow to their proper position and remained scattered in incorrect parts of the brain.  The conditions of this experiment are different from typical fetal scanning because of the long dwell times.  [National Institute of Neurological Disorders; Proceedings of the National Academy of Sciences].  Care should be taken to use low power settings and avoid pulsed wave scanning of the fetal brain unless specifically indicated in high risk pregnancies.


It should be noted that obstetrics is not the only use of ultrasound.  Soft tissue imaging of many other parts of the body is conducted with ultrasound.  Other scans routinely conducted are cardiac, renal, liver and gallbladder ([[hepatic]]).  Other common applications include musculo-skeletal imaging of muscles, ligaments and tendons, [[ophthalmic]] ultrasound (eye) scans and superficial structures such as [[testicle]], [[thyroid]], [[salivary glands]] and [[lymph nodes]].  Because of the [[real time]] nature of ultrasound, it is often used to guide interventional procedures such as fine needle aspiration [[FNA]] or [[biopsy]] of masses for [[cytology]] or [[histology]] testing in the breast, thyroid, liver, kidney, lymph nodes, muscles and joints.
It should be noted that obstetrics is not the only use of ultrasound.  Soft tissue imaging of many other parts of the body is conducted with ultrasound.  Other scans routinely conducted are cardiac, renal, liver and gallbladder ([[hepatic]]).  Other common applications include musculo-skeletal imaging of muscles, ligaments and tendons, [[ophthalmic]] ultrasound (eye) scans and superficial structures such as [[testicle]], [[thyroid]], [[salivary glands]] and [[lymph nodes]].  Because of the real time nature of ultrasound, it is often used to guide interventional procedures such as fine needle aspiration [[FNA]] or [[biopsy]] of masses for [[cytology]] or [[histology]] testing in the breast, thyroid, liver, kidney, lymph nodes, muscles and joints.


Ultrasound scanners using pulsed wave and colour [[Doppler]] are used to visualize arteries and veins.
Ultrasound scanners using pulsed wave and colour [[Doppler]] are used to visualize arteries and veins.
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==Biomedical ultrasonic applications==
==Biomedical ultrasonic applications==
Ultrasound also has therapeutic applications, which can be highly beneficial when used with dosage precautions:<ref>''Essentials of Medical Ultrasound: A Practical Introduction to the Principles, Techniques and Biomedical Applications'', edited by M. H. Rapacholi, Humana Press 1982</ref>
Ultrasound also has therapeutic applications, which can be highly beneficial when used with dosage precautions:<ref>''Essentials of Medical Ultrasound: A Practical Introduction to the Principles, Techniques and Biomedical Applications'', edited by M. H. Rapacholi, Humana Press 1982</ref>
* According to RadiologyInfo <ref>{{cite web |url=http://www.radiologyinfo.org/en/info.cfm?pg=pelvus&bhcp=1 | title=Ultrasound - Pelvis}}</ref>, ultrasounds are useful in the detection of Pelvic abnormalities and can involve techniques known as [[abdominal]] (transabdominal) ultrasound, [[vaginal]] (transvaginal or endovaginal) ultrasound in women, and also [[rectal]] (transrectal) ultrasound in men.
* According to RadiologyInfo <ref>{{cite web |url=http://www.radiologyinfo.org/en/info.cfm?pg=pelvus&bhcp=1 | title=Ultrasound - Pelvis}}</ref>, ultrasounds are useful in the detection of Pelvic abnormalities and can involve techniques known as [[abdominal]] (transabdominal) ultrasound, [[vaginal]] (transvaginal or endovaginal) ultrasound in women, and also [[rectal]] (transrectal) ultrasound in men.


*Treating benign and malignant tumors and other disorders, via a process known as '''Focused Ultrasound Surgery (FUS)''' or '''[[HIFU]], High Intensity Focused Ultrasound'''.  These procedures generally use lower frequencies than medical diagnostic ultrasound (from 250 kHz to 2000 kHz), but significantly higher time-averaged intensities.  The treatment is often guided by [[MRI]], as in [[Magnetic Resonance guided Focused Ultrasound]].
*Treating benign and malignant tumors and other disorders, via a process known as '''Focused Ultrasound Surgery (FUS)''' or '''[[HIFU]], High Intensity Focused Ultrasound'''.  These procedures generally use lower frequencies than medical diagnostic ultrasound (from 250 kHz to 2000 kHz), but significantly higher time-averaged intensities.  The treatment is often guided by [[MRI]], as in [[Magnetic Resonance guided Focused Ultrasound]].
*[[Therapeutic ultrasound]], a technique that uses more powerful ultrasound sources to generate local heating in biological tissue, e.g. in [[occupational therapy]], [[physical therapy]] and [[experimental cancer treatment|cancer treatment]].


* Delivering chemotherapy to brain cancer cells and various drugs to other tissues, via a process known as ''' [[Acoustic Targeted Drug Delivery]] '''<ref>{{cite web |url=http://scitation.aip.org/vsearch/servlet/VerityServlet?KEY=ASADL&smode=strresults&sort=rel&maxdisp=25&threshold=0&pjournals=ARLOFJ%2CJASMAN%2CNOCOAN%2CSOUCAU%2CPMARCW%2CASASTR&possible1=george+lewis&possible1zone=article&OUTLOG=NO&viewabs=JASMAN&key=DISPLAY&docID=1&page=0&chapter=0| title=Acoustic targeted drug delivery in neurological tissue }}</ref> These procedures generally use high frequency ultrasound (from 1 MHz to 10 MHz) and a range of intensities from 0-20 watts/cm<sup>2</sup>. The acoustic energy is focused on the tissue of interest to agitate its matrix and make it more permiable to therapeutic drugs.<ref>{{cite web |url=http://www.ieeexplore.ieee.org/xpl/freeabs_all.jsp?isnumber=4400869&arnumber=4400886&count=67&index=16| title= A phantom feasibility study of acoustic enhanced drug delivery to neurological tissue }}</ref><ref>{{cite web |url=http://www.eurekalert.org/pub_releases/2007-11/aiop-hou110607.php| title=Acoustics and brain cancer }}</ref> [[Image:ATDD_Topical_Application.jpg‎ |thumb|right|Enhanced drug uptake using [[Acoustic Targeted Drug Delivery]]]]
*[[Therapeutic ultrasound]], a technique that uses more powerful ultrasound sources to generate local heating in biological tissue, e.g. in [[occupational therapy]], [[physical therapy]] and [[experimental cancer treatment|cancer treatment]].
*[[Therapeutic ultrasound]], a technique that uses more powerful ultrasound sources to generate local heating in biological tissue, e.g. in [[occupational therapy]], [[physical therapy]] and [[experimental cancer treatment|cancer treatment]].
*Cleaning teeth in [[dental hygienist|dental hygiene]].
*Focused ultrasound sources may be used for [[cataract]] treatment by [[phacoemulsification]].
*Additional physiological effects of low-intensity ultrasound have recently been discovered, e.g. the ability to stimulate bone-growth and its potential to disrupt the [[blood-brain barrier]] for drug delivery.
*Ultrasound is used in [[UAL]] (= ultrasound-assisted [[lipectomy]]), or [[liposuction]].
*Doppler ultrasound is being tested for use in aiding [[tissue plasminogen activator]] treatment in [[stroke]] sufferers.  This procedure is called [[Ultrasound-Enhanced Systemic Thrombolysis]].
*[[Low intensity pulsed ultrasound]] is used for therapeutic tooth and bone regeneration.
*Ultrasound can also be used for [[elastography]].  This can be useful in medical diagnoses, as elasticity can discern healthy from unhealthy tissue for specific organs/growths.  In some cases unhealthy tissue may have a lower system [[Q factor|Q]], meaning that the system acts more like a large heavy spring as compared to higher values of system Q (healthy tissue) that respond to higher forcing frequencies.  Ultrasonic elastography is different from conventional ultrasound, as a transceiver (pair) and a transmitter are used instead of only a transceiver.  One transducer (a single element {or array of elements} acts as both the transmitter and receiver to image the region of interest over time.  The extra transmitter is a very low frequency transmitter, and perturbs the system so the unhealthy tissue oscillates at a low frequency and the healthy tissue does not.  The transceiver, which operates at a high frequency (typically MHz) then measures the displacement of the unhealthy tissue (oscillating at a much lower frequency).  The movement of the slowly oscillating tissue is used to determine the elasticity of the material, which can then be used to distinguish healthy tissue from the unhealthy tissue.
*Ultrasound has been shown to act synergistically with antibiotics in bacterial cell killing.<ref>{{cite web | url=http://jba.sagepub.com/cgi/content/refs/18/4/237 | title=Citation list}}</ref>
*Ultrasound has been postulated to allow thicker eukaryotic cell tissue cultures by promoting nutrient penetration.[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12790676 Scientific Article]
*Ultrasound in the low MHz range in the form of [[standing wave]]s is an emerging tool for contactless separation, concentration and manipulation of microparticles and [[Cell (biology)|biological cells]].  The basis is the acoustic radiation force, a [[non-linear]] effect which causes particles to be attracted to either the [[Node (physics)|nodes]] or [[Node (physics)|anti-nodes]] of the standing wave depending on the [[acoustic contrast factor]], which is a [[Function (mathematics)|function]] of the [[Sound speed|sound velocities]] and [[density|densities]] of the particle and of the medium in which the particle is immersed.


==Industrial ultrasound==
* Delivering chemotherapy to brain cancer cells and various drugs to other tissues, via a process known as ''' [[Acoustic Targeted Drug Delivery]] '''<ref>{{cite web |url=http://scitation.aip.org/vsearch/servlet/VerityServlet?KEY=ASADL&smode=strresults&sort=rel&maxdisp=25&threshold=0&pjournals=ARLOFJ%2CJASMAN%2CNOCOAN%2CSOUCAU%2CPMARCW%2CASASTR&possible1=george+lewis&possible1zone=article&OUTLOG=NO&viewabs=JASMAN&key=DISPLAY&docID=1&page=0&chapter=0| title=Acoustic targeted drug delivery in neurological tissue }}</ref> These procedures generally use high frequency ultrasound (from 1 MHz to 10 MHz) and a range of intensities from 0-20 watts/cm<sup>2</sup>. The acoustic energy is focused on the tissue of interest to agitate its matrix and make it more permeable to therapeutic drugs.<ref>{{cite web |url=http://www.ieeexplore.ieee.org/xpl/freeabs_all.jsp?isnumber=4400869&arnumber=4400886&count=67&index=16| title= A phantom feasibility study of acoustic enhanced drug delivery to neurological tissue }}</ref><ref>{{cite web |url=http://www.eurekalert.org/pub_releases/2007-11/aiop-hou110607.php| title=Acoustics and brain cancer }}</ref> [[Image:ATDD_Topical_Application.jpg‎ |thumb|right|Enhanced drug uptake using [[Acoustic Targeted Drug Delivery]]]]  
{{main|Ultrasonic testing}}
[[Image:Swing shaft spline cracking.png|thumb|right|Non-destructive testing of a swing shaft showing [[spline]] cracking]]
[[Ultrasonic testing]] is a type of [[nondestructive testing]] commonly used to find flaws in materials and to measure the thickness of objects. Frequencies of 2 to 10 MHz are common but for special purposes other frequencies are used. Inspection may be manual or automated and is an essential part of modern manufacturing processes. Most [[metal]]s can be inspected as well as [[plastics]] and [[aerospace]] [[composites]]. Lower frequency ultrasound (50 kHz to 500 kHz) can also be used to inspect less dense materials such as [[wood]], [[concrete]] and [[cement]].


Ultrasound can also be used for heat transfer in liquids.<ref>Milton B. Larson, ''Study of the Effects of Ultrasonic Vibrations on Convective Heat Transfer in Liquids'', (1960)</ref>
*Cleaning teeth in [[dental hygienist|dental hygiene]].


Researchers recently employed ultrasound in dry corn milling plant to enhance ethanol production.<ref>http://www.businessweek.com/magazine/content/06_27/c3991080.htm</ref>
*Focused ultrasound sources may be used for [[cataract]] treatment by [[phacoemulsification]].


==Ultrasonic cleaning==
*Additional physiological effects of low-intensity ultrasound have recently been discovered, e.g. the ability to stimulate bone-growth and its potential to disrupt the [[blood-brain barrier]] for drug delivery.
[[Ultrasonic cleaner]]s, sometimes mistakenly called ''[[supersonic]] cleaners'', are used at frequencies from 20-40 [[Hertz|kHz]] for [[jewellery]], [[lens (optics)|lenses]] and other optical parts, [[watch]]es, [[dentistry|dental instrument]]s, [[surgical instrument]]s and [[Industry|industrial]] parts. An ultrasonic cleaner works mostly by energy released from the collapse of millions of microscopic [[cavitation]]s near the dirty surface.  The bubbles made by [[cavitation]] collapse forming tiny jets directed at the surface.  Home ultrasonic cleaners are available and cost about US $60 or more.


==Ultrasonic humidifier==
*Ultrasound is used in UAL (ultrasound-assisted [[lipectomy]]), or [[liposuction]].
The ultrasonic [[Humidifier|humidifier]] is one popular type of humidifier.  It  works by vibrating a metal plate at ultrasonic frequencies to atomize the water.  Because the water is not heated for evaporation, it  produces a cool mist.  The ultrasonic pressure waves atomize not only the water but also materials in the water including calcium, other minerals, viruses, fungi, bacteria<ref>[http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&uid=1488018&cmd=showdetailview&indexed=google Microbial contamination by ultrasonic humidifier]</ref>, and other impurities.  Illness caused by impurities that reside in a humidifier's reservoir fall under the heading of "Humidifier Fever".


==Ultrasound and animals==
*Doppler ultrasound is being tested for use in aiding [[tissue plasminogen activator]] treatment in [[stroke]] sufferers.  This procedure is called [[Ultrasound-Enhanced Systemic Thrombolysis]].
===Bats===
[[Bat]]s use a variety of ultrasonic ranging ([[Animal echolocation|echolocation]]) techniques to detect their prey.  They can detect frequencies as high as 100 kHz, although there is some disagreement on the upper limit.<ref>{{cite web|url=http://hypertextbook.com/facts/1998/JuanCancel.shtml|title=Frequency of Bat Sonar|work=The Physics Factbook|last=Cancel|first=Juan|year=1998}}</ref>


===Dogs===
*[[Low intensity pulsed ultrasound]] is used for therapeutic tooth and bone regeneration.
[[Dog]]s can hear sound at higher frequencies than humans can.  A [[dog whistle]] exploits this by emitting a high frequency sound to call to a dog.  Many dog whistles emit sound in the upper audible range, but some, such as the '''silent whistle''', emit ultrasound at a frequency in the range of 18 kHz to 22 kHz.


===Dolphins and whales===
*Ultrasound can also be used for [[elastography]].  This can be useful in medical diagnoses, as elasticity can discern healthy from unhealthy tissue for specific organs/growths.  In some cases unhealthy tissue may have a lower system Q, meaning that the system acts more like a large heavy spring as compared to higher values of system Q (healthy tissue) that respond to higher forcing frequencies.  Ultrasonic elastography is different from conventional ultrasound, as a transceiver (pair) and a transmitter are used instead of only a transceiver.  One transducer (a single element {or array of elements} acts as both the transmitter and receiver to image the region of interest over time.  The extra transmitter is a very low frequency transmitter, and perturbs the system so the unhealthy tissue oscillates at a low frequency and the healthy tissue does not.  The transceiver, which operates at a high frequency (typically MHz) then measures the displacement of the unhealthy tissue (oscillating at a much lower frequency).  The movement of the slowly oscillating tissue is used to determine the elasticity of the material, which can then be used to distinguish healthy tissue from the unhealthy tissue.  
It is well known that some whales can hear ultrasound and have their own natural [[sonar]] system.  Some whales use the ultrasound as a hunting tool (for both detection of prey and as an attack).


===Fish===
*Ultrasound has been shown to act synergistically with antibiotics in bacterial cell killing.<ref>{{cite web | url=http://jba.sagepub.com/cgi/content/refs/18/4/237 | title=Citation list}}</ref>
Several types of fish can detect ultrasound.  Of the order [[Clupeiformes]], members of the subfamily [[Alosinae]] ([[shad]]), have been shown to be able to detect sounds up to 180 kHz, while the other subfamilies (e.g. [[herring]]s) can hear only up to 4 kHz.<ref>Mann DA, et al. (2001) Ultrasound detection by clupeiform fishes. JASA 109 (6), 3048-3054 | doi:10.1121/1.1368406</ref>


===Moths===
*Ultrasound has been postulated to allow thicker eukaryotic cell tissue cultures by promoting nutrient penetration.[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12790676 Scientific Article]
There is evidence that ultrasound in the range emitted by [[bat]]s causes flying [[moth]]s to make evasive manoeuvres because bats eat moths.  Ultrasonic frequencies trigger a reflex action in the [[noctuid]] moth that cause it to drop a few inches in its flight to evade attack. [http://www.irysec.vic.edu.au/sci/goneill/butterflyevo.htm]


===Rodents/insects===
*Ultrasound in the low MHz range in the form of [[standing wave]]s is an emerging tool for contactless separation, concentration and manipulation of microparticles and [[Cell (biology)|biological cells]].  The basis is the acoustic radiation force, a [[non-linear]] effect which causes particles to be attracted to either the [[Node (physics)|nodes]] or [[Node (physics)|anti-nodes]] of the standing wave depending on the [[acoustic contrast factor]], which is a [[Function (mathematics)|function]] of the [[Sound speed|sound velocities]] and [[density|densities]] of the particle and of the medium in which the particle is immersed.
Ultrasound generator/speaker systems are sold with claims that they frighten away [[rodent]]s and [[insect]]s, but there is no scientific evidence that the devices work.  Laboratory tests conducted by Kansas State University did show positive results for products from specific manufacturers.  Controlled tests on some of the systems have shown that rodents quickly learn that the speakers are harmless.  The positive results (Kansas State University) were limited to units which use constantly modulating frequencies . The frequency used however is often within the range that most children can hear, and can cause [[headache]]s.
 
===Mosquitoes===
There is a theory that ultrasound of certain frequencies, while not audible to humans, can repel mosquitoes.  There are computer programs available on the internet that claim to use this phenomenon for pest control.  There have been mixed reports about the effectiveness of this method towards mosquito control.
These claims are made questionable by the fact that most if not all computer speakers and the soundcards that drive them are incapable of producing sound far beyond the upper and lower ranges of human hearing.
 
==Sonochemistry==
{{main|Sonochemistry}}
Power ultrasound in the 20-100 kHz range is used in [[chemistry]].  The ultrasound does not interact directly with [[molecule]]s to induce the chemical change, as its typical wavelength (in the millimeter range) is too long compared to the molecules.  Instead:
*It causes [[cavitation]] which causes local extremes of temperature and pressure in the liquid where the reaction happens.
*It breaks up solids and removes [[passivation|passivating]] layers of [[inert]] material to give a larger [[surface area]] for the reaction to occur over.
Both of these make the reaction faster.
 
==Ultrasonic disintegration==
Some sorts of ultrasound can disintegrate [[Cell (biology)|biological cell]]s including [[bacteria]].  This has uses in [[Biology|biological science]] and in killing bacteria in [[sewage]].  High power ultrasound at frequency of around 20 kHz produces cavitation that facilitates particle disintegration.  Dr. Samir Khanal of Iowa State University employed high power ultrasound to disintegrate corn slurry to enhance liquefaction and saccharification for higher ethanol yield in dry corn milling plants.
 
See examples:-
*[http://www.iwaponline.com/ws/00606/ws006060035.htm Ultrasound pre-treatment of waste activated sludge]
*[http://www.ccee.iastate.edu/research/projects/projectid/1140535067 Retooling ethanol industries: integrating ultrasonics into dry corn milling to enhance ethanol yield]
*[http://www.iwaponline.com/wst/04209/wst042090073.htm Enhancement of anaerobic sludge digestion by ultrasonic disintegration]
 
==Ultrasonic range finding==
{{main|sonar}}
A common use of ultrasound is in [[range finding]]; this use is also called [[SONAR]], (sound navigation and ranging).  This works similarly to [[RADAR]] (radio detection and ranging): An ultrasonic pulse is generated in a particular direction.  If there is an object in the path of this pulse, part or all of the pulse will be reflected back to the transmitter as an [[Echo (phenomenon)|echo]] and can be detected through the receiver path.  By measuring the difference in time between the pulse being transmitted and the echo being received, it is possible to determine how far away the object is.
 
The measured travel time of SONAR pulses in water is strongly dependent on the temperature and the salinity of the water.  Ultrasonic ranging is also applied for measurement in air and for short distances.  Such method is capable for easily and rapidly measuring the layout of rooms.
 
Although range finding underwater is performed at both sub-audible and audible frequencies for great distances (1 to several ten kilometers), ultrasonic range finding is used when distances are shorter and the accuracy of the distance measurement is desired to be finer.  Ultrasonic measurements may be limited through barrier layers with large salinity, temperature or vortex differentials.  Ranging in water varies from about hundreds to thousands of meters, but can be performed with centimeters to meters accuracy.
 
==Other uses==
Ultrasound when applied in specific configurations can produce short bursts of light in an exotic phenomenon known as [[sonoluminescence]]. This phenomenon is being investigated partly because of the possibility of [[bubble fusion]] (a [[nuclear fusion]] reaction hypothesized to occur during sonoluminescence).
 
Recently researchers at the [[University of Alberta]] in Canada have successfully used ultrasound to regenerate dental material.
 
Ultrasound is used when characterizing particulates through the technique of [[ultrasound attenuation spectroscopy]] or by observing [[electroacoustic phenomena]].
 
In [[rheology]], an [[acoustic rheometer]] relies on the principle of ultrasound. In [[fluid mechanics]], fluid flow can be measured using an [[ultrasound flow meter]].
 
Ultrasound also plays a role in [[Sonic weaponry]].
 
Audio can be propagated by [[modulated ultrasound]].
 
==Nonlinear propagation effects== 
Because of their high amplitude to wavelength ratio, ultrasonic waves commonly display [[Nonlinear Acoustics|nonlinear propagation]].


==See also==
==See also==
*[[Acoustics]]
*[[Acoustics]]
*[[Infrasound]] — sound at extremely low frequencies
*[[Infrasound]] — sound at extremely low frequencies
*[[Sound from ultrasound]] (also known as Hypersonic sound)
*[[Medical ultrasonography]]
*[[Medical ultrasonography]]
*[[Picosecond Ultrasonics]]
*[[Picosecond Ultrasonics]]
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==Further reading==
* Kundu, Tribikram. ''Ultrasonic nondestructive evaluation : engineering and biological material characterization''. Boca Raton, FL: CRC Press, c2004. ISBN 0849314623.
[[Category:Hearing]]
[[Category:Acoustics]]
[[Category:Ultrasound|Ultrasound]]
[[Category:Ultrasound|Ultrasound]]
[[Category:Medical physics]]
[[Category:Radiology]]
[[Category:Medical ultrasound]]
[[Category:Medical ultrasound]]
[[Category:Emergency medicine]]
[[Category:Obstetrics]]
[[Category:Gynecology]]
[[Category:Gastroenterology]]
[[Category:Hepatology]]


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Latest revision as of 23:36, 21 November 2014

Approximate frequency ranges corresponding to ultrasound, with rough guide of some applications
A fetus in its mother's womb, viewed in a sonogram (brightness scan)

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Editor(s)-in-Chief: C. Michael Gibson, M.S.,M.D. [2] Phone:617-632-7753; Casey Glass, M.D. [3]

Overview

Ultrasound is cyclic sound pressure with a frequency greater than the upper limit of human hearing. Although this limit varies from person to person, it is approximately 20 kilohertz (20,000 hertz) in healthy, young adults and thus, 20 kHz serves as a useful lower limit in describing ultrasound. Ultrasound is manually produced in many different fields, typically to penetrate a medium and measure the reflection signature or supply focused energy. The reflection signature can reveal details about the inner structure of the medium. The most well known application of this technique is its use in sonography to produce pictures of fetuses in the human womb. There are a vast number of other applications as well.

Ability to hear ultrasound

The upper frequency limit in humans (approximately 20 kHz) is caused by the middle ear, which acts as a low-pass filter. If ultrasound is fed directly into the skull bone and reaches the cochlea without passing through the middle ear, much higher frequencies can be heard. This effect is discussed in ultrasonic hearing. Carefully-designed scientific studies have been performed and confirmed what they call the hypersonic effect - that even without consciously hearing it, high-frequency sound can have a measurable effect on the mind.

It is a fact in psychoacoustics that children can hear some high-pitched sounds that older adults cannot hear, because in humans the upper limit pitch of hearing tends to become lower with age.[1] [2] A cell phone company has used this to create ring signals supposedly only able to be heard by younger humans[3]; but many older people claim to be able to hear it, which is likely given the considerable variation of age-related deterioration in the upper hearing threshold.

Some animals – such as dogs, cats, dolphins, bats, and mice have an upper frequency limit that is greater than that of the human ear and thus can hear ultrasound.

Diagnostic sonography

Main article: Medical ultrasonography

Medical sonography (ultrasonography) is an ultrasound-based diagnostic medical imaging technique used to visualize muscles, tendons, and many internal organs, their size, structure and any pathological lesions with real time tomographic images. It is also used to visualize a fetus during routine and emergency prenatal care. Ultrasound scans are performed by medical health care professionals called sonographers. Obstetric sonography is commonly used during pregnancy. Ultrasound has been used to image the human body for at least 50 years. It is one of the most widely used diagnostic tools in modern medicine. The technology is relatively inexpensive and portable, especially when compared with modalities such as magnetic resonance imaging(MRI) and computed tomography (CT). As currently applied in the medical environment, ultrasound poses no known risks to the patient.[4]

Sonogram of a fetus at 14 weeks (Profile)

Sonography is generally described as a "safe test" because it does not use ionizing radiation, which imposes hazards, such as cancer production and chromosome breakage. However, ultrasonic energy has two potential physiological effects: it enhances inflammatory response; and it can heat soft tissue.[5] Ultrasound energy produces a mechanical pressure wave through soft tissue. This pressure wave may cause microscopic bubbles in living tissues, and distortion of the cell membrane, influencing ion fluxes and intracellular activity. When ultrasound enters the body, it causes molecular friction and heats the tissues slightly. This effect is very minor as normal tissue perfusion dissipates heat. With high intensity, it can also cause small pockets of gas in body fluids or tissues to expand and contract/collapse in a phenomenon called cavitation (this is not known to occur at diagnostic power levels used by modern diagnostic ultrasound units). The long-term effects of tissue heating and cavitation are not known.[6] There are several studies that indicate the harmful side effects on animal fetuses associated with the use of sonography on pregnant mammals. A noteworthy study in 2006 suggests exposure to ultrasound can affect fetal brain development in mice. This misplacement of brain cells during their development is linked to disorders ranging "from mental retardation and childhood epilepsy to developmental dyslexia, autism spectrum disorders and schizophrenia, the researchers said. [7]

A fetus, aged 29 weeks, in a "3D ultrasound"

There is no link made yet between the test results on animals, such as mice, and the possible outcome to humans. Widespread clinical use of diagnostic ultrasound testing on humans has not been done for ethical reasons. The possibility exists that biological effects may be identified in the future, currently most doctors feel that based on available information the benefits to patients outweigh the risks.[8] Obstetric ultrasound can be used to identify many conditions that would be harmful to the mother and the baby. For this reason many health care professionals consider that the risk of leaving these conditions undiagnosed is much greater than the very small risk, if any, associated with undergoing the scan. According to Cochrane review, routine ultrasound in early pregnancy (less than 24 weeks) appears to enable better gestational age assessment, earlier detection of multiple pregnancies and earlier detection of clinically unsuspected fetal malformation at a time when termination of pregnancy is possible.[9]

Sonography is used routinely in obstetric appointments during pregnancy, but the FDA discourages its use for non-medical purposes such as fetal keepsake videos and photos, even though it is the same technology used in hospitals.

Obstetric ultrasound is primarily used to:

  • Date the pregnancy (gestational age)
  • Confirm fetal viability
  • Determine location of fetus, intrauterine vs ectopic
  • Check the location of the placenta in relation to the cervix
  • Check for the number of fetuses (multiple pregnancy)
  • Check for major physical abnormalities.
  • Assess fetal growth (for evidence of intrauterine growth restriction (IUGR))
  • Check for fetal movement and heartbeat.
  • Determine the sex of the baby

Unfortunately, results are occasionally wrong, producing a false positive (the Cochrane Collaboration is a relevant effort to improve the reliability of health care trials). False detection may result in patients being warned of birth defects when no such defect exists. Sex determination is only accurate after 12 weeks gestation [Ultrasound in Obstetrics and Gynecology 1999]. When balancing risk and reward, there are recommendations to avoid the use of routine ultrasound for low risk pregnancies [ACOG]. In many countries ultrasound is used routinely in the management of all pregnancies.

According to European Committee of Medical Ultrasound Safety (ECMUS) "Ultrasonic examinations should only be performed by competent personnel who are trained and updated in safety matters. Ultrasound produces heating, pressure changes and mechanical disturbances in tissue. Diagnostic levels of ultrasound can produce temperature rises that are hazardous to sensitive organs and the embryo/fetus. Biological effects of non-thermal origin have been reported in animals but, to date, no such effects have been demonstrated in humans, except when a microbubble contrast agent is present."[10]

A study on rodent fetus brains that are exposed to ultrasound showed signs of damage. Speculation on human fetuses can be in a range of no significant complications to a variety of mental and brain disorders. The study shows that rodent brain cells failed to grow to their proper position and remained scattered in incorrect parts of the brain. The conditions of this experiment are different from typical fetal scanning because of the long dwell times. [National Institute of Neurological Disorders; Proceedings of the National Academy of Sciences]. Care should be taken to use low power settings and avoid pulsed wave scanning of the fetal brain unless specifically indicated in high risk pregnancies.

It should be noted that obstetrics is not the only use of ultrasound. Soft tissue imaging of many other parts of the body is conducted with ultrasound. Other scans routinely conducted are cardiac, renal, liver and gallbladder (hepatic). Other common applications include musculo-skeletal imaging of muscles, ligaments and tendons, ophthalmic ultrasound (eye) scans and superficial structures such as testicle, thyroid, salivary glands and lymph nodes. Because of the real time nature of ultrasound, it is often used to guide interventional procedures such as fine needle aspiration FNA or biopsy of masses for cytology or histology testing in the breast, thyroid, liver, kidney, lymph nodes, muscles and joints.

Ultrasound scanners using pulsed wave and colour Doppler are used to visualize arteries and veins.

Figures released for the period 2005-2006 by UK Government (Department of Health) show that non-obstetric ultrasound examinations contributed to more than 65% of the total number of ultrasound scans conducted.

Biomedical ultrasonic applications

Ultrasound also has therapeutic applications, which can be highly beneficial when used with dosage precautions:[11]

  • According to RadiologyInfo [12], ultrasounds are useful in the detection of Pelvic abnormalities and can involve techniques known as abdominal (transabdominal) ultrasound, vaginal (transvaginal or endovaginal) ultrasound in women, and also rectal (transrectal) ultrasound in men.
  • Treating benign and malignant tumors and other disorders, via a process known as Focused Ultrasound Surgery (FUS) or HIFU, High Intensity Focused Ultrasound. These procedures generally use lower frequencies than medical diagnostic ultrasound (from 250 kHz to 2000 kHz), but significantly higher time-averaged intensities. The treatment is often guided by MRI, as in Magnetic Resonance guided Focused Ultrasound.
  • Delivering chemotherapy to brain cancer cells and various drugs to other tissues, via a process known as Acoustic Targeted Drug Delivery [13] These procedures generally use high frequency ultrasound (from 1 MHz to 10 MHz) and a range of intensities from 0-20 watts/cm2. The acoustic energy is focused on the tissue of interest to agitate its matrix and make it more permeable to therapeutic drugs.[14][15]
    Enhanced drug uptake using Acoustic Targeted Drug Delivery
  • Additional physiological effects of low-intensity ultrasound have recently been discovered, e.g. the ability to stimulate bone-growth and its potential to disrupt the blood-brain barrier for drug delivery.
  • Ultrasound can also be used for elastography. This can be useful in medical diagnoses, as elasticity can discern healthy from unhealthy tissue for specific organs/growths. In some cases unhealthy tissue may have a lower system Q, meaning that the system acts more like a large heavy spring as compared to higher values of system Q (healthy tissue) that respond to higher forcing frequencies. Ultrasonic elastography is different from conventional ultrasound, as a transceiver (pair) and a transmitter are used instead of only a transceiver. One transducer (a single element {or array of elements} acts as both the transmitter and receiver to image the region of interest over time. The extra transmitter is a very low frequency transmitter, and perturbs the system so the unhealthy tissue oscillates at a low frequency and the healthy tissue does not. The transceiver, which operates at a high frequency (typically MHz) then measures the displacement of the unhealthy tissue (oscillating at a much lower frequency). The movement of the slowly oscillating tissue is used to determine the elasticity of the material, which can then be used to distinguish healthy tissue from the unhealthy tissue.
  • Ultrasound has been shown to act synergistically with antibiotics in bacterial cell killing.[16]
  • Ultrasound has been postulated to allow thicker eukaryotic cell tissue cultures by promoting nutrient penetration.Scientific Article

See also

References

  1. ↑ Takeda S et al (1992)
  2. ↑ "Age variation in the upper limit of hearing".European Journal of Applied Physiology 65(5), 403-408
  3. ↑ "A Ring Tone Meant to Fall on Deaf Ears" (New York Times article)
  4. ↑ [1]
  5. ↑ Watson, T. (2006). "Therapeutic Ultrasound". (see here for a pdf version with the author and date information)
  6. ↑ http://www.fda.gov/cdrh/radhealth/products/ultrasound-imaging.html
  7. ↑ http://www.livescience.com/health/060807_ap_baby_ultrasound.html
  8. ↑ http://www.aium.org/patient/aboutExam/safety.asp
  9. ↑ "Ultrasound for fetal assessment in early pregnancy".
  10. ↑ http://www.efsumb.org/efsumb/committees/Safety_Committee/Safety_Eng/Clinical%20Safety%20Statement%202006.pdf
  11. ↑ Essentials of Medical Ultrasound: A Practical Introduction to the Principles, Techniques and Biomedical Applications, edited by M. H. Rapacholi, Humana Press 1982
  12. ↑ "Ultrasound - Pelvis".
  13. ↑ "Acoustic targeted drug delivery in neurological tissue".
  14. ↑ "A phantom feasibility study of acoustic enhanced drug delivery to neurological tissue".
  15. ↑ "Acoustics and brain cancer".
  16. ↑ "Citation list".

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