Dermatofibroma differential diagnosis: Difference between revisions

Revision as of 21:42, 22 August 2019

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Homa Najafi, M.D.[2]

Overview

Deep penetrating dermatofibroma may be difficult to distinguish, even histologically, from rare malignant fibrohistocytic tumors e.g dermatofibrosarcoma protuberans.

Differential Diagnosis

Deep penetrating dermatofibroma may be difficult to distinguish, even histologically, from rare malignant fibrohistocytic tumors e.g dermatofibrosarcoma protuberans.^[1]^[2]

Immunohistochemical Staining

Neoplasm	CD34	Stromelysin-3	Factor XIIIa
Dermatofibroma	+	+	+
Dermatofibrosarcoma protuberans	+	-	-

Overview

[Disease name] must be differentiated from other diseases that cause [clinical feature 1], [clinical feature 2], and [clinical feature 3], such as [differential dx1], [differential dx2], and [differential dx3].

OR

[Disease name] must be differentiated from [[differential dx1], [differential dx2], and [differential dx3].

Differentiating [Disease name] from other Diseases

[Disease name] must be differentiated from other diseases that cause [clinical feature 1], [clinical feature 2], and [clinical feature 3], such as [differential dx1], [differential dx2], and [differential dx3].

OR

[Disease name] must be differentiated from [differential dx1], [differential dx2], and [differential dx3].

OR

As [disease name] manifests in a variety of clinical forms, differentiation must be established in accordance with the particular subtype. [Subtype name 1] must be differentiated from other diseases that cause [clinical feature 1], such as [differential dx1] and [differential dx2]. In contrast, [subtype name 2] must be differentiated from other diseases that cause [clinical feature 2], such as [differential dx3] and [differential dx4].

Differentiating [disease name] from other diseases on the basis of [symptom 1], [symptom 2], and [symptom 3]

On the basis [symptom 1], [symptom 2], and [symptom 3], [disease name] must be differentiated from [disease 1], [disease 2], [disease 3], [disease 4], [disease 5], and [disease 6].

Diseases		Type	Color	Texture	Size	Distribution	Dermoscopic Findings	Histopathology	Additional findings
Diseases		Skin examination					Diagnosis		Additional findings
Dermatofibroma		Nodule	Hyperpigmented	Firm	0.3- 1 cm	Mostly seen in extremities	Localized nodular proliferation of spindle-shaped fibrous cells in a mixture of histocytoid cells inside the dermis Spiculated margin of cells “Storiform” pattern Collagen bundles "Grenz zone" Epidermal hyperplasia
Dermatofibrosarcoma Protuberum
Kaposi sarcoma
Cutaneous squamous cell carcinoma^[3]	SCC in situ (Bowen's disease)	Patch Plaque	Erythematous Skin colored	Scaly	Variable	Fair-skinned individuals: sun-exposed areas In black individuals: legs, anus, and areas of chronic inflammation	Presence of dotted and/or glomerular vessels White to yellowish surface scales Red-yellowish background	Keratinocytic dysplasia of the epidermis No infiltration into dermis Pleomorphic keratinocytes Hyperchromatic nuclei	Slow growth over the years
Cutaneous squamous cell carcinoma^[3]	Invasive squamous cell carcinoma	Papule Plaque Nodule	Skin colored	Indurated + hyperkeratotic (well differentiated) Soft + ulceration (poorly differentiated)	0.5 to 1.5 cm	Fair-skinned individuals: sun-exposed areas In black individuals: legs, anus, and areas of chronic inflammation	White circles White structureless areas Masses of keratin Hairpin and linear-irregular vessels	Keratinocytic dysplasia of the epidermis No infiltration into dermis Pleomorphic keratinocytes Hyperchromatic nuclei	May be painful or pruritic
Keratoacanthoma^[4]		Macule Papule May have telangiectasias	Skin-colored Mildly erythematous	Prominent keratinous core in the center of the nodule	1 to 2.5 cm	Sun-exposed areas Face, neck, hands, and arms	White circles Keratin Blood spots White structureless zones	Well-differentiated squamous epithelium Central keratin core Epidermal hyperplasia + large eosinophilic keratinocytes Dermal inflammatory infiltrate	Rapid growth (within weeks)
Merkel cell carcinoma^[5]		Intracutaneous nodule	Shiny Flesh-colored or bluish-red	Firm	< 1 cm	Sun-exposed areas Head and neck Upper limbs and shoulder Lower limbs and hip Trunk	Milky red areas Linear Irregular vessels Polymorphous vessels	Uniform cells with large basophilic nuclei Single-cell necrosis Frequent mitoses Lymphovascular invasion Perineural invasion Epidermal involvement via pagetoid spread	Older individuals with light skin tones Rapidly growing
Basal cell carcinoma^[6]	Nodular basal cell carcinoma	Papule	Flesh-colored	Small bump	Variable	Face	Focused, bright red, and branching arborizing vessels Loosely arranged blue-gray dots	Nest-like infiltration with basaloid cells	May have a "rolled" border
	Superficial basal cell carcinoma	Patch	Erythematous	Scaly	1 to > 10 cm	Sun-exposed areas Head (cheek and nose) Trunk	Superficial fine telangiectasia Shiny white to red, translucent or opaque structureless areas Multiple small erosions	Large, hyperchromatic, oval nuclei Minimal cytoplasm Small basaloid nodules	Higher incidence in men
	Sclerosing basal cell carcinoma (morpheaform)^[7]	Papule Plaque	Flesh-colored Slightly erythematous	Firm Indurated Indistinct borders	Variable	Sun-exposed areas	Whitish backround Few fine arborizing vessels Multiple brown dots Ulceration	Thin columns + small nodules Highly collagenized stroma	Expression of smooth muscle protein alpha-actin in tumor stroma
Prurigo nodules^[8]^[9]		Dome-shaped nodule	Flesh-colored Erythematous Brown/black	Firm	Few millimeters to several centimeters	Extensor surfaces of the arms and legs and on the trunk Upper back, abdomen, and sacrum	White "starburst pattern" surrounding red/brown/yellow crusts Erosions Hyperkeratosis	Thick and compact orthohyperkeratosis Irregular epidermal hyperplasia Focal parakeratosis with irregular acanthosis Nonspecific dermal infiltrate containing WBCs	Nodules range in number from few to hundreds Worsened by heat, sweating, or irritation from clothing
Melanoma^[10]	Melanoma in situ (Lentigo Maligna)^[11]	Macule	Variable (from light to dark brown, black, pink, red, or white)	Smooth	Around 1 cm	Sun-damaged skin of the head or neck	Asymmetric, pigmented follicular openings Gray angulated lines Gray areas, dots, and globules Circle within a circle	↑ atypical spindle shaped melanocytes Arranged in single cells or in small nests along the dermal-epidermal junction	Darkening of pigmentation, sharpening of borders, or emergence of nodular areas are signs of progression to lentigo maligna melanoma
	Lentigo maligna melanoma^[12]	Macule	Brown/tan	Freckle-like	Variable	Chronically sun-damaged areas	Asymmetric, pigmented follicular openings Gray angulated lines Gray areas, dots, and globules Circle within a circle	"Star-burst giant cells" in epidermis "Swallow's nest" sign along the dermal-epidermal junction Minimal cytoplasm Pale nucleus with small nucleoli	Usually in older individuals
	Superficial spreading melanoma^[13]	Macule Plaque with irregular borders	Variably pigmented (red, blue, black, gray, and white)	Thin	1 mm to > 1 cm	Anywhere but usually: Back (men and women) Lower extremities (women)	Asymmetry of shape > 2 colors Asymmetry of structures	Asymmetric Poorly circumscribed Lack cellular maturation	Lateral (radial) growth before vertical (invasive) growth
	Nodular melanoma^[14]^[15]	Polypoid nodule	Dark color	Lump	6mm to > 1 cm	Trunk Head Neck	Pigment network or pseudonetwork Aggregated brown or black globules Blue pigmentation within lesion Small dotted or comma vessels	Cells proliferate downwards through the skin Dermal growth in isolation or in association with an epidermal component	Two-thirds arise in normal skin, the rest in existing moles Rapidly enlarging
	Acral lentiginous melanoma^[16]	Macule Patch	Dark brown to black	Raised areas Ulceration Bleeding	Variable	Palmar Plantar Subungual Mucosal surfaces	Parallel-ridge pattern Irregular diffuse pigmentation	Asymmetric proliferation of single melanocytes at dermoepidermal junction	Most common among dark skinned individuals
	Amelanotic melanoma^[17]	Patch	Skin color	Slightly elevated borders	Around 6 mm	Sun-exposed areas	No melanin pigmentation Dotted vessels Linear irregular vessels		Lesions not pigmented since they don't produce melanin
Common nevus^[18]^[19]		Dome-shaped nodules	Hypopigmented	Smooth surface Terminal hairs often present	1 cm to > 20 cm	Sun-exposed areas above the waist	Comma-shaped or curved vessels Structureless light brown background Residual brown thick circles around the hair follicles	Multinucleated melanocytes Melanocytes diffusely infiltrate dermis	Also called Miescher nevus
Blue nevus^[20]		Macule Papule	Blue	Smooth	Variable	Head and neck, Dorsal aspect of the distal extremities Sacral area	Structureless blue pigmentation Structureless blue and white or blue and brown on some occasions	Proliferation of dendritic, dermal, melanin-producing melanocytes	Also called Mongolian spots
Spitz nevus^[21]^[22]	Nonpigmented Spitz nevus	Nodule	Pink	Smooth	< 1 cm	Cheek	Coiled vessels White network over a pink to reddish background		In children and adolescents
Spitz nevus^[21]^[22]	Reed-like Spitz^[23]	Papule	Heavily pigmented	Smooth	< 1 cm	Head and neck Upper and lower extremities	Structureless black to gray center Hypopigmented follicular openings Peripheral streaks Pseudopods Globules	Enlarged spindle melanocytes with polyangular form "Ground glass" cytoplasm	Most commonly develops in children, adolescents, and young adults.
Solar lentigo^[24]		Multiple spots	Brown	Smooth	Around 5mm	Sun-exposed areas	Faint pigmented fingerprint structures Structureless pattern Light brown pseudonetwork with well-defined borders and a "moth-eaten" edge	↑ melanin deposition in keratinocytes ↑ linear arrangement of melanocytes at the dermal-epidermal junction	Associated with UV exposure and skin aging
Sebaceous hyperplasia^[25]		Papule	Skin-colored to brownish	Umbilicated	2 - 6 mm	Forehead Nose Cheeks	Structureless yellow to whitish center surrounded by short linear "crown vessels"		Usually in middle-aged or older patients
Lichen planus-like keratosis^[26]		Papule Plaque	Gray to brown	Prominent	Variable	Upper trunk	Shows a coarse or fine, gray to blue, granular pigmentation Diffuse brownish gray granules	Hypergranulosis Epidermal hyperplasia Superficial bandlike infiltrate Melanophages	Appearance depends on stage of evolution

References

↑ Hanly AJ, Jordà M, Elgart GW, Badiavas E, Nassiri M, Nadji M (2006). "High proliferative activity excludes dermatofibroma: report of the utility of MIB-1 in the differential diagnosis of selected fibrohistiocytic tumors". Arch. Pathol. Lab. Med. 130 (6): 831–4. doi:10.1043/1543-2165(2006)130[831:HPAEDR]2.0.CO;2. PMID 16740036. Unknown parameter |month= ignored (help)
↑ Kim HJ, Lee JY, Kim SH; et al. (2007). "Stromelysin-3 expression in the differential diagnosis of dermatofibroma and dermatofibrosarcoma protuberans: comparison with factor XIIIa and CD34". Br. J. Dermatol. 157 (2): 319–24. doi:10.1111/j.1365-2133.2007.08033.x. PMID 17596171. Unknown parameter |month= ignored (help)
↑ Petter G, Haustein UF (2000). "Histologic subtyping and malignancy assessment of cutaneous squamous cell carcinoma". Dermatol Surg. 26 (6): 521–30. PMID 10848931.
↑ Kwiek B, Schwartz RA (2016). "Keratoacanthoma (KA): An update and review". J Am Acad Dermatol. 74 (6): 1220–33. doi:10.1016/j.jaad.2015.11.033. PMID 26853179.
↑ Albores-Saavedra J, Batich K, Chable-Montero F, Sagy N, Schwartz AM, Henson DE (2010). "Merkel cell carcinoma demographics, morphology, and survival based on 3870 cases: a population based study". J Cutan Pathol. 37 (1): 20–7. doi:10.1111/j.1600-0560.2009.01370.x. PMID 19638070.
↑ Wolberink EA, Pasch MC, Zeiler M, van Erp PE, Gerritsen MJ (2013). "High discordance between punch biopsy and excision in establishing basal cell carcinoma subtype: analysis of 500 cases". J Eur Acad Dermatol Venereol. 27 (8): 985–9. doi:10.1111/j.1468-3083.2012.04628.x. PMID 22759209.
↑ Wrone DA, Swetter SM, Egbert BM, Smoller BR, Khavari PA (1996). "Increased proportion of aggressive-growth basal cell carcinoma in the Veterans Affairs population of Palo Alto, California". J Am Acad Dermatol. 35 (6): 907–10. PMID 8959949.
↑ Errichetti E, Piccirillo A, Stinco G (2015). "Dermoscopy of prurigo nodularis". J Dermatol. 42 (6): 632–4. doi:10.1111/1346-8138.12844. PMID 25808786.
↑ Weigelt N, Metze D, Ständer S (2010). "Prurigo nodularis: systematic analysis of 58 histological criteria in 136 patients". J Cutan Pathol. 37 (5): 578–86. doi:10.1111/j.1600-0560.2009.01484.x. PMID 20002240.
↑ Witt C, Krengel S (2010). "Clinical and epidemiological aspects of subtypes of melanocytic nevi (Flat nevi, Miescher nevi, Unna nevi)". Dermatol Online J. 16 (1): 1. PMID 20137743.
↑ Connolly KL, Giordano C, Dusza S, Busam KJ, Nehal K (2019). "Follicular involvement is frequent in lentigo maligna: Implications for treatment". J Am Acad Dermatol. 80 (2): 532–537. doi:10.1016/j.jaad.2018.07.071. PMC 6333487. PMID 30266559.
↑ Connolly KL, Giordano C, Dusza S, Busam KJ, Nehal K (2019). "Follicular involvement is frequent in lentigo maligna: Implications for treatment". J Am Acad Dermatol. 80 (2): 532–537. doi:10.1016/j.jaad.2018.07.071. PMC 6333487. PMID 30266559.
↑ Argenziano G, Ferrara G, Francione S, Di Nola K, Martino A, Zalaudek I (2009). "Dermoscopy--the ultimate tool for melanoma diagnosis". Semin Cutan Med Surg. 28 (3): 142–8. doi:10.1016/j.sder.2009.06.001. PMID 19782937.
↑ Argenziano G, Soyer HP, Chimenti S, Talamini R, Corona R, Sera F; et al. (2003). "Dermoscopy of pigmented skin lesions: results of a consensus meeting via the Internet". J Am Acad Dermatol. 48 (5): 679–93. doi:10.1067/mjd.2003.281. PMID 12734496.
↑ Menzies, Scott W.; Moloney, Fergal J.; Byth, Karen; Avramidis, Michelle; Argenziano, Giuseppe; Zalaudek, Iris; Braun, Ralph P.; Malvehy, Josep; Puig, Susana; Rabinovitz, Harold S.; Oliviero, Margaret; Cabo, Horacio; Bono, Riccardo; Pizzichetta, Maria A.; Claeson, Magdalena; Gaffney, Daniel C.; Soyer, H. Peter; Stanganelli, Ignazio; Scolyer, Richard A.; Guitera, Pascale; Kelly, John; McCurdy, Olivia; Llambrich, Alex; Marghoob, Ashfaq A.; Zaballos, Pedro; Kirchesch, Herbert M.; Piccolo, Domenico; Bowling, Jonathan; Thomas, Luc; Terstappen, Karin; Tanaka, Masaru; Pellacani, Giovanni; Pagnanelli, Gianluca; Ghigliotti, Giovanni; Ortega, Blanca Carlos; Crafter, Greg; Ortiz, Ana María Perusquía; Tromme, Isabelle; Karaarslan, Isil Kilinc; Ozdemir, Fezal; Tam, Anthony; Landi, Christian; Norton, Peter; Kaçar, Nida; Rudnicka, Lidia; Slowinska, Monika; Simionescu, Olga; Di Stefani, Alessandro; Coates, Elliot; Kreusch, Juergen (2013). "Dermoscopic Evaluation of Nodular Melanoma". JAMA Dermatology. 149 (6): 699. doi:10.1001/jamadermatol.2013.2466. ISSN 2168-6068.
↑ Phan A, Dalle S, Touzet S, Ronger-Savlé S, Balme B, Thomas L (2010). "Dermoscopic features of acral lentiginous melanoma in a large series of 110 cases in a white population". Br J Dermatol. 162 (4): 765–71. doi:10.1111/j.1365-2133.2009.09594.x. PMID 19922528.
↑ Steglich RB, Meotti CD, Ferreira MS, Lovatto L, de Carvalho AV, de Castro CG (2012). "Dermoscopic clues in the diagnosis of amelanotic and hypomelanotic malignant melanoma". An Bras Dermatol. 87 (6): 920–3. PMC 3699915. PMID 23197217.
↑ Witt C, Krengel S (2010). "Clinical and epidemiological aspects of subtypes of melanocytic nevi (Flat nevi, Miescher nevi, Unna nevi)". Dermatol Online J. 16 (1): 1. PMID 20137743.
↑ Bauer J, Garbe C (2003). "Acquired melanocytic nevi as risk factor for melanoma development. A comprehensive review of epidemiological data". Pigment Cell Res. 16 (3): 297–306. PMID 12753404.
↑ Granter SR, McKee PH, Calonje E, Mihm MC, Busam K (2001). "Melanoma associated with blue nevus and melanoma mimicking cellular blue nevus: a clinicopathologic study of 10 cases on the spectrum of so-called 'malignant blue nevus'". Am J Surg Pathol. 25 (3): 316–23. PMID 11224601.
↑ Luo S, Sepehr A, Tsao H (2011). "Spitz nevi and other Spitzoid lesions part I. Background and diagnoses". J Am Acad Dermatol. 65 (6): 1073–84. doi:10.1016/j.jaad.2011.04.040. PMC 3217183. PMID 22082838.
↑ Argenziano G, Agozzino M, Bonifazi E, Broganelli P, Brunetti B, Ferrara G; et al. (2011). "Natural evolution of Spitz nevi". Dermatology. 222 (3): 256–60. doi:10.1159/000326109. PMID 21494025.
↑ Pedrosa AF, Lopes JM, Azevedo F, Mota A (2016). "Spitz/Reed nevi: a review of clinical-dermatoscopic and histological correlation". Dermatol Pract Concept. 6 (2): 37–41. doi:10.5826/dpc.0602a07. PMC 4866625. PMID 27222770.
↑ Tanaka M, Sawada M, Kobayashi K (2011). "Key points in dermoscopic differentiation between lentigo maligna and solar lentigo". J Dermatol. 38 (1): 53–8. doi:10.1111/j.1346-8138.2010.01132.x. PMID 21175756.
↑ Sato T, Tanaka M (2014). "Linear sebaceous hyperplasia on the chest". Dermatol Pract Concept. 4 (1): 93–5. doi:10.5826/dpc.0401a16. PMC 3919849. PMID 24520522.
↑ Morgan MB, Stevens GL, Switlyk S (2005). "Benign lichenoid keratosis: a clinical and pathologic reappraisal of 1040 cases". Am J Dermatopathol. 27 (5): 387–92. PMID 16148406.

References

[1] Hanly AJ, Jordà M, Elgart GW, Badiavas E, Nassiri M, Nadji M (2006). "High proliferative activity excludes dermatofibroma: report of the utility of MIB-1 in the differential diagnosis of selected fibrohistiocytic tumors". Arch. Pathol. Lab. Med. 130 (6): 831–4. doi:10.1043/1543-2165(2006)130[831:HPAEDR]2.0.CO;2. PMID 16740036. Unknown parameter |month= ignored (help)

[2] Kim HJ, Lee JY, Kim SH; et al. (2007). "Stromelysin-3 expression in the differential diagnosis of dermatofibroma and dermatofibrosarcoma protuberans: comparison with factor XIIIa and CD34". Br. J. Dermatol. 157 (2): 319–24. doi:10.1111/j.1365-2133.2007.08033.x. PMID 17596171. Unknown parameter |month= ignored (help)

[pmid10848931-3] Petter G, Haustein UF (2000). "Histologic subtyping and malignancy assessment of cutaneous squamous cell carcinoma". Dermatol Surg. 26 (6): 521–30. PMID 10848931.

[pmid26853179-4] Kwiek B, Schwartz RA (2016). "Keratoacanthoma (KA): An update and review". J Am Acad Dermatol. 74 (6): 1220–33. doi:10.1016/j.jaad.2015.11.033. PMID 26853179.

[pmid19638070-5] Albores-Saavedra J, Batich K, Chable-Montero F, Sagy N, Schwartz AM, Henson DE (2010). "Merkel cell carcinoma demographics, morphology, and survival based on 3870 cases: a population based study". J Cutan Pathol. 37 (1): 20–7. doi:10.1111/j.1600-0560.2009.01370.x. PMID 19638070.

[pmid22759209-6] Wolberink EA, Pasch MC, Zeiler M, van Erp PE, Gerritsen MJ (2013). "High discordance between punch biopsy and excision in establishing basal cell carcinoma subtype: analysis of 500 cases". J Eur Acad Dermatol Venereol. 27 (8): 985–9. doi:10.1111/j.1468-3083.2012.04628.x. PMID 22759209.

[pmid8959949-7] Wrone DA, Swetter SM, Egbert BM, Smoller BR, Khavari PA (1996). "Increased proportion of aggressive-growth basal cell carcinoma in the Veterans Affairs population of Palo Alto, California". J Am Acad Dermatol. 35 (6): 907–10. PMID 8959949.

[pmid25808786-8] Errichetti E, Piccirillo A, Stinco G (2015). "Dermoscopy of prurigo nodularis". J Dermatol. 42 (6): 632–4. doi:10.1111/1346-8138.12844. PMID 25808786.

[pmid20002240-9] Weigelt N, Metze D, Ständer S (2010). "Prurigo nodularis: systematic analysis of 58 histological criteria in 136 patients". J Cutan Pathol. 37 (5): 578–86. doi:10.1111/j.1600-0560.2009.01484.x. PMID 20002240.

[pmid201377432-10] Witt C, Krengel S (2010). "Clinical and epidemiological aspects of subtypes of melanocytic nevi (Flat nevi, Miescher nevi, Unna nevi)". Dermatol Online J. 16 (1): 1. PMID 20137743.

[pmid30266559-11] Connolly KL, Giordano C, Dusza S, Busam KJ, Nehal K (2019). "Follicular involvement is frequent in lentigo maligna: Implications for treatment". J Am Acad Dermatol. 80 (2): 532–537. doi:10.1016/j.jaad.2018.07.071. PMC 6333487. PMID 30266559.

[pmid302665592-12] Connolly KL, Giordano C, Dusza S, Busam KJ, Nehal K (2019). "Follicular involvement is frequent in lentigo maligna: Implications for treatment". J Am Acad Dermatol. 80 (2): 532–537. doi:10.1016/j.jaad.2018.07.071. PMC 6333487. PMID 30266559.

[pmid19782937-13] Argenziano G, Ferrara G, Francione S, Di Nola K, Martino A, Zalaudek I (2009). "Dermoscopy--the ultimate tool for melanoma diagnosis". Semin Cutan Med Surg. 28 (3): 142–8. doi:10.1016/j.sder.2009.06.001. PMID 19782937.

[pmid12734496-14] Argenziano G, Soyer HP, Chimenti S, Talamini R, Corona R, Sera F; et al. (2003). "Dermoscopy of pigmented skin lesions: results of a consensus meeting via the Internet". J Am Acad Dermatol. 48 (5): 679–93. doi:10.1067/mjd.2003.281. PMID 12734496.

[MenziesMoloney2013-15] Menzies, Scott W.; Moloney, Fergal J.; Byth, Karen; Avramidis, Michelle; Argenziano, Giuseppe; Zalaudek, Iris; Braun, Ralph P.; Malvehy, Josep; Puig, Susana; Rabinovitz, Harold S.; Oliviero, Margaret; Cabo, Horacio; Bono, Riccardo; Pizzichetta, Maria A.; Claeson, Magdalena; Gaffney, Daniel C.; Soyer, H. Peter; Stanganelli, Ignazio; Scolyer, Richard A.; Guitera, Pascale; Kelly, John; McCurdy, Olivia; Llambrich, Alex; Marghoob, Ashfaq A.; Zaballos, Pedro; Kirchesch, Herbert M.; Piccolo, Domenico; Bowling, Jonathan; Thomas, Luc; Terstappen, Karin; Tanaka, Masaru; Pellacani, Giovanni; Pagnanelli, Gianluca; Ghigliotti, Giovanni; Ortega, Blanca Carlos; Crafter, Greg; Ortiz, Ana María Perusquía; Tromme, Isabelle; Karaarslan, Isil Kilinc; Ozdemir, Fezal; Tam, Anthony; Landi, Christian; Norton, Peter; Kaçar, Nida; Rudnicka, Lidia; Slowinska, Monika; Simionescu, Olga; Di Stefani, Alessandro; Coates, Elliot; Kreusch, Juergen (2013). "Dermoscopic Evaluation of Nodular Melanoma". JAMA Dermatology. 149 (6): 699. doi:10.1001/jamadermatol.2013.2466. ISSN 2168-6068.

[pmid19922528-16] Phan A, Dalle S, Touzet S, Ronger-Savlé S, Balme B, Thomas L (2010). "Dermoscopic features of acral lentiginous melanoma in a large series of 110 cases in a white population". Br J Dermatol. 162 (4): 765–71. doi:10.1111/j.1365-2133.2009.09594.x. PMID 19922528.

[pmid23197217-17] Steglich RB, Meotti CD, Ferreira MS, Lovatto L, de Carvalho AV, de Castro CG (2012). "Dermoscopic clues in the diagnosis of amelanotic and hypomelanotic malignant melanoma". An Bras Dermatol. 87 (6): 920–3. PMC 3699915. PMID 23197217.

[pmid20137743-18] Witt C, Krengel S (2010). "Clinical and epidemiological aspects of subtypes of melanocytic nevi (Flat nevi, Miescher nevi, Unna nevi)". Dermatol Online J. 16 (1): 1. PMID 20137743.

[pmid12753404-19] Bauer J, Garbe C (2003). "Acquired melanocytic nevi as risk factor for melanoma development. A comprehensive review of epidemiological data". Pigment Cell Res. 16 (3): 297–306. PMID 12753404.

[pmid11224601-20] Granter SR, McKee PH, Calonje E, Mihm MC, Busam K (2001). "Melanoma associated with blue nevus and melanoma mimicking cellular blue nevus: a clinicopathologic study of 10 cases on the spectrum of so-called 'malignant blue nevus'". Am J Surg Pathol. 25 (3): 316–23. PMID 11224601.

[pmid22082838-21] Luo S, Sepehr A, Tsao H (2011). "Spitz nevi and other Spitzoid lesions part I. Background and diagnoses". J Am Acad Dermatol. 65 (6): 1073–84. doi:10.1016/j.jaad.2011.04.040. PMC 3217183. PMID 22082838.

[pmid21494025-22] Argenziano G, Agozzino M, Bonifazi E, Broganelli P, Brunetti B, Ferrara G; et al. (2011). "Natural evolution of Spitz nevi". Dermatology. 222 (3): 256–60. doi:10.1159/000326109. PMID 21494025.

[pmid27222770-23] Pedrosa AF, Lopes JM, Azevedo F, Mota A (2016). "Spitz/Reed nevi: a review of clinical-dermatoscopic and histological correlation". Dermatol Pract Concept. 6 (2): 37–41. doi:10.5826/dpc.0602a07. PMC 4866625. PMID 27222770.

[pmid21175756-24] Tanaka M, Sawada M, Kobayashi K (2011). "Key points in dermoscopic differentiation between lentigo maligna and solar lentigo". J Dermatol. 38 (1): 53–8. doi:10.1111/j.1346-8138.2010.01132.x. PMID 21175756.

[pmid24520522-25] Sato T, Tanaka M (2014). "Linear sebaceous hyperplasia on the chest". Dermatol Pract Concept. 4 (1): 93–5. doi:10.5826/dpc.0401a16. PMC 3919849. PMID 24520522.

[pmid16148406-26] Morgan MB, Stevens GL, Switlyk S (2005). "Benign lichenoid keratosis: a clinical and pathologic reappraisal of 1040 cases". Am J Dermatopathol. 27 (5): 387–92. PMID 16148406.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

[18]

[19]

[20]

[21]

[22]

[23]

[24]

[25]

[26]

@@ Line 64: / Line 64: @@
 ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Histopathology
 |-
-! colspan="2" |Dermatofibroma
+| colspan="2" style="background: #C0C0C0; padding: 5px; text-align: center;" |'''Dermatofibroma'''
-!Nodule
+| style="background: #F5F5F5; padding: 5px;" |
-!Hyperpigmented
+* Nodule
-!Firm
+| style="background: #F5F5F5; padding: 5px;" |
-!0.3- 1 cm
+*Hyperpigmented
-!Mostly seen in extremities
+| style="background: #F5F5F5; padding: 5px;" |
-!
+*Firm
-!
+| style="background: #F5F5F5; padding: 5px;" |
+*0.3- 1 cm
+| style="background: #F5F5F5; padding: 5px;" |
+*Mostly seen in extremities
+| style="background: #F5F5F5; padding: 5px;" |
 * Localized [[nodular]] [[proliferation]] of [[spindle]]-shaped [[fibrous]] [[Cells (biology)|cells]] in a [[mixture]] of [[Histiocyte|histocytoid]] [[Cells (biology)|cells]] inside the [[dermis]]
 * Spiculated margin of cells
@@ Line 78: / Line 82: @@
 * "Grenz zone"
 * [[Epidermal]] [[hyperplasia]]
+| style="background: #F5F5F5; padding: 5px;" |
 !
 |-
-! colspan="2" |Dermatofibrosarcoma Protuberum<br />
+| colspan="2" style="background: #C0C0C0; padding: 5px; text-align: center;" |'''Dermatofibrosarcoma Protuberum'''<br />
 !
 !
@@ Line 90: / Line 95: @@
 !
 |-
-! colspan="2" |[[Kaposi sarcoma]]
+| colspan="2" style="background: #C0C0C0; padding: 5px; text-align: center;" |'''[[Kaposi sarcoma]]'''
 !
 !

Dermatofibroma differential diagnosis: Difference between revisions

Revision as of 21:42, 22 August 2019

Overview

Differential Diagnosis

Immunohistochemical Staining

Overview

Differentiating [Disease name] from other Diseases

Differentiating [disease name] from other diseases on the basis of [symptom 1], [symptom 2], and [symptom 3]

References

References

Navigation menu