KLRC2

Killer cell lectin-like receptor subfamily C, member 2
Identifiers
Symbols	KLRC2 ; CD159c; MGC138244; NKG2-C; NKG2C
External IDs	Template:OMIM5
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE KLRC2 206785 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Killer cell lectin-like receptor subfamily C, member 2, also known as KLRC2, is a human gene.

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The group, designated KLRC (NKG2) are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The KLRC (NKG2) gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. KLRC2 alternative splice variants have been described but their full-length nature has not been determined.

See also

• Cluster of differentiation

Further reading

• Houchins JP, Yabe T, McSherry C, Bach FH (1991). "DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells". J. Exp. Med. 173 (4): 1017–20. PMID 2007850.CS1 maint: Multiple names: authors list (link)
• Yabe T, McSherry C, Bach FH; et al. (1993). "A multigene family on human chromosome 12 encodes natural killer-cell lectins". Immunogenetics. 37 (6): 455–60. PMID 8436421.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Houchins JP, Lanier LL, Niemi EC; et al. (1997). "Natural killer cell cytolytic activity is inhibited by NKG2-A and activated by NKG2-C". J. Immunol. 158 (8): 3603–9. PMID 9103421.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Braud VM, Allan DS, O'Callaghan CA; et al. (1998). "HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C.". Nature. 391 (6669): 795–9. doi:10.1038/35869. PMID 9486650.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Plougastel B, Trowsdale J (1998). "Sequence analysis of a 62-kb region overlapping the human KLRC cluster of genes". Genomics. 49 (2): 193–9. doi:10.1006/geno.1997.5197. PMID 9598306.
• Lanier LL, Corliss B, Wu J, Phillips JH (1998). "Association of DAP12 with activating CD94/NKG2C NK cell receptors". Immunity. 8 (6): 693–701. PMID 9655483.CS1 maint: Multiple names: authors list (link)
• Glienke J, Sobanov Y, Brostjan C; et al. (1998). "The genomic organization of NKG2C, E, F, and D receptor genes in the human natural killer gene complex". Immunogenetics. 48 (3): 163–73. PMID 9683661.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ding Y, Sumitran S, Holgersson J (1999). "Direct binding of purified HLA class I antigens by soluble NKG2/CD94 C-type lectins from natural killer cells". Scand. J. Immunol. 49 (5): 459–65. PMID 10320637.CS1 maint: Multiple names: authors list (link)
• Khakoo SI, Rajalingam R, Shum BP; et al. (2000). "Rapid evolution of NK cell receptor systems demonstrated by comparison of chimpanzees and humans". Immunity. 12 (6): 687–98. PMID 10894168.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shum BP, Flodin LR, Muir DG; et al. (2002). "Conservation and variation in human and common chimpanzee CD94 and NKG2 genes". J. Immunol. 168 (1): 240–52. PMID 11751968.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hikami K, Tsuchiya N, Yabe T, Tokunaga K (2003). "Variations of human killer cell lectin-like receptors: common occurrence of NKG2-C deletion in the general population". Genes Immun. 4 (2): 160–7. doi:10.1038/sj.gene.6363940. PMID 12618865.CS1 maint: Multiple names: authors list (link)
• Miyashita R, Tsuchiya N, Hikami K; et al. (2004). "Molecular genetic analyses of human NKG2C (KLRC2) gene deletion". Int. Immunol. 16 (1): 163–8. PMID 14688071.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ortega C, Romero P, Palma A; et al. (2005). "Role for NKG2-A and NKG2-C surface receptors in chronic CD4+ T-cell responses". Immunol. Cell Biol. 82 (6): 587–95. doi:10.1111/j.0818-9641.2004.01284.x. PMID 15550116.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gumá M, Busch LK, Salazar-Fontana LI; et al. (2005). "The CD94/NKG2C killer lectin-like receptor constitutes an alternative activation pathway for a subset of CD8+ T cells". Eur. J. Immunol. 35 (7): 2071–80. doi:10.1002/eji.200425843. PMID 15940674.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.