GNGT1: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Guanine nucleotide-binding protein G(T) subunit gamma-T1''' is a [[protein]] that in humans is encoded by the ''GNGT1'' [[gene]].<ref name="pmid8661128">{{cite journal |vauthors=Scherer SW, Feinstein DS, Oliveira L, Tsui LC, Pittler SJ | title = Gene structure and chromosome localization to 7q21.3 of the human rod photoreceptor transducin gamma-subunit gene (GNGT1) | journal = Genomics | volume = 35 | issue = 1 | pages = 241–3 |date=Sep 1996 | pmid = 8661128 | pmc =  | doi = 10.1006/geno.1996.0346 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2792| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_GNGT1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1a0r.
| PDB = {{PDB2|1a0r}}, {{PDB2|1b9x}}, {{PDB2|1b9y}}, {{PDB2|1got}}, {{PDB2|1tbg}}, {{PDB2|2trc}}
| Name = Guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
| HGNCid = 4411
| Symbol = GNGT1
| AltSymbols =; GNG1
| OMIM = 189970
| ECnumber =
| Homologene = 7738
| MGIid = 109165
  | GeneAtlas_image1 = PBB_GE_GNGT1_207166_at_tn.png
| Function = {{GNF_GO|id=GO:0003924 |text = GTPase activity}} {{GNF_GO|id=GO:0004871 |text = signal transducer activity}}
| Component = {{GNF_GO|id=GO:0005834 |text = heterotrimeric G-protein complex}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2792
    | Hs_Ensembl = ENSG00000127928
    | Hs_RefseqProtein = NP_068774
    | Hs_RefseqmRNA = NM_021955
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 7
    | Hs_GenLoc_start = 93373756
    | Hs_GenLoc_end = 93378421
    | Hs_Uniprot = P63211
    | Mm_EntrezGene = 14699
    | Mm_Ensembl = ENSMUSG00000029663
    | Mm_RefseqmRNA = NM_010314
    | Mm_RefseqProtein = NP_034444
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 6
    | Mm_GenLoc_start = 3944012
    | Mm_GenLoc_end = 3947436
    | Mm_Uniprot = Q8R1U6
  }}
}}
'''Guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1''', also known as '''GNGT1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2792| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Simonds WF, Butrynski JE, Gautam N, ''et al.'' |title=G-protein beta gamma dimers. Membrane targeting requires subunit coexpression and intact gamma C-A-A-X domain. |journal=J. Biol. Chem. |volume=266 |issue= 9 |pages= 5363-6 |year= 1991 |pmid= 1706334 |doi=  }}
*{{cite journal  |vauthors=Simonds WF, Butrynski JE, Gautam N |title=G-protein beta gamma dimers. Membrane targeting requires subunit coexpression and intact gamma C-A-A-X domain. |journal=J. Biol. Chem. |volume=266 |issue= 9 |pages= 5363–6 |year= 1991 |pmid= 1706334 |doi=  |display-authors=etal}}
*{{cite journal  | author=Ray K, Kunsch C, Bonner LM, Robishaw JD |title=Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits. |journal=J. Biol. Chem. |volume=270 |issue= 37 |pages= 21765-71 |year= 1995 |pmid= 7665596 |doi=  }}
*{{cite journal  |vauthors=Ray K, Kunsch C, Bonner LM, Robishaw JD |title=Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits. |journal=J. Biol. Chem. |volume=270 |issue= 37 |pages= 21765–71 |year= 1995 |pmid= 7665596 |doi=10.1074/jbc.270.37.21765 }}
*{{cite journal  | author=Tao L, Pandey S, Simon MI, Fong HK |title=Structure of the bovine transducin gamma subunit gene and analysis of promoter function in transgenic mice. |journal=Exp. Eye Res. |volume=56 |issue= 4 |pages= 497-507 |year= 1993 |pmid= 8500562 |doi= 10.1006/exer.1993.1063 }}
*{{cite journal  |vauthors=Tao L, Pandey S, Simon MI, Fong HK |title=Structure of the bovine transducin gamma subunit gene and analysis of promoter function in transgenic mice. |journal=Exp. Eye Res. |volume=56 |issue= 4 |pages= 497–507 |year= 1993 |pmid= 8500562 |doi= 10.1006/exer.1993.1063 }}
*{{cite journal  | author=Yan K, Kalyanaraman V, Gautam N |title=Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families. |journal=J. Biol. Chem. |volume=271 |issue= 12 |pages= 7141-6 |year= 1996 |pmid= 8636150 |doi=  }}
*{{cite journal  |vauthors=Yan K, Kalyanaraman V, Gautam N |title=Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families. |journal=J. Biol. Chem. |volume=271 |issue= 12 |pages= 7141–6 |year= 1996 |pmid= 8636150 |doi=10.1074/jbc.271.12.7141  }}
*{{cite journal  | author=Scherer SW, Feinstein DS, Oliveira L, ''et al.'' |title=Gene structure and chromosome localization to 7q21.3 of the human rod photoreceptor transducin gamma-subunit gene (GNGT1). |journal=Genomics |volume=35 |issue= 1 |pages= 241-3 |year= 1996 |pmid= 8661128 |doi= 10.1006/geno.1996.0346 }}
*{{cite journal  |vauthors=Gaudet R, Savage JR, McLaughlin JN |title=A molecular mechanism for the phosphorylation-dependent regulation of heterotrimeric G proteins by phosducin. |journal=Mol. Cell |volume=3 |issue= 5 |pages= 649–60 |year= 1999 |pmid= 10360181 |doi=10.1016/S1097-2765(00)80358-5 |display-authors=etal}}
*{{cite journal  | author=Gaudet R, Savage JR, McLaughlin JN, ''et al.'' |title=A molecular mechanism for the phosphorylation-dependent regulation of heterotrimeric G proteins by phosducin. |journal=Mol. Cell |volume=3 |issue= 5 |pages= 649-60 |year= 1999 |pmid= 10360181 |doi=  }}
*{{cite journal  |vauthors=Xu S, Ladak R, Swanson DA |title=PHR1 encodes an abundant, pleckstrin homology domain-containing integral membrane protein in the photoreceptor outer segments. |journal=J. Biol. Chem. |volume=274 |issue= 50 |pages= 35676–85 |year= 2000 |pmid= 10585447 |doi=10.1074/jbc.274.50.35676 |display-authors=etal}}
*{{cite journal  | author=Xu S, Ladak R, Swanson DA, ''et al.'' |title=PHR1 encodes an abundant, pleckstrin homology domain-containing integral membrane protein in the photoreceptor outer segments. |journal=J. Biol. Chem. |volume=274 |issue= 50 |pages= 35676-85 |year= 2000 |pmid= 10585447 |doi=  }}
*{{cite journal  |vauthors=Marin EP, Krishna AG, Zvyaga TA |title=The amino terminus of the fourth cytoplasmic loop of rhodopsin modulates rhodopsin-transducin interaction. |journal=J. Biol. Chem. |volume=275 |issue= 3 |pages= 1930–6 |year= 2000 |pmid= 10636894 |doi=10.1074/jbc.275.3.1930 |display-authors=etal}}
*{{cite journal  | author=Marin EP, Krishna AG, Zvyaga TA, ''et al.'' |title=The amino terminus of the fourth cytoplasmic loop of rhodopsin modulates rhodopsin-transducin interaction. |journal=J. Biol. Chem. |volume=275 |issue= 3 |pages= 1930-6 |year= 2000 |pmid= 10636894 |doi=  }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=Cuello F, Schulze RA, Heemeyer F |title=Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Complex formation of NDPK B with Gbeta gamma dimers and phosphorylation of His-266 IN Gbeta. |journal=J. Biol. Chem. |volume=278 |issue= 9 |pages= 7220–6 |year= 2003 |pmid= 12486123 |doi= 10.1074/jbc.M210304200 |display-authors=etal}}
*{{cite journal  | author=Cuello F, Schulze RA, Heemeyer F, ''et al.'' |title=Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Complex formation of NDPK B with Gbeta gamma dimers and phosphorylation of His-266 IN Gbeta. |journal=J. Biol. Chem. |volume=278 |issue= 9 |pages= 7220-6 |year= 2003 |pmid= 12486123 |doi= 10.1074/jbc.M210304200 }}
*{{cite journal  |vauthors=Scherer SW, Cheung J, MacDonald JR |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423 | pmc=2882961 |display-authors=etal}}
*{{cite journal  | author=Scherer SW, Cheung J, MacDonald JR, ''et al.'' |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767-72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423 }}
*{{cite journal  |vauthors=Hillier LW, Fulton RS, Fulton LA |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 |display-authors=etal}}
*{{cite journal  | author=Hillier LW, Fulton RS, Fulton LA, ''et al.'' |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157-64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 }}
*{{cite journal  |vauthors=Hinrichs MV, Montecino M, Bunster M, Olate J |title=Mutation of the highly conserved Arg165 and Glu168 residues of human Gsalpha disrupts the alphaD-alphaE loop and enhances basal GDP/GTP exchange rate. |journal=J. Cell. Biochem. |volume=93 |issue= 2 |pages= 409–17 |year= 2005 |pmid= 15368366 |doi= 10.1002/jcb.20193 }}
*{{cite journal  | author=Hinrichs MV, Montecino M, Bunster M, Olate J |title=Mutation of the highly conserved Arg165 and Glu168 residues of human Gsalpha disrupts the alphaD-alphaE loop and enhances basal GDP/GTP exchange rate. |journal=J. Cell. Biochem. |volume=93 |issue= 2 |pages= 409-17 |year= 2005 |pmid= 15368366 |doi= 10.1002/jcb.20193 }}
*{{cite journal  |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  |vauthors=Gao X, Sadana R, Dessauer CW, Patel TB |title=Conditional stimulation of type V and VI adenylyl cyclases by G protein betagamma subunits. |journal=J. Biol. Chem. |volume=282 |issue= 1 |pages= 294–302 |year= 2007 |pmid= 17110384 |doi= 10.1074/jbc.M607522200 }}
*{{cite journal  | author=Gao X, Sadana R, Dessauer CW, Patel TB |title=Conditional stimulation of type V and VI adenylyl cyclases by G protein betagamma subunits. |journal=J. Biol. Chem. |volume=282 |issue= 1 |pages= 294-302 |year= 2007 |pmid= 17110384 |doi= 10.1074/jbc.M607522200 }}
*{{cite journal  |vauthors=Seo M, Lee MJ, Heo JH |title=G Protein betagamma subunits augment UVB-induced apoptosis by stimulating the release of soluble heparin-binding epidermal growth factor from human keratinocytes. |journal=J. Biol. Chem. |volume=282 |issue= 34 |pages= 24720–30 |year= 2007 |pmid= 17548351 |doi= 10.1074/jbc.M702343200 |display-authors=etal}}
*{{cite journal  | author=Seo M, Lee MJ, Heo JH, ''et al.'' |title=G Protein betagamma subunits augment UVB-induced apoptosis by stimulating the release of soluble heparin-binding epidermal growth factor from human keratinocytes. |journal=J. Biol. Chem. |volume=282 |issue= 34 |pages= 24720-30 |year= 2007 |pmid= 17548351 |doi= 10.1074/jbc.M702343200 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 08:52, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Guanine nucleotide-binding protein G(T) subunit gamma-T1 is a protein that in humans is encoded by the GNGT1 gene.[1][2]


References

  1. ↑ Scherer SW, Feinstein DS, Oliveira L, Tsui LC, Pittler SJ (Sep 1996). "Gene structure and chromosome localization to 7q21.3 of the human rod photoreceptor transducin gamma-subunit gene (GNGT1)". Genomics. 35 (1): 241–3. doi:10.1006/geno.1996.0346. PMID 8661128.
  2. ↑ "Entrez Gene: GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1".

Further reading



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