Mycosis fungoides laboratory findings: Difference between revisions

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{{Cutaneous T cell lymphoma}}
{{Mycosis fungoides}}
{{CMG}}; {{AE}} {{AS}}
{{CMG}}; {{AE}} {{S.G.}}
==Overview==
==Overview==
Laboratory tests for cutaneous T cell lymphoma include [[complete blood count]] (CBC), blood chemistry studies, [[flow cytometry]], [[immunohistochemistry]],  and [[immunophenotyping]].<ref name= seer.cancer> Cutaneous T cell lymphoma. Surveillance, Epidemiology, and End Results . http://seer.cancer.gov/seertools/hemelymph/51f6cf56e3e27c3994bd52f7/ Accessed on January 19, 2016</ref>
Laboratory tests for cutaneous T cell lymphoma include [[complete blood count]] (CBC), blood chemistry studies, [[flow cytometry]], [[immunohistochemistry]],  and [[immunophenotyping]].
==Laboratory tests==
 
Laboratory tests for splenic marginal zone lymphoma include:<ref name= seer.cancer> Cutaneous T cell lymphoma. Surveillance, Epidemiology, and End Results . http://seer.cancer.gov/seertools/hemelymph/51f6cf56e3e27c3994bd52f7/ Accessed on January 19, 2016</ref>
==Laboratory Tests==
* [[Complete blood count]] (CBC)
[[Medical laboratory|Laboratory]] tests for mycosis fungoides include:<ref name="VuralAkay2018">{{cite journal|last1=Vural|first1=Seçil|last2=Akay|first2=Bengü Nisa|last3=Botsali|first3=Ayşenur|last4=Atilla|first4=Erden|last5=Parlak|first5=Nehir|last6=Okcu Heper|first6=Aylin|last7=Şanlı|first7=Hatice|title=Transformation of Mycosis Fungoides/Sezary Syndrome: Clinical Characteristics and Prognosis|journal=Turkish Journal of Hematology|volume=35|issue=1|year=2018|pages=35–41|issn=13007777|doi=10.4274/tjh.2016.0502}}</ref>
* Peripheral blood
* [[Complete blood count]] ([[Complete blood count|CBC]])
:* Atypical T-cells ("Sezary cells")  
* Peripheral [[blood]] [[Smear test|smear]]
* Blood chemistry studies
:* Atypical [[T cell|T-cells]] (Sezary [[Cell (biology)|cells]])
:* [[Allogeneic]] [[hematopoietic stem cell transplantation]] (allo-[[Hematopoietic stem cell transplantation|HSCT]]) demonstrated progressive [[disease]] had undergone.
* [[Blood]] [[chemistry]] studies
:* High level [[lactate dehydrogenase]] ([[LDH]])in andvanced [[disease]] stage [[Patient|patients]]
* [[Biopsy]] of [[skin]] ( multiple [[Biopsy|biopsies]])
**A rare evaluated finding observed [[Mononucleosis|mono]] [[nuclear]] [[Cell (biology)|cells]] aggrigation by cerebriform [[nuclei]] in the [[Epidermis (skin)|epidermis]] surrounding [[Langerhans cell|langerhans cells]].
**Atypical [[Lymphocyte|lymphocytes]] observed in the [[Epidermis (skin)|epidermis]] or [[Superficial anatomy|superficial]] [[Dermis|dermi]]<nowiki/>[[Dermis|s]].
*[[Lymph node]] [[Biopsy|biopsies]] is recommended.
* complete [[Metabolic control analysis|metabolic]] [[Panel data|panel]]
* [[Flow cytometry]]
* [[Flow cytometry]]
* [[Immunohistochemistry]]
* [[Immunohistochemistry]]
* [[Immunophenotyping]]: Beta F1+, [[CD2]]-/+, [[CD3]]+, [[CD3]]- ([[CD4]]-positive variant), [[CD4]]+ ([[CD4]]-positive variant), [[CD4]]-, [[CD5]]-, [[CD7]]+/-, [[CD8]]+, [[CD8]]- ([[CD4]]-positive variant), Granzyme B+, Perforin+
* [[Immunophenotyping]]: Beta F1+, [[CD2]]-/+, [[CD3]]+, [[CD3]]- ([[CD4]]-positive variant), [[CD4]]+ ([[CD4]]-positive variant), [[CD4]]-, [[CD5]]-, [[CD7]]+/-, [[CD8]]+, [[CD8]]- ([[CD4]]-positive variant), [[Granzyme B|Granzyme B+]], and [[perforin]]+
* Loss of CD26 and [[CD7]] [[expression]]
* [[Polymerase chain reaction|PCR]]
* [[Southern blot]]


==References==
==References==
{{Reflist|2}}
{{Reflist|1}}


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Latest revision as of 07:10, 11 February 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sogand Goudarzi, MD [2]

Overview

Laboratory tests for cutaneous T cell lymphoma include complete blood count (CBC), blood chemistry studies, flow cytometry, immunohistochemistry, and immunophenotyping.

Laboratory Tests

Laboratory tests for mycosis fungoides include:[1]

References

  1. Vural, Seçil; Akay, Bengü Nisa; Botsali, Ayşenur; Atilla, Erden; Parlak, Nehir; Okcu Heper, Aylin; Şanlı, Hatice (2018). "Transformation of Mycosis Fungoides/Sezary Syndrome: Clinical Characteristics and Prognosis". Turkish Journal of Hematology. 35 (1): 35–41. doi:10.4274/tjh.2016.0502. ISSN 1300-7777.


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