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{{PBB_Controls
{{Infobox_gene}}
| update_page = yes
'''Carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)''' ('''CEACAM1''') also known as '''CD66a''' ('''C'''luster of '''D'''ifferentiation '''66a'''), is a human glycoprotein, and a member of the [[carcinoembryonic antigen]] (CEA) [[gene]] family.<ref name="entrez"/>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_CEACAM1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2gk2.
| PDB = {{PDB2|2gk2}}
| Name = Carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
| HGNCid = 1814
| Symbol = CEACAM1
| AltSymbols =; BGP; BGP1; BGPI; CD66a
| OMIM = 109770
| ECnumber = 
| Homologene = 86044
| MGIid = 1347245
| GeneAtlas_image1 = PBB_GE_CEACAM1_206576_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_CEACAM1_209498_at_tn.png
| GeneAtlas_image3 = PBB_GE_CEACAM1_211883_x_at_tn.png
| Function = {{GNF_GO|id=GO:0003674 |text = molecular_function}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0001525 |text = angiogenesis}} {{GNF_GO|id=GO:0007156 |text = homophilic cell adhesion}} {{GNF_GO|id=GO:0007229 |text = integrin-mediated signaling pathway}} {{GNF_GO|id=GO:0007565 |text = female pregnancy}} {{GNF_GO|id=GO:0008150 |text = biological_process}} {{GNF_GO|id=GO:0016477 |text = cell migration}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 634
    | Hs_Ensembl = ENSG00000079385
    | Hs_RefseqProtein = NP_001020083
    | Hs_RefseqmRNA = NM_001024912
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 47703298
    | Hs_GenLoc_end = 47724479
    | Hs_Uniprot = P13688
    | Mm_EntrezGene = 26365
    | Mm_Ensembl = ENSMUSG00000074272
    | Mm_RefseqmRNA = XM_989614
    | Mm_RefseqProtein = XP_994708
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 24990200
    | Mm_GenLoc_end = 25186385
    | Mm_Uniprot = Q3LFS7
  }}
}}
'''Carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)''' ('''CEACAM1''') also known as '''CD66a''' ('''C'''luster of '''D'''ifferentiation '''66a'''), is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=634| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell–cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of only two has been determined.<ref name="entrez">{{cite web | title = Entrez Gene: CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=634| accessdate = }}</ref>
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of only two has been determined.<ref name="entrez">{{cite web | title = Entrez Gene: CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=634| accessdate = }}</ref>
}}


==See also==
In melanocytic cells CEACAM1 gene expression may be regulated by [[Microphthalmia-associated transcription factor|MITF]].<ref name="pmid19067971">{{cite journal | vauthors = Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E | title = Novel MITF targets identified using a two-step DNA microarray strategy | journal = Pigment Cell & Melanoma Research | volume = 21 | issue = 6 | pages = 665–76 | date = December 2008 | pmid = 19067971 | doi = 10.1111/j.1755-148X.2008.00505.x }}</ref>
 
== Interactions ==
 
CEACAM1 has been shown to [[Protein-protein interaction|interact]] with [[PTPN11]]<ref name=pmid9867848>{{cite journal | vauthors = Huber M, Izzi L, Grondin P, Houde C, Kunath T, Veillette A, Beauchemin N | title = The carboxyl-terminal region of biliary glycoprotein controls its tyrosine phosphorylation and association with protein-tyrosine phosphatases SHP-1 and SHP-2 in epithelial cells | journal = The Journal of Biological Chemistry | volume = 274 | issue = 1 | pages = 335–44 | date = January 1999 | pmid = 9867848 | doi = 10.1074/jbc.274.1.335 }}</ref> and [[Annexin A2]].<ref name=pmid14522961>{{cite journal | vauthors = Kirshner J, Schumann D, Shively JE | title = CEACAM1, a cell-cell adhesion molecule, directly associates with annexin II in a three-dimensional model of mammary morphogenesis | journal = The Journal of Biological Chemistry | volume = 278 | issue = 50 | pages = 50338–45 | date = December 2003 | pmid = 14522961 | doi = 10.1074/jbc.M309115200 }}</ref>
 
== See also ==
* [[Carcinoembryonic antigen]]
* [[Carcinoembryonic antigen]]
* [[Cluster of differentiation]]
* [[Cluster of differentiation]]


==References==
== References ==
{{reflist|2}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Gray-Owen SD, Blumberg RS | title = CEACAM1: contact-dependent control of immunity | journal = Nature Reviews. Immunology | volume = 6 | issue = 6 | pages = 433–46 | date = June 2006 | pmid = 16724098 | doi = 10.1038/nri1864 }}
| citations =
* {{cite journal | vauthors = Svenberg T, Hammarström S, Zeromski J | title = Immunofluorescence studies on the occurrence and localization of the CEA-related biliary glycoprotein I (BGP I) in normal human gastrointestinal tissues | journal = Clinical and Experimental Immunology | volume = 36 | issue = 3 | pages = 436–41 | date = June 1979 | pmid = 385181 | pmc = 1537745 | doi =  }}
*{{cite journal | author=Gray-Owen SD, Blumberg RS |title=CEACAM1: contact-dependent control of immunity. |journal=Nat. Rev. Immunol. |volume=6 |issue= 6 |pages= 433-46 |year= 2006 |pmid= 16724098 |doi= 10.1038/nri1864 }}
* {{cite journal | vauthors = Thompson J, Zimmermann W, Osthus-Bugat P, Schleussner C, Eades-Perner AM, Barnert S, Von Kleist S, Willcocks T, Craig I, Tynan K | title = Long-range chromosomal mapping of the carcinoembryonic antigen (CEA) gene family cluster | journal = Genomics | volume = 12 | issue = 4 | pages = 761–72 | date = April 1992 | pmid = 1572649 | doi = 10.1016/0888-7543(92)90307-E }}
*{{cite journal | author=Svenberg T, Hammarström S, Zeromski J |title=Immunofluorescence studies on the occurrence and localization of the CEA-related biliary glycoprotein I (BGP I) in normal human gastrointestinal tissues. |journal=Clin. Exp. Immunol. |volume=36 |issue= 3 |pages= 436-41 |year= 1979 |pmid= 385181 |doi=  }}
* {{cite journal | vauthors = Kuroki M, Arakawa F, Matsuo Y, Oikawa S, Nakazato H, Matsuoka Y | title = Three novel molecular forms of biliary glycoprotein deduced from cDNA clones from a human leukocyte library | journal = Biochemical and Biophysical Research Communications | volume = 176 | issue = 2 | pages = 578–85 | date = April 1991 | pmid = 2025273 | doi = 10.1016/S0006-291X(05)80223-2 }}
*{{cite journal | author=Thompson J, Zimmermann W, Osthus-Bugat P, ''et al.'' |title=Long-range chromosomal mapping of the carcinoembryonic antigen (CEA) gene family cluster. |journal=Genomics |volume=12 |issue= 4 |pages= 761-72 |year= 1992 |pmid= 1572649 |doi= }}
* {{cite journal | vauthors = Hinoda Y, Neumaier M, Hefta SA, Drzeniek Z, Wagener C, Shively L, Hefta LJ, Shively JE, Paxton RJ | title = Molecular cloning of a cDNA coding biliary glycoprotein I: primary structure of a glycoprotein immunologically crossreactive with carcinoembryonic antigen | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 85 | issue = 18 | pages = 6959–63 | date = September 1988 | pmid = 2457922 | pmc = 282098 | doi = 10.1073/pnas.85.18.6959 }}
*{{cite journal | author=Kuroki M, Arakawa F, Matsuo Y, ''et al.'' |title=Three novel molecular forms of biliary glycoprotein deduced from cDNA clones from a human leukocyte library. |journal=Biochem. Biophys. Res. Commun. |volume=176 |issue= 2 |pages= 578-85 |year= 1991 |pmid= 2025273 |doi= }}
* {{cite journal | vauthors = Barnett TR, Kretschmer A, Austen DA, Goebel SJ, Hart JT, Elting JJ, Kamarck ME | title = Carcinoembryonic antigens: alternative splicing accounts for the multiple mRNAs that code for novel members of the carcinoembryonic antigen family | journal = The Journal of Cell Biology | volume = 108 | issue = 2 | pages = 267–76 | date = February 1989 | pmid = 2537311 | pmc = 2115422 | doi = 10.1083/jcb.108.2.267 }}
*{{cite journal | author=Hinoda Y, Neumaier M, Hefta SA, ''et al.'' |title=Molecular cloning of a cDNA coding biliary glycoprotein I: primary structure of a glycoprotein immunologically crossreactive with carcinoembryonic antigen. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=85 |issue= 18 |pages= 6959-63 |year= 1988 |pmid= 2457922 |doi= }}
* {{cite journal | vauthors = Neumaier M, Paululat S, Chan A, Matthaes P, Wagener C | title = Biliary glycoprotein, a potential human cell adhesion molecule, is down-regulated in colorectal carcinomas | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 90 | issue = 22 | pages = 10744–8 | date = November 1993 | pmid = 7504281 | pmc = 47854 | doi = 10.1073/pnas.90.22.10744 }}
*{{cite journal | author=Barnett TR, Kretschmer A, Austen DA, ''et al.'' |title=Carcinoembryonic antigens: alternative splicing accounts for the multiple mRNAs that code for novel members of the carcinoembryonic antigen family. |journal=J. Cell Biol. |volume=108 |issue= 2 |pages= 267-76 |year= 1989 |pmid= 2537311 |doi= }}
* {{cite journal | vauthors = Formisano P, Najjar SM, Gross CN, Philippe N, Oriente F, Kern-Buell CL, Accili D, Gorden P | title = Receptor-mediated internalization of insulin. Potential role of pp120/HA4, a substrate of the insulin receptor kinase | journal = The Journal of Biological Chemistry | volume = 270 | issue = 41 | pages = 24073–7 | date = October 1995 | pmid = 7592607 | doi = 10.1074/jbc.270.26.15844 }}
*{{cite journal | author=Neumaier M, Paululat S, Chan A, ''et al.'' |title=Biliary glycoprotein, a potential human cell adhesion molecule, is down-regulated in colorectal carcinomas. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 22 |pages= 10744-8 |year= 1993 |pmid= 7504281 |doi= }}
* {{cite journal | vauthors = Frängsmyr L, Baranov V, Prall F, Yeung MM, Wagener C, Hammarström S | title = Cell- and region-specific expression of biliary glycoprotein and its messenger RNA in normal human colonic mucosa | journal = Cancer Research | volume = 55 | issue = 14 | pages = 2963–7 | date = July 1995 | pmid = 7606710 | doi =  }}
*{{cite journal | author=Formisano P, Najjar SM, Gross CN, ''et al.'' |title=Receptor-mediated internalization of insulin. Potential role of pp120/HA4, a substrate of the insulin receptor kinase. |journal=J. Biol. Chem. |volume=270 |issue= 41 |pages= 24073-7 |year= 1995 |pmid= 7592607 |doi= }}
* {{cite journal | vauthors = Najjar SM, Philippe N, Suzuki Y, Ignacio GA, Formisano P, Accili D, Taylor SI | title = Insulin-stimulated phosphorylation of recombinant pp120/HA4, an endogenous substrate of the insulin receptor tyrosine kinase | journal = Biochemistry | volume = 34 | issue = 29 | pages = 9341–9 | date = July 1995 | pmid = 7626603 | doi = 10.1021/bi00029a009 }}
*{{cite journal | author=Frängsmyr L, Baranov V, Prall F, ''et al.'' |title=Cell- and region-specific expression of biliary glycoprotein and its messenger RNA in normal human colonic mucosa. |journal=Cancer Res. |volume=55 |issue= 14 |pages= 2963-7 |year= 1995 |pmid= 7606710 |doi=  }}
* {{cite journal | vauthors = Nédellec P, Turbide C, Beauchemin N | title = Characterization and transcriptional activity of the mouse biliary glycoprotein 1 gene, a carcinoembryonic antigen-related gene | journal = European Journal of Biochemistry / FEBS | volume = 231 | issue = 1 | pages = 104–14 | date = July 1995 | pmid = 7628460 | doi = 10.1111/j.1432-1033.1995.tb20676.x }}
*{{cite journal | author=Najjar SM, Philippe N, Suzuki Y, ''et al.'' |title=Insulin-stimulated phosphorylation of recombinant pp120/HA4, an endogenous substrate of the insulin receptor tyrosine kinase. |journal=Biochemistry |volume=34 |issue= 29 |pages= 9341-9 |year= 1995 |pmid= 7626603 |doi= }}
* {{cite journal | vauthors = Watt SM, Fawcett J, Murdoch SJ, Teixeira AM, Gschmeissner SE, Hajibagheri NM, Simmons DL | title = CD66 identifies the biliary glycoprotein (BGP) adhesion molecule: cloning, expression, and adhesion functions of the BGPc splice variant | journal = Blood | volume = 84 | issue = 1 | pages = 200–10 | date = July 1994 | pmid = 8018919 | doi =  }}
*{{cite journal | author=Nédellec P, Turbide C, Beauchemin N |title=Characterization and transcriptional activity of the mouse biliary glycoprotein 1 gene, a carcinoembryonic antigen-related gene. |journal=Eur. J. Biochem. |volume=231 |issue= 1 |pages= 104-14 |year= 1995 |pmid= 7628460 |doi= }}
* {{cite journal | vauthors = Hauck W, Nédellec P, Turbide C, Stanners CP, Barnett TR, Beauchemin N | title = Transcriptional control of the human biliary glycoprotein gene, a CEA gene family member down-regulated in colorectal carcinomas | journal = European Journal of Biochemistry / FEBS | volume = 223 | issue = 2 | pages = 529–41 | date = July 1994 | pmid = 8055923 | doi = 10.1111/j.1432-1033.1994.tb19022.x }}
*{{cite journal | author=Watt SM, Fawcett J, Murdoch SJ, ''et al.'' |title=CD66 identifies the biliary glycoprotein (BGP) adhesion molecule: cloning, expression, and adhesion functions of the BGPc splice variant. |journal=Blood |volume=84 |issue= 1 |pages= 200-10 |year= 1994 |pmid= 8018919 |doi=  }}
* {{cite journal | vauthors = Barnett TR, Drake L, Pickle W | title = Human biliary glycoprotein gene: characterization of a family of novel alternatively spliced RNAs and their expressed proteins | journal = Molecular and Cellular Biology | volume = 13 | issue = 2 | pages = 1273–82 | date = February 1993 | pmid = 8423792 | pmc = 359012 | doi =  10.1128/mcb.13.2.1273}}
*{{cite journal | author=Hauck W, Nédellec P, Turbide C, ''et al.'' |title=Transcriptional control of the human biliary glycoprotein gene, a CEA gene family member down-regulated in colorectal carcinomas. |journal=Eur. J. Biochem. |volume=223 |issue= 2 |pages= 529-41 |year= 1994 |pmid= 8055923 |doi= }}
* {{cite journal | vauthors = Kuroki M, Yamanaka T, Matsuo Y, Oikawa S, Nakazato H, Matsuoka Y | title = Immunochemical analysis of carcinoembryonic antigen (CEA)-related antigens differentially localized in intracellular granules of human neutrophils | journal = Immunological Investigations | volume = 24 | issue = 5 | pages = 829–43 | date = August 1995 | pmid = 8543346 | doi = 10.3109/08820139509060710 }}
*{{cite journal | author=Barnett TR, Drake L, Pickle W |title=Human biliary glycoprotein gene: characterization of a family of novel alternatively spliced RNAs and their expressed proteins. |journal=Mol. Cell. Biol. |volume=13 |issue= 2 |pages= 1273-82 |year= 1993 |pmid= 8423792 |doi=  }}
* {{cite journal | vauthors = Huber M, Izzi L, Grondin P, Houde C, Kunath T, Veillette A, Beauchemin N | title = The carboxyl-terminal region of biliary glycoprotein controls its tyrosine phosphorylation and association with protein-tyrosine phosphatases SHP-1 and SHP-2 in epithelial cells | journal = The Journal of Biological Chemistry | volume = 274 | issue = 1 | pages = 335–44 | date = January 1999 | pmid = 9867848 | doi = 10.1074/jbc.274.1.335 }}
*{{cite journal | author=Kuroki M, Yamanaka T, Matsuo Y, ''et al.'' |title=Immunochemical analysis of carcinoembryonic antigen (CEA)-related antigens differentially localized in intracellular granules of human neutrophils. |journal=Immunol. Invest. |volume=24 |issue= 5 |pages= 829-43 |year= 1996 |pmid= 8543346 |doi= }}
* {{cite journal | vauthors = Feuk-Lagerstedt E, Jordan ET, Leffler H, Dahlgren C, Karlsson A | title = Identification of CD66a and CD66b as the major galectin-3 receptor candidates in human neutrophils | journal = Journal of Immunology | volume = 163 | issue = 10 | pages = 5592–8 | date = November 1999 | pmid = 10553088 | doi =  }}
*{{cite journal | author=Huber M, Izzi L, Grondin P, ''et al.'' |title=The carboxyl-terminal region of biliary glycoprotein controls its tyrosine phosphorylation and association with protein-tyrosine phosphatases SHP-1 and SHP-2 in epithelial cells. |journal=J. Biol. Chem. |volume=274 |issue= 1 |pages= 335-44 |year= 1999 |pmid= 9867848 |doi= }}
* {{cite journal | vauthors = Soni P, Lakkis M, Poy MN, Fernström MA, Najjar SM | title = The differential effects of pp120 (Ceacam 1) on the mitogenic action of insulin and insulin-like growth factor 1 are regulated by the nonconserved tyrosine 1316 in the insulin receptor | journal = Molecular and Cellular Biology | volume = 20 | issue = 11 | pages = 3896–905 | date = June 2000 | pmid = 10805733 | pmc = 85733 | doi = 10.1128/MCB.20.11.3896-3905.2000 }}
*{{cite journal | author=Feuk-Lagerstedt E, Jordan ET, Leffler H, ''et al.'' |title=Identification of CD66a and CD66b as the major galectin-3 receptor candidates in human neutrophils. |journal=J. Immunol. |volume=163 |issue= 10 |pages= 5592-8 |year= 1999 |pmid= 10553088 |doi=  }}
* {{cite journal | vauthors = Ergün S, Kilik N, Ziegeler G, Hansen A, Nollau P, Götze J, Wurmbach JH, Horst A, Weil J, Fernando M, Wagener C | title = CEA-related cell adhesion molecule 1: a potent angiogenic factor and a major effector of vascular endothelial growth factor | journal = Molecular Cell | volume = 5 | issue = 2 | pages = 311–20 | date = February 2000 | pmid = 10882072 | doi = 10.1016/S1097-2765(00)80426-8 }}
*{{cite journal | author=Soni P, Lakkis M, Poy MN, ''et al.'' |title=The differential effects of pp120 (Ceacam 1) on the mitogenic action of insulin and insulin-like growth factor 1 are regulated by the nonconserved tyrosine 1316 in the insulin receptor. |journal=Mol. Cell. Biol. |volume=20 |issue= 11 |pages= 3896-905 |year= 2000 |pmid= 10805733 |doi= }}
* {{cite journal | vauthors = Wang L, Lin SH, Wu WG, Kemp BL, Walsh GL, Hong WK, Mao L | title = C-CAM1, a candidate tumor suppressor gene, is abnormally expressed in primary lung cancers | journal = Clinical Cancer Research | volume = 6 | issue = 8 | pages = 2988–93 | date = August 2000 | pmid = 10955775 | doi =  }}
*{{cite journal | author=Ergün S, Kilik N, Ziegeler G, ''et al.'' |title=CEA-related cell adhesion molecule 1: a potent angiogenic factor and a major effector of vascular endothelial growth factor. |journal=Mol. Cell |volume=5 |issue= 2 |pages= 311-20 |year= 2000 |pmid= 10882072 |doi= }}
*{{cite journal  | author=Wang L, Lin SH, Wu WG, ''et al.'' |title=C-CAM1, a candidate tumor suppressor gene, is abnormally expressed in primary lung cancers. |journal=Clin. Cancer Res. |volume=6 |issue= 8 |pages= 2988-93 |year= 2000 |pmid= 10955775 |doi=  }}
}}
{{refend}}
{{refend}}


==External links==
== External links ==
* {{MeshName|CEACAM1+protein,+human}}
* {{MeshName|CEACAM1+protein,+human}}
* {{UCSC gene info|CEACAM1}}


{{membrane-protein-stub}}
{{NLM content}}
{{NLM content}}
{{PDB Gallery|geneid=634}}
{{Clusters of differentiation}}
{{Clusters of differentiation}}
{{DEFAULTSORT:Ceacam1}}
[[Category:Clusters of differentiation]]
[[Category:Clusters of differentiation]]
{{WikiDoc Sources}}

Latest revision as of 20:57, 5 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

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Ensembl

n/a

n/a

UniProt

n/a

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) (CEACAM1) also known as CD66a (Cluster of Differentiation 66a), is a human glycoprotein, and a member of the carcinoembryonic antigen (CEA) gene family.[1]

Function

This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell–cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of only two has been determined.[1]

In melanocytic cells CEACAM1 gene expression may be regulated by MITF.[2]

Interactions

CEACAM1 has been shown to interact with PTPN11[3] and Annexin A2.[4]

See also

References

  1. ↑ 1.0 1.1 "Entrez Gene: CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)".
  2. ↑ Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (December 2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell & Melanoma Research. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.
  3. ↑ Huber M, Izzi L, Grondin P, Houde C, Kunath T, Veillette A, Beauchemin N (January 1999). "The carboxyl-terminal region of biliary glycoprotein controls its tyrosine phosphorylation and association with protein-tyrosine phosphatases SHP-1 and SHP-2 in epithelial cells". The Journal of Biological Chemistry. 274 (1): 335–44. doi:10.1074/jbc.274.1.335. PMID 9867848.
  4. ↑ Kirshner J, Schumann D, Shively JE (December 2003). "CEACAM1, a cell-cell adhesion molecule, directly associates with annexin II in a three-dimensional model of mammary morphogenesis". The Journal of Biological Chemistry. 278 (50): 50338–45. doi:10.1074/jbc.M309115200. PMID 14522961.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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