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{{IgA nephropathy  }}
{{IgA nephropathy  }}
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==Overview==
==Overview==
[[IgA nephropathy]] (Berger disease) was first described by Jean Berger, a pathologist, and Nicole Hinglais, an electron microscopist, in 1968 in France.
==Historical Perspective==
==Historical Perspective==
IgA nephropathy was first described by Jean Berger, a pathologist, and Nicole Hinglais, an electron microscopist, in 1968 in France.<ref name="pmid4107073">{{cite journal| author=Berger J| title=IgA glomerular deposits in renal disease. | journal=Transplant Proc | year= 1969 | volume= 1 | issue= 4 | pages= 939-44 | pmid=4107073 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=4107073 }} </ref><ref name="pmid4180586">{{cite journal| author=Berger J, Hinglais N| title=[Intercapillary deposits of IgA-IgG]. | journal=J Urol Nephrol (Paris) | year= 1968 | volume= 74 | issue= 9 | pages= 694-5 | pmid=4180586 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=4180586 }} </ref><ref name="pmid21705126">{{cite journal| author=Feehally J, Cameron JS| title=IgA nephropathy: progress before and since Berger. | journal=Am J Kidney Dis | year= 2011 | volume= 58 | issue= 2 | pages= 310-9 | pmid=21705126 | doi=10.1053/j.ajkd.2011.03.024 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21705126 }} </ref> In the original one-page article titled “Les depots intercapillaires d'IgA-IgG” in the “journal d’Urologie-Nephrologie”, the authors describe the renal disease under light microscopy showing focal and segmental mesangial proliferation with expansion of the matrix. Under electron microscopy, they noted the predominance of IgA deposits in the renal mesangium that were associated with the presence of less significant presence of IgG and C3. The association of IgA nephropathy with Henoch-Schonlein purpura was made very shortly by Berger following the first description of IgA nephropathy in 1969.<ref name="pmid4107073">{{cite journal| author=Berger J| title=IgA glomerular deposits in renal disease. | journal=Transplant Proc | year= 1969 | volume= 1 | issue= 4 | pages= 939-44 | pmid=4107073 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=4107073 }} </ref>
*In 1968, [[IgA nephropathy]] was first described by Jean Berger, a pathologist, and Nicole Hinglais, an electron microscopist, in France.<ref name="pmid4107073">{{cite journal| author=Berger J| title=IgA glomerular deposits in renal disease. | journal=Transplant Proc | year= 1969 | volume= 1 | issue= 4 | pages= 939-44 | pmid=4107073 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=4107073 }} </ref><ref name="pmid4180586">{{cite journal| author=Berger J, Hinglais N| title=[Intercapillary deposits of IgA-IgG]. | journal=J Urol Nephrol (Paris) | year= 1968 | volume= 74 | issue= 9 | pages= 694-5 | pmid=4180586 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=4180586 }} </ref><ref name="pmid21705126">{{cite journal| author=Feehally J, Cameron JS| title=IgA nephropathy: progress before and since Berger. | journal=Am J Kidney Dis | year= 2011 | volume= 58 | issue= 2 | pages= 310-9 | pmid=21705126 | doi=10.1053/j.ajkd.2011.03.024 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21705126 }} </ref><ref name="FeehallyCameron2011">{{cite journal|last1=Feehally|first1=John|last2=Cameron|first2=J. Stewart|title=IgA Nephropathy: Progress Before and Since Berger|journal=American Journal of Kidney Diseases|volume=58|issue=2|year=2011|pages=310–319|issn=02726386|doi=10.1053/j.ajkd.2011.03.024}}</ref>
 
*[[IgA nephropathy]] was originally described by Berger and Hinglais in 1968. In the original one-page article titled “Les depots intercapillaires d'IgA-IgG” in the “journal d’Urologie-Nephrologie”, the authors described the renal disease under [[light microscopy]] showing focal and segmental [[Mesangium|mesangial]] proliferation with expansion of the [[matrix]]. Under [[electron microscopy]], they noted the predominance of [[IgA|IgA deposits]] in the [[Mesangium|renal mesangium]] that were associated with the presence of less significant presence of [[IgG]] and [[C3 (complement)|C3]].
*In 1969, following the first description of IgA nephropathy, the association of [[IgA nephropathy]] with [[Henoch-Schönlein purpura]] was described by Berger.<ref name="pmid4107073" />


==References==
==References==
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[[Category:Nephrology]]
[[Category:Nephrology]]
[[Category:Genetic disorders]]
[[Category:Genetic disorders]]

Latest revision as of 13:12, 18 July 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Ali Poyan Mehr, M.D. [2] Associate Editor(s)-in-Chief: Olufunmilola Olubukola M.D.[3]

Overview

IgA nephropathy (Berger disease) was first described by Jean Berger, a pathologist, and Nicole Hinglais, an electron microscopist, in 1968 in France.

Historical Perspective

  • In 1968, IgA nephropathy was first described by Jean Berger, a pathologist, and Nicole Hinglais, an electron microscopist, in France.[1][2][3][4]

References

  1. 1.0 1.1 Berger J (1969). "IgA glomerular deposits in renal disease". Transplant Proc. 1 (4): 939–44. PMID 4107073.
  2. Berger J, Hinglais N (1968). "[Intercapillary deposits of IgA-IgG]". J Urol Nephrol (Paris). 74 (9): 694–5. PMID 4180586.
  3. Feehally J, Cameron JS (2011). "IgA nephropathy: progress before and since Berger". Am J Kidney Dis. 58 (2): 310–9. doi:10.1053/j.ajkd.2011.03.024. PMID 21705126.
  4. Feehally, John; Cameron, J. Stewart (2011). "IgA Nephropathy: Progress Before and Since Berger". American Journal of Kidney Diseases. 58 (2): 310–319. doi:10.1053/j.ajkd.2011.03.024. ISSN 0272-6386.

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