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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''CD276''' ('''C'''luster of '''D'''ifferentiation 276) is a human [[protein]] encoded by the {{gene|CD276}} [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CD276 CD276 molecule| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=80381| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = CD276 molecule
| HGNCid = 19137
| Symbol = CD276
| AltSymbols =; B7-H3; B7H3
| OMIM = 605715
| ECnumber = 
| Homologene = 11892
| MGIid = 2183926
| Function = {{GNF_GO|id=GO:0005102 |text = receptor binding}}
| Component = {{GNF_GO|id=GO:0009897 |text = external side of plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0030501 |text = positive regulation of bone mineralization}} {{GNF_GO|id=GO:0042102 |text = positive regulation of T cell proliferation}} {{GNF_GO|id=GO:0042130 |text = negative regulation of T cell proliferation}} {{GNF_GO|id=GO:0045077 |text = negative regulation of interferon-gamma biosynthetic process}} {{GNF_GO|id=GO:0045078 |text = positive regulation of interferon-gamma biosynthetic process}} {{GNF_GO|id=GO:0045085 |text = negative regulation of interleukin-2 biosynthetic process}} {{GNF_GO|id=GO:0045669 |text = positive regulation of osteoblast differentiation}} {{GNF_GO|id=GO:0050728 |text = negative regulation of inflammatory response}} {{GNF_GO|id=GO:0050776 |text = regulation of immune response}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 80381
    | Hs_Ensembl = ENSG00000103855
    | Hs_RefseqProtein = XP_001133846
    | Hs_RefseqmRNA = XM_001133846
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 15
    | Hs_GenLoc_start = 71763675
    | Hs_GenLoc_end = 71793903
    | Hs_Uniprot = Q5ZPR3
    | Mm_EntrezGene = 102657
    | Mm_Ensembl = ENSMUSG00000035914
    | Mm_RefseqmRNA = NM_133983
    | Mm_RefseqProtein = NP_598744
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 9
    | Mm_GenLoc_start = 58322260
    | Mm_GenLoc_end = 58338882
    | Mm_Uniprot = Q8VE98
  }}
}}
'''CD276''' ('''C'''luster of '''D'''ifferentiation 276) is a human [[protein]] encoded by the {{gene|CD276}} [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CD276 CD276 molecule| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=80381| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Costimulatory B7 molecules (e.g., B7-1, or CD80; MIM 112203) signal through CD28 (MIM 186760) family molecules such as CD28, CTLA4 (MIM 123890), and ICOS (MIM 604558).[supplied by OMIM]<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = Costimulatory B7 molecules (e.g., B7-1, or CD80; MIM 112203) signal through CD28 (MIM 186760) family molecules such as CD28, CTLA4 (MIM 123890), and ICOS (MIM 604558).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: CD276 CD276 molecule| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=80381| accessdate = }}</ref>
}}


==See also==
CD276 (aka B7-H3), an [[immune checkpoint]] molecule, is expressed by some solid tumours and is the target of anticancer candidates such as [[MGA271]].<ref>{{cite web|url=http://www.genengnews.com/gen-news-highlights/servier-pays-macrogenics-20m-for-option-to-anticancer-antibody/81246017/|title=Servier Pays MacroGenics $20M for Option to Anticancer Antibody - GEN|author=|date=|website=GEN}}</ref>
 
== See also ==
* [[Cluster of differentiation]]
* [[Cluster of differentiation]]


==References==
== References ==
{{reflist|2}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Chapoval AI, Ni J, Lau JS, Wilcox RA, Flies DB, Liu D, Dong H, Sica GL, Zhu G, Tamada K, Chen L | title = B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production | journal = Nature Immunology | volume = 2 | issue = 3 | pages = 269-74 | date = March 2001 | pmid = 11224528 | doi = 10.1038/85339 }}
| citations =
* {{cite journal | vauthors = Sun M, Richards S, Prasad DV, Mai XM, Rudensky A, Dong C | title = Characterization of mouse and human B7-H3 genes | journal = Journal of Immunology | volume = 168 | issue = 12 | pages = 6294-7 | date = June 2002 | pmid = 12055244 | doi = 10.4049/jimmunol.168.12.6294 }}
*{{cite journal | author=Chapoval AI, Ni J, Lau JS, ''et al.'' |title=B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production. |journal=Nat. Immunol. |volume=2 |issue= 3 |pages= 269-74 |year= 2001 |pmid= 11224528 |doi= 10.1038/85339 }}
* {{cite journal | vauthors = Ling V, Wu PW, Spaulding V, Kieleczawa J, Luxenberg D, Carreno BM, Collins M | title = Duplication of primate and rodent B7-H3 immunoglobulin V- and C-like domains: divergent history of functional redundancy and exon loss | journal = Genomics | volume = 82 | issue = 3 | pages = 365-77 | date = September 2003 | pmid = 12906861 | doi = 10.1016/S0888-7543(03)00126-5 }}
*{{cite journal | author=Sun M, Richards S, Prasad DV, ''et al.'' |title=Characterization of mouse and human B7-H3 genes. |journal=J. Immunol. |volume=168 |issue= 12 |pages= 6294-7 |year= 2002 |pmid= 12055244 |doi= }}
* {{cite journal | vauthors = Steinberger P, Majdic O, Derdak SV, Pfistershammer K, Kirchberger S, Klauser C, Zlabinger G, Pickl WF, Stöckl J, Knapp W | title = Molecular characterization of human 4Ig-B7-H3, a member of the B7 family with four Ig-like domains | journal = Journal of Immunology | volume = 172 | issue = 4 | pages = 2352-9 | date = February 2004 | pmid = 14764704 | doi = 10.4049/jimmunol.172.4.2352 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Zhang GB, Chen YJ, Shi Q, Ma HB, Ge Y, Wang Q, Jiang Z, Xu Y, Zhang XG | title = Human recombinant B7-H3 expressed in E. coli enhances T lymphocyte proliferation and IL-10 secretion in vitro | journal = Acta Biochimica et Biophysica Sinica | volume = 36 | issue = 6 | pages = 430-6 | date = June 2004 | pmid = 15188059 | doi = 10.1093/abbs/36.6.430 }}
*{{cite journal | author=Ling V, Wu PW, Spaulding V, ''et al.'' |title=Duplication of primate and rodent B7-H3 immunoglobulin V- and C-like domains: divergent history of functional redundancy and exon loss. |journal=Genomics |volume=82 |issue= 3 |pages= 365-77 |year= 2004 |pmid= 12906861 |doi=  }}
* {{cite journal | vauthors = Castriconi R, Dondero A, Augugliaro R, Cantoni C, Carnemolla B, Sementa AR, Negri F, Conte R, Corrias MV, Moretta L, Moretta A, Bottino C | title = Identification of 4Ig-B7-H3 as a neuroblastoma-associated molecule that exerts a protective role from an NK cell-mediated lysis | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 34 | pages = 12640-5 | date = August 2004 | pmid = 15314238 | pmc = 515110 | doi = 10.1073/pnas.0405025101 }}
*{{cite journal  | author=Clark HF, Gurney AL, Abaya E, ''et al.'' |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265-70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 }}
* {{cite journal | vauthors = Wang L, Fraser CC, Kikly K, Wells AD, Han R, Coyle AJ, Chen L, Hancock WW | title = B7-H3 promotes acute and chronic allograft rejection | journal = European Journal of Immunology | volume = 35 | issue = 2 | pages = 428-38 | date = February 2005 | pmid = 15682454 | doi = 10.1002/eji.200425518 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
* {{cite journal | vauthors = Kim J, Myers AC, Chen L, Pardoll DM, Truong-Tran QA, Lane AP, McDyer JF, Fortuno L, Schleimer RP | title = Constitutive and inducible expression of b7 family of ligands by human airway epithelial cells | journal = American Journal of Respiratory Cell and Molecular Biology | volume = 33 | issue = 3 | pages = 280-9 | date = September 2005 | pmid = 15961727 | pmc = 2715317 | doi = 10.1165/rcmb.2004-0129OC }}
*{{cite journal | author=Steinberger P, Majdic O, Derdak SV, ''et al.'' |title=Molecular characterization of human 4Ig-B7-H3, a member of the B7 family with four Ig-like domains. |journal=J. Immunol. |volume=172 |issue= 4 |pages= 2352-9 |year= 2004 |pmid= 14764704 |doi= }}
* {{cite journal | vauthors = Petroff MG, Kharatyan E, Torry DS, Holets L | title = The immunomodulatory proteins B7-DC, B7-H2, and B7-H3 are differentially expressed across gestation in the human placenta | journal = The American Journal of Pathology | volume = 167 | issue = 2 | pages = 465-73 | date = August 2005 | pmid = 16049332 | pmc = 1603571 | doi = 10.1016/S0002-9440(10)62990-2 }}
*{{cite journal | author=Zhang GB, Chen YJ, Shi Q, ''et al.'' |title=Human recombinant B7-H3 expressed in E. coli enhances T lymphocyte proliferation and IL-10 secretion in vitro. |journal=Acta Biochim. Biophys. Sin. (Shanghai) |volume=36 |issue= 6 |pages= 430-6 |year= 2005 |pmid= 15188059 |doi= }}
* {{cite journal | vauthors = Zhang G, Dong Q, Xu Y, Yu G, Zhang X | title = B7-H3: another molecule marker for Mo-DCs? | journal = Cellular & Molecular Immunology | volume = 2 | issue = 4 | pages = 307-11 | date = August 2005 | pmid = 16274630 | doi =  }}
*{{cite journal | author=Castriconi R, Dondero A, Augugliaro R, ''et al.'' |title=Identification of 4Ig-B7-H3 as a neuroblastoma-associated molecule that exerts a protective role from an NK cell-mediated lysis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 34 |pages= 12640-5 |year= 2004 |pmid= 15314238 |doi= 10.1073/pnas.0405025101 }}
* {{cite journal | vauthors = Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T | title = Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries | journal = DNA Research | volume = 12 | issue = 2 | pages = 117-26 | year = 2007 | pmid = 16303743 | doi = 10.1093/dnares/12.2.117 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
* {{cite journal | vauthors = Sakthivel P, Wang X, Gharizadeh B, Giscombe R, Pirskanen R, Nyren P, Lefvert AK | title = Single-nucleotide polymorphisms in the B7H3 gene are not associated with human autoimmune myasthenia gravis | journal = Journal of Genetics | volume = 85 | issue = 3 | pages = 217-20 | date = December 2006 | pmid = 17406098 | doi = 10.1007/BF02935335 }}
*{{cite journal  | author=Wang L, Fraser CC, Kikly K, ''et al.'' |title=B7-H3 promotes acute and chronic allograft rejection. |journal=Eur. J. Immunol. |volume=35 |issue= 2 |pages= 428-38 |year= 2005 |pmid= 15682454 |doi= 10.1002/eji.200425518 }}
*{{cite journal | author=Kim J, Myers AC, Chen L, ''et al.'' |title=Constitutive and inducible expression of b7 family of ligands by human airway epithelial cells. |journal=Am. J. Respir. Cell Mol. Biol. |volume=33 |issue= 3 |pages= 280-9 |year= 2005 |pmid= 15961727 |doi= 10.1165/rcmb.2004-0129OC }}
*{{cite journal | author=Petroff MG, Kharatyan E, Torry DS, Holets L |title=The immunomodulatory proteins B7-DC, B7-H2, and B7-H3 are differentially expressed across gestation in the human placenta. |journal=Am. J. Pathol. |volume=167 |issue= 2 |pages= 465-73 |year= 2005 |pmid= 16049332 |doi= }}
*{{cite journal | author=Zhang GB, Dong QM, Xu Y, ''et al.'' |title=B7-H3: Another Molecule Marker for Mo-DCs? |journal=Cell. Mol. Immunol. |volume=2 |issue= 4 |pages= 307-11 |year= |pmid= 16274630 |doi=  }}
*{{cite journal | author=Otsuki T, Ota T, Nishikawa T, ''et al.'' |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. |journal=DNA Res. |volume=12 |issue= 2 |pages= 117-26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 }}
*{{cite journal | author=Sakthivel P, Wang X, Gharizadeh B, ''et al.'' |title=Single-nucleotide polymorphisms in the B7H3 gene are not associated with human autoimmune myasthenia gravis. |journal=J. Genet. |volume=85 |issue= 3 |pages= 217-20 |year= 2007 |pmid= 17406098 |doi= }}
}}
{{refend}}
{{refend}}


==External links==
== External links ==
* {{MeshName|CD276+protein,+human}}
* {{MeshName|CD276+protein,+human}}
* {{UCSC gene info|CD276}}


{{membrane-protein-stub}}
{{B7 family}}
{{Clusters of differentiation}}
{{Clusters of differentiation}}
[[Category:Clusters of differentiation]]
[[Category:Clusters of differentiation]]
{{WikiDoc Sources}}
[[Category:Single-pass transmembrane proteins]]
 
{{membrane-protein-stub}}

Latest revision as of 12:45, 9 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

CD276 (Cluster of Differentiation 276) is a human protein encoded by the CD276 gene.[1]

Function

Costimulatory B7 molecules (e.g., B7-1, or CD80; MIM 112203) signal through CD28 (MIM 186760) family molecules such as CD28, CTLA4 (MIM 123890), and ICOS (MIM 604558).[supplied by OMIM][1]

CD276 (aka B7-H3), an immune checkpoint molecule, is expressed by some solid tumours and is the target of anticancer candidates such as MGA271.[2]

See also

References

  1. ↑ 1.0 1.1 "Entrez Gene: CD276 CD276 molecule".
  2. ↑ "Servier Pays MacroGenics $20M for Option to Anticancer Antibody - GEN". GEN.

Further reading

External links

Retrieved from "https://www.wikidoc.org/index.php?title=CD276&oldid=1519545"