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{{Infobox_gene}}
{{PBB_Controls
'''M-phase inducer phosphatase 3''' is an [[enzyme]] that in humans is encoded by the ''CDC25C'' [[gene]].<ref name="pmid1703321">{{cite journal | vauthors = Gould KL, Moreno S, Tonks NK, Nurse P | title = Complementation of the mitotic activator, p80cdc25, by a human protein-tyrosine phosphatase | journal = Science | volume = 250 | issue = 4987 | pages = 1573–6 |date=Feb 1991 | pmid = 1703321 | pmc =  | doi =10.1126/science.1703321 | bibcode =1990Sci...250.1573G }}</ref>
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{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = Cell division cycle 25 homolog C (S. pombe)
| HGNCid = 1727
| Symbol = CDC25C
| AltSymbols =; CDC25
| OMIM = 157680
| ECnumber = 
| Homologene = 1356
| MGIid = 88350
| GeneAtlas_image1 = PBB_GE_CDC25C_205167_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_CDC25C_217010_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004725 |text = protein tyrosine phosphatase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
  | Process = {{GNF_GO|id=GO:0000079 |text = regulation of cyclin-dependent protein kinase activity}} {{GNF_GO|id=GO:0000087 |text = M phase of mitotic cell cycle}} {{GNF_GO|id=GO:0006470 |text = protein amino acid dephosphorylation}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007088 |text = regulation of mitosis}} {{GNF_GO|id=GO:0007089 |text = traversing start control point of mitotic cell cycle}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0051301 |text = cell division}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 995
    | Hs_Ensembl = ENSG00000158402
    | Hs_RefseqProtein = NP_001781
    | Hs_RefseqmRNA = NM_001790
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 5
    | Hs_GenLoc_start = 137649168
    | Hs_GenLoc_end = 137701943
    | Hs_Uniprot = P30307
    | Mm_EntrezGene = 12532
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = NM_009860
    | Mm_RefseqProtein = NP_033990
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Cell division cycle 25 homolog C (S. pombe)''', also known as '''CDC25C''', is a human [[gene]].


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene is highly conserved during evolution and it plays a key role in the regulation of cell division. The encoded protein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It is also thought to suppress p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described, however, the full-length nature of many of them is not known.<ref name="entrez">{{cite web | title = Entrez Gene: CDC25C cell division cycle 25 homolog C (S. pombe)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=995| accessdate = }}</ref>
| summary_text = This gene is highly conserved during evolution and it plays a key role in the regulation of cell division. The encoded protein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin B-bound CDC2 (CDK1) and triggers entry into mitosis. It is also thought to suppress p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described, however, the full-length nature of many of them is not known.<ref name="entrez">{{cite web | title = Entrez Gene: CDC25C cell division cycle 25 homolog C (S. pombe)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=995| accessdate = }}</ref>
}}
}}
==Interactions==
CDC25C has been shown to [[Protein-protein interaction|interact]] with [[MAPK14]],<ref name=pmid11333986>{{cite journal |last=Bulavin |first=D V |author2=Higashimoto Y|author3=Popoff I J|author4=Gaarde W A|author5=Basrur V|author6=Potapova O|author7=Appella E|author8=Fornace A J |date=May 2001 |title=Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase |journal=[[Nature (journal)|Nature]] |volume=411 |issue=6833 |pages=102–7 |publisher= |location = England| issn = 0028-0836| pmid = 11333986 |doi = 10.1038/35075107 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[CHEK1]],<ref name=pmid9278511>{{cite journal |last=Sanchez |first=Y |author2=Wong C|author3=Thoma R S|author4=Richman R|author5=Wu Z|author6=Piwnica-Worms H|author7=Elledge S J |date=Sep 1997 |title=Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25 |journal=[[Science (journal)|Science]] |volume=277 |issue=5331 |pages=1497–501 |publisher= |location = UNITED STATES| issn = 0036-8075| pmid = 9278511 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = | doi = 10.1126/science.277.5331.1497 }}</ref> [[PCNA]],<ref name=pmid11896603>{{cite journal |last=Kawabe |first=Takumi |author2=Suganuma Masashi |author3=Ando Tomoaki |author4=Kimura Mayumi |author5=Hori Haruna |author6=Okamoto Takashi  |date=Mar 2002 |title=Cdc25C interacts with PCNA at G2/M transition |journal=Oncogene |volume=21 |issue=11 |pages=1717–26 |publisher= |location = England| issn = 0950-9232| pmid = 11896603 |doi = 10.1038/sj.onc.1205229 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[PIN1]],<ref name=pmid9499405>{{cite journal |last=Shen |first=M |author2=Stukenberg P T|author3=Kirschner M W|author4=Lu K P |date=Mar 1998 |title=The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins |journal=Genes Dev. |volume=12 |issue=5 |pages=706–20 |publisher= |location = UNITED STATES| issn = 0890-9369| pmid = 9499405 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = | doi = 10.1101/gad.12.5.706 | pmc = 316589 }}</ref><ref name=pmid11604498>{{cite journal |last=Goldstrohm |first=A C |author2=Albrecht T R|author3=Suñé C|author4=Bedford M T|author5=Garcia-Blanco M A |date=Nov 2001 |title=The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1 |journal=Mol. Cell. Biol. |volume=21 |issue=22 |pages=7617–28 |publisher= |location = United States| issn = 0270-7306| pmid = 11604498 |doi = 10.1128/MCB.21.22.7617-7628.2001 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = | pmc = 99933 }}</ref><ref name=pmid10037602>{{cite journal |last=Lu |first=P J |author2=Zhou X Z|author3=Shen M|author4=Lu K P |date=Feb 1999 |title=Function of WW domains as phosphoserine- or phosphothreonine-binding modules |journal=[[Science (journal)|Science]] |volume=283 |issue=5406 |pages=1325–8 |publisher= |location = UNITED STATES| issn = 0036-8075| pmid = 10037602 | bibcode =1999Sci...283.1325L | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = | doi = 10.1126/science.283.5406.1325 }}</ref> [[PLK3]]<ref name=pmid10557092>{{cite journal |last=Ouyang |first=B |author2=Li W|author3=Pan H|author4=Meadows J|author5=Hoffmann I|author6=Dai W |date=Oct 1999 |title=The physical association and phosphorylation of Cdc25C protein phosphatase by Prk |journal=Oncogene |volume=18 |issue=44 |pages=6029–36 |publisher= |location = ENGLAND| issn = 0950-9232| pmid = 10557092 |doi = 10.1038/sj.onc.1202983 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> and [[NEDD4]].<ref name=pmid10037602/>


==See also==
==See also==
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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|CDC25C}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Draetta G, Eckstein J |title=Cdc25 protein phosphatases in cell proliferation. |journal=Biochim. Biophys. Acta |volume=1332 |issue= 2 |pages= M53-63 |year= 1997 |pmid= 9141461 |doi=  }}
*{{cite journal  | vauthors=Draetta G, Eckstein J |title=Cdc25 protein phosphatases in cell proliferation. |journal=Biochim. Biophys. Acta |volume=1332 |issue= 2 |pages= M53–63 |year= 1997 |pmid= 9141461 |doi=  10.1016/S0304-419X(96)00049-2}}
*{{cite journal  | author=Nilsson I, Hoffmann I |title=Cell cycle regulation by the Cdc25 phosphatase family. |journal=Progress in cell cycle research |volume=4 |issue=  |pages= 107-14 |year= 2000 |pmid= 10740819 |doi=  }}
*{{cite journal  | vauthors=Nilsson I, Hoffmann I |title=Cell cycle regulation by the Cdc25 phosphatase family. |journal=Progress in cell cycle research |volume=4 |issue=  |pages= 107–14 |year= 2000 |pmid= 10740819 |doi=  10.1007/978-1-4615-4253-7_10}}
*{{cite journal  | author=Amini S, Khalili K, Sawaya BE |title=Effect of HIV-1 Vpr on cell cycle regulators. |journal=DNA Cell Biol. |volume=23 |issue= 4 |pages= 249-60 |year= 2004 |pmid= 15142382 |doi= 10.1089/104454904773819833 }}
*{{cite journal  | vauthors=Amini S, Khalili K, Sawaya BE |title=Effect of HIV-1 Vpr on cell cycle regulators. |journal=DNA Cell Biol. |volume=23 |issue= 4 |pages= 249–60 |year= 2004 |pmid= 15142382 |doi= 10.1089/104454904773819833 }}
*{{cite journal  | author=Kino T, Chrousos GP |title=Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome? |journal=Ann. N. Y. Acad. Sci. |volume=1024 |issue=  |pages= 153-67 |year= 2004 |pmid= 15265780 |doi= 10.1196/annals.1321.013 }}
*{{cite journal  | vauthors=Kino T, Chrousos GP |title=Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome? |journal=Ann. N. Y. Acad. Sci. |volume=1024 |issue=  |pages= 153–67 |year= 2004 |pmid= 15265780 |doi= 10.1196/annals.1321.013 |bibcode=2004NYASA1024..153K }}
*{{cite journal  | author=Andersen JL, Planelles V |title=The role of Vpr in HIV-1 pathogenesis. |journal=Curr. HIV Res. |volume=3 |issue= 1 |pages= 43-51 |year= 2005 |pmid= 15638722 |doi=  }}
*{{cite journal  | vauthors=Andersen JL, Planelles V |title=The role of Vpr in HIV-1 pathogenesis. |journal=Curr. HIV Res. |volume=3 |issue= 1 |pages= 43–51 |year= 2005 |pmid= 15638722 |doi=10.2174/1570162052772988 }}
*{{cite journal  | author=Sartor H, Ehlert F, Grzeschik KH, ''et al.'' |title=Assignment of two human cell cycle genes, CDC25C and CCNB1, to 5q31 and 5q12, respectively. |journal=Genomics |volume=13 |issue= 3 |pages= 911-2 |year= 1992 |pmid= 1386342 |doi=  }}
*{{cite journal  | author=Sartor H |title=Assignment of two human cell cycle genes, CDC25C and CCNB1, to 5q31 and 5q12, respectively |journal=Genomics |volume=13 |issue= 3 |pages= 911–2 |year= 1992 |pmid= 1386342 |doi=10.1016/0888-7543(92)90190-4 |name-list-format=vanc| author2=Ehlert F  | author3=Grzeschik KH  | display-authors=3  | last4=Mu¨Ller  | first4=Rolf  | last5=Adolph  | first5=Sabine  }}
*{{cite journal  | author=Gould KL, Moreno S, Tonks NK, Nurse P |title=Complementation of the mitotic activator, p80cdc25, by a human protein-tyrosine phosphatase. |journal=Science |volume=250 |issue= 4987 |pages= 1573-6 |year= 1991 |pmid= 1703321 |doi=  }}
*{{cite journal  | author=Strausfeld U |title=Dephosphorylation and activation of a p34cdc2/cyclin B complex in vitro by human CDC25 protein |journal=Nature |volume=351 |issue= 6323 |pages= 242–5 |year= 1991 |pmid= 1828290 |doi= 10.1038/351242a0  |name-list-format=vanc| author2=Labbé JC  | author3=Fesquet D | display-authors=3  | last4=Cavadore  | first4=J. C.  | last5=Picard  | first5=A.  | last6=Sadhu  | first6=K.  | last7=Russell | first7=P.  | last8=Dorée  | first8=M. |bibcode=1991Natur.351..242S}}
*{{cite journal  | author=Strausfeld U, Labbé JC, Fesquet D, ''et al.'' |title=Dephosphorylation and activation of a p34cdc2/cyclin B complex in vitro by human CDC25 protein. |journal=Nature |volume=351 |issue= 6323 |pages= 242-5 |year= 1991 |pmid= 1828290 |doi= 10.1038/351242a0 }}
*{{cite journal  | vauthors=Galaktionov K, Beach D |title=Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple roles of mitotic cyclins |journal=Cell |volume=67 |issue= 6 |pages= 1181–94 |year= 1992 |pmid= 1836978 |doi=10.1016/0092-8674(91)90294-9 }}
*{{cite journal | author=Galaktionov K, Beach D |title=Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple roles of mitotic cyclins. |journal=Cell |volume=67 |issue= 6 |pages= 1181-94 |year= 1992 |pmid= 1836978 |doi=  }}
*{{cite journal  | vauthors=Sadhu K, Reed SI, Richardson H, Russell P |title=Human homolog of fission yeast cdc25 mitotic inducer is predominantly expressed in G2 |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 13 |pages= 5139–43 |year= 1990 |pmid= 2195549 |doi=10.1073/pnas.87.13.5139  | pmc=54277 |bibcode=1990PNAS...87.5139S }}
*{{cite journal  | author=Sadhu K, Reed SI, Richardson H, Russell P |title=Human homolog of fission yeast cdc25 mitotic inducer is predominantly expressed in G2. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 13 |pages= 5139-43 |year= 1990 |pmid= 2195549 |doi=  }}
*{{cite journal  | vauthors=Re F, Braaten D, Franke EK, Luban J |title=Human immunodeficiency virus type 1 Vpr arrests the cell cycle in G2 by inhibiting the activation of p34cdc2-cyclin B |journal=J. Virol. |volume=69 |issue= 11 |pages= 6859–64 |year= 1995 |pmid= 7474100 |doi= | pmc=189600 }}
*{{cite journal  | author=Re F, Braaten D, Franke EK, Luban J |title=Human immunodeficiency virus type 1 Vpr arrests the cell cycle in G2 by inhibiting the activation of p34cdc2-cyclin B. |journal=J. Virol. |volume=69 |issue= 11 |pages= 6859-64 |year= 1995 |pmid= 7474100 |doi=  }}
*{{cite journal  | author=Zwicker J |title=Cell cycle regulation of cdc25C transcription is mediated by the periodic repression of the glutamine-rich activators NF-Y and Sp1 |journal=Nucleic Acids Res. |volume=23 |issue= 19 |pages= 3822–30 |year= 1995 |pmid= 7479023 |doi=10.1093/nar/23.19.3822  | pmc=307297 |name-list-format=vanc| author2=Gross C  | author3=Lucibello FC  | display-authors=3  | last4=Truss  | first4=Mathias  | last5=Ehiert  | first5=Frauke  | last6=Engeland  | first6=Kurt  | last7=Müller  | first7=Rolf }}
*{{cite journal  | author=Zwicker J, Gross C, Lucibello FC, ''et al.'' |title=Cell cycle regulation of cdc25C transcription is mediated by the periodic repression of the glutamine-rich activators NF-Y and Sp1. |journal=Nucleic Acids Res. |volume=23 |issue= 19 |pages= 3822-30 |year= 1995 |pmid= 7479023 |doi=  }}
*{{cite journal  | author=Di Marzio P |title=Mutational analysis of cell cycle arrest, nuclear localization and virion packaging of human immunodeficiency virus type 1 Vpr |journal=J. Virol. |volume=69 |issue= 12 |pages= 7909–16 |year= 1996 |pmid= 7494303 |doi=  | pmc=189735 |name-list-format=vanc| author2=Choe S  | author3=Ebright M  | display-authors=3  | last4=Knoblauch  | first4=R  | last5=Landau  | first5=NR  }}
*{{cite journal  | author=Di Marzio P, Choe S, Ebright M, ''et al.'' |title=Mutational analysis of cell cycle arrest, nuclear localization and virion packaging of human immunodeficiency virus type 1 Vpr. |journal=J. Virol. |volume=69 |issue= 12 |pages= 7909-16 |year= 1996 |pmid= 7494303 |doi= }}
*{{cite journal  | author=Strausfeld U |title=Activation of p34cdc2 protein kinase by microinjection of human cdc25C into mammalian cells. Requirement for prior phosphorylation of cdc25C by p34cdc2 on sites phosphorylated at mitosis |journal=J. Biol. Chem. |volume=269 |issue= 8 |pages= 5989–6000 |year= 1994 |pmid= 8119945 |doi= |name-list-format=vanc| author2=Fernandez A  | author3=Capony JP  | display-authors=3  | last4=Girard | first4=F  | last5=Lautredou | first5=N  | last6=Derancourt  | first6=J | last7=Labbe  | first7=JC  | last8=Lamb  | first8=NJ }}
*{{cite journal | author=Strausfeld U, Fernandez A, Capony JP, ''et al.'' |title=Activation of p34cdc2 protein kinase by microinjection of human cdc25C into mammalian cells. Requirement for prior phosphorylation of cdc25C by p34cdc2 on sites phosphorylated at mitosis. |journal=J. Biol. Chem. |volume=269 |issue= 8 |pages= 5989-6000 |year= 1994 |pmid= 8119945 |doi=  }}
*{{cite journal  | vauthors=Zheng XF, Ruderman JV |title=Functional analysis of the P box, a domain in cyclin B required for the activation of Cdc25 |journal=Cell |volume=75 |issue= 1 |pages= 155–64 |year= 1993 |pmid= 8402895 |doi= 10.1016/S0092-8674(05)80092-3 }}
*{{cite journal  | author=Zheng XF, Ruderman JV |title=Functional analysis of the P box, a domain in cyclin B required for the activation of Cdc25. |journal=Cell |volume=75 |issue= 1 |pages= 155-64 |year= 1993 |pmid= 8402895 |doi=  }}
*{{cite journal  | vauthors=Taviaux SA, Demaille JG |title=Localization of human cell cycle regulatory genes CDC25C to 5q31 and WEE1 to 11p15.3-11p15.1 by fluorescence in situ hybridization |journal=Genomics |volume=15 |issue= 1 |pages= 194–6 |year= 1993 |pmid= 8432534 |doi= 10.1006/geno.1993.1032 }}
*{{cite journal | author=Taviaux SA, Demaille JG |title=Localization of human cell cycle regulatory genes CDC25C to 5q31 and WEE1 to 11p15.3-11p15.1 by fluorescence in situ hybridization. |journal=Genomics |volume=15 |issue= 1 |pages= 194-6 |year= 1993 |pmid= 8432534 |doi= 10.1006/geno.1993.1032 }}
*{{cite journal  | author=Honda R |title=Dephosphorylation of human p34cdc2 kinase on both Thr-14 and Tyr-15 by human cdc25B phosphatase |journal=FEBS Lett. |volume=318 |issue= 3 |pages= 331–4 |year= 1993 |pmid= 8440392 |doi=10.1016/0014-5793(93)80540-B  |name-list-format=vanc| author2=Ohba Y  | author3=Nagata A  | display-authors=3  | last4=Okayama  | first4=H  | last5=Yasuda  | first5=H  }}
*{{cite journal | author=Honda R, Ohba Y, Nagata A, ''et al.'' |title=Dephosphorylation of human p34cdc2 kinase on both Thr-14 and Tyr-15 by human cdc25B phosphatase. |journal=FEBS Lett. |volume=318 |issue= 3 |pages= 331-4 |year= 1993 |pmid= 8440392 |doi=  }}
*{{cite journal  | vauthors=Booher RN, Holman PS, Fattaey A |title=Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity |journal=J. Biol. Chem. |volume=272 |issue= 35 |pages= 22300–6 |year= 1997 |pmid= 9268380 |doi=10.1074/jbc.272.35.22300  }}
*{{cite journal | author=Booher RN, Holman PS, Fattaey A |title=Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity. |journal=J. Biol. Chem. |volume=272 |issue= 35 |pages= 22300-6 |year= 1997 |pmid= 9268380 |doi=  }}
*{{cite journal  | author=Sanchez Y |title=Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25 |journal=Science |volume=277 |issue= 5331 |pages= 1497–501 |year= 1997 |pmid= 9278511 |doi=10.1126/science.277.5331.1497  |name-list-format=vanc| author2=Wong C  | author3=Thoma RS  | display-authors=3  | last4=Richman  | first4=R  | last5=Wu  | first5=Z  | last6=Piwnica-Worms  | first6=H  | last7=Elledge  | first7=SJ }}
*{{cite journal  | author=Sanchez Y, Wong C, Thoma RS, ''et al.'' |title=Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25. |journal=Science |volume=277 |issue= 5331 |pages= 1497-501 |year= 1997 |pmid= 9278511 |doi=  }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{Protein tyrosine phosphatases}}
{{WikiDoc Sources}}
 
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Latest revision as of 01:07, 23 June 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Wikidata
View/Edit Human

M-phase inducer phosphatase 3 is an enzyme that in humans is encoded by the CDC25C gene.[1]

This gene is highly conserved during evolution and it plays a key role in the regulation of cell division. The encoded protein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin B-bound CDC2 (CDK1) and triggers entry into mitosis. It is also thought to suppress p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described, however, the full-length nature of many of them is not known.[2]

Interactions

CDC25C has been shown to interact with MAPK14,[3] CHEK1,[4] PCNA,[5] PIN1,[6][7][8] PLK3[9] and NEDD4.[8]

See also

References

  1. ↑ Gould KL, Moreno S, Tonks NK, Nurse P (Feb 1991). "Complementation of the mitotic activator, p80cdc25, by a human protein-tyrosine phosphatase". Science. 250 (4987): 1573–6. Bibcode:1990Sci...250.1573G. doi:10.1126/science.1703321. PMID 1703321.
  2. ↑ "Entrez Gene: CDC25C cell division cycle 25 homolog C (S. pombe)".
  3. ↑ Bulavin, D V; Higashimoto Y; Popoff I J; Gaarde W A; Basrur V; Potapova O; Appella E; Fornace A J (May 2001). "Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase". Nature. England. 411 (6833): 102–7. doi:10.1038/35075107. ISSN 0028-0836. PMID 11333986.
  4. ↑ Sanchez, Y; Wong C; Thoma R S; Richman R; Wu Z; Piwnica-Worms H; Elledge S J (Sep 1997). "Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25". Science. UNITED STATES. 277 (5331): 1497–501. doi:10.1126/science.277.5331.1497. ISSN 0036-8075. PMID 9278511.
  5. ↑ Kawabe, Takumi; Suganuma Masashi; Ando Tomoaki; Kimura Mayumi; Hori Haruna; Okamoto Takashi (Mar 2002). "Cdc25C interacts with PCNA at G2/M transition". Oncogene. England. 21 (11): 1717–26. doi:10.1038/sj.onc.1205229. ISSN 0950-9232. PMID 11896603.
  6. ↑ Shen, M; Stukenberg P T; Kirschner M W; Lu K P (Mar 1998). "The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins". Genes Dev. UNITED STATES. 12 (5): 706–20. doi:10.1101/gad.12.5.706. ISSN 0890-9369. PMC 316589. PMID 9499405.
  7. ↑ Goldstrohm, A C; Albrecht T R; Suñé C; Bedford M T; Garcia-Blanco M A (Nov 2001). "The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1". Mol. Cell. Biol. United States. 21 (22): 7617–28. doi:10.1128/MCB.21.22.7617-7628.2001. ISSN 0270-7306. PMC 99933. PMID 11604498.
  8. ↑ 8.0 8.1 Lu, P J; Zhou X Z; Shen M; Lu K P (Feb 1999). "Function of WW domains as phosphoserine- or phosphothreonine-binding modules". Science. UNITED STATES. 283 (5406): 1325–8. Bibcode:1999Sci...283.1325L. doi:10.1126/science.283.5406.1325. ISSN 0036-8075. PMID 10037602.
  9. ↑ Ouyang, B; Li W; Pan H; Meadows J; Hoffmann I; Dai W (Oct 1999). "The physical association and phosphorylation of Cdc25C protein phosphatase by Prk". Oncogene. ENGLAND. 18 (44): 6029–36. doi:10.1038/sj.onc.1202983. ISSN 0950-9232. PMID 10557092.

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Further reading


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