FGF8: Difference between revisions

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Latest revision as of 22:22, 5 October 2017

Fibroblast growth factor 8 is a protein that in humans is encoded by the FGF8 gene.^[1]^[2]

Function

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion.^[2]

Fgf8 is important and necessary for setting up and maintaining the midbrain/hindbrain border (or mesencephalon/met-encephalon border) which plays the vital role of “organizer” in development, like the Spemann “organizer” of the gastrulating embryo. Fgf8 is expressed in the region where Otx2 and Gbx2 cross inhibit each other and is maintained expression by this interaction. Once expressed, the Fgf8 induces other transcription factors to form cross-regulatory loops between cells, thus the border is established. Through development, the Fgf8 goes to regulate the growth and differentiation of progenitor cells in this region to produce ultimate structure of midbrain and hindbrain.^[3] Crossely’s experiment proves that the Fgf8 is sufficient to induce the repatterning of midbrain and hindbrain structure.^[4]

In the development of forebrain, cortical patterning centers are the boundaries or poles of cortical primordium, where multiple BMP and WNT genes are expressed. Besides, at the anterior pole several FGF family including Fgf3, 8,17 and 18 overlap in expression.^[5] The similarity in cortical gene expression in Emx2 mutants and mice in which the anterior FGF8 source is augmented suggests that FGF8 controls the graded expression(low anterior, high posterior) of Emx2 in the cortical primordium. Emx2 is one of the protomap molecular determinants that prove to be closely interacted with Pax6. Emx2 and Pax6 are expressed in opposing gradients along the A/P axis of the cortical primordium and cooperate to set up area pattern. Fgf8 and Emx2 antagonize each other to create the development map. Fgf8 promotes the development of anterior part and suppresses posterior fate, while the Emx2 does the reverse. What's more, FGF8 manipulations suggest FGF8 controls the cortical graded expression of COUP-TF1.^[6] Moreover, the sharpness of both COUPTF1 and COUP-TF2 expression borders would be expected of genes involved in boundary specification.Thus, the interaction between them regulates the A/P axis of cortical primordium and directs the development map of cortical area.

Clinical significance

This protein is known to be a factor that supports androgen and anchorage independent growth of mammary tumor cells. Overexpression of this gene has been shown to increase tumor growth and angiogenesis. The adult expression of this gene is restricted to testes and ovaries. Temporal and spatial pattern of this gene expression suggests its function as an embryonic epithelial factor. Studies of the mouse and chick homologs reveal roles in midbrain and limb development, organogenesis, embryo gastrulation and left-right axis determination. The alternative splicing of this gene results in four transcript variants.^[2]

References

↑ White RA, Dowler LL, Angeloni SV, Pasztor LM, MacArthur CA (Apr 1996). "Assignment of FGF8 to human chromosome 10q25-q26: mutations in FGF8 may be responsible for some types of acrocephalosyndactyly linked to this region". Genomics. 30 (1): 109–11. doi:10.1006/geno.1995.0020. PMID 8595889.
↑ ^2.0 ^2.1 ^2.2 "Entrez Gene: FGF8 fibroblast growth factor 8 (androgen-induced)".
↑ Harris WA, Sanes DH, Reh TA (2011). Development of the Nervous System, Third Edition. Boston: Academic Press. pp. 33–34. ISBN 0-12-374539-X.
↑ Crossley PH, Martin GR (February 1995). "The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo". Development. 121 (2): 439–51. PMID 7768185.
↑ Grove EA, Fukuchi-Shimogori T (2003). "Generating the cerebral cortical area map". Annu. Rev. Neurosci. 26: 355–80. doi:10.1146/annurev.neuro.26.041002.131137. PMID 14527269.
↑ Rebsam A, Seif I, Gaspar P (October 2002). "Refinement of thalamocortical arbors and emergence of barrel domains in primary somatosensory cortex: a study of normal and monoamine oxidase A knock-out mice". J. Neurosci. 22 (19): 8541–8552. PMID 12351728.

External links

GeneReviews/NCBI/NIH/UW entry on Kallmann syndrome
FGF8 human gene location in the UCSC Genome Browser.
FGF8 human gene details in the UCSC Genome Browser.

[pmid8595889-1] White RA, Dowler LL, Angeloni SV, Pasztor LM, MacArthur CA (Apr 1996). "Assignment of FGF8 to human chromosome 10q25-q26: mutations in FGF8 may be responsible for some types of acrocephalosyndactyly linked to this region". Genomics. 30 (1): 109–11. doi:10.1006/geno.1995.0020. PMID 8595889.

[entrez-2] 2.0 ^2.1 ^2.2 "Entrez Gene: FGF8 fibroblast growth factor 8 (androgen-induced)".

[isbn0-12-374539-X-3] Harris WA, Sanes DH, Reh TA (2011). Development of the Nervous System, Third Edition. Boston: Academic Press. pp. 33–34. ISBN 0-12-374539-X.

[pmid7768185-4] Crossley PH, Martin GR (February 1995). "The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo". Development. 121 (2): 439–51. PMID 7768185.

[pmid14527269-5] Grove EA, Fukuchi-Shimogori T (2003). "Generating the cerebral cortical area map". Annu. Rev. Neurosci. 26: 355–80. doi:10.1146/annurev.neuro.26.041002.131137. PMID 14527269.

[pmid12351728-6] Rebsam A, Seif I, Gaspar P (October 2002). "Refinement of thalamocortical arbors and emergence of barrel domains in primary somatosensory cortex: a study of normal and monoamine oxidase A knock-out mice". J. Neurosci. 22 (19): 8541–8552. PMID 12351728.

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@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Fibroblast growth factor 8''' is a [[protein]] that in humans is encoded by the ''FGF8'' [[gene]].<ref name="pmid8595889">{{cite journal |vauthors=White RA, Dowler LL, Angeloni SV, Pasztor LM, MacArthur CA | title = Assignment of FGF8 to human chromosome 10q25-q26: mutations in FGF8 may be responsible for some types of acrocephalosyndactyly linked to this region | journal = Genomics | volume = 30 | issue = 1 | pages = 109–11 |date=Apr 1996 | pmid = 8595889 | pmc =  | doi = 10.1006/geno.1995.0020 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FGF8 fibroblast growth factor 8 (androgen-induced)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2253| accessdate = }}</ref>
-| update_page = yes
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+== Function ==
-{{GNF_Protein_box
- | image = PBB_Protein_FGF8_image.jpg
- | image_source = [[Protein_Data_Bank|PDB]] rendering based on 2fdb.
- | PDB = {{PDB2|2fdb}}
- | Name = Fibroblast growth factor 8 (androgen-induced)
- | HGNCid = 3686
- | Symbol = FGF8
- | AltSymbols =; AIGF; HBGF-8; MGC149376
- | OMIM = 600483
- | ECnumber =
- | Homologene = 7715
- | MGIid = 99604
- | GeneAtlas_image1 = PBB_GE_FGF8_208449_s_at_tn.png
- | Function = {{GNF_GO|id=GO:0008083 |text = growth factor activity}}
- | Component = {{GNF_GO|id=GO:0005615 |text = extracellular space}}
- | Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007369 |text = gastrulation}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 2253
-    | Hs_Ensembl = ENSG00000107831
-    | Hs_RefseqProtein = NP_006110
-    | Hs_RefseqmRNA = NM_006119
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 10
-    | Hs_GenLoc_start = 103519877
-    | Hs_GenLoc_end = 103525817
-    | Hs_Uniprot = P55075
-    | Mm_EntrezGene = 14179
-    | Mm_Ensembl = ENSMUSG00000025219
-    | Mm_RefseqmRNA = NM_010205
-    | Mm_RefseqProtein = NP_034335
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 19
-    | Mm_GenLoc_start = 45790110
-    | Mm_GenLoc_end = 45796185
-    | Mm_Uniprot = P37237
-  }}
-}}
-'''Fibroblast growth factor 8 (androgen-induced)''', also known as '''FGF8''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: FGF8 fibroblast growth factor 8 (androgen-induced)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2253| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+The protein encoded by this gene is a member of the [[fibroblast growth factor]] (FGF) family. FGF family members possess broad [[mitogenic]] and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, [[morphogenesis]], tissue repair, tumor growth and invasion.<ref name="entrez"/>
-{{PBB_Summary
-| section_title =
+Fgf8 is important and necessary for setting up and maintaining the [[Isthmic Organizer|midbrain/hindbrain border]] (or [[mesencephalon]]/[[Metencephalon|met-encephalon]] border) which plays the vital role of “organizer” in development, like the [[Hans Spemann|Spemann]] “[[Regional specification|organizer]]” of the [[Gastrulation|gastrulating]] embryo. Fgf8 is expressed in the region where [[Orthodenticle homeobox 2|Otx2]] and [[GBX2|Gbx2]] cross inhibit each other and is maintained expression by this interaction. Once expressed, the Fgf8 induces other [[transcription factors]] to form cross-regulatory loops between cells, thus the border is established. Through development, the Fgf8 goes to regulate the growth and [[Cellular differentiation|differentiation]] of [[progenitor cells]] in this region to produce ultimate structure of [[midbrain]] and [[hindbrain]].<ref name="isbn0-12-374539-X">{{cite book |vauthors=Harris WA, Sanes DH, Reh TA | title = Development of the Nervous System, Third Edition | publisher = Academic Press | location = Boston | year = 2011 | pages = 33–34 | isbn = 0-12-374539-X | oclc = | doi = | accessdate = }}</ref> Crossely’s experiment proves that the Fgf8 is sufficient to induce the repatterning of midbrain and hindbrain structure.<ref name="pmid7768185">{{cite journal |vauthors=Crossley PH, Martin GR | title = The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo | journal = Development | volume = 121 | issue = 2 | pages = 439–51 |date=February 1995 | pmid = 7768185 | doi = | url = http://dev.biologists.org/content/121/2/439.long }}</ref>
-| summary_text = The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is known to be a factor that supports androgen and anchorage independent growth of mammary tumor cells. Overexpression of this gene has been shown to increase tumor growth and angiogensis. The adult expression of this gene is restricted to testes and ovaries. Temporal and spatial pattern of this gene expression suggests its function as an embryonic epithelial factor. Studies of the mouse and chick homologs revealed roles in midbrain and limb development, organogenesis, embryo gastrulation and left-right axis determination. The alternative splicing of this gene results in four transcript variants.<ref name="entrez">{{cite web | title = Entrez Gene: FGF8 fibroblast growth factor 8 (androgen-induced)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2253| accessdate = }}</ref>
-}}
+In the development of [[forebrain]], cortical patterning centers are the boundaries or poles of cortical primordium, where multiple [[Bone morphogenetic proteins|BMP]] and [[Wnt signaling pathway|WNT]] genes are expressed. Besides, at the anterior pole several FGF family including [[FGF3|Fgf3]], 8,[[FGF17|17]] and [[FGF18|18]] overlap in expression.<ref name="pmid14527269">{{cite journal |vauthors=Grove EA, Fukuchi-Shimogori T | title = Generating the cerebral cortical area map | journal = Annu. Rev. Neurosci. | volume = 26 | issue = | pages = 355–80 | year = 2003 | pmid = 14527269 | doi = 10.1146/annurev.neuro.26.041002.131137 }}</ref> The similarity in cortical gene expression in [[EMX2|Emx2]] mutants and mice in which the anterior FGF8 source is augmented suggests that FGF8 controls the graded expression(low anterior, high posterior) of [[EMX2|Emx2]] in the cortical primordium. Emx2 is one of the protomap molecular determinants that prove to be closely interacted with [[Pax6]]. Emx2 and Pax6 are expressed in opposing gradients along the A/P axis of the cortical primordium and cooperate to set up area pattern. Fgf8 and [[EMX2|Emx2]] antagonize each other to create the development map. Fgf8 promotes the development of anterior part and suppresses posterior fate, while the Emx2 does the reverse. What's more, FGF8 manipulations suggest FGF8 controls the cortical graded expression of COUP-TF1.<ref name="pmid12351728">{{cite journal |vauthors=Rebsam A, Seif I, Gaspar P | title = Refinement of thalamocortical arbors and emergence of barrel domains in primary somatosensory cortex: a study of normal and monoamine oxidase A knock-out mice | journal = J. Neurosci. | volume = 22| issue =19  | pages = 8541–8552 |date=October 2002 | pmid = 12351728 | doi = | url = http://www.jneurosci.org/content/22/19/8541.long }}</ref> Moreover, the sharpness of both COUPTF1 and COUP-TF2 expression borders would be expected of genes involved in boundary specification.Thus, the interaction between them regulates the A/P axis of cortical [[primordium]] and directs the development map of [[cortical area]].
+== Clinical significance ==
+This protein is known to be a factor that supports [[androgen]] and anchorage independent growth of mammary tumor cells. Overexpression of this gene has been shown to increase tumor growth and [[angiogenesis]]. The adult expression of this gene is restricted to [[testes]] and [[ovaries]]. Temporal and spatial pattern of this gene expression suggests its function as an embryonic epithelial factor. Studies of the mouse and chick homologs reveal roles in midbrain and limb development, [[organogenesis]], embryo gastrulation and left-right axis determination. The alternative splicing of this gene results in four transcript variants.<ref name="entrez"/>
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
-{{refbegin | 2}}
+{{refbegin|35em}}
-{{PBB_Further_reading
+*{{cite journal  |vauthors=Powers CJ, McLeskey SW, Wellstein A |title=Fibroblast growth factors, their receptors and signaling. |journal=Endocr. Relat. Cancer |volume=7 |issue= 3 |pages= 165–97 |year= 2000 |pmid= 11021964 |doi=10.1677/erc.0.0070165  }}
-| citations =
+*{{cite journal  |vauthors=Mattila MM, Härkönen PL |title=Role of fibroblast growth factor 8 in growth and progression of hormonal cancer. |journal=Cytokine Growth Factor Rev. |volume=18 |issue= 3–4 |pages= 257–66 |year= 2007 |pmid= 17512240 |doi= 10.1016/j.cytogfr.2007.04.010 }}
-*{{cite journal  | author=Powers CJ, McLeskey SW, Wellstein A |title=Fibroblast growth factors, their receptors and signaling. |journal=Endocr. Relat. Cancer |volume=7 |issue= 3 |pages= 165-97 |year= 2000 |pmid= 11021964 |doi=  }}
+*{{cite journal  | author=Duester G |title=Retinoic acid regulation of the somitogenesis clock |journal=Birth Defects Res. C Embryo Today |volume=81 |issue= 2 |pages= 84–92 |year= 2007 |pmid= 17600781 |doi= 10.1002/bdrc.20092  | pmc=2235195 }}
-*{{cite journal  | author=Mattila MM, Härkönen PL |title=Role of fibroblast growth factor 8 in growth and progression of hormonal cancer. |journal=Cytokine Growth Factor Rev. |volume=18 |issue= 3-4 |pages= 257-66 |year= 2007 |pmid= 17512240 |doi= 10.1016/j.cytogfr.2007.04.010 }}
+*{{cite journal  |vauthors=Tanaka A, Miyamoto K, Matsuo H |title=Human androgen-induced growth factor in prostate and breast cancer cells: its molecular cloning and growth properties |journal=FEBS Lett. |volume=363 |issue= 3 |pages= 226–30 |year= 1995 |pmid= 7737407 |doi=10.1016/0014-5793(95)00324-3  |display-authors=etal}}
-*{{cite journal  | author=Duester G |title=Retinoic acid regulation of the somitogenesis clock. |journal=Birth Defects Res. C Embryo Today |volume=81 |issue= 2 |pages= 84-92 |year= 2007 |pmid= 17600781 |doi= 10.1002/bdrc.20092 }}
+*{{cite journal  |vauthors=Gemel J, Gorry M, Ehrlich GD, MacArthur CA |title=Structure and sequence of human FGF8 |journal=Genomics |volume=35 |issue= 1 |pages= 253–7 |year= 1996 |pmid= 8661131 |doi= 10.1006/geno.1996.0349 }}
-*{{cite journal  | author=Tanaka A, Miyamoto K, Matsuo H, ''et al.'' |title=Human androgen-induced growth factor in prostate and breast cancer cells: its molecular cloning and growth properties. |journal=FEBS Lett. |volume=363 |issue= 3 |pages= 226-30 |year= 1995 |pmid= 7737407 |doi=  }}
+*{{cite journal  |vauthors=Ornitz DM, Xu J, Colvin JS |title=Receptor specificity of the fibroblast growth factor family |journal=J. Biol. Chem. |volume=271 |issue= 25 |pages= 15292–7 |year= 1996 |pmid= 8663044 |doi=10.1074/jbc.271.25.15292  |display-authors=etal}}
-*{{cite journal  | author=White RA, Dowler LL, Angeloni SV, ''et al.'' |title=Assignment of FGF8 to human chromosome 10q25-q26: mutations in FGF8 may be responsible for some types of acrocephalosyndactyly linked to this region. |journal=Genomics |volume=30 |issue= 1 |pages= 109-11 |year= 1996 |pmid= 8595889 |doi= 10.1006/geno.1995.0020 }}
+*{{cite journal  |vauthors=Payson RA, Wu J, Liu Y, Chiu IM |title=The human FGF-8 gene localizes on chromosome 10q24 and is subjected to induction by androgen in breast cancer cells |journal=Oncogene |volume=13 |issue= 1 |pages= 47–53 |year= 1996 |pmid= 8700553 |doi=  }}
-*{{cite journal  | author=Gemel J, Gorry M, Ehrlich GD, MacArthur CA |title=Structure and sequence of human FGF8. |journal=Genomics |volume=35 |issue= 1 |pages= 253-7 |year= 1996 |pmid= 8661131 |doi= 10.1006/geno.1996.0349 }}
+*{{cite journal  |vauthors=Ghosh AK, Shankar DB, Shackleford GM |title=Molecular cloning and characterization of human FGF8 alternative messenger RNA forms |journal=Cell Growth Differ. |volume=7 |issue= 10 |pages= 1425–34 |year= 1997 |pmid= 8891346 |doi=  |display-authors=etal}}
-*{{cite journal  | author=Ornitz DM, Xu J, Colvin JS, ''et al.'' |title=Receptor specificity of the fibroblast growth factor family. |journal=J. Biol. Chem. |volume=271 |issue= 25 |pages= 15292-7 |year= 1996 |pmid= 8663044 |doi=  }}
+*{{cite journal  |vauthors=Yoshiura K, Leysens NJ, Chang J |title=Genomic structure, sequence, and mapping of human FGF8 with no evidence for its role in craniosynostosis/limb defect syndromes |journal=Am. J. Med. Genet. |volume=72 |issue= 3 |pages= 354–62 |year= 1997 |pmid= 9332670 |doi=10.1002/(SICI)1096-8628(19971031)72:3<354::AID-AJMG21>3.0.CO;2-R  |display-authors=etal}}
-*{{cite journal  | author=Payson RA, Wu J, Liu Y, Chiu IM |title=The human FGF-8 gene localizes on chromosome 10q24 and is subjected to induction by androgen in breast cancer cells. |journal=Oncogene |volume=13 |issue= 1 |pages= 47-53 |year= 1996 |pmid= 8700553 |doi=  }}
+*{{cite journal  |vauthors=Chellaiah A, Yuan W, Chellaiah M, Ornitz DM |title=Mapping ligand binding domains in chimeric fibroblast growth factor receptor molecules. Multiple regions determine ligand binding specificity |journal=J. Biol. Chem. |volume=274 |issue= 49 |pages= 34785–94 |year= 2000 |pmid= 10574949 |doi=10.1074/jbc.274.49.34785  }}
-*{{cite journal  | author=Ghosh AK, Shankar DB, Shackleford GM, ''et al.'' |title=Molecular cloning and characterization of human FGF8 alternative messenger RNA forms. |journal=Cell Growth Differ. |volume=7 |issue= 10 |pages= 1425-34 |year= 1997 |pmid= 8891346 |doi=  }}
+*{{cite journal  |vauthors=Loo BB, Darwish KK, Vainikka SS |title=Production and characterization of the extracellular domain of recombinant human fibroblast growth factor receptor 4 |journal=Int. J. Biochem. Cell Biol. |volume=32 |issue= 5 |pages= 489–97 |year= 2001 |pmid= 10736564 |doi=10.1016/S1357-2725(99)00145-4  |display-authors=etal}}
-*{{cite journal  | author=Yoshiura K, Leysens NJ, Chang J, ''et al.'' |title=Genomic structure, sequence, and mapping of human FGF8 with no evidence for its role in craniosynostosis/limb defect syndromes. |journal=Am. J. Med. Genet. |volume=72 |issue= 3 |pages= 354-62 |year= 1997 |pmid= 9332670 |doi=  }}
+*{{cite journal  |vauthors=Xu J, Liu Z, Ornitz DM |title=Temporal and spatial gradients of Fgf8 and Fgf17 regulate proliferation and differentiation of midline cerebellar structures |journal=Development |volume=127 |issue= 9 |pages= 1833–43 |year= 2000 |pmid= 10751172 |doi=  }}
-*{{cite journal  | author=Chellaiah A, Yuan W, Chellaiah M, Ornitz DM |title=Mapping ligand binding domains in chimeric fibroblast growth factor receptor molecules. Multiple regions determine ligand binding specificity. |journal=J. Biol. Chem. |volume=274 |issue= 49 |pages= 34785-94 |year= 2000 |pmid= 10574949 |doi=  }}
+*{{cite journal  |vauthors=Tanaka S, Ueo H, Mafune K |title=A novel isoform of human fibroblast growth factor 8 is induced by androgens and associated with progression of esophageal carcinoma |journal=Dig. Dis. Sci. |volume=46 |issue= 5 |pages= 1016–21 |year= 2001 |pmid= 11341643 |doi=10.1023/A:1010753826788  |display-authors=etal}}
-*{{cite journal  | author=Loo BB, Darwish KK, Vainikka SS, ''et al.'' |title=Production and characterization of the extracellular domain of recombinant human fibroblast growth factor receptor 4. |journal=Int. J. Biochem. Cell Biol. |volume=32 |issue= 5 |pages= 489-97 |year= 2001 |pmid= 10736564 |doi=  }}
+*{{cite journal  |vauthors=Ruohola JK, Viitanen TP, Valve EM |title=Enhanced invasion and tumor growth of fibroblast growth factor 8b-overexpressing MCF-7 human breast cancer cells |journal=Cancer Res. |volume=61 |issue= 10 |pages= 4229–37 |year= 2001 |pmid= 11358849 |doi=  |display-authors=etal}}
-*{{cite journal  | author=Xu J, Liu Z, Ornitz DM |title=Temporal and spatial gradients of Fgf8 and Fgf17 regulate proliferation and differentiation of midline cerebellar structures. |journal=Development |volume=127 |issue= 9 |pages= 1833-43 |year= 2000 |pmid= 10751172 |doi=  }}
+*{{cite journal  |vauthors=Mattila MM, Ruohola JK, Valve EM |title=FGF-8b increases angiogenic capacity and tumor growth of androgen-regulated S115 breast cancer cells |journal=Oncogene |volume=20 |issue= 22 |pages= 2791–804 |year= 2001 |pmid= 11420691 |doi= 10.1038/sj.onc.1204430 |display-authors=etal}}
-*{{cite journal  | author=Tanaka S, Ueo H, Mafune K, ''et al.'' |title=A novel isoform of human fibroblast growth factor 8 is induced by androgens and associated with progression of esophageal carcinoma. |journal=Dig. Dis. Sci. |volume=46 |issue= 5 |pages= 1016-21 |year= 2001 |pmid= 11341643 |doi=  }}
+*{{cite journal  |vauthors=Zammit C, Coope R, Gomm JJ |title=Fibroblast growth factor 8 is expressed at higher levels in lactating human breast and in breast cancer |journal=Br. J. Cancer |volume=86 |issue= 7 |pages= 1097–103 |year= 2002 |pmid= 11953856 |doi= 10.1038/sj.bjc.6600213  | pmc=2364190 |display-authors=etal}}
-*{{cite journal  | author=Ruohola JK, Viitanen TP, Valve EM, ''et al.'' |title=Enhanced invasion and tumor growth of fibroblast growth factor 8b-overexpressing MCF-7 human breast cancer cells. |journal=Cancer Res. |volume=61 |issue= 10 |pages= 4229-37 |year= 2001 |pmid= 11358849 |doi=  }}
+*{{cite journal  |vauthors=Brondani V, Klimkait T, Egly JM, Hamy F |title=Promoter of FGF8 reveals a unique regulation by unliganded RARalpha |journal=J. Mol. Biol. |volume=319 |issue= 3 |pages= 715–28 |year= 2002 |pmid= 12054865 |doi= 10.1016/S0022-2836(02)00376-5 }}
-*{{cite journal  | author=Mattila MM, Ruohola JK, Valve EM, ''et al.'' |title=FGF-8b increases angiogenic capacity and tumor growth of androgen-regulated S115 breast cancer cells. |journal=Oncogene |volume=20 |issue= 22 |pages= 2791-804 |year= 2001 |pmid= 11420691 |doi= 10.1038/sj.onc.1204430 }}
+*{{cite journal  |vauthors=Gnanapragasam VJ, Robson CN, Neal DE, Leung HY |title=Regulation of FGF8 expression by the androgen receptor in human prostate cancer |journal=Oncogene |volume=21 |issue= 33 |pages= 5069–80 |year= 2002 |pmid= 12140757 |doi= 10.1038/sj.onc.1205663 }}
-*{{cite journal  | author=Zammit C, Coope R, Gomm JJ, ''et al.'' |title=Fibroblast growth factor 8 is expressed at higher levels in lactating human breast and in breast cancer. |journal=Br. J. Cancer |volume=86 |issue= 7 |pages= 1097-103 |year= 2002 |pmid= 11953856 |doi= 10.1038/sj.bjc.6600213 }}
-*{{cite journal  | author=Brondani V, Klimkait T, Egly JM, Hamy F |title=Promoter of FGF8 reveals a unique regulation by unliganded RARalpha. |journal=J. Mol. Biol. |volume=319 |issue= 3 |pages= 715-28 |year= 2002 |pmid= 12054865 |doi= 10.1016/S0022-2836(02)00376-5 }}
-*{{cite journal  | author=Gnanapragasam VJ, Robson CN, Neal DE, Leung HY |title=Regulation of FGF8 expression by the androgen receptor in human prostate cancer. |journal=Oncogene |volume=21 |issue= 33 |pages= 5069-80 |year= 2002 |pmid= 12140757 |doi= 10.1038/sj.onc.1205663 }}
-}}
 {{refend}}
-{{protein-stub}}
+==External links==
+*[https://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=kms  GeneReviews/NCBI/NIH/UW entry on Kallmann syndrome]
+* {{UCSC genome browser|FGF8}}
+* {{UCSC gene details|FGF8}}
+{{PDB Gallery|geneid=2253}}
+{{Growth factors}}
 {{Intercellular signaling peptides and proteins}}
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+{{Growth factor receptor modulators}}

v t e Intercellular signaling peptides and proteins / ligands
Growth factors	Epidermal growth factor Fibroblast growth factor Nerve growth factor Platelet-derived growth factor Transforming growth factor beta superfamily Vascular endothelial growth factor
Ephrin	EFNA1 EFNA2 EFNA3 EFNA4 EFNA5 EFNB1 EFNB2 EFNB3
Other	Adipokine Agouti signaling protein Agouti-related protein Angiogenic protein CCN intercellular signaling protein Cysteine-rich protein 61 Connective tissue growth factor Nephroblastoma overexpressed protein Cytokine Endothelin EDN1 EDN2 EDN3 Hedgehog protein Interferon Kinin Parathyroid hormone-related protein Semaphorin Somatomedin Tolloid-like metalloproteinase Tumor necrosis factor Wnt protein
see also extracellular ligand disorders

FGF8: Difference between revisions

Latest revision as of 22:22, 5 October 2017

Contents

Function

Clinical significance

References

Further reading

External links

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