GP5: Difference between revisions

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{{about|the glycoprotein V| the GP5 computer chip |GP5 chip | the Soviet-era civilian gas mask |GP-5 gas mask }}
{{PBB_Controls
{{Infobox_gene}}
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'''Glycoprotein V (platelet)''' ('''GP5''') also known as '''CD42d''' ('''C'''luster of '''D'''ifferentiation '''42d'''), is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GP5 glycoprotein V (platelet)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2814| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Glycoprotein V (platelet)
| HGNCid = 4443
  | Symbol = GP5
| AltSymbols =; CD42d
| OMIM = 173511
| ECnumber = 
| Homologene = 74523
| MGIid = 1096363
| GeneAtlas_image1 = PBB_GE_GP5_211525_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}}
| Process = {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007596 |text = blood coagulation}}  
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2814
    | Hs_Ensembl = ENSG00000178732
    | Hs_RefseqProtein = NP_004479
    | Hs_RefseqmRNA = NM_004488
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 195598618
    | Hs_GenLoc_end = 195600300
    | Hs_Uniprot = P40197
    | Mm_EntrezGene = 14729
    | Mm_Ensembl = ENSMUSG00000047953
    | Mm_RefseqmRNA = NM_008148
    | Mm_RefseqProtein = NP_032174
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 16
    | Mm_GenLoc_start = 30227440
    | Mm_GenLoc_end = 30230526
    | Mm_Uniprot = Q3TA66
  }}
}}
'''Glycoprotein V (platelet)''' ('''GP5''') also known as '''CD42d''' ('''C'''luster of '''D'''ifferentiation '''42d'''), is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GP5 glycoprotein V (platelet)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2814| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = Human platelet glycoprotein V (GP5) is a part of the Ib-V-IX system of surface glycoproteins that constitute the receptor for von Willebrand factor (VWF; MIM 193400) and mediate the adhesion of platelets to injured vascular surfaces in the arterial circulation, a critical initiating event in hemostasis. The main portion of the receptor is a heterodimer composed of 2 polypeptide chains, an alpha chain (GP1BA; MIM 606672) and a beta chain (GP1BB; MIM 138720), that are linked by disulfide bonds. The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX (GP9; MIM 173515) and GP5. Mutations in GP1BA, GP1BB, and GP9 have been shown to cause Bernard-Soulier syndrome (MIM 231200), a bleeding disorder.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: GP5 glycoprotein V (platelet)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2814| accessdate = }}</ref>
| summary_text = Human platelet glycoprotein V (GP5) is a part of the [[Glycoprotein Ib-IX-V Receptor Complex|Ib-V-IX system]] of surface glycoproteins that constitute the receptor for von Willebrand factor (VWF; MIM 193400) and mediate the adhesion of platelets to injured vascular surfaces in the arterial circulation, a critical initiating event in hemostasis. The main portion of the receptor is a heterodimer composed of 2 polypeptide chains, an alpha chain (GP1BA; MIM 606672) and a beta chain (GP1BB; MIM 138720), that are linked by disulfide bonds. The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX (GP9; MIM 173515) and GP5. Mutations in GP1BA, GP1BB, and GP9 have been shown to cause Bernard-Soulier syndrome (MIM 231200), a bleeding disorder.[supplied by OMIM]<ref name="entrez" />
}}
}}


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==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
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{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Modderman PW, Admiraal LG, Sonnenberg A, von dem Borne AE |title=Glycoproteins V and Ib-IX form a noncovalent complex in the platelet membrane. |journal=J. Biol. Chem. |volume=267 |issue= 1 |pages= 364-9 |year= 1992 |pmid= 1730602 |doi=  }}
*{{cite journal  |vauthors=Modderman PW, Admiraal LG, Sonnenberg A, von dem Borne AE |title=Glycoproteins V and Ib-IX form a noncovalent complex in the platelet membrane. |journal=J. Biol. Chem. |volume=267 |issue= 1 |pages= 364–9 |year= 1992 |pmid= 1730602 |doi=  }}
*{{cite journal  | author=Shimomura T, Fujimura K, Maehama S, ''et al.'' |title=Rapid purification and characterization of human platelet glycoprotein V: the amino acid sequence contains leucine-rich repetitive modules as in glycoprotein Ib. |journal=Blood |volume=75 |issue= 12 |pages= 2349-56 |year= 1990 |pmid= 2350580 |doi=  }}
*{{cite journal  |vauthors=Shimomura T, Fujimura K, Maehama S |title=Rapid purification and characterization of human platelet glycoprotein V: the amino acid sequence contains leucine-rich repetitive modules as in glycoprotein Ib. |journal=Blood |volume=75 |issue= 12 |pages= 2349–56 |year= 1990 |pmid= 2350580 |doi=  |display-authors=etal}}
*{{cite journal  | author=Roth GJ, Church TA, McMullen BA, Williams SA |title=Human platelet glycoprotein V: a surface leucine-rich glycoprotein related to adhesion. |journal=Biochem. Biophys. Res. Commun. |volume=170 |issue= 1 |pages= 153-61 |year= 1990 |pmid= 2372284 |doi=  }}
*{{cite journal  |vauthors=Roth GJ, Church TA, McMullen BA, Williams SA |title=Human platelet glycoprotein V: a surface leucine-rich glycoprotein related to adhesion. |journal=Biochem. Biophys. Res. Commun. |volume=170 |issue= 1 |pages= 153–61 |year= 1990 |pmid= 2372284 |doi=10.1016/0006-291X(90)91253-O }}
*{{cite journal  | author=Hickey MJ, Hagen FS, Yagi M, Roth GJ |title=Human platelet glycoprotein V: characterization of the polypeptide and the related Ib-V-IX receptor system of adhesive, leucine-rich glycoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 18 |pages= 8327-31 |year= 1993 |pmid= 7690959 |doi= }}
*{{cite journal  |vauthors=Hickey MJ, Hagen FS, Yagi M, Roth GJ |title=Human platelet glycoprotein V: characterization of the polypeptide and the related Ib-V-IX receptor system of adhesive, leucine-rich glycoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 18 |pages= 8327–31 |year= 1993 |pmid= 7690959 |doi=10.1073/pnas.90.18.8327  | pmc=47349  }}
*{{cite journal  | author=Meyer SC, Fox JE |title=Interaction of platelet glycoprotein V with glycoprotein Ib-IX regulates expression of the glycoproteins and binding of von Willebrand factor to glycoprotein Ib-IX in transfected cells. |journal=J. Biol. Chem. |volume=270 |issue= 24 |pages= 14693-9 |year= 1995 |pmid= 7782333 |doi=  }}
*{{cite journal  |vauthors=Meyer SC, Fox JE |title=Interaction of platelet glycoprotein V with glycoprotein Ib-IX regulates expression of the glycoproteins and binding of von Willebrand factor to glycoprotein Ib-IX in transfected cells. |journal=J. Biol. Chem. |volume=270 |issue= 24 |pages= 14693–9 |year= 1995 |pmid= 7782333 |doi=10.1074/jbc.270.24.14693 }}
*{{cite journal  | author=Takafuta T, Fujimura K, Kawano H, ''et al.'' |title=Expression of platelet membrane glycoprotein V in human megakaryocytes and megakaryocytic cell lines: a study using a novel monoclonal antibody against GPV. |journal=Thromb. Haemost. |volume=72 |issue= 5 |pages= 762-9 |year= 1995 |pmid= 7900083 |doi=  }}
*{{cite journal  |vauthors=Takafuta T, Fujimura K, Kawano H |title=Expression of platelet membrane glycoprotein V in human megakaryocytes and megakaryocytic cell lines: a study using a novel monoclonal antibody against GPV. |journal=Thromb. Haemost. |volume=72 |issue= 5 |pages= 762–9 |year= 1995 |pmid= 7900083 |doi=  |display-authors=etal}}
*{{cite journal  | author=Lanza F, Morales M, de La Salle C, ''et al.'' |title=Cloning and characterization of the gene encoding the human platelet glycoprotein V. A member of the leucine-rich glycoprotein family cleaved during thrombin-induced platelet activation. |journal=J. Biol. Chem. |volume=268 |issue= 28 |pages= 20801-7 |year= 1993 |pmid= 8407908 |doi=  }}
*{{cite journal  |vauthors=Lanza F, Morales M, de La Salle C |title=Cloning and characterization of the gene encoding the human platelet glycoprotein V. A member of the leucine-rich glycoprotein family cleaved during thrombin-induced platelet activation. |journal=J. Biol. Chem. |volume=268 |issue= 28 |pages= 20801–7 |year= 1993 |pmid= 8407908 |doi=  |display-authors=etal}}
*{{cite journal  | author=Yagi M, Edelhoff S, Disteche CM, Roth GJ |title=Human platelet glycoproteins V and IX: mapping of two leucine-rich glycoprotein genes to chromosome 3 and analysis of structures. |journal=Biochemistry |volume=34 |issue= 49 |pages= 16132-7 |year= 1996 |pmid= 8519770 |doi=  }}
*{{cite journal  |vauthors=Yagi M, Edelhoff S, Disteche CM, Roth GJ |title=Human platelet glycoproteins V and IX: mapping of two leucine-rich glycoprotein genes to chromosome 3 and analysis of structures. |journal=Biochemistry |volume=34 |issue= 49 |pages= 16132–7 |year= 1996 |pmid= 8519770 |doi=10.1021/bi00049a028 }}
*{{cite journal  | author=Berger G, Massé JM, Cramer EM |title=Alpha-granule membrane mirrors the platelet plasma membrane and contains the glycoproteins Ib, IX, and V. |journal=Blood |volume=87 |issue= 4 |pages= 1385-95 |year= 1996 |pmid= 8608228 |doi=  }}
*{{cite journal  |vauthors=Berger G, Massé JM, Cramer EM |title=Alpha-granule membrane mirrors the platelet plasma membrane and contains the glycoproteins Ib, IX, and V. |journal=Blood |volume=87 |issue= 4 |pages= 1385–95 |year= 1996 |pmid= 8608228 |doi=  }}
*{{cite journal  | author=Ravanat C, Morales M, Azorsa DO, ''et al.'' |title=Gene cloning of rat and mouse platelet glycoprotein V: identification of megakaryocyte-specific promoters and demonstration of functional thrombin cleavage. |journal=Blood |volume=89 |issue= 9 |pages= 3253-62 |year= 1997 |pmid= 9129030 |doi=  }}
*{{cite journal  |vauthors=Ravanat C, Morales M, Azorsa DO |title=Gene cloning of rat and mouse platelet glycoprotein V: identification of megakaryocyte-specific promoters and demonstration of functional thrombin cleavage. |journal=Blood |volume=89 |issue= 9 |pages= 3253–62 |year= 1997 |pmid= 9129030 |doi=  |display-authors=etal}}
*{{cite journal  | author=Bradford HN, Dela Cadena RA, Kunapuli SP, ''et al.'' |title=Human kininogens regulate thrombin binding to platelets through the glycoprotein Ib-IX-V complex. |journal=Blood |volume=90 |issue= 4 |pages= 1508-15 |year= 1997 |pmid= 9269768 |doi=  }}
*{{cite journal  |vauthors=Bradford HN, Dela Cadena RA, Kunapuli SP |title=Human kininogens regulate thrombin binding to platelets through the glycoprotein Ib-IX-V complex. |journal=Blood |volume=90 |issue= 4 |pages= 1508–15 |year= 1997 |pmid= 9269768 |doi=  |display-authors=etal}}
*{{cite journal  | author=Wu G, Essex DW, Meloni FJ, ''et al.'' |title=Human endothelial cells in culture and in vivo express on their surface all four components of the glycoprotein Ib/IX/V complex. |journal=Blood |volume=90 |issue= 7 |pages= 2660-9 |year= 1997 |pmid= 9326233 |doi=  }}
*{{cite journal  |vauthors=Wu G, Essex DW, Meloni FJ |title=Human endothelial cells in culture and in vivo express on their surface all four components of the glycoprotein Ib/IX/V complex. |journal=Blood |volume=90 |issue= 7 |pages= 2660–9 |year= 1997 |pmid= 9326233 |doi=  |display-authors=etal}}
*{{cite journal  | author=Andrews RK, Harris SJ, McNally T, Berndt MC |title=Binding of purified 14-3-3 zeta signaling protein to discrete amino acid sequences within the cytoplasmic domain of the platelet membrane glycoprotein Ib-IX-V complex. |journal=Biochemistry |volume=37 |issue= 2 |pages= 638-47 |year= 1998 |pmid= 9425086 |doi= 10.1021/bi970893g }}
*{{cite journal  |vauthors=Andrews RK, Harris SJ, McNally T, Berndt MC |title=Binding of purified 14-3-3 zeta signaling protein to discrete amino acid sequences within the cytoplasmic domain of the platelet membrane glycoprotein Ib-IX-V complex. |journal=Biochemistry |volume=37 |issue= 2 |pages= 638–47 |year= 1998 |pmid= 9425086 |doi= 10.1021/bi970893g }}
*{{cite journal  | author=Longhurst CM, White MM, Wilkinson DA, Jennings LK |title=A CD9, alphaIIbbeta3, integrin-associated protein, and GPIb/V/IX complex on the surface of human platelets is influenced by alphaIIbbeta3 conformational states. |journal=Eur. J. Biochem. |volume=263 |issue= 1 |pages= 104-11 |year= 1999 |pmid= 10429193 |doi=  }}
*{{cite journal  |vauthors=Longhurst CM, White MM, Wilkinson DA, Jennings LK |title=A CD9, alphaIIbbeta3, integrin-associated protein, and GPIb/V/IX complex on the surface of human platelets is influenced by alphaIIbbeta3 conformational states. |journal=Eur. J. Biochem. |volume=263 |issue= 1 |pages= 104–11 |year= 1999 |pmid= 10429193 |doi=10.1046/j.1432-1327.1999.00467.x }}
*{{cite journal  | author=Dicker IB, Pedicord DL, Seiffert DA, ''et al.'' |title=Both the high affinity thrombin receptor (GPIb-IX-V) and GPIIb/IIIa are implicated in expression of thrombin-induced platelet procoagulant activity. |journal=Thromb. Haemost. |volume=86 |issue= 4 |pages= 1065-9 |year= 2002 |pmid= 11686325 |doi=  }}
*{{cite journal  |vauthors=Dicker IB, Pedicord DL, Seiffert DA |title=Both the high affinity thrombin receptor (GPIb-IX-V) and GPIIb/IIIa are implicated in expression of thrombin-induced platelet procoagulant activity. |journal=Thromb. Haemost. |volume=86 |issue= 4 |pages= 1065–9 |year= 2002 |pmid= 11686325 |doi=  |display-authors=etal}}
*{{cite journal  | author=Rabie T, Strehl A, Ludwig A, Nieswandt B |title=Evidence for a role of ADAM17 (TACE) in the regulation of platelet glycoprotein V. |journal=J. Biol. Chem. |volume=280 |issue= 15 |pages= 14462-8 |year= 2005 |pmid= 15691827 |doi= 10.1074/jbc.M500041200 }}
*{{cite journal  |vauthors=Rabie T, Strehl A, Ludwig A, Nieswandt B |title=Evidence for a role of ADAM17 (TACE) in the regulation of platelet glycoprotein V. |journal=J. Biol. Chem. |volume=280 |issue= 15 |pages= 14462–8 |year= 2005 |pmid= 15691827 |doi= 10.1074/jbc.M500041200 }}
*{{cite journal  | author=Aktas B, Pozgajova M, Bergmeier W, ''et al.'' |title=Aspirin induces platelet receptor shedding via ADAM17 (TACE). |journal=J. Biol. Chem. |volume=280 |issue= 48 |pages= 39716-22 |year= 2006 |pmid= 16179345 |doi= 10.1074/jbc.M507762200 }}
*{{cite journal  |vauthors=Aktas B, Pozgajova M, Bergmeier W |title=Aspirin induces platelet receptor shedding via ADAM17 (TACE). |journal=J. Biol. Chem. |volume=280 |issue= 48 |pages= 39716–22 |year= 2006 |pmid= 16179345 |doi= 10.1074/jbc.M507762200 |display-authors=etal}}
*{{cite journal  | author=Lewandrowski U, Moebius J, Walter U, Sickmann A |title=Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach. |journal=Mol. Cell Proteomics |volume=5 |issue= 2 |pages= 226-33 |year= 2006 |pmid= 16263699 |doi= 10.1074/mcp.M500324-MCP200 }}
*{{cite journal  |vauthors=Lewandrowski U, Moebius J, Walter U, Sickmann A |title=Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach. |journal=Mol. Cell. Proteomics |volume=5 |issue= 2 |pages= 226–33 |year= 2006 |pmid= 16263699 |doi= 10.1074/mcp.M500324-MCP200 }}
}}
}}
{{refend}}
{{refend}}
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* {{MeshName|GP5+protein,+human}}
* {{MeshName|GP5+protein,+human}}


{{membrane-protein-stub}}
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Latest revision as of 02:11, 27 October 2017

This article is about the glycoprotein V. For the GP5 computer chip, see GP5 chip. For the Soviet-era civilian gas mask, see GP-5 gas mask.
VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Glycoprotein V (platelet) (GP5) also known as CD42d (Cluster of Differentiation 42d), is a human gene.[1]

Human platelet glycoprotein V (GP5) is a part of the Ib-V-IX system of surface glycoproteins that constitute the receptor for von Willebrand factor (VWF; MIM 193400) and mediate the adhesion of platelets to injured vascular surfaces in the arterial circulation, a critical initiating event in hemostasis. The main portion of the receptor is a heterodimer composed of 2 polypeptide chains, an alpha chain (GP1BA; MIM 606672) and a beta chain (GP1BB; MIM 138720), that are linked by disulfide bonds. The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX (GP9; MIM 173515) and GP5. Mutations in GP1BA, GP1BB, and GP9 have been shown to cause Bernard-Soulier syndrome (MIM 231200), a bleeding disorder.[supplied by OMIM][1]

See also

References

  1. ↑ 1.0 1.1 "Entrez Gene: GP5 glycoprotein V (platelet)".

Further reading

  • Modderman PW, Admiraal LG, Sonnenberg A, von dem Borne AE (1992). "Glycoproteins V and Ib-IX form a noncovalent complex in the platelet membrane". J. Biol. Chem. 267 (1): 364–9. PMID 1730602.
  • Shimomura T, Fujimura K, Maehama S, et al. (1990). "Rapid purification and characterization of human platelet glycoprotein V: the amino acid sequence contains leucine-rich repetitive modules as in glycoprotein Ib". Blood. 75 (12): 2349–56. PMID 2350580.
  • Roth GJ, Church TA, McMullen BA, Williams SA (1990). "Human platelet glycoprotein V: a surface leucine-rich glycoprotein related to adhesion". Biochem. Biophys. Res. Commun. 170 (1): 153–61. doi:10.1016/0006-291X(90)91253-O. PMID 2372284.
  • Hickey MJ, Hagen FS, Yagi M, Roth GJ (1993). "Human platelet glycoprotein V: characterization of the polypeptide and the related Ib-V-IX receptor system of adhesive, leucine-rich glycoproteins". Proc. Natl. Acad. Sci. U.S.A. 90 (18): 8327–31. doi:10.1073/pnas.90.18.8327. PMC 47349. PMID 7690959.
  • Meyer SC, Fox JE (1995). "Interaction of platelet glycoprotein V with glycoprotein Ib-IX regulates expression of the glycoproteins and binding of von Willebrand factor to glycoprotein Ib-IX in transfected cells". J. Biol. Chem. 270 (24): 14693–9. doi:10.1074/jbc.270.24.14693. PMID 7782333.
  • Takafuta T, Fujimura K, Kawano H, et al. (1995). "Expression of platelet membrane glycoprotein V in human megakaryocytes and megakaryocytic cell lines: a study using a novel monoclonal antibody against GPV". Thromb. Haemost. 72 (5): 762–9. PMID 7900083.
  • Lanza F, Morales M, de La Salle C, et al. (1993). "Cloning and characterization of the gene encoding the human platelet glycoprotein V. A member of the leucine-rich glycoprotein family cleaved during thrombin-induced platelet activation". J. Biol. Chem. 268 (28): 20801–7. PMID 8407908.
  • Yagi M, Edelhoff S, Disteche CM, Roth GJ (1996). "Human platelet glycoproteins V and IX: mapping of two leucine-rich glycoprotein genes to chromosome 3 and analysis of structures". Biochemistry. 34 (49): 16132–7. doi:10.1021/bi00049a028. PMID 8519770.
  • Berger G, Massé JM, Cramer EM (1996). "Alpha-granule membrane mirrors the platelet plasma membrane and contains the glycoproteins Ib, IX, and V.". Blood. 87 (4): 1385–95. PMID 8608228.
  • Ravanat C, Morales M, Azorsa DO, et al. (1997). "Gene cloning of rat and mouse platelet glycoprotein V: identification of megakaryocyte-specific promoters and demonstration of functional thrombin cleavage". Blood. 89 (9): 3253–62. PMID 9129030.
  • Bradford HN, Dela Cadena RA, Kunapuli SP, et al. (1997). "Human kininogens regulate thrombin binding to platelets through the glycoprotein Ib-IX-V complex". Blood. 90 (4): 1508–15. PMID 9269768.
  • Wu G, Essex DW, Meloni FJ, et al. (1997). "Human endothelial cells in culture and in vivo express on their surface all four components of the glycoprotein Ib/IX/V complex". Blood. 90 (7): 2660–9. PMID 9326233.
  • Andrews RK, Harris SJ, McNally T, Berndt MC (1998). "Binding of purified 14-3-3 zeta signaling protein to discrete amino acid sequences within the cytoplasmic domain of the platelet membrane glycoprotein Ib-IX-V complex". Biochemistry. 37 (2): 638–47. doi:10.1021/bi970893g. PMID 9425086.
  • Longhurst CM, White MM, Wilkinson DA, Jennings LK (1999). "A CD9, alphaIIbbeta3, integrin-associated protein, and GPIb/V/IX complex on the surface of human platelets is influenced by alphaIIbbeta3 conformational states". Eur. J. Biochem. 263 (1): 104–11. doi:10.1046/j.1432-1327.1999.00467.x. PMID 10429193.
  • Dicker IB, Pedicord DL, Seiffert DA, et al. (2002). "Both the high affinity thrombin receptor (GPIb-IX-V) and GPIIb/IIIa are implicated in expression of thrombin-induced platelet procoagulant activity". Thromb. Haemost. 86 (4): 1065–9. PMID 11686325.
  • Rabie T, Strehl A, Ludwig A, Nieswandt B (2005). "Evidence for a role of ADAM17 (TACE) in the regulation of platelet glycoprotein V.". J. Biol. Chem. 280 (15): 14462–8. doi:10.1074/jbc.M500041200. PMID 15691827.
  • Aktas B, Pozgajova M, Bergmeier W, et al. (2006). "Aspirin induces platelet receptor shedding via ADAM17 (TACE)". J. Biol. Chem. 280 (48): 39716–22. doi:10.1074/jbc.M507762200. PMID 16179345.
  • Lewandrowski U, Moebius J, Walter U, Sickmann A (2006). "Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach". Mol. Cell. Proteomics. 5 (2): 226–33. doi:10.1074/mcp.M500324-MCP200. PMID 16263699.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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