GNG12: Difference between revisions

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{{Underlinked|date=June 2016}}
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{{Infobox_gene}}
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'''Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12''' is a [[protein]] that in humans is encoded by the ''GNG12'' [[gene]].<ref name="pmid10819326">{{cite journal |vauthors=Hurowitz EH, Melnyk JM, Chen YJ, Kouros-Mehr H, Simon MI, Shizuya H | title = Genomic characterization of the human heterotrimeric G protein alpha, beta, and gamma subunit genes | journal = DNA Res | volume = 7 | issue = 2 | pages = 111–20 |date=Sep 2000 | pmid = 10819326 | pmc =  | doi =10.1093/dnares/7.2.111 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GNG12 guanine nucleotide binding protein (G protein), gamma 12| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55970| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Guanine nucleotide binding protein (G protein), gamma 12
| HGNCid = 19663
| Symbol = GNG12
| AltSymbols =; FLJ31352; FLJ34695
| OMIM = 
| ECnumber = 
| Homologene = 32427
| MGIid = 1336171
| GeneAtlas_image1 = PBB_GE_GNG12_212294_at_tn.png
| Function = {{GNF_GO|id=GO:0004871 |text = signal transducer activity}}
| Component = {{GNF_GO|id=GO:0005834 |text = heterotrimeric G-protein complex}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 55970
    | Hs_Ensembl = ENSG00000172380
    | Hs_RefseqProtein = NP_061329
    | Hs_RefseqmRNA = NM_018841
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 67939737
    | Hs_GenLoc_end = 68071738
    | Hs_Uniprot = Q9UBI6
    | Mm_EntrezGene = 14701
    | Mm_Ensembl = ENSMUSG00000036402
    | Mm_RefseqmRNA = NM_025278
    | Mm_RefseqProtein = NP_079554
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 6
    | Mm_GenLoc_start = 66945329
    | Mm_GenLoc_end = 66950872
    | Mm_Uniprot = Q9DAS9
  }}
}}
'''Guanine nucleotide binding protein (G protein), gamma 12''', also known as '''GNG12''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GNG12 guanine nucleotide binding protein (G protein), gamma 12| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55970| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Morishita R, Nakayama H, Isobe T, ''et al.'' |title=Primary structure of a gamma subunit of G protein, gamma 12, and its phosphorylation by protein kinase C. |journal=J. Biol. Chem. |volume=270 |issue= 49 |pages= 29469-75 |year= 1996 |pmid= 7493986 |doi=  }}
*{{cite journal  |vauthors=Morishita R, Nakayama H, Isobe T |title=Primary structure of a gamma subunit of G protein, gamma 12, and its phosphorylation by protein kinase C. |journal=J. Biol. Chem. |volume=270 |issue= 49 |pages= 29469–75 |year= 1996 |pmid= 7493986 |doi=10.1074/jbc.270.49.29469 |display-authors=etal}}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal  | author=Morishita R, Saga S, Kawamura N, ''et al.'' |title=Differential localization of the gamma 3 and gamma 12 subunits of G proteins in the mammalian brain. |journal=J. Neurochem. |volume=68 |issue= 2 |pages= 820-7 |year= 1997 |pmid= 9003074 |doi=  }}
*{{cite journal  |vauthors=Morishita R, Saga S, Kawamura N |title=Differential localization of the gamma 3 and gamma 12 subunits of G proteins in the mammalian brain |journal=J. Neurochem. |volume=68 |issue= 2 |pages= 820–7 |year= 1997 |pmid= 9003074 |doi=10.1046/j.1471-4159.1997.68020820.x |display-authors=etal}}
*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal  |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |display-authors=etal}}
*{{cite journal  | author=Asano T, Morishita R, Ueda H, Kato K |title=Selective association of G protein beta(4) with gamma(5) and gamma(12) subunits in bovine tissues. |journal=J. Biol. Chem. |volume=274 |issue= 30 |pages= 21425-9 |year= 1999 |pmid= 10409705 |doi= }}
*{{cite journal  |vauthors=Asano T, Morishita R, Ueda H, Kato K |title=Selective association of G protein beta(4) with gamma(5) and gamma(12) subunits in bovine tissues |journal=J. Biol. Chem. |volume=274 |issue= 30 |pages= 21425–9 |year= 1999 |pmid= 10409705 |doi=10.1074/jbc.274.30.21425 }}
*{{cite journal  | author=Hurowitz EH, Melnyk JM, Chen YJ, ''et al.'' |title=Genomic characterization of the human heterotrimeric G protein alpha, beta, and gamma subunit genes. |journal=DNA Res. |volume=7 |issue= 2 |pages= 111-20 |year= 2000 |pmid= 10819326 |doi= }}
*{{cite journal  |vauthors=Hu RM, Han ZG, Song HD |title=Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 17 |pages= 9543–8 |year= 2000 |pmid= 10931946 |doi= 10.1073/pnas.160270997 | pmc=16901 |display-authors=etal}}
*{{cite journal  | author=Hu RM, Han ZG, Song HD, ''et al.'' |title=Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 17 |pages= 9543-8 |year= 2000 |pmid= 10931946 |doi= 10.1073/pnas.160270997 }}
*{{cite journal  |vauthors=Cook LA, Schey KL, Cleator JH |title=Identification of a region in G protein gamma subunits conserved across species but hypervariable among subunit isoforms |journal=Protein Sci. |volume=10 |issue= 12 |pages= 2548–55 |year= 2002 |pmid= 11714923 |doi=10.1110/ps.ps.26401 | pmc=2374038  |display-authors=etal}}
*{{cite journal  | author=Cook LA, Schey KL, Cleator JH, ''et al.'' |title=Identification of a region in G protein gamma subunits conserved across species but hypervariable among subunit isoforms. |journal=Protein Sci. |volume=10 |issue= 12 |pages= 2548-55 |year= 2002 |pmid= 11714923 |doi=  }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=Cuello F, Schulze RA, Heemeyer F |title=Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Complex formation of NDPK B with Gbeta gamma dimers and phosphorylation of His-266 IN Gbeta |journal=J. Biol. Chem. |volume=278 |issue= 9 |pages= 7220–6 |year= 2003 |pmid= 12486123 |doi= 10.1074/jbc.M210304200 |display-authors=etal}}
*{{cite journal  | author=Cuello F, Schulze RA, Heemeyer F, ''et al.'' |title=Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Complex formation of NDPK B with Gbeta gamma dimers and phosphorylation of His-266 IN Gbeta. |journal=J. Biol. Chem. |volume=278 |issue= 9 |pages= 7220-6 |year= 2003 |pmid= 12486123 |doi= 10.1074/jbc.M210304200 }}
*{{cite journal  |vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  |vauthors=Bouwmeester T, Bauch A, Ruffner H |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97–105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086 |display-authors=etal}}
*{{cite journal  | author=Bouwmeester T, Bauch A, Ruffner H, ''et al.'' |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97-105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086 }}
*{{cite journal  |vauthors=Kato C, Mizutani T, Tamaki H |title=Characterization of heterotrimeric G protein complexes in rice plasma membrane |journal=Plant J. |volume=38 |issue= 2 |pages= 320–31 |year= 2004 |pmid= 15078334 |doi= 10.1111/j.1365-313X.2004.02046.x |display-authors=etal}}
*{{cite journal  | author=Kato C, Mizutani T, Tamaki H, ''et al.'' |title=Characterization of heterotrimeric G protein complexes in rice plasma membrane. |journal=Plant J. |volume=38 |issue= 2 |pages= 320-31 |year= 2004 |pmid= 15078334 |doi= 10.1111/j.1365-313X.2004.02046.x }}
*{{cite journal  |vauthors=Suzuki Y, Yamashita R, Shirota M |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711–8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604 | pmc=515316 |display-authors=etal}}
*{{cite journal  | author=Suzuki Y, Yamashita R, Shirota M, ''et al.'' |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711-8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604 }}
*{{cite journal  |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  |vauthors=Olsen JV, Blagoev B, Gnad F |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |display-authors=etal}}
*{{cite journal  | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
}}
}}
{{refend}}
{{refend}}


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{{Intracellular signaling peptides and proteins}}
 
 
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Latest revision as of 08:52, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 is a protein that in humans is encoded by the GNG12 gene.[1][2]


References

  1. ↑ Hurowitz EH, Melnyk JM, Chen YJ, Kouros-Mehr H, Simon MI, Shizuya H (Sep 2000). "Genomic characterization of the human heterotrimeric G protein alpha, beta, and gamma subunit genes". DNA Res. 7 (2): 111–20. doi:10.1093/dnares/7.2.111. PMID 10819326.
  2. ↑ "Entrez Gene: GNG12 guanine nucleotide binding protein (G protein), gamma 12".

Further reading



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