GZMB
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| Granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
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| PDB rendering based on 1fq3. | ||||||||||||||
| Identifiers | ||||||||||||||
| Symbol(s) | GZMB; HLP; CTLA1; CCPI; CGL-1; CGL1; CSP-B; CSPB; CTSGL1; SECT | |||||||||||||
| External IDs | OMIM: 123910 MGI: 109267 Homologene: 20876 | |||||||||||||
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| RNA expression pattern | ||||||||||||||
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| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 3002 | 14939 | ||||||||||||
| Ensembl | ENSG00000100453 | ENSMUSG00000015437 | ||||||||||||
| Uniprot | P10144 | Q3TIP3 | ||||||||||||
| Refseq | NM_004131 (mRNA) NP_004122 (protein) | NM_013542 (mRNA) NP_038570 (protein) | ||||||||||||
| Location | Chr 14: 24.17 - 24.17 Mb | Chr 14: 55.21 - 55.22 Mb | ||||||||||||
| Pubmed search | [1] | [2] | ||||||||||||
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Evidence Based Medicine | |
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Clinical Trials | |
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Ongoing Trials on GZMB at Clinical Trials.gov Clinical Trials on GZMB at Google
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US National Guidelines Clearinghouse on GZMB
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Patient Resources / Community | |
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Directions to Hospitals Treating GZMB Risk calculators and risk factors for GZMB
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [3] Phone:617-632-7753
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Granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1), also known as GZMB, is a human gene.
Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response.[1]
See also
References
Further reading
- Trapani JA (1996). "Target cell apoptosis induced by cytotoxic T cells and natural killer cells involves synergy between the pore-forming protein, perforin, and the serine protease, granzyme B.". Australian and New Zealand journal of medicine 25 (6): 793-9. PMID 8770355.
- Cohen GM (1997). "Caspases: the executioners of apoptosis.". Biochem. J. 326 ( Pt 1): 1-16. PMID 9337844.
- Trapani JA, Sutton VR (2004). "Granzyme B: pro-apoptotic, antiviral and antitumor functions.". Curr. Opin. Immunol. 15 (5): 533-43. PMID 14499262.
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
