GNA11: Difference between revisions

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{{Infobox_gene}}
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'''Guanine nucleotide-binding protein subunit alpha-11''' is a [[protein]] that in humans is encoded by the ''GNA11'' [[gene]].<ref name="pmid1302014">{{cite journal |vauthors=Wilkie TM, Gilbert DJ, Olsen AS, Chen XN, Amatruda TT, Korenberg JR, Trask BJ, de Jong P, Reed RR, Simon MI | title = Evolution of the mammalian G protein alpha subunit multigene family | journal = Nat Genet | volume = 1 | issue = 2 | pages = 85–91 |date=Jun 1993 | pmid = 1302014 | pmc =  | doi = 10.1038/ng0592-85 |display-authors=etal}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2767| accessdate = }}</ref> Together with [[GNAQ]] (its [[paralogue]]), it functions as a [[Gq alpha subunit]].<ref>[http://www.omim.org/entry/139313 139313 GUANINE NUCLEOTIDE-BINDING PROTEIN, ALPHA-11; GNA11] at [[OMIM]]. Retrieved January 1, 2015.</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
| HGNCid = 4379
| Symbol = GNA11
| AltSymbols =; GNA-11
| OMIM = 139313
| ECnumber = 
| Homologene = 20474
| MGIid = 95766
| GeneAtlas_image1 = PBB_GE_GNA11_564_at_tn.png
| GeneAtlas_image2 = PBB_GE_GNA11_40562_at_tn.png
| GeneAtlas_image3 = PBB_GE_GNA11_204248_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003774 |text = motor activity}} {{GNF_GO|id=GO:0003924 |text = GTPase activity}} {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005525 |text = GTP binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0016459 |text = myosin complex}}
| Process = {{GNF_GO|id=GO:0001501 |text = skeletal development}} {{GNF_GO|id=GO:0001508 |text = regulation of action potential}} {{GNF_GO|id=GO:0006471 |text = protein amino acid ADP-ribosylation}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007507 |text = heart development}} {{GNF_GO|id=GO:0045634 |text = regulation of melanocyte differentiation}} {{GNF_GO|id=GO:0048066 |text = pigmentation during development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2767
    | Hs_Ensembl = ENSG00000088256
    | Hs_RefseqProtein = NP_002058
    | Hs_RefseqmRNA = NM_002067
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 3045408
    | Hs_GenLoc_end = 3072452
    | Hs_Uniprot = P29992
    | Mm_EntrezGene = 14672
    | Mm_Ensembl = ENSMUSG00000034781
    | Mm_RefseqmRNA = NM_010301
    | Mm_RefseqProtein = NP_034431
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 10
    | Mm_GenLoc_start = 80931861
    | Mm_GenLoc_end = 80948175
    | Mm_Uniprot = Q3UPA1
  }}
}}
{{SI}}
 
 
'''Guanine nucleotide binding protein (G protein), alpha 11 (Gq class)''', also known as '''GNA11''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2767| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Wilkie TM, Gilbert DJ, Olsen AS, ''et al.'' |title=Evolution of the mammalian G protein alpha subunit multigene family. |journal=Nat. Genet. |volume=1 |issue= 2 |pages= 85–91 |year= 1993 |pmid= 1302014 |doi= 10.1038/ng0592-85 }}
*{{cite journal  |vauthors=Raymond JR, Mukhin YV, Gelasco A |title=Multiplicity of mechanisms of serotonin receptor signal transduction. |journal=Pharmacol. Ther. |volume=92 |issue= 2–3 |pages= 179–212 |year= 2002 |pmid= 11916537 |doi=10.1016/S0163-7258(01)00169-3 |display-authors=etal}}
*{{cite journal  | author=Raymond JR, Mukhin YV, Gelasco A, ''et al.'' |title=Multiplicity of mechanisms of serotonin receptor signal transduction. |journal=Pharmacol. Ther. |volume=92 |issue= 2-3 |pages= 179–212 |year= 2002 |pmid= 11916537 |doi=  }}
*{{cite journal  |vauthors=Jiang M, Pandey S, Tran VT, Fong HK |title=Guanine nucleotide-binding regulatory proteins in retinal pigment epithelial cells |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 9 |pages= 3907–11 |year= 1991 |pmid= 1902575 |doi=10.1073/pnas.88.9.3907  | pmc=51562 }}
*{{cite journal  | author=Jiang M, Pandey S, Tran VT, Fong HK |title=Guanine nucleotide-binding regulatory proteins in retinal pigment epithelial cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 9 |pages= 3907–11 |year= 1991 |pmid= 1902575 |doi=  }}
*{{cite journal  |vauthors=Thomas CP, Dunn MJ, Mattera R |title=Ca2+ signalling in K562 human erythroleukaemia cells: effect of dimethyl sulphoxide and role of G-proteins in thrombin- and thromboxane A2-activated pathways |journal=Biochem. J. |volume=312 |issue=  1|pages= 151–8 |year= 1996 |pmid= 7492305 |doi= | pmc=1136238 }}
*{{cite journal  | author=Thomas CP, Dunn MJ, Mattera R |title=Ca2+ signalling in K562 human erythroleukaemia cells: effect of dimethyl sulphoxide and role of G-proteins in thrombin- and thromboxane A2-activated pathways. |journal=Biochem. J. |volume=312 ( Pt 1) |issue=  |pages= 151–8 |year= 1996 |pmid= 7492305 |doi=  }}
*{{cite journal  |vauthors=Offermanns S, Simon MI |title=G alpha 15 and G alpha 16 couple a wide variety of receptors to phospholipase C |journal=J. Biol. Chem. |volume=270 |issue= 25 |pages= 15175–80 |year= 1995 |pmid= 7797501 |doi=10.1074/jbc.270.25.15175 }}
*{{cite journal  | author=Offermanns S, Simon MI |title=G alpha 15 and G alpha 16 couple a wide variety of receptors to phospholipase C. |journal=J. Biol. Chem. |volume=270 |issue= 25 |pages= 15175–80 |year= 1995 |pmid= 7797501 |doi=  }}
*{{cite journal  |vauthors=Stanners J, Kabouridis PS, McGuire KL, Tsoukas CD |title=Interaction between G proteins and tyrosine kinases upon T cell receptor.CD3-mediated signaling |journal=J. Biol. Chem. |volume=270 |issue= 51 |pages= 30635–42 |year= 1996 |pmid= 8530500 |doi=10.1074/jbc.270.51.30635 }}
*{{cite journal  | author=Stanners J, Kabouridis PS, McGuire KL, Tsoukas CD |title=Interaction between G proteins and tyrosine kinases upon T cell receptor.CD3-mediated signaling. |journal=J. Biol. Chem. |volume=270 |issue= 51 |pages= 30635–42 |year= 1996 |pmid= 8530500 |doi=  }}
*{{cite journal  |vauthors=Laugwitz KL, Allgeier A, Offermanns S |title=The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 1 |pages= 116–20 |year= 1996 |pmid= 8552586 |doi=10.1073/pnas.93.1.116  | pmc=40189 |display-authors=etal}}
*{{cite journal  | author=Laugwitz KL, Allgeier A, Offermanns S, ''et al.'' |title=The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 1 |pages= 116–20 |year= 1996 |pmid= 8552586 |doi=  }}
*{{cite journal  |vauthors=Launay JM, Birraux G, Bondoux D |title=Ras involvement in signal transduction by the serotonin 5-HT2B receptor |journal=J. Biol. Chem. |volume=271 |issue= 6 |pages= 3141–7 |year= 1996 |pmid= 8621713 |doi=10.1074/jbc.271.6.3141 |display-authors=etal}}
*{{cite journal  | author=Launay JM, Birraux G, Bondoux D, ''et al.'' |title=Ras involvement in signal transduction by the serotonin 5-HT2B receptor. |journal=J. Biol. Chem. |volume=271 |issue= 6 |pages= 3141–7 |year= 1996 |pmid= 8621713 |doi=  }}
*{{cite journal  |vauthors=Johnson GJ, Leis LA, Dunlop PC |title=Specificity of G alpha q and G alpha 11 gene expression in platelets and erythrocytes. Expressions of cellular differentiation and species differences |journal=Biochem. J. |volume=318 |issue=  3|pages= 1023–31 |year= 1996 |pmid= 8836152 |doi= | pmc=1217719 }}
*{{cite journal  | author=Johnson GJ, Leis LA, Dunlop PC |title=Specificity of G alpha q and G alpha 11 gene expression in platelets and erythrocytes. Expressions of cellular differentiation and species differences. |journal=Biochem. J. |volume=318 ( Pt 3) |issue=  |pages= 1023–31 |year= 1996 |pmid= 8836152 |doi=  }}
*{{cite journal  |vauthors=Kinsella BT, O'Mahony DJ, Fitzgerald GA |title=The human thromboxane A2 receptor alpha isoform (TP alpha) functionally couples to the G proteins Gq and G11 in vivo and is activated by the isoprostane 8-epi prostaglandin F2 alpha |journal=J. Pharmacol. Exp. Ther. |volume=281 |issue= 2 |pages= 957–64 |year= 1997 |pmid= 9152406 |doi=  }}
*{{cite journal  | author=Kinsella BT, O'Mahony DJ, Fitzgerald GA |title=The human thromboxane A2 receptor alpha isoform (TP alpha) functionally couples to the G proteins Gq and G11 in vivo and is activated by the isoprostane 8-epi prostaglandin F2 alpha. |journal=J. Pharmacol. Exp. Ther. |volume=281 |issue= 2 |pages= 957–64 |year= 1997 |pmid= 9152406 |doi=  }}
*{{cite journal  |vauthors=Wise A, Parenti M, Milligan G |title=Interaction of the G-protein G11alpha with receptors and phosphoinositidase C: the contribution of G-protein palmitoylation and membrane association |journal=FEBS Lett. |volume=407 |issue= 3 |pages= 257–60 |year= 1997 |pmid= 9175863 |doi=10.1016/S0014-5793(97)00300-1 }}
*{{cite journal  | author=Wise A, Parenti M, Milligan G |title=Interaction of the G-protein G11alpha with receptors and phosphoinositidase C: the contribution of G-protein palmitoylation and membrane association. |journal=FEBS Lett. |volume=407 |issue= 3 |pages= 257–60 |year= 1997 |pmid= 9175863 |doi=  }}
*{{cite journal  |vauthors=Carrasco MP, Asbóth G, Phaneuf S, López Bernal A |title=Activation of the prostaglandin FP receptor in human granulosa cells |journal=J. Reprod. Fertil. |volume=111 |issue= 2 |pages= 309–17 |year= 1998 |pmid= 9462300 |doi=  10.1530/jrf.0.1110309}}
*{{cite journal  | author=Carrasco MP, Asbóth G, Phaneuf S, López Bernal A |title=Activation of the prostaglandin FP receptor in human granulosa cells. |journal=J. Reprod. Fertil. |volume=111 |issue= 2 |pages= 309–17 |year= 1998 |pmid= 9462300 |doi=  }}
*{{cite journal  |vauthors=Qian A, Wang W, Sanborn BM |title=Evidence for the involvement of several intracellular domains in the coupling of oxytocin receptor to G alpha(q/11) |journal=Cell. Signal. |volume=10 |issue= 2 |pages= 101–5 |year= 1998 |pmid= 9481484 |doi=10.1016/S0898-6568(97)00097-1 }}
*{{cite journal  | author=Qian A, Wang W, Sanborn BM |title=Evidence for the involvement of several intracellular domains in the coupling of oxytocin receptor to G alpha(q/11). |journal=Cell. Signal. |volume=10 |issue= 2 |pages= 101–5 |year= 1998 |pmid= 9481484 |doi=  }}
*{{cite journal  |vauthors=Dulin NO, Sorokin A, Reed E |title=RGS3 inhibits G protein-mediated signaling via translocation to the membrane and binding to Galpha11 |journal=Mol. Cell. Biol. |volume=19 |issue= 1 |pages= 714–23 |year= 1999 |pmid= 9858594 |doi=  | pmc=83928  |display-authors=etal}}
*{{cite journal  | author=Dulin NO, Sorokin A, Reed E, ''et al.'' |title=RGS3 inhibits G protein-mediated signaling via translocation to the membrane and binding to Galpha11. |journal=Mol. Cell. Biol. |volume=19 |issue= 1 |pages= 714–23 |year= 1999 |pmid= 9858594 |doi=  }}
*{{cite journal  |vauthors=Hayes JS, Lawler OA, Walsh MT, Kinsella BT |title=The prostacyclin receptor is isoprenylated. Isoprenylation is required for efficient receptor-effector coupling |journal=J. Biol. Chem. |volume=274 |issue= 34 |pages= 23707–18 |year= 1999 |pmid= 10446129 |doi=10.1074/jbc.274.34.23707 }}
*{{cite journal  | author=Hayes JS, Lawler OA, Walsh MT, Kinsella BT |title=The prostacyclin receptor is isoprenylated. Isoprenylation is required for efficient receptor-effector coupling. |journal=J. Biol. Chem. |volume=274 |issue= 34 |pages= 23707–18 |year= 1999 |pmid= 10446129 |doi=  }}
*{{cite journal  |vauthors=Brydon L, Roka F, Petit L |title=Dual signaling of human Mel1a melatonin receptors via G(i2), G(i3), and G(q/11) proteins |journal=Mol. Endocrinol. |volume=13 |issue= 12 |pages= 2025–38 |year= 2000 |pmid= 10598579 |doi=10.1210/me.13.12.2025 |display-authors=etal}}
*{{cite journal  | author=Brydon L, Roka F, Petit L, ''et al.'' |title=Dual signaling of human Mel1a melatonin receptors via G(i2), G(i3), and G(q/11) proteins. |journal=Mol. Endocrinol. |volume=13 |issue= 12 |pages= 2025–38 |year= 2000 |pmid= 10598579 |doi=  }}
*{{cite journal  |vauthors=Corbetta S, Mantovani G, Lania A |title=Calcium-sensing receptor expression and signalling in human parathyroid adenomas and primary hyperplasia |journal=Clin. Endocrinol. |volume=52 |issue= 3 |pages= 339–48 |year= 2000 |pmid= 10718832 |doi=10.1046/j.1365-2265.2000.00933.x |display-authors=etal}}
*{{cite journal  | author=Corbetta S, Mantovani G, Lania A, ''et al.'' |title=Calcium-sensing receptor expression and signalling in human parathyroid adenomas and primary hyperplasia. |journal=Clin. Endocrinol. (Oxf) |volume=52 |issue= 3 |pages= 339–48 |year= 2000 |pmid= 10718832 |doi=  }}
*{{cite journal  |vauthors=Shraga-Levine Z, Sokolovsky M |title=Functional coupling of G proteins to endothelin receptors is ligand and receptor subtype specific |journal=Cell. Mol. Neurobiol. |volume=20 |issue= 3 |pages= 305–17 |year= 2000 |pmid= 10789830 |doi=10.1023/A:1007010125316 }}
*{{cite journal  | author=Shraga-Levine Z, Sokolovsky M |title=Functional coupling of G proteins to endothelin receptors is ligand and receptor subtype specific. |journal=Cell. Mol. Neurobiol. |volume=20 |issue= 3 |pages= 305–17 |year= 2000 |pmid= 10789830 |doi=  }}
*{{cite journal  |vauthors=AbdAlla S, Lother H, Abdel-tawab AM, Quitterer U |title=The angiotensin II AT2 receptor is an AT1 receptor antagonist |journal=J. Biol. Chem. |volume=276 |issue= 43 |pages= 39721–6 |year= 2001 |pmid= 11507095 |doi= 10.1074/jbc.M105253200 }}
*{{cite journal  | author=AbdAlla S, Lother H, Abdel-tawab AM, Quitterer U |title=The angiotensin II AT2 receptor is an AT1 receptor antagonist. |journal=J. Biol. Chem. |volume=276 |issue= 43 |pages= 39721–6 |year= 2001 |pmid= 11507095 |doi= 10.1074/jbc.M105253200 }}
}}
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{{refend}}
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Revision as of 08:50, 31 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Guanine nucleotide-binding protein subunit alpha-11 is a protein that in humans is encoded by the GNA11 gene.[1][2] Together with GNAQ (its paralogue), it functions as a Gq alpha subunit.[3]


See also

References

  1. Wilkie TM, Gilbert DJ, Olsen AS, Chen XN, Amatruda TT, Korenberg JR, Trask BJ, de Jong P, Reed RR, Simon MI, et al. (Jun 1993). "Evolution of the mammalian G protein alpha subunit multigene family". Nat Genet. 1 (2): 85–91. doi:10.1038/ng0592-85. PMID 1302014.
  2. "Entrez Gene: GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)".
  3. 139313 GUANINE NUCLEOTIDE-BINDING PROTEIN, ALPHA-11; GNA11 at OMIM. Retrieved January 1, 2015.

Further reading