Reading frame
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In biology, a reading frame is a contiguous and non-overlapping set of three-nucleotide codons in DNA or RNA. There are 3 possible reading frames in a mRNA strand and six in a double stranded DNA molecule due to the two strands from which transcription is possible. This leads to the possibility of overlapping genes and there may be many of these in bacteria.[1] Some viruses e.g. HBV and BYDV use several overlapping genes in different reading frames.
In rare cases a translating ribosome may shift from one frame to another, a translational frameshift. It is distinct from a frameshift mutation as the nucleotide sequence (DNA or RNA) is not altered only the frame in which it is read.
A reading frame that contains a start codon and a stop codon is called an open reading frame (ORF).
References
- ↑ Johnson Z, Chisholm S (2004). "Properties of overlapping genes are conserved across microbial genomes.". Genome Res 14 (11): 2268-72. PMID 15520290.
See also
de:LeserasterHe:מסגרת קריאה (ביולוגיה) hu:Reading frame
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Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
