MRPL12

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39S ribosomal protein L12, mitochondrial is a protein that in humans is encoded by the MRPL12 gene.[1][2][3]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein which forms homodimers. In prokaryotic ribosomes, two L7/L12 dimers and one L10 protein form the L8 protein complex.[3]

References

  1. Marty L, Fort P (Jun 1996). "A delayed-early response nuclear gene encoding MRPL12, the mitochondrial homologue to the bacterial translational regulator L7/L12 protein". J Biol Chem. 271 (19): 11468–76. doi:10.1074/jbc.271.19.11468. PMID 8626705.
  2. Marty L, Taviaux S, Fort P (Jul 1997). "Expression and human chromosomal localization to 17q25 of the growth-regulated gene encoding the mitochondrial ribosomal protein MRPL12". Genomics. 41 (3): 453–7. doi:10.1006/geno.1997.4691. PMID 9169145.
  3. 3.0 3.1 "Entrez Gene: MRPL12 mitochondrial ribosomal protein L12".

Further reading



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