TNFRSF19: Difference between revisions

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'''Tumor necrosis factor receptor superfamily, member 19''', also known as '''TNFRSF19''' and '''TROY''' is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TNFRSF19 tumor necrosis factor receptor superfamily, member 19| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55504| accessdate = }}</ref>
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| image = 
| image_source = 
| PDB =
| Name = Tumor necrosis factor receptor superfamily, member 19
| HGNCid = 11915
| Symbol = TNFRSF19
| AltSymbols =; TAJ; TAJ-alpha; TRADE; TROY
| OMIM = 606122
| ECnumber = 
| Homologene = 8481
| MGIid = 1352474
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005031 |text = tumor necrosis factor receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0006917 |text = induction of apoptosis}} {{GNF_GO|id=GO:0007254 |text = JNK cascade}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 55504
    | Hs_Ensembl = ENSG00000127863
    | Hs_RefseqProtein = NP_061117
    | Hs_RefseqmRNA = NM_018647
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 13
    | Hs_GenLoc_start = 23042723
    | Hs_GenLoc_end = 23148232
    | Hs_Uniprot = Q9NS68
    | Mm_EntrezGene = 29820
    | Mm_Ensembl = ENSMUSG00000060548
    | Mm_RefseqmRNA = NM_013869
    | Mm_RefseqProtein = NP_038897
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 14
    | Mm_GenLoc_start = 59924933
    | Mm_GenLoc_end = 59978922
    | Mm_Uniprot = Q80T13
  }}
}}
'''Tumor necrosis factor receptor superfamily, member 19''', also known as '''TNFRSF19''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TNFRSF19 tumor necrosis factor receptor superfamily, member 19| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55504| accessdate = }}</ref>


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| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is highly expressed during embryonic development. It has been shown to interact with TRAF family members, and to activate JNK signaling pathway when overexpressed in cells. This receptor is capable of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. Alternatively spliced transcript variants encoding distinct isoforms have been described.<ref name="entrez">{{cite web | title = Entrez Gene: TNFRSF19 tumor necrosis factor receptor superfamily, member 19| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55504| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is highly expressed during embryonic development. It has been shown to interact with TRAF family members, and to activate JNK signaling pathway when overexpressed in cells. This receptor is capable of inducing [[apoptosis]] by a [[caspase]]-independent mechanism, and it is thought to play an essential role in embryonic development. Alternatively, spliced transcript variants encoding distinct [[isoform]]s have been described.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
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| citations =  
| citations =  
*{{cite journal | author=Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, ''et al.'' |title=Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening. |journal=Genomics |volume=23 |issue= 1 |pages= 42-50 |year= 1995 |pmid= 7829101 |doi= 10.1006/geno.1994.1457 }}
*{{cite journal   |vauthors=Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, etal |title=Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening |journal=Genomics |volume=23 |issue= 1 |pages= 42–50 |year= 1995 |pmid= 7829101 |doi= 10.1006/geno.1994.1457 }}
*{{cite journal | author=Kojima T, Morikawa Y, Copeland NG, ''et al.'' |title=TROY, a newly identified member of the tumor necrosis factor receptor superfamily, exhibits a homology with Edar and is expressed in embryonic skin and hair follicles. |journal=J. Biol. Chem. |volume=275 |issue= 27 |pages= 20742-7 |year= 2000 |pmid= 10764796 |doi= 10.1074/jbc.M002691200 }}
*{{cite journal   |vauthors=Kojima T, Morikawa Y, Copeland NG, etal |title=TROY, a newly identified member of the tumor necrosis factor receptor superfamily, exhibits a homology with Edar and is expressed in embryonic skin and hair follicles |journal=J. Biol. Chem. |volume=275 |issue= 27 |pages= 20742–7 |year= 2000 |pmid= 10764796 |doi= 10.1074/jbc.M002691200 }}
*{{cite journal | author=Eby MT, Jasmin A, Kumar A, ''et al.'' |title=TAJ, a novel member of the tumor necrosis factor receptor family, activates the c-Jun N-terminal kinase pathway and mediates caspase-independent cell death. |journal=J. Biol. Chem. |volume=275 |issue= 20 |pages= 15336-42 |year= 2000 |pmid= 10809768 |doi=  }}
*{{cite journal   |vauthors=Eby MT, Jasmin A, Kumar A, etal |title=TAJ, a novel member of the tumor necrosis factor receptor family, activates the c-Jun N-terminal kinase pathway and mediates caspase-independent cell death |journal=J. Biol. Chem. |volume=275 |issue= 20 |pages= 15336–42 |year= 2000 |pmid= 10809768 |doi=10.1074/jbc.275.20.15336 }}
*{{cite journal | author=Naito A, Yoshida H, Nishioka E, ''et al.'' |title=TRAF6-deficient mice display hypohidrotic ectodermal dysplasia. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 13 |pages= 8766-71 |year= 2002 |pmid= 12060722 |doi= 10.1073/pnas.132636999 }}
*{{cite journal   |vauthors=Naito A, Yoshida H, Nishioka E, etal |title=TRAF6-deficient mice display hypohidrotic ectodermal dysplasia |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 13 |pages= 8766–71 |year= 2002 |pmid= 12060722 |doi= 10.1073/pnas.132636999 | pmc=124373 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Clark HF, Gurney AL, Abaya E, ''et al.'' |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265-70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 }}
*{{cite journal   |vauthors=Clark HF, Gurney AL, Abaya E, etal |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 | pmc=403697 }}
*{{cite journal  | author=Zhang Z, Henzel WJ |title=Signal peptide prediction based on analysis of experimentally verified cleavage sites. |journal=Protein Sci. |volume=13 |issue= 10 |pages= 2819-24 |year= 2005 |pmid= 15340161 |doi= 10.1110/ps.04682504 }}
*{{cite journal  | vauthors=Zhang Z, Henzel WJ |title=Signal peptide prediction based on analysis of experimentally verified cleavage sites |journal=Protein Sci. |volume=13 |issue= 10 |pages= 2819–24 |year= 2005 |pmid= 15340161 |doi= 10.1110/ps.04682504 | pmc=2286551 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Park JB, Yiu G, Kaneko S, ''et al.'' |title=A TNF receptor family member, TROY, is a coreceptor with Nogo receptor in mediating the inhibitory activity of myelin inhibitors. |journal=Neuron |volume=45 |issue= 3 |pages= 345-51 |year= 2005 |pmid= 15694321 |doi= 10.1016/j.neuron.2004.12.040 }}
*{{cite journal   |vauthors=Park JB, Yiu G, Kaneko S, etal |title=A TNF receptor family member, TROY, is a coreceptor with Nogo receptor in mediating the inhibitory activity of myelin inhibitors |journal=Neuron |volume=45 |issue= 3 |pages= 345–51 |year= 2005 |pmid= 15694321 |doi= 10.1016/j.neuron.2004.12.040 }}
*{{cite journal | author=Shao Z, Browning JL, Lee X, ''et al.'' |title=TAJ/TROY, an orphan TNF receptor family member, binds Nogo-66 receptor 1 and regulates axonal regeneration. |journal=Neuron |volume=45 |issue= 3 |pages= 353-9 |year= 2005 |pmid= 15694322 |doi= 10.1016/j.neuron.2004.12.050 }}
*{{cite journal   |vauthors=Shao Z, Browning JL, Lee X, etal |title=TAJ/TROY, an orphan TNF receptor family member, binds Nogo-66 receptor 1 and regulates axonal regeneration |journal=Neuron |volume=45 |issue= 3 |pages= 353–9 |year= 2005 |pmid= 15694322 |doi= 10.1016/j.neuron.2004.12.050 }}
*{{cite journal  | author=Spanjaard RA, Whren KM, Graves C, Bhawan J |title=Tumor necrosis factor receptor superfamily member TROY is a novel melanoma biomarker and potential therapeutic target. |journal=Int. J. Cancer |volume=120 |issue= 6 |pages= 1304-10 |year= 2007 |pmid= 17187358 |doi= 10.1002/ijc.22367 }}
*{{cite journal  | vauthors=Spanjaard RA, Whren KM, Graves C, Bhawan J |title=Tumor necrosis factor receptor superfamily member TROY is a novel melanoma biomarker and potential therapeutic target |journal=Int. J. Cancer |volume=120 |issue= 6 |pages= 1304–10 |year= 2007 |pmid= 17187358 |doi= 10.1002/ijc.22367 }}
*{{cite journal | author=Satoh J, Tabunoki H, Yamamura T, ''et al.'' |title=TROY and LINGO-1 expression in astrocytes and macrophages/microglia in multiple sclerosis lesions. |journal=Neuropathol. Appl. Neurobiol. |volume=33 |issue= 1 |pages= 99-107 |year= 2007 |pmid= 17239012 |doi= 10.1111/j.1365-2990.2006.00787.x }}
*{{cite journal   |vauthors=Satoh J, Tabunoki H, Yamamura T, etal |title=TROY and LINGO-1 expression in astrocytes and macrophages/microglia in multiple sclerosis lesions |journal=Neuropathol. Appl. Neurobiol. |volume=33 |issue= 1 |pages= 99–107 |year= 2007 |pmid= 17239012 |doi= 10.1111/j.1365-2990.2006.00787.x }}
}}
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{{membrane-protein-stub}}
{{NLM content}}
{{NLM content}}
{{Tumor necrosis factor receptor superfamily}}
{{Tumor necrosis factor receptor superfamily}}
[[Category:Cytokine receptors]]
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[[Category:TNF receptor family]]
 
 
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Latest revision as of 12:04, 15 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Tumor necrosis factor receptor superfamily, member 19, also known as TNFRSF19 and TROY is a human gene.[1]

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is highly expressed during embryonic development. It has been shown to interact with TRAF family members, and to activate JNK signaling pathway when overexpressed in cells. This receptor is capable of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. Alternatively, spliced transcript variants encoding distinct isoforms have been described.[1]

References

  1. ↑ 1.0 1.1 "Entrez Gene: TNFRSF19 tumor necrosis factor receptor superfamily, member 19".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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