GNG2: Difference between revisions

VALUE_ERROR (nil)
Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
	n/a
	n/a
	n/a
	n/a
	n/a
	n/a
	n/a
	n/a
	n/a
	n/a
	Wikidata
View/Edit Human

VisualWikitext

Latest revision as of 06:23, 10 January 2019

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 is a protein that in humans is encoded by the GNG2 gene.^[1]^[2]

Heterotrimeric G proteins play vital roles in cellular responses to external signals. The specificity of a G protein-receptor interaction is primarily mediated by the gamma subunit.[supplied by OMIM]^[2]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.^{[§ 1]}

[[File:

<imagemap> Image:NicotineDopaminergic_WP1602.png

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

<imagemap> Image:NicotineDopaminergic_WP1602.png

|{{{bSize}}}px|alt=Nicotine Activity on Dopaminergic Neurons edit]]

Nicotine Activity on Dopaminergic Neurons edit

↑ The interactive pathway map can be edited at WikiPathways: "NicotineDopaminergic_WP1602".

References

↑ Modarressi MH, Taylor KE, Wolfe J (Jul 2000). "Cloning, characterization, and mapping of the gene encoding the human G protein gamma 2 subunit". Biochem Biophys Res Commun. 272 (2): 610–5. doi:10.1006/bbrc.2000.2832. PMID 10833460.
↑ ^2.0 ^2.1 "Entrez Gene: GNG2 guanine nucleotide binding protein (G protein), gamma 2".

Pumiglia KM, LeVine H, Haske T, et al. (1995). "A direct interaction between G-protein beta gamma subunits and the Raf-1 protein kinase". J. Biol. Chem. 270 (24): 14251–4. doi:10.1074/jbc.270.24.14251. PMID 7782277.
Tsukada S, Simon MI, Witte ON, Katz A (1994). "Binding of beta gamma subunits of heterotrimeric G proteins to the PH domain of Bruton tyrosine kinase". Proc. Natl. Acad. Sci. U.S.A. 91 (23): 11256–60. doi:10.1073/pnas.91.23.11256. PMC 45206. PMID 7972043.
Yan K, Kalyanaraman V, Gautam N (1996). "Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families". J. Biol. Chem. 271 (12): 7141–6. doi:10.1074/jbc.271.12.7141. PMID 8636150.
De Waard M, Liu H, Walker D, et al. (1997). "Direct binding of G-protein betagamma complex to voltage-dependent calcium channels". Nature. 385 (6615): 446–50. doi:10.1038/385446a0. PMID 9009193.
Kostenis E, Conklin BR, Wess J (1997). "Molecular basis of receptor/G protein coupling selectivity studied by coexpression of wild type and mutant m2 muscarinic receptors with mutant G alpha(q) subunits". Biochemistry. 36 (6): 1487–95. doi:10.1021/bi962554d. PMID 9063897.
Qin N, Platano D, Olcese R, et al. (1997). "Direct interaction of gbetagamma with a C-terminal gbetagamma-binding domain of the Ca2+ channel alpha1 subunit is responsible for channel inhibition by G protein-coupled receptors". Proc. Natl. Acad. Sci. U.S.A. 94 (16): 8866–71. doi:10.1073/pnas.94.16.8866. PMC 23172. PMID 9238069.
Ong OC, Hu K, Rong H, et al. (1997). "Gene structure and chromosome localization of the G gamma c subunit of human cone G-protein (GNGT2)". Genomics. 44 (1): 101–9. doi:10.1006/geno.1997.4814. PMID 9286705.
Nishida K, Kaziro Y, Satoh T (1999). "Association of the proto-oncogene product dbl with G protein betagamma subunits". FEBS Lett. 459 (2): 186–90. doi:10.1016/S0014-5793(99)01244-2. PMID 10518015.
Carman CV, Barak LS, Chen C, et al. (2000). "Mutational analysis of Gbetagamma and phospholipid interaction with G protein-coupled receptor kinase 2". J. Biol. Chem. 275 (14): 10443–52. doi:10.1074/jbc.275.14.10443. PMID 10744734.
Evanko DS, Thiyagarajan MM, Siderovski DP, Wedegaertner PB (2001). "Gbeta gamma isoforms selectively rescue plasma membrane localization and palmitoylation of mutant Galphas and Galphaq". J. Biol. Chem. 276 (26): 23945–53. doi:10.1074/jbc.M101154200. PMID 11294873.
Yu Y, Zhang C, Zhou G, et al. (2001). "Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs". Genome Res. 11 (8): 1392–403. doi:10.1101/gr.175501. PMC 311073. PMID 11483580.
Lowry WE, Huang XY (2002). "G Protein beta gamma subunits act on the catalytic domain to stimulate Bruton's agammaglobulinemia tyrosine kinase". J. Biol. Chem. 277 (2): 1488–92. doi:10.1074/jbc.M110390200. PMID 11698416.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Cuello F, Schulze RA, Heemeyer F, et al. (2003). "Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Complex formation of NDPK B with Gbeta gamma dimers and phosphorylation of His-266 IN Gbeta". J. Biol. Chem. 278 (9): 7220–6. doi:10.1074/jbc.M210304200. PMID 12486123.
Melliti K, Grabner M, Seabrook GR (2003). "The familial hemiplegic migraine mutation R192Q reduces G-protein-mediated inhibition of P/Q-type (Ca(V)2.1) calcium channels expressed in human embryonic kidney cells". J. Physiol. 546 (Pt 2): 337–47. doi:10.1113/jphysiol.2002.026716. PMC 2342512. PMID 12527722.
Wolfe JT, Wang H, Howard J, et al. (2003). "T-type calcium channel regulation by specific G-protein betagamma subunits". Nature. 424 (6945): 209–13. doi:10.1038/nature01772. PMID 12853961.
Niu J, Profirovic J, Pan H, et al. (2003). "G Protein betagamma subunits stimulate p114RhoGEF, a guanine nucleotide exchange factor for RhoA and Rac1: regulation of cell shape and reactive oxygen species production". Circ. Res. 93 (9): 848–56. doi:10.1161/01.RES.0000097607.14733.0C. PMID 14512443.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Doering CJ, Kisilevsky AE, Feng ZP, et al. (2004). "A single Gbeta subunit locus controls cross-talk between protein kinase C and G protein regulation of N-type calcium channels". J. Biol. Chem. 279 (28): 29709–17. doi:10.1074/jbc.M308693200. PMID 15105422.

This article on a gene on human chromosome 14 is a stub. You can help Wikipedia by expanding it.

[WikiPathways-3] The interactive pathway map can be edited at WikiPathways: "NicotineDopaminergic_WP1602".

[pmid10833460-1] Modarressi MH, Taylor KE, Wolfe J (Jul 2000). "Cloning, characterization, and mapping of the gene encoding the human G protein gamma 2 subunit". Biochem Biophys Res Commun. 272 (2): 610–5. doi:10.1006/bbrc.2000.2832. PMID 10833460.

[entrez-2] 2.0 ^2.1 "Entrez Gene: GNG2 guanine nucleotide binding protein (G protein), gamma 2".

[1]

[2]

[§ 1]

@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2''' is a [[protein]] that in humans is encoded by the ''GNG2'' [[gene]].<ref name="pmid10833460">{{cite journal |vauthors=Modarressi MH, Taylor KE, Wolfe J | title = Cloning, characterization, and mapping of the gene encoding the human G protein gamma 2 subunit | journal = Biochem Biophys Res Commun | volume = 272 | issue = 2 | pages = 610–5 |date=Jul 2000 | pmid = 10833460 | pmc =  | doi = 10.1006/bbrc.2000.2832 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GNG2 guanine nucleotide binding protein (G protein), gamma 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54331| accessdate = }}</ref>
-| update_page = yes
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{GNF_Protein_box
- | image = PBB_Protein_GNG2_image.jpg
- | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1gg2.
- | PDB = {{PDB2|1gg2}}, {{PDB2|1gp2}}, {{PDB2|1omw}}, {{PDB2|1xhm}}, {{PDB2|2bcj}}
- | Name = Guanine nucleotide binding protein (G protein), gamma 2
- | HGNCid = 4404
- | Symbol = GNG2
- | AltSymbols =;
- | OMIM = 606981
- | ECnumber =
- | Homologene = 40715
- | MGIid = 102705
-  | Function = {{GNF_GO|id=GO:0004871 |text = signal transducer activity}}
- | Component = {{GNF_GO|id=GO:0005834 |text = heterotrimeric G-protein complex}} {{GNF_GO|id=GO:0016020 |text = membrane}}
- | Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 54331
-    | Hs_Ensembl = ENSG00000186469
-    | Hs_RefseqProtein = NP_444292
-    | Hs_RefseqmRNA = NM_053064
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 14
-    | Hs_GenLoc_start = 51383702
-    | Hs_GenLoc_end = 51503506
-    | Hs_Uniprot = P59768
-    | Mm_EntrezGene = 14702
-    | Mm_Ensembl = ENSMUSG00000043004
-    | Mm_RefseqmRNA = NM_001038637
-    | Mm_RefseqProtein = NP_001033726
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 14
-    | Mm_GenLoc_start = 18663255
-    | Mm_GenLoc_end = 18767945
-    | Mm_Uniprot = P63213
-  }}
-}}
-'''Guanine nucleotide binding protein (G protein), gamma 2''', also known as '''GNG2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GNG2 guanine nucleotide binding protein (G protein), gamma 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54331| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
 {{PBB_Summary
 | section_title =
-| summary_text = Heterotrimeric G proteins play vital roles in cellular responses to external signals. The specificity of a G protein-receptor interaction is primarily mediated by the gamma subunit.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: GNG2 guanine nucleotide binding protein (G protein), gamma 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54331| accessdate = }}</ref>
+| summary_text = Heterotrimeric [[G proteins]] play vital roles in cellular responses to external signals. The specificity of a G protein-receptor interaction is primarily mediated by the gamma subunit.[supplied by OMIM]<ref name="entrez" />
 }}
+== Interactive pathway map ==
+{{NicotineDopaminergicActivity_WP1602|highlight=GNG2}}
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
 {{refbegin | 2}}
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Pumiglia KM, LeVine H, Haske T, ''et al.'' |title=A direct interaction between G-protein beta gamma subunits and the Raf-1 protein kinase. |journal=J. Biol. Chem. |volume=270 |issue= 24 |pages= 14251-4 |year= 1995 |pmid= 7782277 |doi=  }}
+*{{cite journal  | author=Pumiglia KM |title=A direct interaction between G-protein beta gamma subunits and the Raf-1 protein kinase |journal=J. Biol. Chem. |volume=270 |issue= 24 |pages= 14251–4 |year= 1995 |pmid= 7782277 |doi=10.1074/jbc.270.24.14251  |name-list-format=vanc| author2=LeVine H  | author3=Haske T  | display-authors=3  | last4=Habib  | first4=T  | last5=Jove  | first5=R  | last6=Decker  | first6=SJ  }}
-*{{cite journal  | author=Tsukada S, Simon MI, Witte ON, Katz A |title=Binding of beta gamma subunits of heterotrimeric G proteins to the PH domain of Bruton tyrosine kinase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 23 |pages= 11256-60 |year= 1994 |pmid= 7972043 |doi=  }}
+*{{cite journal  |vauthors=Tsukada S, Simon MI, Witte ON, Katz A |title=Binding of beta gamma subunits of heterotrimeric G proteins to the PH domain of Bruton tyrosine kinase |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 23 |pages= 11256–60 |year= 1994 |pmid= 7972043 |doi=10.1073/pnas.91.23.11256  | pmc=45206  }}
-*{{cite journal  | author=Yan K, Kalyanaraman V, Gautam N |title=Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families. |journal=J. Biol. Chem. |volume=271 |issue= 12 |pages= 7141-6 |year= 1996 |pmid= 8636150 |doi=  }}
+*{{cite journal  |vauthors=Yan K, Kalyanaraman V, Gautam N |title=Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families |journal=J. Biol. Chem. |volume=271 |issue= 12 |pages= 7141–6 |year= 1996 |pmid= 8636150 |doi=10.1074/jbc.271.12.7141  }}
-*{{cite journal  | author=De Waard M, Liu H, Walker D, ''et al.'' |title=Direct binding of G-protein betagamma complex to voltage-dependent calcium channels. |journal=Nature |volume=385 |issue= 6615 |pages= 446-50 |year= 1997 |pmid= 9009193 |doi= 10.1038/385446a0 }}
+*{{cite journal  | author=De Waard M |title=Direct binding of G-protein betagamma complex to voltage-dependent calcium channels |journal=Nature |volume=385 |issue= 6615 |pages= 446–50 |year= 1997 |pmid= 9009193 |doi= 10.1038/385446a0  |name-list-format=vanc| author2=Liu H  | author3=Walker D  | display-authors=3  | last4=Scott  | first4=Victoria E. S.  | last5=Gurnett  | first5=Christina A.  | last6=Campbell  | first6=Kevin P. }}
-*{{cite journal  | author=Kostenis E, Conklin BR, Wess J |title=Molecular basis of receptor/G protein coupling selectivity studied by coexpression of wild type and mutant m2 muscarinic receptors with mutant G alpha(q) subunits. |journal=Biochemistry |volume=36 |issue= 6 |pages= 1487-95 |year= 1997 |pmid= 9063897 |doi= 10.1021/bi962554d }}
+*{{cite journal  |vauthors=Kostenis E, Conklin BR, Wess J |title=Molecular basis of receptor/G protein coupling selectivity studied by coexpression of wild type and mutant m2 muscarinic receptors with mutant G alpha(q) subunits |journal=Biochemistry |volume=36 |issue= 6 |pages= 1487–95 |year= 1997 |pmid= 9063897 |doi= 10.1021/bi962554d }}
-*{{cite journal  | author=Qin N, Platano D, Olcese R, ''et al.'' |title=Direct interaction of gbetagamma with a C-terminal gbetagamma-binding domain of the Ca2+ channel alpha1 subunit is responsible for channel inhibition by G protein-coupled receptors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 16 |pages= 8866-71 |year= 1997 |pmid= 9238069 |doi=  }}
+*{{cite journal  | author=Qin N |title=Direct interaction of gbetagamma with a C-terminal gbetagamma-binding domain of the Ca2+ channel alpha1 subunit is responsible for channel inhibition by G protein-coupled receptors |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 16 |pages= 8866–71 |year= 1997 |pmid= 9238069 |doi=10.1073/pnas.94.16.8866  | pmc=23172  |name-list-format=vanc| author2=Platano D  | author3=Olcese R  | display-authors=3  | last4=Stefani  | first4=E  | last5=Birnbaumer  | first5=L  }}
-*{{cite journal  | author=Ong OC, Hu K, Rong H, ''et al.'' |title=Gene structure and chromosome localization of the G gamma c subunit of human cone G-protein (GNGT2). |journal=Genomics |volume=44 |issue= 1 |pages= 101-9 |year= 1997 |pmid= 9286705 |doi= 10.1006/geno.1997.4814 }}
+*{{cite journal  | author=Ong OC |title=Gene structure and chromosome localization of the G gamma c subunit of human cone G-protein (GNGT2) |journal=Genomics |volume=44 |issue= 1 |pages= 101–9 |year= 1997 |pmid= 9286705 |doi= 10.1006/geno.1997.4814  |name-list-format=vanc| author2=Hu K  | author3=Rong H  | display-authors=3  | last4=Lee  | first4=Rehwa H.  | last5=Fung  | first5=Bernard K.-K. }}
-*{{cite journal  | author=Nishida K, Kaziro Y, Satoh T |title=Association of the proto-oncogene product dbl with G protein betagamma subunits. |journal=FEBS Lett. |volume=459 |issue= 2 |pages= 186-90 |year= 1999 |pmid= 10518015 |doi=  }}
+*{{cite journal  |vauthors=Nishida K, Kaziro Y, Satoh T |title=Association of the proto-oncogene product dbl with G protein betagamma subunits |journal=FEBS Lett. |volume=459 |issue= 2 |pages= 186–90 |year= 1999 |pmid= 10518015 |doi=10.1016/S0014-5793(99)01244-2  }}
-*{{cite journal  | author=Carman CV, Barak LS, Chen C, ''et al.'' |title=Mutational analysis of Gbetagamma and phospholipid interaction with G protein-coupled receptor kinase 2. |journal=J. Biol. Chem. |volume=275 |issue= 14 |pages= 10443-52 |year= 2000 |pmid= 10744734 |doi=  }}
+*{{cite journal  | author=Carman CV |title=Mutational analysis of Gbetagamma and phospholipid interaction with G protein-coupled receptor kinase 2 |journal=J. Biol. Chem. |volume=275 |issue= 14 |pages= 10443–52 |year= 2000 |pmid= 10744734 |doi=10.1074/jbc.275.14.10443  |name-list-format=vanc| author2=Barak LS  | author3=Chen C  | display-authors=3  | last4=Liu-Chen  | first4=LY  | last5=Onorato  | first5=JJ  | last6=Kennedy  | first6=SP  | last7=Caron  | first7=MG  | last8=Benovic  | first8=JL  }}
-*{{cite journal  | author=Modarressi MH, Taylor KE, Wolfe J |title=Cloning, characterization, and mapping of the gene encoding the human G protein gamma 2 subunit. |journal=Biochem. Biophys. Res. Commun. |volume=272 |issue= 2 |pages= 610-5 |year= 2000 |pmid= 10833460 |doi= 10.1006/bbrc.2000.2832 }}
+*{{cite journal  |vauthors=Evanko DS, Thiyagarajan MM, Siderovski DP, Wedegaertner PB |title=Gbeta gamma isoforms selectively rescue plasma membrane localization and palmitoylation of mutant Galphas and Galphaq |journal=J. Biol. Chem. |volume=276 |issue= 26 |pages= 23945–53 |year= 2001 |pmid= 11294873 |doi= 10.1074/jbc.M101154200 }}
-*{{cite journal  | author=Evanko DS, Thiyagarajan MM, Siderovski DP, Wedegaertner PB |title=Gbeta gamma isoforms selectively rescue plasma membrane localization and palmitoylation of mutant Galphas and Galphaq. |journal=J. Biol. Chem. |volume=276 |issue= 26 |pages= 23945-53 |year= 2001 |pmid= 11294873 |doi= 10.1074/jbc.M101154200 }}
+*{{cite journal  | author=Yu Y |title=Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs |journal=Genome Res. |volume=11 |issue= 8 |pages= 1392–403 |year= 2001 |pmid= 11483580 |doi= 10.1101/gr.175501  | pmc=311073  |name-list-format=vanc| author2=Zhang C  | author3=Zhou G  | display-authors=3  | last4=Wu  | first4=S  | last5=Qu  | first5=X  | last6=Wei  | first6=H  | last7=Xing  | first7=G  | last8=Dong  | first8=C  | last9=Zhai  | first9=Y }}
-*{{cite journal  | author=Yu Y, Zhang C, Zhou G, ''et al.'' |title=Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs. |journal=Genome Res. |volume=11 |issue= 8 |pages= 1392-403 |year= 2001 |pmid= 11483580 |doi= 10.1101/gr.175501 }}
+*{{cite journal  |vauthors=Lowry WE, Huang XY |title=G Protein beta gamma subunits act on the catalytic domain to stimulate Bruton's agammaglobulinemia tyrosine kinase |journal=J. Biol. Chem. |volume=277 |issue= 2 |pages= 1488–92 |year= 2002 |pmid= 11698416 |doi= 10.1074/jbc.M110390200 }}
-*{{cite journal  | author=Lowry WE, Huang XY |title=G Protein beta gamma subunits act on the catalytic domain to stimulate Bruton's agammaglobulinemia tyrosine kinase. |journal=J. Biol. Chem. |volume=277 |issue= 2 |pages= 1488-92 |year= 2002 |pmid= 11698416 |doi= 10.1074/jbc.M110390200 }}
+*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal  | author=Cuello F |title=Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Complex formation of NDPK B with Gbeta gamma dimers and phosphorylation of His-266 IN Gbeta |journal=J. Biol. Chem. |volume=278 |issue= 9 |pages= 7220–6 |year= 2003 |pmid= 12486123 |doi= 10.1074/jbc.M210304200  |name-list-format=vanc| author2=Schulze RA  | author3=Heemeyer F  | display-authors=3  | last4=Meyer  | first4=HE  | last5=Lutz  | first5=S  | last6=Jakobs  | first6=KH  | last7=Niroomand  | first7=F  | last8=Wieland  | first8=T }}
-*{{cite journal  | author=Cuello F, Schulze RA, Heemeyer F, ''et al.'' |title=Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Complex formation of NDPK B with Gbeta gamma dimers and phosphorylation of His-266 IN Gbeta. |journal=J. Biol. Chem. |volume=278 |issue= 9 |pages= 7220-6 |year= 2003 |pmid= 12486123 |doi= 10.1074/jbc.M210304200 }}
+*{{cite journal  |vauthors=Melliti K, Grabner M, Seabrook GR |title=The familial hemiplegic migraine mutation R192Q reduces G-protein-mediated inhibition of P/Q-type (Ca(V)2.1) calcium channels expressed in human embryonic kidney cells |journal=J. Physiol. |volume=546 |issue= Pt 2 |pages= 337–47 |year= 2003 |pmid= 12527722 |doi=10.1113/jphysiol.2002.026716  | pmc=2342512  }}
-*{{cite journal  | author=Melliti K, Grabner M, Seabrook GR |title=The familial hemiplegic migraine mutation R192Q reduces G-protein-mediated inhibition of P/Q-type (Ca(V)2.1) calcium channels expressed in human embryonic kidney cells. |journal=J. Physiol. (Lond.) |volume=546 |issue= Pt 2 |pages= 337-47 |year= 2003 |pmid= 12527722 |doi=  }}
+*{{cite journal  | author=Wolfe JT |title=T-type calcium channel regulation by specific G-protein betagamma subunits |journal=Nature |volume=424 |issue= 6945 |pages= 209–13 |year= 2003 |pmid= 12853961 |doi= 10.1038/nature01772  |name-list-format=vanc| author2=Wang H  | author3=Howard J  | display-authors=3  | last4=Garrison  | first4=James C.  | last5=Barrett  | first5=Paula Q. }}
-*{{cite journal  | author=Wolfe JT, Wang H, Howard J, ''et al.'' |title=T-type calcium channel regulation by specific G-protein betagamma subunits. |journal=Nature |volume=424 |issue= 6945 |pages= 209-13 |year= 2003 |pmid= 12853961 |doi= 10.1038/nature01772 }}
+*{{cite journal  | author=Niu J |title=G Protein betagamma subunits stimulate p114RhoGEF, a guanine nucleotide exchange factor for RhoA and Rac1: regulation of cell shape and reactive oxygen species production |journal=Circ. Res. |volume=93 |issue= 9 |pages= 848–56 |year= 2003 |pmid= 14512443 |doi= 10.1161/01.RES.0000097607.14733.0C  |name-list-format=vanc| author2=Profirovic J  | author3=Pan H  | display-authors=3  | last4=Vaiskunaite  | first4=R  | last5=Voyno-Yasenetskaya  | first5=T }}
-*{{cite journal  | author=Niu J, Profirovic J, Pan H, ''et al.'' |title=G Protein betagamma subunits stimulate p114RhoGEF, a guanine nucleotide exchange factor for RhoA and Rac1: regulation of cell shape and reactive oxygen species production. |journal=Circ. Res. |volume=93 |issue= 9 |pages= 848-56 |year= 2003 |pmid= 14512443 |doi= 10.1161/01.RES.0000097607.14733.0C }}
+*{{cite journal  | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285  |name-list-format=vanc| author2=Suzuki Y  | author3=Nishikawa T  | display-authors=3  | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro  | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki }}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
+*{{cite journal  | author=Doering CJ |title=A single Gbeta subunit locus controls cross-talk between protein kinase C and G protein regulation of N-type calcium channels |journal=J. Biol. Chem. |volume=279 |issue= 28 |pages= 29709–17 |year= 2004 |pmid= 15105422 |doi= 10.1074/jbc.M308693200  |name-list-format=vanc| author2=Kisilevsky AE  | author3=Feng ZP  | display-authors=3  | last4=Arnot  | first4=MI  | last5=Peloquin  | first5=J  | last6=Hamid  | first6=J  | last7=Barr  | first7=W  | last8=Nirdosh  | first8=A  | last9=Simms  | first9=B }}
-*{{cite journal  | author=Doering CJ, Kisilevsky AE, Feng ZP, ''et al.'' |title=A single Gbeta subunit locus controls cross-talk between protein kinase C and G protein regulation of N-type calcium channels. |journal=J. Biol. Chem. |volume=279 |issue= 28 |pages= 29709-17 |year= 2004 |pmid= 15105422 |doi= 10.1074/jbc.M308693200 }}
 }}
 {{refend}}
-{{protein-stub}}
+<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
-{{WikiDoc Sources}}
+{{PBB_Controls
+| update_page = yes
+| require_manual_inspection = no
+| update_protein_box = yes
+| update_summary = yes
+| update_citations = yes
+}}
+{{PDB Gallery|geneid=54331}}
+{{Intracellular signaling peptides and proteins}}
+{{gene-14-stub}}

GNG2: Difference between revisions

Latest revision as of 06:23, 10 January 2019

Interactive pathway map

References

Further reading

Navigation menu