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External IDsGeneCards: [1]
RefSeq (mRNA)



RefSeq (protein)



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Guanine nucleotide-binding protein subunit beta-5 is a protein that in humans is encoded by the GNB5 gene.[1] Alternatively spliced transcript variants encoding different isoforms exist.[2]


Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors.[2]

GNB5 has been shown to differentially control RGS protein stability and membrane anchor binding, and therefore is involved in the control of complex neuronal G protein signaling pathways.[3]


GNB5 has been shown to interact with:


  1. Jones PG, Lombardi SJ, Cockett MI (Jun 1998). "Cloning and tissue distribution of the human G protein beta 5 cDNA". Biochim. Biophys. Acta. 1402 (3): 288–91. doi:10.1016/S0167-4889(98)00017-2. PMID 9606987.
  2. 2.0 2.1 "Entrez Gene: GNB5 guanine nucleotide binding protein (G protein), beta 5".
  3. 3.0 3.1 Masuho I, Wakasugi-Masuho H, Posokhova EN, Patton JR, Martemyanov KA (June 2011). "Type 5 G protein beta subunit (Gbeta5) controls the interaction of regulator of G protein signaling 9 (RGS9) with membrane anchors". J. Biol. Chem. 286 (24): 21806–13. doi:10.1074/jbc.M111.241513. PMC 3122235. PMID 21511947.
  4. Yan K, Kalyanaraman V, Gautam N (March 1996). "Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families". J. Biol. Chem. 271 (12): 7141–6. doi:10.1074/jbc.271.12.7141. PMID 8636150.
  5. Blake BL, Wing MR, Zhou JY, Lei Q, Hillmann JR, Behe CI, Morris RA, Harden TK, Bayliss DA, Miller RJ, Siderovski DP (December 2001). "G beta association and effector interaction selectivities of the divergent G gamma subunit G gamma(13)". J. Biol. Chem. 276 (52): 49267–74. doi:10.1074/jbc.M106565200. PMID 11675383.
  6. Levay K, Cabrera JL, Satpaev DK, Slepak VZ (March 1999). "Gbeta5 prevents the RGS7-Galphao interaction through binding to a distinct Ggamma-like domain found in RGS7 and other RGS proteins". Proc. Natl. Acad. Sci. U.S.A. 96 (5): 2503–7. doi:10.1073/pnas.96.5.2503. PMC 26814. PMID 10051672.
  7. Posner BA, Gilman AG, Harris BA (October 1999). "Regulators of G protein signaling 6 and 7. Purification of complexes with gbeta5 and assessment of their effects on g protein-mediated signaling pathways". J. Biol. Chem. 274 (43): 31087–93. doi:10.1074/jbc.274.43.31087. PMID 10521509.

Further reading