Pharyngitis differential diagnosis: Difference between revisions

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|[[Hemolysis|H. influenza type b, beta-hemolytic]] [[streptococci]], ''[[Staphylococcus aureus]],'' [[fungi]] and [[viruses]].
|[[Hemolysis|H. influenza type b, beta-hemolytic]] [[streptococci]], ''[[Staphylococcus aureus]],'' [[fungi]] and [[viruses]].
|Most common cause is viral including [[adenovirus]], [[rhinovirus]], [[influenza]], [[coronavirus]], and [[respiratory syncytial virus]]. Second most common causes are bacterial; ''[[Group A streptococcal infection|Group A streptococcal bacteria]]'',<sup>[[Epiglottitis differential diagnosis|[5]]]</sup> 
|Most common cause is viral including [[adenovirus]], [[rhinovirus]], [[influenza]], [[coronavirus]], and [[respiratory syncytial virus]]. Second most common causes are bacterial; ''[[Group A streptococcal infection|Group A streptococcal bacteria]]'',<sup>[[Epiglottitis differential diagnosis|[5]]]</sup> 
|Polymicrobial infection. Mostly; [[Streptococcus pyogenes]], [[Staphylococcus aureus]] and respiratory anaerobes (e.g. [[Fusobacterium|Fusobacteria]], [[Prevotella species|Prevotella]], and Veillonella species)<sup>[[Epiglottitis differential diagnosis|[6][7][8][9][10][11]]]</sup>
|Polymicrobial infection. Mostly; [[Streptococcus pyogenes]], [[Staphylococcus aureus]] and respiratory anaerobes (e.g. [[Fusobacterium|Fusobacteria]], [[Prevotella species|Prevotella]], and Veillonella species)<ref name="pmid23520072">{{cite journal| author=Cheng J, Elden L| title=Children with deep space neck infections: our experience with 178 children. | journal=Otolaryngol Head Neck Surg | year= 2013 | volume= 148 | issue= 6 | pages= 1037-42 | pmid=23520072 | doi=10.1177/0194599813482292 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23520072  }} </ref><ref name="pmid22481424">{{cite journal| author=Abdel-Haq N, Quezada M, Asmar BI| title=Retropharyngeal abscess in children: the rising incidence of methicillin-resistant Staphylococcus aureus. | journal=Pediatr Infect Dis J | year= 2012 | volume= 31 | issue= 7 | pages= 696-9 | pmid=22481424 | doi=10.1097/INF.0b013e318256fff0 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22481424  }} </ref><ref name="pmid18948832">{{cite journal| author=Inman JC, Rowe M, Ghostine M, Fleck T| title=Pediatric neck abscesses: changing organisms and empiric therapies. | journal=Laryngoscope | year= 2008 | volume= 118 | issue= 12 | pages= 2111-4 | pmid=18948832 | doi=10.1097/MLG.0b013e318182a4fb | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18948832  }} </ref><ref name="pmid15573356">{{cite journal| author=Brook I| title=Microbiology and management of peritonsillar, retropharyngeal, and parapharyngeal abscesses. | journal=J Oral Maxillofac Surg | year= 2004 | volume= 62 | issue= 12 | pages= 1545-50 | pmid=15573356 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15573356  }} </ref><ref name="pmid18427007">{{cite journal| author=Wright CT, Stocks RM, Armstrong DL, Arnold SR, Gould HJ| title=Pediatric mediastinitis as a complication of methicillin-resistant Staphylococcus aureus retropharyngeal abscess. | journal=Arch Otolaryngol Head Neck Surg | year= 2008 | volume= 134 | issue= 4 | pages= 408-13 | pmid=18427007 | doi=10.1001/archotol.134.4.408 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18427007  }} </ref><ref name="pmid2235179">{{cite journal| author=Asmar BI| title=Bacteriology of retropharyngeal abscess in children. | journal=Pediatr Infect Dis J | year= 1990 | volume= 9 | issue= 8 | pages= 595-7 | pmid=2235179 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2235179  }} </ref>
|-
|-
|Physical exams findings
|Physical exams findings
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|Diffuse lymphadenopathy, particularly bilateral and posterior cervical,[[Splenomegaly]] in 50% of cases, [[Hepatomegaly]] in 10% of cases, Pharyngeal petechiae, Rash in 90% of patients will develop a pruritic, [[maculopapular rash]] after the use of [[ampicillin]] or [[amoxicillin]]
|Diffuse lymphadenopathy, particularly bilateral and posterior cervical,[[Splenomegaly]] in 50% of cases, [[Hepatomegaly]] in 10% of cases, Pharyngeal petechiae, Rash in 90% of patients will develop a pruritic, [[maculopapular rash]] after the use of [[ampicillin]] or [[amoxicillin]]
|[[Cyanosis]], [[Cervical]][[lymphadenopathy]], Inflammed [[epiglottis]]
|[[Cyanosis]], [[Cervical]][[lymphadenopathy]], Inflammed [[epiglottis]]
|[[Fever]], especially 100°F or higher.<sup>[[Epiglottitis differential diagnosis|[17][18]]]</sup>[[Erythema]], [[edema]] and [[Exudate]] of the [[tonsils]].<sup>[[Epiglottitis differential diagnosis|[19]]]</sup> cervical [[lymphadenopathy]], [[Dysphonia]].<sup>[[Epiglottitis differential diagnosis|[20]]]</sup>
|[[Fever]], especially 100°F or higher.[[Erythema]], [[edema]] and [[Exudate]] of the [[tonsils]].cervical [[lymphadenopathy]], [[Dysphonia]].<ref name="Tonsillitis">Tonsillitis. Medline Plus. https://www.nlm.nih.gov/medlineplus/ency/article/001043.htm. Accessed May 2nd, 2016.</ref><ref name="urlTonsillitis - NHS Choices">{{cite web |url=http://www.nhs.uk/Conditions/Tonsillitis/Pages/Introduction.aspx |title=Tonsillitis - NHS Choices |format= |work= |accessdate=}}</ref><ref name="pmid25587367">{{cite journal |vauthors=Stelter K |title=Tonsillitis and sore throat in children |journal=GMS Curr Top Otorhinolaryngol Head Neck Surg |volume=13 |issue= |pages=Doc07 |year=2014 |pmid=25587367 |pmc=4273168 |doi=10.3205/cto000110 |url=}}</ref><ref name="urlTonsillitis - Symptoms - NHS Choices">{{cite web |url=http://www.nhs.uk/Conditions/Tonsillitis/Pages/Symptoms.aspx |title=Tonsillitis - Symptoms - NHS Choices |format= |work= |accessdate=}}</ref>
|Child may be unable to open the mouth widely. May have enlarged
|Child may be unable to open the mouth widely. May have enlarged
[[cervical]] [[lymph nodes]] and neck mass.
[[cervical]] [[lymph nodes]] and neck mass.
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with 50% of cases identified
with 50% of cases identified


between the ages of 5 to 24 years.<sup>[[Epiglottitis differential diagnosis|[23]]]</sup>
between the ages of 5 to 24 years.<ref>{{cite book | last = Bennett | first = John | title = Mandell, Douglas, and Bennett's principles and practice of infectious diseases | publisher = Elsevier/Saunders | location = Philadelphia, PA | year = 2015 | isbn = 978-1455748013 }}</ref>
|Usually in [[immunocompromised]] patients, including those with advanced [[Human Immunodeficiency Virus (HIV)|HIV]]/AIDS
|Usually in [[immunocompromised]] patients, including those with advanced [[Human Immunodeficiency Virus (HIV)|HIV]]/AIDS
|Common in adolescents between 15-25
|Common in adolescents between 15-25
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however, recent trend favors adults
however, recent trend favors adults


as most commonly affected individuals<sup>[[Epiglottitis differential diagnosis|[22]]]</sup>
as most commonly affected individuals with a mean age of 44.94 years.<ref name="pmid270310102">{{cite journal| author=Lichtor JL, Roche Rodriguez M, Aaronson NL, Spock T, Goodman TR, Baum ED| title=Epiglottitis: It Hasn't Gone Away. | journal=Anesthesiology | year= 2016 | volume= 124 | issue= 6 | pages= 1404-7 | pmid=27031010 | doi=10.1097/ALN.0000000000001125 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27031010  }}</ref>
 
with a mean age of 44.94 years.
|Primarily affects children
|Primarily affects children
between 5 and 15 years old.<sup>[[Epiglottitis differential diagnosis|[24]]]</sup>
between 5 and 15 years old.<ref name="Oroface">{{cite book |last1=Sharav |first1=Yair |last2=Benoliel |first2=Rafael |date=2008 |title=Orofacial Pain and Headache |url= |location= |publisher=Elsevier |page= |isbn=0723434123}}</ref>
|Mostly between 2-4 years, but can occur in other age groups.<sup>[[Epiglottitis differential diagnosis|[25][26]]]</sup>
|Mostly between 2-4 years, but can occur in other age groups.<ref name="pmid12777558">{{cite journal| author=Craig FW, Schunk JE| title=Retropharyngeal abscess in children: clinical presentation, utility of imaging, and current management. | journal=Pediatrics | year= 2003 | volume= 111 | issue= 6 Pt 1 | pages= 1394-8 | pmid=12777558 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12777558  }}</ref><ref name="pmid1876473">{{cite journal| author=Coulthard M, Isaacs D| title=Neonatal retropharyngeal abscess. | journal=Pediatr Infect Dis J | year= 1991 | volume= 10 | issue= 7 | pages= 547-9 | pmid=1876473 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1876473  }}</ref>
|-
|-
|Imaging finding
|Imaging finding
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|—
|—
|[[Thumbprint sign]] on neck x-ray
|[[Thumbprint sign]] on neck x-ray
|Intraoral or transcutaneous USG may show an abscess making CT scan unnecessary.<sup>[[Epiglottitis differential diagnosis|[27][28][29]]]</sup>
|Intraoral or transcutaneous USG may show an abscess making CT scan unnecessary.<ref name="pmid26527518">{{cite journal| author=Kawabata M, Umakoshi M, Makise T, Miyashita K, Harada M, Nagano H et al.| title=Clinical classification of peritonsillar abscess based on CT and indications for immediate abscess tonsillectomy. | journal=Auris Nasus Larynx | year= 2016 | volume= 43 | issue= 2 | pages= 182-6 | pmid=26527518 | doi=10.1016/j.anl.2015.09.014 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26527518  }} </ref><ref name="pmid25946659">{{cite journal| author=Nogan S, Jandali D, Cipolla M, DeSilva B| title=The use of ultrasound imaging in evaluation of peritonsillar infections. | journal=Laryngoscope | year= 2015 | volume= 125 | issue= 11 | pages= 2604-7 | pmid=25946659 | doi=10.1002/lary.25313 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25946659  }} </ref><ref name="pmid25945805">{{cite journal| author=Fordham MT, Rock AN, Bandarkar A, Preciado D, Levy M, Cohen J et al.| title=Transcervical ultrasonography in the diagnosis of pediatric peritonsillar abscess. | journal=Laryngoscope | year= 2015 | volume= 125 | issue= 12 | pages= 2799-804 | pmid=25945805 | doi=10.1002/lary.25354 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25945805  }} </ref>
|On CT scan, a mass impinging on the posterior pharyngeal wall with rim enhancement is seen<sup>[[Epiglottitis differential diagnosis|[30][31]]]</sup>
|On CT scan, a mass impinging on the posterior pharyngeal wall with rim enhancement is seen.<ref name="pmid15667676">{{cite journal| author=Philpott CM, Selvadurai D, Banerjee AR| title=Paediatric retropharyngeal abscess. | journal=J Laryngol Otol | year= 2004 | volume= 118 | issue= 12 | pages= 919-26 | pmid=15667676 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15667676  }}</ref><ref name="pmid12761699">{{cite journal| author=Vural C, Gungor A, Comerci S| title=Accuracy of computerized tomography in deep neck infections in the pediatric population. | journal=Am J Otolaryngol | year= 2003 | volume= 24 | issue= 3 | pages= 143-8 | pmid=12761699 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12761699  }}</ref>
|-
|-
|Treatment
|Treatment
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[[Glucocorticoids]] may be indicated in such cases of severe airway obstruction.
[[Glucocorticoids]] may be indicated in such cases of severe airway obstruction.
|Airway maintenance, p[[Parenteral|arenteral]] [[Cefotaxime]] or [[Ceftriaxone]] in combination with [[Vancomycin]]. Adjuvant therapy includes [[corticosteroids]] and racemic [[Epinephrine]].<sup>[[Epiglottitis differential diagnosis|[32][33]]]</sup>
|Airway maintenance, p[[Parenteral|arenteral]] [[Cefotaxime]] or [[Ceftriaxone]] in combination with [[Vancomycin]]. Adjuvant therapy includes [[corticosteroids]] and racemic [[Epinephrine]].<ref name="pmid15983574">{{cite journal| author=Nickas BJ| title=A 60-year-old man with stridor, drooling, and "tripoding" following a nasal polypectomy. | journal=J Emerg Nurs | year= 2005 | volume= 31 | issue= 3 | pages= 234-5; quiz 321 | pmid=15983574 | doi=10.1016/j.jen.2004.10.015 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15983574  }}</ref><ref name="pmid12557859">{{cite journal| author=Wick F, Ballmer PE, Haller A| title=Acute epiglottis in adults. | journal=Swiss Med Wkly | year= 2002 | volume= 132 | issue= 37-38 | pages= 541-7 | pmid=12557859 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12557859  }}</ref>
|[[Antimicrobial]] therapy mainly [[penicillin]]-based and [[analgesics]] with [[tonsilectomy]] in selected cases.
|[[Antimicrobial]] therapy mainly [[penicillin]]-based and [[analgesics]] with [[tonsilectomy]] in selected cases.
|Immediate surgical drainage and antimicrobial therapy. emperic therapy involves; [[Ampicillin-Sulbactam|ampicillin-sulbactam]] or [[clindamycin]].
|Immediate surgical drainage and antimicrobial therapy. emperic therapy involves; [[Ampicillin-Sulbactam|ampicillin-sulbactam]] or [[clindamycin]].

Revision as of 23:03, 29 January 2017

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Venkata Sivakrishna Kumar Pulivarthi M.B.B.S [2]

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Overview

Pharyngitis should be differentiated from other infectious causes which mimic sore throat that includes oral thrush, infectious mononucleosis, epiglottitis and peritonsilar abscess.[1]

Differentiating Pharyngitis from other Diseases

The major goal of the differentiating patients with sore throat or acute pharyngitis is to exclude potentially dangerous causes (e.g. Group A streptococcus), to identify any treatable causes, and to improve symptoms. Identifying the treatable causes is important because timely treatment with antibiotics helps prevent complications such as acute rheumatic fever, post streptococcal glomerulonephritis.[2]

Thrush Mononucleosis Epiglottitis Peritonsillar abscess
  • Thrush is caused by candidal infection
  • Dysphagia without odynophagia which will differentiate it from pharyngitis.
  • White plaques that reveal an erythematous base when scraped
  • Usually in immunocompromised patients, including those with advanced HIV/AIDS
  • Epiglottitis is an inflammation of the epiglottis and adjacent structures that can be life-threatening caused by Hemophilus influenzae especially unimmunized children.
  • In adults, epiglottitis has widely varying presentations and symptoms:
    • Odynophagia (most commonly)
    • Fever, toxicity
    • Dyspnea, respiratory distress
    • Dysphagia
    • Drooling
    • Dysphonia
    • Inspiratory stridor
  • The classic tripod positioning (patient sits or stands leaning forward and supporting the upper body with hands on the knees), is seen only in 5% of cases
  • If epiglottitis is suspected, immediate referral to the emergency department for airway management
  • Diagnosis requires laryngoscopy
  • If the patient is in respiratory distress, prompt intubation is required to maintain airway.
  • Peritonsillar abscess is the collection of pus behind the tonsil in the superior arch of the soft palate
  • It might develop as a complication of oropharyngeal infection, such as tonsillitis
  • The most common bacteria is group A streptococci, but the causative organism could be polymicrobial
  • Symptoms include fever, malaise, dysphagia, drooling, muffled or 'hot potato' voice, and referred ear pain.
  • Diagnosis is a combination of physical examination and imaging with computed tomography (CT) or ultrasonography
  • Management requires urgent referral to a specialist or surgeon for surgical drainage, in addition to antibiotic treatment.
Variable Pharyngitis Oral thrush Mononucleosis Epiglottitis Tonsilitis Retropharyngeal abscess
Presentation Dysphagia without odynophagia which will differentiate it from pharyngitis. Usually presents with a classic triad of Usually present with stridor and drooling; and other symptoms include difficulty breathingfever, chills, difficulty swallowinghoarseness of voice Sore throat, pain on swallowing, feverheadachecough Neck painstiff necktorticollis

fevermalaisestridor, and barking cough

Causes Group A beta-hemolytic streptococcus. candidal infection Epstein-Barr virus H. influenza type b, beta-hemolytic streptococciStaphylococcus aureus, fungi and viruses. Most common cause is viral including adenovirusrhinovirusinfluenzacoronavirus, and respiratory syncytial virus. Second most common causes are bacterial; Group A streptococcal bacteria,[5]  Polymicrobial infection. Mostly; Streptococcus pyogenesStaphylococcus aureus and respiratory anaerobes (e.g. FusobacteriaPrevotella, and Veillonella species)[3][4][5][6][7][8]
Physical exams findings Inflammed pharynx with or without exudate White plaques that reveal an erythematous base when scraped Diffuse lymphadenopathy, particularly bilateral and posterior cervical,Splenomegaly in 50% of cases, Hepatomegaly in 10% of cases, Pharyngeal petechiae, Rash in 90% of patients will develop a pruritic, maculopapular rash after the use of ampicillin or amoxicillin CyanosisCervicallymphadenopathy, Inflammed epiglottis Fever, especially 100°F or higher.Erythemaedema and Exudate of the tonsils.cervical lymphadenopathyDysphonia.[9][10][11][12] Child may be unable to open the mouth widely. May have enlarged

cervical lymph nodes and neck mass.

Age commonly affected Mostly in children and young adults,

with 50% of cases identified

between the ages of 5 to 24 years.[13]

Usually in immunocompromised patients, including those with advanced HIV/AIDS Common in adolescents between 15-25 Used to be mostly found in

pediatric age group between 3 to 5 years,

however, recent trend favors adults

as most commonly affected individuals with a mean age of 44.94 years.[14]

Primarily affects children

between 5 and 15 years old.[15]

Mostly between 2-4 years, but can occur in other age groups.[16][17]
Imaging finding Thumbprint sign on neck x-ray Intraoral or transcutaneous USG may show an abscess making CT scan unnecessary.[18][19][20] On CT scan, a mass impinging on the posterior pharyngeal wall with rim enhancement is seen.[21][22]
Treatment Antimicrobial therapy mainly penicillin-based and analgesics. oral fluconazole Supportive therapy

Glucocorticoids may be indicated in such cases of severe airway obstruction.

Airway maintenance, parenteral Cefotaxime or Ceftriaxone in combination with Vancomycin. Adjuvant therapy includes corticosteroids and racemic Epinephrine.[23][24] Antimicrobial therapy mainly penicillin-based and analgesics with tonsilectomy in selected cases. Immediate surgical drainage and antimicrobial therapy. emperic therapy involves; ampicillin-sulbactam or clindamycin.

References

  1. Vincent MT, Celestin N, Hussain AN (2004) Pharyngitis. Am Fam Physician 69 (6):1465-70. PMID: 15053411
  2. Del Mar CB, Glasziou PP, Spinks AB (2006) Antibiotics for sore throat. Cochrane Database Syst Rev (4):CD000023. DOI:10.1002/14651858.CD000023.pub3 PMID: 17054126
  3. Cheng J, Elden L (2013). "Children with deep space neck infections: our experience with 178 children". Otolaryngol Head Neck Surg. 148 (6): 1037–42. doi:10.1177/0194599813482292. PMID 23520072.
  4. Abdel-Haq N, Quezada M, Asmar BI (2012). "Retropharyngeal abscess in children: the rising incidence of methicillin-resistant Staphylococcus aureus". Pediatr Infect Dis J. 31 (7): 696–9. doi:10.1097/INF.0b013e318256fff0. PMID 22481424.
  5. Inman JC, Rowe M, Ghostine M, Fleck T (2008). "Pediatric neck abscesses: changing organisms and empiric therapies". Laryngoscope. 118 (12): 2111–4. doi:10.1097/MLG.0b013e318182a4fb. PMID 18948832.
  6. Brook I (2004). "Microbiology and management of peritonsillar, retropharyngeal, and parapharyngeal abscesses". J Oral Maxillofac Surg. 62 (12): 1545–50. PMID 15573356.
  7. Wright CT, Stocks RM, Armstrong DL, Arnold SR, Gould HJ (2008). "Pediatric mediastinitis as a complication of methicillin-resistant Staphylococcus aureus retropharyngeal abscess". Arch Otolaryngol Head Neck Surg. 134 (4): 408–13. doi:10.1001/archotol.134.4.408. PMID 18427007.
  8. Asmar BI (1990). "Bacteriology of retropharyngeal abscess in children". Pediatr Infect Dis J. 9 (8): 595–7. PMID 2235179.
  9. Tonsillitis. Medline Plus. https://www.nlm.nih.gov/medlineplus/ency/article/001043.htm. Accessed May 2nd, 2016.
  10. "Tonsillitis - NHS Choices".
  11. Stelter K (2014). "Tonsillitis and sore throat in children". GMS Curr Top Otorhinolaryngol Head Neck Surg. 13: Doc07. doi:10.3205/cto000110. PMC 4273168. PMID 25587367.
  12. "Tonsillitis - Symptoms - NHS Choices".
  13. Bennett, John (2015). Mandell, Douglas, and Bennett's principles and practice of infectious diseases. Philadelphia, PA: Elsevier/Saunders. ISBN 978-1455748013.
  14. Lichtor JL, Roche Rodriguez M, Aaronson NL, Spock T, Goodman TR, Baum ED (2016). "Epiglottitis: It Hasn't Gone Away". Anesthesiology. 124 (6): 1404–7. doi:10.1097/ALN.0000000000001125. PMID 27031010.
  15. Sharav, Yair; Benoliel, Rafael (2008). Orofacial Pain and Headache. Elsevier. ISBN 0723434123.
  16. Craig FW, Schunk JE (2003). "Retropharyngeal abscess in children: clinical presentation, utility of imaging, and current management". Pediatrics. 111 (6 Pt 1): 1394–8. PMID 12777558.
  17. Coulthard M, Isaacs D (1991). "Neonatal retropharyngeal abscess". Pediatr Infect Dis J. 10 (7): 547–9. PMID 1876473.
  18. Kawabata M, Umakoshi M, Makise T, Miyashita K, Harada M, Nagano H; et al. (2016). "Clinical classification of peritonsillar abscess based on CT and indications for immediate abscess tonsillectomy". Auris Nasus Larynx. 43 (2): 182–6. doi:10.1016/j.anl.2015.09.014. PMID 26527518.
  19. Nogan S, Jandali D, Cipolla M, DeSilva B (2015). "The use of ultrasound imaging in evaluation of peritonsillar infections". Laryngoscope. 125 (11): 2604–7. doi:10.1002/lary.25313. PMID 25946659.
  20. Fordham MT, Rock AN, Bandarkar A, Preciado D, Levy M, Cohen J; et al. (2015). "Transcervical ultrasonography in the diagnosis of pediatric peritonsillar abscess". Laryngoscope. 125 (12): 2799–804. doi:10.1002/lary.25354. PMID 25945805.
  21. Philpott CM, Selvadurai D, Banerjee AR (2004). "Paediatric retropharyngeal abscess". J Laryngol Otol. 118 (12): 919–26. PMID 15667676.
  22. Vural C, Gungor A, Comerci S (2003). "Accuracy of computerized tomography in deep neck infections in the pediatric population". Am J Otolaryngol. 24 (3): 143–8. PMID 12761699.
  23. Nickas BJ (2005). "A 60-year-old man with stridor, drooling, and "tripoding" following a nasal polypectomy". J Emerg Nurs. 31 (3): 234–5, quiz 321. doi:10.1016/j.jen.2004.10.015. PMID 15983574.
  24. Wick F, Ballmer PE, Haller A (2002). "Acute epiglottis in adults". Swiss Med Wkly. 132 (37–38): 541–7. PMID 12557859.


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