Calcineurin
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| Image:Calcineurin.png | |
| protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform (calcineurin A alpha)
| |
| Identifiers | |
| Symbol | PPP3CA |
| Alt. Symbols | CALN, CALNA |
| Entrez | 5530 |
| HUGO | 9314 |
| OMIM | 114105 |
| RefSeq | NM_000944 |
| UniProt | Q08209 |
| Other data | |
| EC number | 3.1.3.16 |
| Locus | Chr. 4 q21-q24 |
Calcineurin (CN) is a protein phosphatase also known as protein phosphatase 2B (PP2B). Calcineurin is responsible for activating the transcription of interleukin 2 (IL-2), that stimulates the growth and differentiation of T cell response. In immunosuppressive therapy it is inhibited by cyclosporin, pimecrolimus (Elidel) and tacrolimus (FK506) - these drugs are known as calcineurin inhibitors. Calcineurin dephosphorylates NFATc, a transcription factor that can then go into the nucleus and turn on genes involved in IL-2 synthesis.
Contents |
Mechanism of action
When T-helper cell's receptor interacts with an antigen, the intracellular concentration of calcium in the cell rises. This increase activates calcineurin, by binding a regulatory subunit and activating calmodulin binding. Calcineurin induces different transcription factors (NF-ATs) that are important in the transcription of IL-2 genes. IL-2 activates T-helper lymphocytes and induces the production of other cytokines. In this way, it governs the action of cytotoxic lymphocytes and NK cells. The amount of IL-2 being produced by the T-helper cells is believed to influence the extent of the immune response significantly.
Research into Schizophrenia
Calcineurin is linked to receptors for two brain chemicals, NMDA and dopamine. A MIT experiment with genetically altered mice who could not produce calcineurin showed similar symptoms as in humans with schizophrenia: impairment in working memory, attention deficits, aberrant social behavior and several other abnormalities characteristic of schizophrenia.[1]
Research into Diabetes
Scientist believe that calcineurin might prove to be one of the two keys, along with NFAT, in improving the function of diabetics' pancreatic beta cells.[2][3]
Calcineurin/Nfat signaling is required for perinatal lung maturation and function:[4]
References
- ↑ http://web.mit.edu/newsoffice/2003/mice.html
- ↑ http://news.bbc.co.uk/1/hi/health/5363150.stm
- ↑ http://www.eurekalert.org/pub_releases/2006-09/sumc-hfs091406.php
- ↑ http://www.eurekalert.org/pub_releases/2006-09/joci-chn091406.php
External links
- MeSH Calcineurin
- Calcineurin at eMedicine Dictionary
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
