FCGR2A: Difference between revisions

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{{Infobox_gene}}
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'''Low affinity immunoglobulin gamma Fc region receptor II-a''' is a [[protein]] that in humans is encoded by the ''FCGR2A'' [[gene]].<ref name="pmid2139735">{{cite journal | vauthors = Qiu WQ, de Bruin D, Brownstein BH, Pearse R, Ravetch JV | title = Organization of the human and mouse low-affinity Fc gamma R genes: duplication and recombination | journal = Science | volume = 248 | issue = 4956 | pages = 732–5 | date=June 1990| pmid = 2139735 | pmc =  | doi =10.1126/science.2139735 }}</ref><ref>{{cite web | title = Entrez Gene: FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2212| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_FCGR2A_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1fcg.
| PDB = {{PDB2|1fcg}}, {{PDB2|1h9v}}, {{PDB2|2fcb}}
| Name = Fc fragment of IgG, low affinity IIa, receptor (CD32)
| HGNCid = 3616
| Symbol = FCGR2A
| AltSymbols =; CD32; CD32A; CDw32; FCG2; FCGR2; FCGR2A1; FcGR; IGFR2; MGC23887; MGC30032
| OMIM = 146790
| ECnumber =
| Homologene = 47936
| MGIid = 95500
| GeneAtlas_image1 = PBB_GE_FCGR2A_203561_at_tn.png
  | GeneAtlas_image2 = PBB_GE_FCGR2A_210992_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_FCGR2A_211395_x_at_tn.png
  | Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005057 |text = receptor signaling protein activity}} {{GNF_GO|id=GO:0019864 |text = IgG binding}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006955 |text = immune response}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2212
    | Hs_Ensembl = ENSG00000143226
    | Hs_RefseqProtein = XP_001129584
    | Hs_RefseqmRNA = XM_001129584
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 159741844
    | Hs_GenLoc_end = 159755982
    | Hs_Uniprot = P12318
    | Mm_EntrezGene = 14131
    | Mm_Ensembl = ENSMUSG00000059498
    | Mm_RefseqmRNA = NM_010188
    | Mm_RefseqProtein = NP_034318
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 172887850
    | Mm_GenLoc_end = 172896037
    | Mm_Uniprot = Q5D5I8
  }}
}}
'''Fc fragment of IgG, low affinity IIa, receptor (CD32)''', also known as '''FCGR2A''', is a human [[gene]].<ref>{{cite web | title = Entrez Gene: FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2212| accessdate = }}</ref>
 
 
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==Interactions==
FCGR2A has been shown to [[Protein-protein interaction|interact]] with [[PIK3R1]]<ref name=pmid8631888>{{cite journal |last=Chacko |first=G W |author2=Brandt J T |author3=Coggeshall K M |author4=Anderson C L  |date=May 1996|title=Phosphoinositide 3-kinase and p72syk noncovalently associate with the low affinity Fc gamma receptor on human platelets through an immunoreceptor tyrosine-based activation motif. Reconstitution with synthetic phosphopeptides |journal=J. Biol. Chem. |volume=271 |issue=18 |pages=10775–81 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 8631888 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1074/jbc.271.18.10775 }}</ref><ref name=pmid9268059>{{cite journal |last=Ibarrola |first=I |author2=Vossebeld P J |author3=Homburg C H |author4=Thelen M |author5=Roos D |author6=Verhoeven A J  |date=July 1997|title=Influence of tyrosine phosphorylation on protein interaction with FcgammaRIIa |journal=Biochim. Biophys. Acta |volume=1357 |issue=3 |pages=348–58 |publisher= |location = NETHERLANDS| issn = 0006-3002| pmid = 9268059 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = | doi=10.1016/S0167-4889(97)00034-7}}</ref> and [[Syk]].<ref name=pmid9268059/><ref name=pmid11141335>{{cite journal |last=Kim |first=M K |author2=Pan X Q |author3=Huang Z Y |author4=Hunter S |author5=Hwang P H |author6=Indik Z K |author7=Schreiber A D  |date=January 2001|title=Fc gamma receptors differ in their structural requirements for interaction with the tyrosine kinase Syk in the initial steps of signaling for phagocytosis |journal=Clin. Immunol. |volume=98 |issue=1 |pages=125–32 |publisher= |location = UNITED STATES| issn = 1521-6616| pmid = 11141335 |doi = 10.1006/clim.2000.4955 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>


==See also==
==See also==
Line 61: Line 14:


==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading
| citations =  
| citations =
*{{cite journal  | author=McKenzie SE |title=Humanized mouse models of FcR clearance in immune platelet disorders. |journal=Blood Rev. |volume=16 |issue= 1 |pages= 3-5 |year= 2002 |pmid= 11913983 |doi= 10.1054/blre.2001.0170 }}
*{{cite journal  | author=McKenzie SE |title=Humanized mouse models of FcR clearance in immune platelet disorders. |journal=Blood Rev. |volume=16 |issue= 1 |pages= 3–5 |year= 2002 |pmid= 11913983 |doi= 10.1054/blre.2001.0170 }}
*{{cite journal  | author=Ernst LK, van de Winkel JG, Chiu IM, Anderson CL |title=Three genes for the human high affinity Fc receptor for IgG (Fc gamma RI) encode four distinct transcription products. |journal=J. Biol. Chem. |volume=267 |issue= 22 |pages= 15692-700 |year= 1992 |pmid= 1379234 |doi=  }}
*{{cite journal  | vauthors=Ernst LK, van de Winkel JG, Chiu IM, Anderson CL |title=Three genes for the human high affinity Fc receptor for IgG (Fc gamma RI) encode four distinct transcription products. |journal=J. Biol. Chem. |volume=267 |issue= 22 |pages= 15692–700 |year= 1992 |pmid= 1379234 |doi=  }}
*{{cite journal  | author=Qiu WQ, de Bruin D, Brownstein BH, ''et al.'' |title=Organization of the human and mouse low-affinity Fc gamma R genes: duplication and recombination. |journal=Science |volume=248 |issue= 4956 |pages= 732-5 |year= 1990 |pmid= 2139735 |doi=  }}
*{{cite journal  | author=Seki T |title=Identification of multiple isoforms of the low-affinity human IgG Fc receptor. |journal=Immunogenetics |volume=30 |issue= 1 |pages= 5–12 |year= 1989 |pmid= 2526077 |doi=10.1007/BF02421463 }}
*{{cite journal  | author=Seki T |title=Identification of multiple isoforms of the low-affinity human IgG Fc receptor. |journal=Immunogenetics |volume=30 |issue= 1 |pages= 5-12 |year= 1989 |pmid= 2526077 |doi=  }}
*{{cite journal  | vauthors=Hessian PA, Highton J, Palmer DG |title=Quantification of macrophage cell surface molecules in rheumatoid arthritis |journal=Clin. Exp. Immunol. |volume=77 |issue= 1 |pages= 47–51 |year= 1989 |pmid= 2527651 |doi= | pmc=1541930 }}
*{{cite journal  | author=Hessian PA, Highton J, Palmer DG |title=Quantification of macrophage cell surface molecules in rheumatoid arthritis. |journal=Clin. Exp. Immunol. |volume=77 |issue= 1 |pages= 47-51 |year= 1989 |pmid= 2527651 |doi= }}
*{{cite journal  | vauthors=Brooks DG, Qiu WQ, Luster AD, Ravetch JV |title=Structure and expression of human IgG FcRII(CD32). Functional heterogeneity is encoded by the alternatively spliced products of multiple genes |journal=J. Exp. Med. |volume=170 |issue= 4 |pages= 1369–85 |year= 1989 |pmid= 2529342 |doi=10.1084/jem.170.4.1369  | pmc=2189488  }}
*{{cite journal  | author=Brooks DG, Qiu WQ, Luster AD, Ravetch JV |title=Structure and expression of human IgG FcRII(CD32). Functional heterogeneity is encoded by the alternatively spliced products of multiple genes. |journal=J. Exp. Med. |volume=170 |issue= 4 |pages= 1369-85 |year= 1989 |pmid= 2529342 |doi= }}
*{{cite journal  | vauthors=Lanier LL, Cwirla S, Yu G |title=Membrane anchoring of a human IgG Fc receptor (CD16) determined by a single amino acid |journal=Science |volume=246 |issue= 4937 |pages= 1611–3 |year= 1990 |pmid= 2531919 |doi=10.1126/science.2531919  |display-authors=etal}}
*{{cite journal  | author=Lanier LL, Cwirla S, Yu G, ''et al.'' |title=Membrane anchoring of a human IgG Fc receptor (CD16) determined by a single amino acid. |journal=Science |volume=246 |issue= 4937 |pages= 1611-3 |year= 1990 |pmid= 2531919 |doi=  }}
*{{cite journal  | vauthors=Stuart SG, Trounstine ML, Vaux DJ |title=Isolation and expression of cDNA clones encoding a human receptor for IgG (Fc gamma RII) |journal=J. Exp. Med. |volume=166 |issue= 6 |pages= 1668–84 |year= 1987 |pmid= 2824655 |doi=10.1084/jem.166.6.1668  | pmc=2188792 |display-authors=etal}}
*{{cite journal  | author=Stuart SG, Trounstine ML, Vaux DJ, ''et al.'' |title=Isolation and expression of cDNA clones encoding a human receptor for IgG (Fc gamma RII). |journal=J. Exp. Med. |volume=166 |issue= 6 |pages= 1668-84 |year= 1987 |pmid= 2824655 |doi= }}
*{{cite journal  | vauthors=Hibbs ML, Bonadonna L, Scott BM |title=Molecular cloning of a human immunoglobulin G Fc receptor |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=85 |issue= 7 |pages= 2240–4 |year= 1988 |pmid= 2965389 |doi=10.1073/pnas.85.7.2240  | pmc=279966  |display-authors=etal}}
*{{cite journal  | author=Hibbs ML, Bonadonna L, Scott BM, ''et al.'' |title=Molecular cloning of a human immunoglobulin G Fc receptor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=85 |issue= 7 |pages= 2240-4 |year= 1988 |pmid= 2965389 |doi= }}
*{{cite journal  | vauthors=Huizinga TW, van der Schoot CE, Jost C |title=The PI-linked receptor FcRIII is released on stimulation of neutrophils |journal=Nature |volume=333 |issue= 6174 |pages= 667–9 |year= 1988 |pmid= 2967437 |doi= 10.1038/333667a0 |display-authors=etal}}
*{{cite journal  | author=Huizinga TW, van der Schoot CE, Jost C, ''et al.'' |title=The PI-linked receptor FcRIII is released on stimulation of neutrophils. |journal=Nature |volume=333 |issue= 6174 |pages= 667-9 |year= 1988 |pmid= 2967437 |doi= 10.1038/333667a0 }}
*{{cite journal  | vauthors=Sammartino L, Webber LM, Hogarth PM |title=Assignment of the gene coding for human FcRII (CD32) to bands q23q24 on chromosome 1 |journal=Immunogenetics |volume=28 |issue= 5 |pages= 380–1 |year= 1988 |pmid= 2971615 |doi=10.1007/BF00364238  |display-authors=etal}}
*{{cite journal  | author=Sammartino L, Webber LM, Hogarth PM, ''et al.'' |title=Assignment of the gene coding for human FcRII (CD32) to bands q23q24 on chromosome 1. |journal=Immunogenetics |volume=28 |issue= 5 |pages= 380-1 |year= 1988 |pmid= 2971615 |doi=  }}
*{{cite journal  | vauthors=Stengelin S, Stamenkovic I, Seed B |title=Isolation of cDNAs for two distinct human Fc receptors by ligand affinity cloning |journal=EMBO J. |volume=7 |issue= 4 |pages= 1053–9 |year= 1988 |pmid= 3402431 |doi= | pmc=454434 }}
*{{cite journal  | author=Stengelin S, Stamenkovic I, Seed B |title=Isolation of cDNAs for two distinct human Fc receptors by ligand affinity cloning. |journal=EMBO J. |volume=7 |issue= 4 |pages= 1053-9 |year= 1988 |pmid= 3402431 |doi=  }}
*{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
*{{cite journal  | vauthors=Chacko GW, Brandt JT, Coggeshall KM, Anderson CL |title=Phosphoinositide 3-kinase and p72syk noncovalently associate with the low affinity Fc gamma receptor on human platelets through an immunoreceptor tyrosine-based activation motif. Reconstitution with synthetic phosphopeptides |journal=J. Biol. Chem. |volume=271 |issue= 18 |pages= 10775–81 |year= 1996 |pmid= 8631888 |doi=10.1074/jbc.271.18.10775  }}
*{{cite journal  | author=Chacko GW, Brandt JT, Coggeshall KM, Anderson CL |title=Phosphoinositide 3-kinase and p72syk noncovalently associate with the low affinity Fc gamma receptor on human platelets through an immunoreceptor tyrosine-based activation motif. Reconstitution with synthetic phosphopeptides. |journal=J. Biol. Chem. |volume=271 |issue= 18 |pages= 10775-81 |year= 1996 |pmid= 8631888 |doi=  }}
*{{cite journal  | vauthors=Salmon JE, Millard S, Schachter LA |title=Fc gamma RIIA alleles are heritable risk factors for lupus nephritis in African Americans |journal=J. Clin. Invest. |volume=97 |issue= 5 |pages= 1348–54 |year= 1996 |pmid= 8636449 |doi=10.1172/JCI118552  | pmc=507190 |display-authors=etal}}
*{{cite journal  | author=Salmon JE, Millard S, Schachter LA, ''et al.'' |title=Fc gamma RIIA alleles are heritable risk factors for lupus nephritis in African Americans. |journal=J. Clin. Invest. |volume=97 |issue= 5 |pages= 1348-54 |year= 1996 |pmid= 8636449 |doi=  }}
*{{cite journal  | vauthors=Bewarder N, Weinrich V, Budde P |title=In vivo and in vitro specificity of protein tyrosine kinases for immunoglobulin G receptor (FcgammaRII) phosphorylation |journal=Mol. Cell. Biol. |volume=16 |issue= 9 |pages= 4735–43 |year= 1996 |pmid= 8756631 |doi=  | pmc=231474  |display-authors=etal}}
*{{cite journal  | author=Bewarder N, Weinrich V, Budde P, ''et al.'' |title=In vivo and in vitro specificity of protein tyrosine kinases for immunoglobulin G receptor (FcgammaRII) phosphorylation. |journal=Mol. Cell. Biol. |volume=16 |issue= 9 |pages= 4735-43 |year= 1996 |pmid= 8756631 |doi= }}
*{{cite journal  | vauthors=Sármay G, Koncz G, Gergely J |title=Human type II Fcgamma receptors inhibit B cell activation by interacting with the p21(ras)-dependent pathway |journal=J. Biol. Chem. |volume=271 |issue= 48 |pages= 30499–504 |year= 1997 |pmid= 8940017 |doi=10.1074/jbc.271.48.30499  }}
*{{cite journal  | author=Sármay G, Koncz G, Gergely J |title=Human type II Fcgamma receptors inhibit B cell activation by interacting with the p21(ras)-dependent pathway. |journal=J. Biol. Chem. |volume=271 |issue= 48 |pages= 30499-504 |year= 1997 |pmid= 8940017 |doi=  }}
*{{cite journal  | vauthors=Ibarrola I, Vossebeld PJ, Homburg CH |title=Influence of tyrosine phosphorylation on protein interaction with FcgammaRIIa |journal=Biochim. Biophys. Acta |volume=1357 |issue= 3 |pages= 348–58 |year= 1997 |pmid= 9268059 |doi=10.1016/S0167-4889(97)00034-7 |display-authors=etal}}
*{{cite journal  | author=Ibarrola I, Vossebeld PJ, Homburg CH, ''et al.'' |title=Influence of tyrosine phosphorylation on protein interaction with FcgammaRIIa. |journal=Biochim. Biophys. Acta |volume=1357 |issue= 3 |pages= 348-58 |year= 1997 |pmid= 9268059 |doi=  }}
*{{cite journal  | vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |display-authors=etal}}
*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal  | vauthors=De SK, Venkateshan CN, Seth P |title=Adenovirus-mediated human immunodeficiency virus-1 Nef expression in human monocytes/macrophages and effect of Nef on downmodulation of Fcgamma receptors and expression of monokines |journal=Blood |volume=91 |issue= 6 |pages= 2108–17 |year= 1998 |pmid= 9490697 |doi=  |display-authors=etal}}
*{{cite journal  | author=De SK, Venkateshan CN, Seth P, ''et al.'' |title=Adenovirus-mediated human immunodeficiency virus-1 Nef expression in human monocytes/macrophages and effect of Nef on downmodulation of Fcgamma receptors and expression of monokines. |journal=Blood |volume=91 |issue= 6 |pages= 2108-17 |year= 1998 |pmid= 9490697 |doi=  }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=2212}}


== External links ==
== External links ==
* {{MeshName|FCGR2A+protein,+human}}
* {{MeshName|FCGR2A+protein,+human}}


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[[Category:Clusters of differentiation]]
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[[Category:Fc receptors]]
 
 
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Revision as of 00:44, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Wikidata
View/Edit Human

Low affinity immunoglobulin gamma Fc region receptor II-a is a protein that in humans is encoded by the FCGR2A gene.[1][2]


Interactions

FCGR2A has been shown to interact with PIK3R1[3][4] and Syk.[4][5]

See also

References

  1. ↑ Qiu WQ, de Bruin D, Brownstein BH, Pearse R, Ravetch JV (June 1990). "Organization of the human and mouse low-affinity Fc gamma R genes: duplication and recombination". Science. 248 (4956): 732–5. doi:10.1126/science.2139735. PMID 2139735.
  2. ↑ "Entrez Gene: FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)".
  3. ↑ Chacko, G W; Brandt J T; Coggeshall K M; Anderson C L (May 1996). "Phosphoinositide 3-kinase and p72syk noncovalently associate with the low affinity Fc gamma receptor on human platelets through an immunoreceptor tyrosine-based activation motif. Reconstitution with synthetic phosphopeptides". J. Biol. Chem. UNITED STATES. 271 (18): 10775–81. doi:10.1074/jbc.271.18.10775. ISSN 0021-9258. PMID 8631888.
  4. ↑ 4.0 4.1 Ibarrola, I; Vossebeld P J; Homburg C H; Thelen M; Roos D; Verhoeven A J (July 1997). "Influence of tyrosine phosphorylation on protein interaction with FcgammaRIIa". Biochim. Biophys. Acta. NETHERLANDS. 1357 (3): 348–58. doi:10.1016/S0167-4889(97)00034-7. ISSN 0006-3002. PMID 9268059.
  5. ↑ Kim, M K; Pan X Q; Huang Z Y; Hunter S; Hwang P H; Indik Z K; Schreiber A D (January 2001). "Fc gamma receptors differ in their structural requirements for interaction with the tyrosine kinase Syk in the initial steps of signaling for phagocytosis". Clin. Immunol. UNITED STATES. 98 (1): 125–32. doi:10.1006/clim.2000.4955. ISSN 1521-6616. PMID 11141335.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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