Thrombosis natural history, complications and prognosis
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Thrombosis Microchapters |
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Site of Thrombosis |
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Differentiating Thrombosis from other Diseases |
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Diagnosis |
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Treatment |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editors-in-Chief: Ujjwal Rastogi, MBBS [2]
Overview
A stable thrombus when dislodged from its place is called an Embolus (pleural Emboli). Without an infection, the thrombus may become detached and enter circulation as an embolus, finally lodging in and completely obstructing a blood vessel (an infarction). The effects of an infarction depend on where it occurs.
Most thrombi, however, become organized into fibrous tissue, and the thrombosed vessel is gradually recanalized. If a bacterial infection is present at the site of thrombosis, the thrombus may break down, spreading particles of infected material (septic embolus) throughout the circulatory system and setting up metastatic abscesses wherever they come to rest. This might cause pyemia.
The major outcomes of thrombosis are death, recurrence, post-thrombotic syndrome and major bleeding due to anticoagulation. Thrombosis is also associated with impaired quality of life, particularly when post-thrombotic syndrome develops. Death occurs within one month of an episode in about 6% of those with Deep Venous Thrombosis and 10% of those with Pulmonary Embolism
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