CD244
| CD244 molecule, natural killer cell receptor 2B4 | |||||||||||
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| Identifiers | |||||||||||
| Symbols | CD244 ; 2B4; NAIL; NKR2B4; Nmrk; SLAMF4 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 9493 | ||||||||||
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| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
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| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
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CD244 (Cluster of Differentiation 244) is a human protein encoded by the CD244 gene.[1]
See also
References
Further reading
- Vaidya SV, Mathew PA (2006). "Of mice and men: different functions of the murine and human 2B4 (CD244) receptor on NK cells". Immunol. Lett. 105 (2): 180–4. doi:10.1016/j.imlet.2006.02.006. PMID 16621032.
- Siu G, Strauss EC, Lai E, Hood LE (1986). "Analysis of a human V beta gene subfamily". J. Exp. Med. 164 (5): 1600–14. PMID 3772297.
- Latchman Y, McKay PF, Reiser H (1998). "Identification of the 2B4 molecule as a counter-receptor for CD48". J. Immunol. 161 (11): 5809–12. PMID 9834056.
- Brown MH, Boles K, van der Merwe PA; et al. (1999). "2B4, the natural killer and T cell immunoglobulin superfamily surface protein, is a ligand for CD48". J. Exp. Med. 188 (11): 2083–90. PMID 9841922.
- Tangye SG, Lazetic S, Woollatt E; et al. (1999). "Cutting edge: human 2B4, an activating NK cell receptor, recruits the protein tyrosine phosphatase SHP-2 and the adaptor signaling protein SAP". J. Immunol. 162 (12): 6981–5. PMID 10358138.
- Nakajima H, Cella M, Langen H; et al. (1999). "Activating interactions in human NK cell recognition: the role of 2B4-CD48". Eur. J. Immunol. 29 (5): 1676–83. PMID 10359122.
- Boles KS, Nakajima H, Colonna M; et al. (1999). "Molecular characterization of a novel human natural killer cell receptor homologous to mouse 2B4". Tissue Antigens. 54 (1): 27–34. PMID 10458320.
- Kubin MZ, Parshley DL, Din W; et al. (1999). "Molecular cloning and biological characterization of NK cell activation-inducing ligand, a counterstructure for CD48". Eur. J. Immunol. 29 (11): 3466–77. PMID 10556801.
- Parolini S, Bottino C, Falco M; et al. (2000). "X-linked lymphoproliferative disease. 2B4 molecules displaying inhibitory rather than activating function are responsible for the inability of natural killer cells to kill Epstein-Barr virus-infected cells". J. Exp. Med. 192 (3): 337–46. PMID 10934222.
- Kumaresan PR, Mathew PA (2000). "Structure of the human natural killer cell receptor 2B4 gene and identification of a novel alternative transcript". Immunogenetics. 51 (11): 987–92. PMID 11003394.
- Watzl C, Stebbins CC, Long EO (2000). "NK cell inhibitory receptors prevent tyrosine phosphorylation of the activation receptor 2B4 (CD244)". J. Immunol. 165 (7): 3545–8. PMID 11034353.
- Tangye SG, Cherwinski H, Lanier LL, Phillips JH (2001). "2B4-mediated activation of human natural killer cells". Mol. Immunol. 37 (9): 493–501. PMID 11163399.
- Chuang SS, Pham HT, Kumaresan PR, Mathew PA (2001). "A prominent role for activator protein-1 in the transcription of the human 2B4 (CD244) gene in NK cells". J. Immunol. 166 (10): 6188–95. PMID 11342640.
- Morra M, Simarro-Grande M, Martin M; et al. (2001). "Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients". J. Biol. Chem. 276 (39): 36809–16. doi:10.1074/jbc.M101305200. PMID 11477068.
- Morra M, Lu J, Poy F; et al. (2001). "Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells". EMBO J. 20 (21): 5840–52. doi:10.1093/emboj/20.21.5840. PMID 11689425.
- Speiser DE, Colonna M, Ayyoub M; et al. (2002). "The activatory receptor 2B4 is expressed in vivo by human CD8+ effector alpha beta T cells". J. Immunol. 167 (11): 6165–70. PMID 11714776.
- Chuang SS, Kumaresan PR, Mathew PA (2002). "2B4 (CD244)-mediated activation of cytotoxicity and IFN-gamma release in human NK cells involves distinct pathways". J. Immunol. 167 (11): 6210–6. PMID 11714782.
- Bottino C, Parolini S, Biassoni R; et al. (2002). "X-linked lymphoproliferative disease: the dark side of 2b4 function". Adv. Exp. Med. Biol. 495: 63–7. PMID 11774610.
- Aoukaty A, Tan R (2002). "Association of the X-linked lymphoproliferative disease gene product SAP/SH2D1A with 2B4, a natural killer cell-activating molecule, is dependent on phosphoinositide 3-kinase". J. Biol. Chem. 277 (15): 13331–7. doi:10.1074/jbc.M112029200. PMID 11815622.
- Sivori S, Falco M, Marcenaro E; et al. (2002). "Early expression of triggering receptors and regulatory role of 2B4 in human natural killer cell precursors undergoing in vitro differentiation". Proc. Natl. Acad. Sci. U.S.A. 99 (7): 4526–31. doi:10.1073/pnas.072065999. PMID 11917118.
External links
- CD244+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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