Chlorhexidine gluconate

Revision as of 14:58, 29 December 2012 by C Michael Gibson (talk | contribs)
Jump to navigation Jump to search
Chlorhexidine gluconate
Clinical data
ATC code
Pharmacokinetic data
Protein binding87%
Identifiers
CAS Number
PubChem CID
DrugBank
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
FormulaC22H30Cl2N10
Molar mass505.446 g/mol

WikiDoc Resources for Chlorhexidine gluconate

Articles

Most recent articles on Chlorhexidine gluconate

Most cited articles on Chlorhexidine gluconate

Review articles on Chlorhexidine gluconate

Articles on Chlorhexidine gluconate in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Chlorhexidine gluconate

Images of Chlorhexidine gluconate

Photos of Chlorhexidine gluconate

Podcasts & MP3s on Chlorhexidine gluconate

Videos on Chlorhexidine gluconate

Evidence Based Medicine

Cochrane Collaboration on Chlorhexidine gluconate

Bandolier on Chlorhexidine gluconate

TRIP on Chlorhexidine gluconate

Clinical Trials

Ongoing Trials on Chlorhexidine gluconate at Clinical Trials.gov

Trial results on Chlorhexidine gluconate

Clinical Trials on Chlorhexidine gluconate at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Chlorhexidine gluconate

NICE Guidance on Chlorhexidine gluconate

NHS PRODIGY Guidance

FDA on Chlorhexidine gluconate

CDC on Chlorhexidine gluconate

Books

Books on Chlorhexidine gluconate

News

Chlorhexidine gluconate in the news

Be alerted to news on Chlorhexidine gluconate

News trends on Chlorhexidine gluconate

Commentary

Blogs on Chlorhexidine gluconate

Definitions

Definitions of Chlorhexidine gluconate

Patient Resources / Community

Patient resources on Chlorhexidine gluconate

Discussion groups on Chlorhexidine gluconate

Patient Handouts on Chlorhexidine gluconate

Directions to Hospitals Treating Chlorhexidine gluconate

Risk calculators and risk factors for Chlorhexidine gluconate

Healthcare Provider Resources

Symptoms of Chlorhexidine gluconate

Causes & Risk Factors for Chlorhexidine gluconate

Diagnostic studies for Chlorhexidine gluconate

Treatment of Chlorhexidine gluconate

Continuing Medical Education (CME)

CME Programs on Chlorhexidine gluconate

International

Chlorhexidine gluconate en Espanol

Chlorhexidine gluconate en Francais

Business

Chlorhexidine gluconate in the Marketplace

Patents on Chlorhexidine gluconate

Experimental / Informatics

List of terms related to Chlorhexidine gluconate

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


Chlorhexidine gluconate is a chemical antiseptic, to combat both Gram-positive and Gram-negative microbes. It is both bacteriostatic and bactericidal.

The mechanism of action is believed to be membrane disruption, and not ATPase inactivation as previously thought.

Products containing chlorhexidine gluconate in high concentrations must be kept away from eyes (corneal ulcers) and the inner ear (deafness), although it is used in minute concentrations in some contact lens solutions.

Availability

It is sometimes marketed under the brand names Peridex, Periochip, Periogard Oral Rinse. In the UK it is sometimes marketed under the brand names Corsodyl or Chlorohex, in Germany as Chlorhexamed, and in Australia as Savacol.

In some countries it is available by prescription only.

Dental applications

It is often used as an active ingredient in mouthwash designed to kill dental plaque and other oral bacteria. Chlorhexidine gluconate can thus be used to improve bad breath.

Chlorhexidine Gluconate-based products are usually utilized to combat or prevent gum diseases such as gingivitis. According to Colgate [2], chlorhexidine gluconate has not been proven to reduce subgingivial calculus and in some studies actually increased deposits.

Deactivation

Chlorhexidine is deactivated by anionic compounds, including the anionic surfactants commonly used as detergents in toothpastes and mouthwashes. For this reason, chlorhexidine mouth rinses should be used at least 30 minutes after other dental products.[1] For best effectiveness, food, drink, smoking, and mouth rinses should be avoided for at least one hour after use.

Non-dental applications

Chlorhexidine Gluconate is also used in non-dental applications, most notably under the brand names Oronine, Avagard, Hibiclens, Hibiscrub, ChloraPrep, BIOPATCH, and Exidine. It is also a component of the famous household antiseptic Savlon. It is used for general skin cleansing, a surgical scrub and a pre-operative skin preparation. Due to other chemicals listed as inactive ingredients, the cleanser solution is not suitable for use as mouthwash. It is often used as a rubbing agent prior to the use of hypodermic or intravenous needles in place of iodine.

References

  1. Denton W , Chlorhexidine In: Sterilisation and Preservation 5th Edition, Block SS, eds. Lippincott Williams & Williams, Philadelphia, 2001; 321-36.

External links

Template:Periodontology

Template:Antiseptics and disinfectants Template:Medicated dressings Template:Throat preparations Template:Otologicals
da:Klorhexidin de:Chlorhexidin it:Clorexidina hu:Klórhexidin nl:Chloorhexidinedigluconaat

Template:WS Template:Jb1