IgA nephropathy history and symptoms: Difference between revisions

Jump to navigation Jump to search
(Created page with "__NOTOC__ {{IgA nephropathy }} {{CMG}} ==Overview== ==History and Symptoms== The classic presentation (in 40-50% of the cases) is episodic frank hematuria which usually s...")
 
No edit summary
 
(21 intermediate revisions by 3 users not shown)
Line 1: Line 1:
__NOTOC__
__NOTOC__
{{IgA nephropathy  }}
{{IgA nephropathy  }}
{{CMG}}
{{CMG}}; {{AE}} {{SH}}, {{Rim}}
==Overview==
==Overview==
The majority of patients with IgA nephropathy are asymptomatic. Some patients with IgA nephropathy may develop intermittent gross [[hematuria]] which is often termed as synpharyngitic [[hematuria]], because it occurs after the episodes of [[Bacteria|bacterial]] [[tonsillitis]] or [[Virus|viral]] [[Upper respiratory tract infection|URTI's]]. The patient may also have a positive history of [[flank pain]], [[Low-grade fever|low grade fever]].
==History and Symptoms==
==History and Symptoms==
The classic presentation (in 40-50% of the cases) is episodic frank [[hematuria]] which usually starts within a day of an [[upper respiratory tract infection]] (hence ''synpharyngitic'', as opposed to [[post-streptococcal glomerulonephritis]] which occurs some time after an initial infection). Flank pain can also occur. The frank hematuria resolves after a few days, though the [[microscopic hematuria]] persists. These episodes occur on an irregular basis, and in most patients, this eventually stops (although it can take many years). Renal function usually remains normal, though rarely, [[acute renal failure]] may occur (see below). This presentation is more common in younger adults.  
*The majority of patients with IgA nephropathy may be asymptomatic.


A smaller proportion (20-30%), usually the older population, have microscopic hematuria and [[proteinuria]] (less than 2 grams of protein per 24 hours). These patients may not have any symptoms and are only picked up if a doctor decides to take a urine sample. Hence, the disease is picked up more commonly in situations where screening of urine is compulsory, e.g. school children in Japan.  
===History===
Patients with IgA nephropathy may have a positive history of:<ref name="pmid7723227">{{cite journal |vauthors=Galla JH |title=IgA nephropathy |journal=Kidney Int. |volume=47 |issue=2 |pages=377–87 |date=February 1995 |pmid=7723227 |doi= |url=}}</ref><ref name="pmid12213946">{{cite journal |vauthors=Donadio JV, Grande JP |title=IgA nephropathy |journal=N. Engl. J. Med. |volume=347 |issue=10 |pages=738–48 |date=September 2002 |pmid=12213946 |doi=10.1056/NEJMra020109 |url=}}</ref>
*Intermittent gross [[hematuria]]
*Synpharyngitic [[hematuria]]
*The precipitating factors for synpharyngitic hematuria are:
**[[Bacteria|Bacterial]] [[tonsillitis]]
**[[Virus|Viral]] [[Upper respiratory tract infection|URTI's]]
*[[Microscopic hematuria]]
*[[Flank pain]]
*[[Low-grade fever|Low grade fever]]
*Mild [[proteinuria]]


Very rarely (5% each), the presenting history is:
===Common Symptoms===
* [[Nephrotic syndrome]] (excessive protein loss in the urine, associated with an excellent prognosis)
Common symptoms of IgA nephropathy include:<ref name="pmid15524056">{{cite journal |vauthors=Hall CL, Bradley R, Kerr A, Attoti R, Peat D |title=Clinical value of renal biopsy in patients with asymptomatic microscopic hematuria with and without low-grade proteinuria |journal=Clin. Nephrol. |volume=62 |issue=4 |pages=267–72 |date=October 2004 |pmid=15524056 |doi= |url=}}</ref><ref name="pmid8041865">{{cite journal |vauthors=Topham PS, Harper SJ, Furness PN, Harris KP, Walls J, Feehally J |title=Glomerular disease as a cause of isolated microscopic haematuria |journal=Q. J. Med. |volume=87 |issue=6 |pages=329–35 |date=June 1994 |pmid=8041865 |doi= |url=}}</ref>
* [[Acute renal failure]] (either as a complication of the frank hematuria, when it usually recovers, or due to [[rapidly progressive glomerulonephritis]] which often leads to [[chronic renal failure]])
*[[Flank pain]]
* [[Chronic renal failure]] (no previous symptoms, presents with [[anemia]], [[hypertension]] and other symptoms of renal failure,  in people who probably had longstanding undetected microscopic hematuria and/or proteinuria)
*[[Low-grade fever|Low grade fever]]
*Mild [[proteinuria]]
*[[Microscopic hematuria]]


A variety of systemic diseases are associated with IgA nephropathy such as [[liver failure]], [[coeliac disease]], [[rheumatoid arthritis]], [[Reiter's disease]], [[ankylosing spondylitis]] and [[HIV]]. Diagnosis of IgA Nephropathy and a search for any associated disease occasionally reveals such an underlying serious systemic disease. Occasionally, there are simultaneous symptoms of [[Henoch-Schönlein purpura]]; see below for more details on the association.
===Less Common Symptoms===
Less common symptoms of IgA nephropathy include: <ref name="GutierrezGonzalez2006">{{cite journal|last1=Gutierrez|first1=E.|last2=Gonzalez|first2=E.|last3=Hernandez|first3=E.|last4=Morales|first4=E.|last5=Martinez|first5=M. A.|last6=Usera|first6=G.|last7=Praga|first7=M.|title=Factors That Determine an Incomplete Recovery of Renal Function in Macrohematuria-Induced Acute Renal Failure of IgA Nephropathy|journal=Clinical Journal of the American Society of Nephrology|volume=2|issue=1|year=2006|pages=51–57|issn=1555-9041|doi=10.2215/CJN.02670706}}</ref>
*[[Acute (medicine)|Acute]] [[rapidly progressive glomerulonephritis]]
**[[Edema]]
**[[Hypertension]]
**[[Renal insufficiency]]
**[[Hematuria]]
*[[Oliguria]]


==References==
==References==
Line 19: Line 40:
{{WH}}
{{WH}}
{{WS}}
{{WS}}


[[Category:Nephrology]]
[[Category:Nephrology]]
[[Category:Genetic disorders]]
[[Category:Genetic disorders]]

Latest revision as of 18:24, 18 July 2018

IgA nephropathy Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating IgA nephropathy from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X-ray

CT

MRI

Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

IgA nephropathy history and symptoms On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of IgA nephropathy history and symptoms

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on IgA nephropathy history and symptoms

CDC on IgA nephropathy history and symptoms

IgA nephropathy history and symptoms in the news

Blogs on IgA nephropathy history and symptoms

Directions to Hospitals Treating IgA nephropathy

Risk calculators and risk factors for IgA nephropathy history and symptoms

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Dildar Hussain, MBBS [2], Rim Halaby, M.D. [3]

Overview

The majority of patients with IgA nephropathy are asymptomatic. Some patients with IgA nephropathy may develop intermittent gross hematuria which is often termed as synpharyngitic hematuria, because it occurs after the episodes of bacterial tonsillitis or viral URTI's. The patient may also have a positive history of flank pain, low grade fever.

History and Symptoms

  • The majority of patients with IgA nephropathy may be asymptomatic.

History

Patients with IgA nephropathy may have a positive history of:[1][2]

Common Symptoms

Common symptoms of IgA nephropathy include:[3][4]

Less Common Symptoms

Less common symptoms of IgA nephropathy include: [5]

References

  1. Galla JH (February 1995). "IgA nephropathy". Kidney Int. 47 (2): 377–87. PMID 7723227.
  2. Donadio JV, Grande JP (September 2002). "IgA nephropathy". N. Engl. J. Med. 347 (10): 738–48. doi:10.1056/NEJMra020109. PMID 12213946.
  3. Hall CL, Bradley R, Kerr A, Attoti R, Peat D (October 2004). "Clinical value of renal biopsy in patients with asymptomatic microscopic hematuria with and without low-grade proteinuria". Clin. Nephrol. 62 (4): 267–72. PMID 15524056.
  4. Topham PS, Harper SJ, Furness PN, Harris KP, Walls J, Feehally J (June 1994). "Glomerular disease as a cause of isolated microscopic haematuria". Q. J. Med. 87 (6): 329–35. PMID 8041865.
  5. Gutierrez, E.; Gonzalez, E.; Hernandez, E.; Morales, E.; Martinez, M. A.; Usera, G.; Praga, M. (2006). "Factors That Determine an Incomplete Recovery of Renal Function in Macrohematuria-Induced Acute Renal Failure of IgA Nephropathy". Clinical Journal of the American Society of Nephrology. 2 (1): 51–57. doi:10.2215/CJN.02670706. ISSN 1555-9041.

Template:WH Template:WS