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{{Infobox_gene}}
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'''39S ribosomal protein L28, mitochondrial''' is a [[protein]] that in humans is encoded by the ''MRPL28'' [[gene]].<ref name="pmid7751637">{{cite journal |vauthors=Robbins PF, el-Gamil M, Li YF, Topalian SL, Rivoltini L, Sakaguchi K, Appella E, Kawakami Y, Rosenberg SA | title = Cloning of a new gene encoding an antigen recognized by melanoma-specific HLA-A24-restricted tumor-infiltrating lymphocytes | journal = J Immunol | volume = 154 | issue = 11 | pages = 5944–50 |date=Jun 1995 | pmid = 7751637 | pmc =  | doi =  }}</ref><ref name="pmid7751637" /><ref name="pmid11551941">{{cite journal |vauthors=Koc EC, Burkhart W, Blackburn K, Moyer MB, Schlatzer DM, Moseley A, Spremulli LL | title = The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present | journal = J Biol Chem | volume = 276 | issue = 47 | pages = 43958–69 |date=Nov 2001 | pmid = 11551941 | pmc = | doi = 10.1074/jbc.M106510200 }}</ref><ref name="pmid11551941" /><ref name="entrez">{{cite web | title = Entrez Gene: MRPL28 mitochondrial ribosomal protein L28| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10573| accessdate = }}</ref>
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Mammalian [[Mitochondrial ribosome|mitochondrial ribosomal]] proteins are encoded by [[nuclear gene]]s and help in [[protein synthesis]] within the [[mitochondrion]]. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% [[protein]] to [[rRNA]] composition compared to [[prokaryotic]] ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a [[5S rRNA]]. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by [[sequence homology]]. This gene encodes a 39S subunit protein, a part of which was originally isolated by its ability to recognize [[tyrosinase]] in an [[HLA-A24]]-restricted fashion.<ref name="entrez"/>
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Mitochondrial ribosomal protein L28
| HGNCid = 14484
| Symbol = MRPL28
| AltSymbols =; MAAT1; MGC8499; p15
| OMIM = 604853
| ECnumber = 
| Homologene = 4693
| MGIid = 1915861
| GeneAtlas_image1 = PBB_GE_MRPL28_204599_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003735 |text = structural constituent of ribosome}} {{GNF_GO|id=GO:0045182 |text = translation regulator activity}}
| Component = {{GNF_GO|id=GO:0005739 |text = mitochondrion}} {{GNF_GO|id=GO:0005761 |text = mitochondrial ribosome}} {{GNF_GO|id=GO:0030529 |text = ribonucleoprotein complex}}
| Process = {{GNF_GO|id=GO:0006412 |text = translation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10573
    | Hs_Ensembl = ENSG00000086504
    | Hs_RefseqProtein = NP_006419
    | Hs_RefseqmRNA = NM_006428
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 16
    | Hs_GenLoc_start = 357437
    | Hs_GenLoc_end = 360585
    | Hs_Uniprot = Q13084
    | Mm_EntrezGene = 68611
    | Mm_Ensembl = ENSMUSG00000024181
    | Mm_RefseqmRNA = NM_024227
    | Mm_RefseqProtein = NP_077189
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 17
    | Mm_GenLoc_start = 25851122
    | Mm_GenLoc_end = 25854211
    | Mm_Uniprot = Q497Y8
  }}
}}
'''Mitochondrial ribosomal protein L28''', also known as '''MRPL28''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MRPL28 mitochondrial ribosomal protein L28| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10573| accessdate = }}</ref>


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==References==
{{PBB_Summary
{{reflist}}
| section_title =  
| summary_text = Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein, a part of which was originally isolated by its ability to recognize tyrosinase in an HLA-A24-restricted fashion.<ref name="entrez">{{cite web | title = Entrez Gene: MRPL28 mitochondrial ribosomal protein L28| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10573| accessdate = }}</ref>
}}


==References==
{{reflist|2}}
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Kawakami Y, Robbins PF, Wang RF, ''et al.'' |title=The use of melanosomal proteins in the immunotherapy of melanoma. |journal=J. Immunother. |volume=21 |issue= 4 |pages= 237-46 |year= 1998 |pmid= 9672845 |doi=  }}
*{{cite journal   |vauthors=Kawakami Y, Robbins PF, Wang RF, etal |title=The use of melanosomal proteins in the immunotherapy of melanoma. |journal=J. Immunother. |volume=21 |issue= 4 |pages= 237–46 |year= 1998 |pmid= 9672845 |doi=10.1097/00002371-199807000-00001 }}
*{{cite journal | author=Martin J, Han C, Gordon LA, ''et al.'' |title=The sequence and analysis of duplication-rich human chromosome 16. |journal=Nature |volume=432 |issue= 7020 |pages= 988-94 |year= 2005 |pmid= 15616553 |doi= 10.1038/nature03187 }}
*{{cite journal   |vauthors=Martin J, Han C, Gordon LA, etal |title=The sequence and analysis of duplication-rich human chromosome 16. |journal=Nature |volume=432 |issue= 7020 |pages= 988–94 |year= 2005 |pmid= 15616553 |doi= 10.1038/nature03187 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Zhang Z, Gerstein M |title=Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome. |journal=Genomics |volume=81 |issue= 5 |pages= 468-80 |year= 2003 |pmid= 12706105 |doi=  }}
*{{cite journal  |vauthors=Zhang Z, Gerstein M |title=Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome |journal=Genomics |volume=81 |issue= 5 |pages= 468–80 |year= 2003 |pmid= 12706105 |doi=10.1016/S0888-7543(03)00004-1 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal | author=Koc EC, Burkhart W, Blackburn K, ''et al.'' |title=The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present. |journal=J. Biol. Chem. |volume=276 |issue= 47 |pages= 43958-69 |year= 2001 |pmid= 11551941 |doi= 10.1074/jbc.M106510200 }}
*{{cite journal   |vauthors=Kenmochi N, Suzuki T, Uechi T, etal |title=The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders |journal=Genomics |volume=77 |issue= 1–2 |pages= 65–70 |year= 2001 |pmid= 11543634 |doi= 10.1006/geno.2001.6622 }}
*{{cite journal | author=Kenmochi N, Suzuki T, Uechi T, ''et al.'' |title=The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. |journal=Genomics |volume=77 |issue= 1-2 |pages= 65-70 |year= 2001 |pmid= 11543634 |doi= 10.1006/geno.2001.6622 }}
*{{cite journal   |vauthors=Daniels RJ, Peden JF, Lloyd C, etal |title=Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16 |journal=Hum. Mol. Genet. |volume=10 |issue= 4 |pages= 339–52 |year= 2001 |pmid= 11157797 |doi=10.1093/hmg/10.4.339 }}
*{{cite journal | author=Daniels RJ, Peden JF, Lloyd C, ''et al.'' |title=Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. |journal=Hum. Mol. Genet. |volume=10 |issue= 4 |pages= 339-52 |year= 2001 |pmid= 11157797 |doi=  }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal  |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
*{{cite journal  | author=Robbins PF, el-Gamil M, Li YF, ''et al.'' |title=Cloning of a new gene encoding an antigen recognized by melanoma-specific HLA-A24-restricted tumor-infiltrating lymphocytes. |journal=J. Immunol. |volume=154 |issue= 11 |pages= 5944-50 |year= 1995 |pmid= 7751637 |doi= }}
}}
}}
{{refend}}
{{refend}}


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{{GeneticTranslation}}
{{Ribosome subunits}}
{{gene-16-stub}}
{{protein-stub}}
{{protein-stub}}
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[[Category:Ribosomal proteins]]

Latest revision as of 06:50, 4 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

39S ribosomal protein L28, mitochondrial is a protein that in humans is encoded by the MRPL28 gene.[1][1][2][2][3]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein, a part of which was originally isolated by its ability to recognize tyrosinase in an HLA-A24-restricted fashion.[3]

References

  1. ↑ 1.0 1.1 Robbins PF, el-Gamil M, Li YF, Topalian SL, Rivoltini L, Sakaguchi K, Appella E, Kawakami Y, Rosenberg SA (Jun 1995). "Cloning of a new gene encoding an antigen recognized by melanoma-specific HLA-A24-restricted tumor-infiltrating lymphocytes". J Immunol. 154 (11): 5944–50. PMID 7751637.
  2. ↑ 2.0 2.1 Koc EC, Burkhart W, Blackburn K, Moyer MB, Schlatzer DM, Moseley A, Spremulli LL (Nov 2001). "The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present". J Biol Chem. 276 (47): 43958–69. doi:10.1074/jbc.M106510200. PMID 11551941.
  3. ↑ 3.0 3.1 "Entrez Gene: MRPL28 mitochondrial ribosomal protein L28".

Further reading


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