Melanoma differential diagnosis: Difference between revisions
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*Can spread to [[TMJ]] | *Can spread to [[TMJ]] | ||
*Some times associated with [[leukoplakia]] | *Some times associated with [[leukoplakia]] | ||
|[[File: | |[[File:PLoS oral cancer.png|thumb|400x400px| |Squamous cell carcinoma - By Luca Pastore, Maria Luisa Fiorella, Raffaele Fiorella, Lorenzo Lo Muzio - http://www.plosmedicine.org/article/showImageLarge.action?uri=info%3Adoi%2F10.1371%2Fjournal.pmed.0050212.g001, CC BY 2.5, https://commons.wikimedia.org/w/index.php?curid=15252632]] | ||
|- | |- | ||
|[[Leukoplakia]] | |[[Leukoplakia]] | ||
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| pmid = 24113312 | | pmid = 24113312 | ||
}}</ref> | }}</ref> | ||
|[[File:Oral hairy leukoplakia (EBV, in HIV)a.jpg| | |[[File:Oral hairy leukoplakia (EBV, in HIV)a.jpg|thumb|400x300px|Leukoplakia - By Aitor III - Own work, Public Domain, https://commons.wikimedia.org/w/index.php?curid=9873087]] | ||
|- | |- | ||
|[[Melanoma]] | |[[Melanoma]] | ||
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*Progression involves [[MAPK/ERK pathway]] | *Progression involves [[MAPK/ERK pathway]] | ||
*[[RAS|N-RAS]] or [[BRAF]] [[oncogene]] also involved | *[[RAS|N-RAS]] or [[BRAF]] [[oncogene]] also involved | ||
|[[File: | |[[File:Palate malign melanoma 01.jpg|thumb|400x400px|Oral melanoma - By Emmanouil K Symvoulakis, Dionysios E Kyrmizakis, Emmanouil I Drivas, Anastassios V Koutsopoulos, Stylianos G Malandrakis, Charalambos E Skoulakis and John G Bizakis - Symvoulakis et al. Head & Face Medicine 2006 2:7 doi:10.1186/1746-160X-2-7 (Open Access), [1], CC BY-SA 2.0, https://commons.wikimedia.org/w/index.php?curid=9839811]] | ||
|- | |- | ||
|[[Fordyce spots]] | |[[Fordyce spots]] | ||
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*No surrounding [[mucosal]] change | *No surrounding [[mucosal]] change | ||
*Several adjacent [[glands]] may coalesce into a larger cauliflower-like cluster | *Several adjacent [[glands]] may coalesce into a larger cauliflower-like cluster | ||
|[[File: | |[[File:Fospot.jpg|thumb|400x400px|Fordyce spots - Por Perene - Obra do próprio, CC BY-SA 3.0, https://commons.wikimedia.org/w/index.php?curid=19772899]] | ||
|- | |- | ||
|[[Burning mouth syndrome]] | |[[Burning mouth syndrome]] | ||
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*Repeated [[trauma]] can cause [[bleeding]] | *Repeated [[trauma]] can cause [[bleeding]] | ||
*[[Surgery]] may be required in symptomatic | *[[Surgery]] may be required in symptomatic | ||
|[[File:06-06-06palataltoria.jpg|Torus palatinus|400x400px]] | |[[File:06-06-06palataltoria.jpg|thumb|Torus palatinus|400x400px|Torus palatinus - By Photo taken by dozenist, CC BY-SA 3.0, https://commons.wikimedia.org/w/index.php?curid=846591]] | ||
|- | |- | ||
| colspan="4" |'''Diseases involving oral cavity and other organ systems''' | | colspan="4" |'''Diseases involving oral cavity and other organ systems''' | ||
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*[[Outbreaks]] of exaggerated [[inflammation]] | *[[Outbreaks]] of exaggerated [[inflammation]] | ||
*Affects smaller [[blood vessels]] | *Affects smaller [[blood vessels]] | ||
|[[File: | |[[File:Behcets disease.jpg|thumb|400x400px|Behcet's disease - By Ahmet Altiner MD, Rajni Mandal MD - http://dermatology.cdlib.org/1611/articles/18_2009-10-20/2.jpg, CC BY-SA 3.0, https://commons.wikimedia.org/w/index.php?curid=17863021]] | ||
|- | |- | ||
|[[Crohn's disease]] | |[[Crohn's disease]] | ||
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**[[Gumma|Gummas]] | **[[Gumma|Gummas]] | ||
**[[Neurosyphilis]] | **[[Neurosyphilis]] | ||
|[[File: | |[[File:Hutchinson teeth congenital syphilis PHIL 2385.rsh.jpg|thumb|400x400px|oral syphilis - By CDC/Susan Lindsley - http://phil.cdc.gov/phil_images/20021114/34/PHIL_2385_lores.jpg, Public Domain, https://commons.wikimedia.org/w/index.php?curid=2134349]] | ||
|- | |- | ||
|[[Coxsackie virus]] | |[[Coxsackie virus]] | ||
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*[[Pregnancy]] | *[[Pregnancy]] | ||
*[[Premature infants]] born to susceptible mothers | *[[Premature infants]] born to susceptible mothers | ||
*All [[infants]] born at less than 28 weeks [[gestation]] or who weigh | *All [[infants]] born at less than 28 weeks [[gestation]] or who weigh =1000 grams | ||
*[[Immunocompromised]] | *[[Immunocompromised]] | ||
| | | | ||
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*[[Paracetamol]] ([[acetaminophen]]) for [[fever]] | *[[Paracetamol]] ([[acetaminophen]]) for [[fever]] | ||
*[[Prednisolone]] is [[contraindicated]] | *[[Prednisolone]] is [[contraindicated]] | ||
|[[File: | |[[File:Herpangina2016.jpg|thumb|400x400px|Chickenpox - By James Heilman, MD - Own work, CC BY-SA 4.0, https://commons.wikimedia.org/w/index.php?curid=52872565]] | ||
|- | |- | ||
|[[Measles]] | |[[Measles]] | ||
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*Primary site of infection is the [[respiratory epithelium]] of the [[nasopharynx]] | *Primary site of infection is the [[respiratory epithelium]] of the [[nasopharynx]] | ||
*Transmitted in [[respiratory secretions]], via [[aerosol droplets]] containing [[Virus|virus particles]] | *Transmitted in [[respiratory secretions]], via [[aerosol droplets]] containing [[Virus|virus particles]] | ||
|[[File: | |[[File:Koplik spots, measles 6111 lores.jpg|thumb|400x400px|Koplick spots (Measles) - By CDC - http://phil.cdc.gov/PHIL_Images/20040908/4f54ee8f0e5f49f58aaa30c1bc6413ba/6111_lores.jpg, Public Domain, https://commons.wikimedia.org/w/index.php?curid=824483]] | ||
|}</small></small> | |}</small></small> | ||
</div> | </div> |
Revision as of 21:35, 13 September 2017
Melanoma Microchapters |
Diagnosis |
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Treatment |
Case Studies |
Melanoma differential diagnosis On the Web |
American Roentgen Ray Society Images of Melanoma differential diagnosis |
Risk calculators and risk factors for Melanoma differential diagnosis |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Yazan Daaboul, M.D.; Serge Korjian M.D.
Overview
Melanoma must be differentiated from other causes of skin lesions, such as other skin cancers, premalignant skin tumors, and benign skin lesions.
Differential Diagnosis
Melanoma must be differentiated from other causes of skin lesions, such as:
- Angiokeratoma
- Atypical fibroxanthoma*Basal cell carcinoma of the skin
- Dermatofibroma
- Dermatofibroma protuberans
- Dysplastic nevus
- Epithelioid (Spitz) tumors
- Halo nevus
- Histiocytoid hemangioma
- Keratoacanthoma
- Lentigo
- Lentigo maligna
- Metastasis of other primary tumors
- Mycosis fungoides
- Oral candidiasis
- Peripheral nerve sheath tumor
- Pigmented actinic keratosis
- Scar tissue or keloid
- Sclerosing angioma
- Sclerosing blue nevus
- Sarcoma
- Sebaceous carcinoma
- Seborrheic keratosis
- Spindle cell squamous cell carcinoma
- Squamous cell carcinoma of the skin
- Traumatic hematoma
- Melanocytic nevus and other benign melanocytic lesions
- Traumatized nevus
- Venous lake
- Vitiligo
Oral melanoma must be differentiated from other mouth lesions such as oral candidiasis and aphthous ulcer
Disease | Presentation | Risk Factors | Diagnosis | Affected Organ Systems | Important features | Picture |
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Diseases predominantly affecting the oral cavity | ||||||
Oral Candidiasis |
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Localized candidiasis
Invasive candidasis |
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Herpes simplex oral lesions |
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Aphthous ulcers |
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Squamous cell carcinoma |
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Leukoplakia |
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Melanoma |
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Fordyce spots |
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Burning mouth syndrome |
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Torus palatinus |
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Diseases involving oral cavity and other organ systems | ||||||
Behcet's disease |
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Crohn's disease |
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Agranulocytosis |
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Syphilis[3] |
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Coxsackie virus |
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Chicken pox |
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Measles |
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References
- ↑ Ann M. Gillenwater, Nadarajah Vigneswaran, Hanadi Fatani, Pierre Saintigny & Adel K. El-Naggar (2013). "Proliferative verrucous leukoplakia (PVL): a review of an elusive pathologic entity!". Advances in anatomic pathology. 20 (6): 416–423. doi:10.1097/PAP.0b013e3182a92df1. PMID 24113312. Unknown parameter
|month=
ignored (help) - ↑ Andrès E, Zimmer J, Affenberger S, Federici L, Alt M, Maloisel F. (2006). "Idiosyncratic drug-induced agranulocytosis: Update of an old disorder". Eur J Intern Med. 17 (8): 529–35. Text "pmid 17142169" ignored (help)
- ↑ title="By Internet Archive Book Images [No restrictions], via Wikimedia Commons" href="https://commons.wikimedia.org/wiki/File:A_manual_of_syphilis_and_the_venereal_diseases%2C_(1900)_(14595882378).jpg"
- ↑ Feikin DR, Lezotte DC, Hamman RF, Salmon DA, Chen RT, Hoffman RE (2000). "Individual and community risks of measles and pertussis associated with personal exemptions to immunization". JAMA. 284 (24): 3145–50. PMID 11135778.
- ↑ Ratnam S, West R, Gadag V, Williams B, Oates E (1996). "Immunity against measles in school-aged children: implications for measles revaccination strategies". Can J Public Health. 87 (6): 407–10. PMID 9009400.