Kawasaki disease causes: Difference between revisions
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==Causes== | ==Causes== | ||
*The exact cause of | *The exact cause of Kawasaki disease has not been identified. | ||
*The current [[etiology|etiological]] theories center primarily on [[immune system|immunological]] causes for the disease. | *The current [[etiology|etiological]] theories center primarily on [[immune system|immunological]] causes for the disease. | ||
* | *Studies have failed to discover a definitive [[toxin]] or [[antigen]]ic substance,a [[superantigen]] may be a possible etiology. | ||
*An unknown virus may play a role as an inciting factor as well. | *An unknown virus may play a role as an inciting factor as well. | ||
*There are several hypothesis for the causes of Kawasaki disease, the | *There are several hypothesis for the causes of Kawasaki disease, the infectious agents which are thought to induce Kawasaki disease are:<ref name="pmid18448971">{{cite journal |vauthors=Pinna GS, Kafetzis DA, Tselkas OI, Skevaki CL |title=Kawasaki disease: an overview |journal=Curr. Opin. Infect. Dis. |volume=21 |issue=3 |pages=263–70 |date=June 2008 |pmid=18448971 |doi=10.1097/QCO.0b013e3282fbf9cd |url=}}</ref><ref name="pmid9832593">{{cite journal |vauthors=Yanagawa H, Nakamura Y, Yashiro M, Ojima T, Tanihara S, Oki I, Zhang T |title=Results of the nationwide epidemiologic survey of Kawasaki disease in 1995 and 1996 in Japan |journal=Pediatrics |volume=102 |issue=6 |pages=E65 |date=December 1998 |pmid=9832593 |doi= |url=}}</ref><ref name="Sundel2015">{{cite journal|last1=Sundel|first1=Robert P.|title=Kawasaki Disease|journal=Rheumatic Disease Clinics of North America|volume=41|issue=1|year=2015|pages=63–73|issn=0889857X|doi=10.1016/j.rdc.2014.09.010}}</ref> | ||
**[[Parvovirus]] B19 | **[[Parvovirus]] B19 | ||
**[[Meningococcal]] septicemia | **[[Meningococcal]] septicemia | ||
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**[[Cytomegalovirus]] | **[[Cytomegalovirus]] | ||
**[[Epstein Barr virus|Epstein-Barr virus]] | **[[Epstein Barr virus|Epstein-Barr virus]] | ||
**Human lymphotropic virus | **Human lymphotropic virus | ||
**[[Klebsiella pneumoniae]] | **[[Klebsiella pneumoniae]] | ||
**[[Mycoplasma pneumoniae]] | **[[Mycoplasma pneumoniae]] | ||
**[[Mite]]-associated bacteria | **[[Mite]]-associated bacteria | ||
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**[[Propionibacterium acnes]] | **[[Propionibacterium acnes]] | ||
**[[Human parainfluenza viruses|Parainfluenza type 3 virus]] | **[[Human parainfluenza viruses|Parainfluenza type 3 virus]] | ||
**[[Rotavirus]] | **[[Rotavirus]] | ||
**[[Rickettsiae|Rickettsia]] species | **[[Rickettsiae|Rickettsia]] species | ||
**[[Tick-borne disease|Tick-borne diseases]] | **[[Tick-borne disease|Tick-borne diseases]] | ||
Revision as of 19:19, 16 April 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Dildar Hussain, MBBS [2]
Overview
The exact cause of Kawasaki disease has not been identified. The current etiological theories center primarily on immunological causes for the disease, much research has been carried out to discover a definitive toxin or antigenic substance, possibly a superantigen, that is the specific cause of the disease. There are several hypothesis for the cause of Kawasaki disease - infectious agents which are thought to induce Kawasaki disease include parvovirus B19, meningococcal septicemia, adenovirus, bacterial toxin–mediated, superantigens, cytomegalovirus, Epstein-Barr virus, human lymphotropic virus, klebsiella pneumoniae, mycoplasma pneumoniae, mite-associated bacteria, measles, propionibacterium acnes, parainfluenza type 3 virus, rotavirus infection, rickettsia species and tick-borne diseases.
Causes
- The exact cause of Kawasaki disease has not been identified.
- The current etiological theories center primarily on immunological causes for the disease.
- Studies have failed to discover a definitive toxin or antigenic substance,a superantigen may be a possible etiology.
- An unknown virus may play a role as an inciting factor as well.
- There are several hypothesis for the causes of Kawasaki disease, the infectious agents which are thought to induce Kawasaki disease are:[1][2][3]
- Parvovirus B19
- Meningococcal septicemia
- Adenovirus
- Bacterial toxin–mediated superantigens
- Cytomegalovirus
- Epstein-Barr virus
- Human lymphotropic virus
- Klebsiella pneumoniae
- Mycoplasma pneumoniae
- Mite-associated bacteria
- Measles
- Propionibacterium acnes
- Parainfluenza type 3 virus
- Rotavirus
- Rickettsia species
- Tick-borne diseases
References
- ↑ Pinna GS, Kafetzis DA, Tselkas OI, Skevaki CL (June 2008). "Kawasaki disease: an overview". Curr. Opin. Infect. Dis. 21 (3): 263–70. doi:10.1097/QCO.0b013e3282fbf9cd. PMID 18448971.
- ↑ Yanagawa H, Nakamura Y, Yashiro M, Ojima T, Tanihara S, Oki I, Zhang T (December 1998). "Results of the nationwide epidemiologic survey of Kawasaki disease in 1995 and 1996 in Japan". Pediatrics. 102 (6): E65. PMID 9832593.
- ↑ Sundel, Robert P. (2015). "Kawasaki Disease". Rheumatic Disease Clinics of North America. 41 (1): 63–73. doi:10.1016/j.rdc.2014.09.010. ISSN 0889-857X.