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{{distinguish|KIR2DL4}}
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{{Infobox_gene}}
{{GNF_Protein_box
'''CD244''' ('''C'''luster of '''D'''ifferentiation 244) is a human [[protein]] encoded by the {{gene|CD244}} [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CD244 CD244 molecule, natural killer cell receptor 2B4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51744| accessdate = }}</ref> It is also known as Natural Killer Cell Receptor 2B4<ref>{{OMIM|605554}}</ref>
| image = 
| image_source = 
| PDB =
| Name = CD244 molecule, natural killer cell receptor 2B4
| HGNCid = 18171
| Symbol = CD244
| AltSymbols =; 2B4; NAIL; NKR2B4; Nmrk; SLAMF4
| OMIM = 605554
| ECnumber = 
| Homologene = 9493
| MGIid = 109294
| GeneAtlas_image1 = PBB_GE_CD244_220307_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0009897 |text = external side of plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0006968 |text = cellular defense response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 51744
    | Hs_Ensembl = ENSG00000122223
    | Hs_RefseqProtein = NP_057466
    | Hs_RefseqmRNA = NM_016382
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 159066574
    | Hs_GenLoc_end = 159099269
    | Hs_Uniprot = Q9BZW8
    | Mm_EntrezGene = 18106
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = XM_001000500
    | Mm_RefseqProtein = XP_001000500
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''CD244''' ('''C'''luster of '''D'''ifferentiation 244) is a human [[protein]] encoded by the {{gene|CD244}} [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CD244 CD244 molecule, natural killer cell receptor 2B4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51744| accessdate = }}</ref>


This gene encodes a cell surface receptor expressed on [[natural killer cells]] (NK cells) (and some T cells) mediating non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via this receptor is thought to modulate NK-cell cytolytic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.<ref name="NCBI">{{cite web | title = CD244 molecule, natural killer cell receptor 2B4 ( Homo sapiens (human) ) | url = https://www.ncbi.nlm.nih.gov/gene/51744| accessdate = }}</ref>
CD244 can also be expressed on non-lymphocytes such as eosinophils, mast cells and dendritic cells.<ref>{{PMID | 25643613}}</ref>
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==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
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| citations =  
| citations =  
*{{cite journal  | author=Vaidya SV, Mathew PA |title=Of mice and men: different functions of the murine and human 2B4 (CD244) receptor on NK cells. |journal=Immunol. Lett. |volume=105 |issue= 2 |pages= 180-4 |year= 2006 |pmid= 16621032 |doi= 10.1016/j.imlet.2006.02.006 }}
*{{cite journal  | vauthors=Vaidya SV, Mathew PA |title=Of mice and men: different functions of the murine and human 2B4 (CD244) receptor on NK cells. |journal=Immunol. Lett. |volume=105 |issue= 2 |pages= 180–4 |year= 2006 |pmid= 16621032 |doi= 10.1016/j.imlet.2006.02.006 }}
*{{cite journal  | author=Siu G, Strauss EC, Lai E, Hood LE |title=Analysis of a human V beta gene subfamily. |journal=J. Exp. Med. |volume=164 |issue= 5 |pages= 1600-14 |year= 1986 |pmid= 3772297 |doi=  }}
*{{cite journal  | vauthors=Siu G, Strauss EC, Lai E, Hood LE |title=Analysis of a human V beta gene subfamily |journal=J. Exp. Med. |volume=164 |issue= 5 |pages= 1600–14 |year= 1986 |pmid= 3772297 |doi=10.1084/jem.164.5.1600  | pmc=2188445 }}
*{{cite journal  | author=Latchman Y, McKay PF, Reiser H |title=Identification of the 2B4 molecule as a counter-receptor for CD48. |journal=J. Immunol. |volume=161 |issue= 11 |pages= 5809-12 |year= 1998 |pmid= 9834056 |doi=  }}
*{{cite journal  | vauthors=Latchman Y, McKay PF, Reiser H |title=Identification of the 2B4 molecule as a counter-receptor for CD48 |journal=J. Immunol. |volume=161 |issue= 11 |pages= 5809–12 |year= 1998 |pmid= 9834056 |doi=  }}
*{{cite journal  | author=Brown MH, Boles K, van der Merwe PA, ''et al.'' |title=2B4, the natural killer and T cell immunoglobulin superfamily surface protein, is a ligand for CD48. |journal=J. Exp. Med. |volume=188 |issue= 11 |pages= 2083-90 |year= 1999 |pmid= 9841922 |doi=  }}
*{{cite journal  | vauthors=Brown MH, Boles K, van der Merwe PA |title=2B4, the Natural Killer and T Cell Immunoglobulin Superfamily Surface Protein, Is a Ligand for CD48 |journal=J. Exp. Med. |volume=188 |issue= 11 |pages= 2083–90 |year= 1999 |pmid= 9841922 |doi=10.1084/jem.188.11.2083 | pmc=2212392  |display-authors=etal}}
*{{cite journal  | author=Tangye SG, Lazetic S, Woollatt E, ''et al.'' |title=Cutting edge: human 2B4, an activating NK cell receptor, recruits the protein tyrosine phosphatase SHP-2 and the adaptor signaling protein SAP. |journal=J. Immunol. |volume=162 |issue= 12 |pages= 6981-5 |year= 1999 |pmid= 10358138 |doi=  }}
*{{cite journal  | vauthors=Tangye SG, Lazetic S, Woollatt E |title=Cutting edge: human 2B4, an activating NK cell receptor, recruits the protein tyrosine phosphatase SHP-2 and the adaptor signaling protein SAP |journal=J. Immunol. |volume=162 |issue= 12 |pages= 6981–5 |year= 1999 |pmid= 10358138 |doi=  |display-authors=etal}}
*{{cite journal  | author=Nakajima H, Cella M, Langen H, ''et al.'' |title=Activating interactions in human NK cell recognition: the role of 2B4-CD48. |journal=Eur. J. Immunol. |volume=29 |issue= 5 |pages= 1676-83 |year= 1999 |pmid= 10359122 |doi=  }}
*{{cite journal  | vauthors=Nakajima H, Cella M, Langen H |title=Activating interactions in human NK cell recognition: the role of 2B4-CD48 |journal=Eur. J. Immunol. |volume=29 |issue= 5 |pages= 1676–83 |year= 1999 |pmid= 10359122 |doi=10.1002/(SICI)1521-4141(199905)29:05<1676::AID-IMMU1676>3.0.CO;2-Y |display-authors=etal}}
*{{cite journal  | author=Boles KS, Nakajima H, Colonna M, ''et al.'' |title=Molecular characterization of a novel human natural killer cell receptor homologous to mouse 2B4. |journal=Tissue Antigens |volume=54 |issue= 1 |pages= 27-34 |year= 1999 |pmid= 10458320 |doi=  }}
*{{cite journal  | vauthors=Boles KS, Nakajima H, Colonna M |title=Molecular characterization of a novel human natural killer cell receptor homologous to mouse 2B4 |journal=Tissue Antigens |volume=54 |issue= 1 |pages= 27–34 |year= 1999 |pmid= 10458320 |doi=10.1034/j.1399-0039.1999.540103.x |display-authors=etal}}
*{{cite journal  | author=Kubin MZ, Parshley DL, Din W, ''et al.'' |title=Molecular cloning and biological characterization of NK cell activation-inducing ligand, a counterstructure for CD48. |journal=Eur. J. Immunol. |volume=29 |issue= 11 |pages= 3466-77 |year= 1999 |pmid= 10556801 |doi= }}
*{{cite journal  | vauthors=Kubin MZ, Parshley DL, Din W |title=Molecular cloning and biological characterization of NK cell activation-inducing ligand, a counterstructure for CD48 |journal=Eur. J. Immunol. |volume=29 |issue= 11 |pages= 3466–77 |year= 1999 |pmid= 10556801 |doi=10.1002/(SICI)1521-4141(199911)29:11<3466::AID-IMMU3466>3.0.CO;2-9  |display-authors=etal}}
*{{cite journal  | author=Parolini S, Bottino C, Falco M, ''et al.'' |title=X-linked lymphoproliferative disease. 2B4 molecules displaying inhibitory rather than activating function are responsible for the inability of natural killer cells to kill Epstein-Barr virus-infected cells. |journal=J. Exp. Med. |volume=192 |issue= 3 |pages= 337-46 |year= 2000 |pmid= 10934222 |doi=  }}
*{{cite journal  | vauthors=Parolini S, Bottino C, Falco M |title=X-Linked Lymphoproliferative Disease: 2b4 Molecules Displaying Inhibitory Rather than Activating Function Are Responsible for the Inability of Natural Killer Cells to Kill Epstein-Barr Virus–Infected Cells |journal=J. Exp. Med. |volume=192 |issue= 3 |pages= 337–46 |year= 2000 |pmid= 10934222 |doi=10.1084/jem.192.3.337 | pmc=2193227  |display-authors=etal}}
*{{cite journal  | author=Kumaresan PR, Mathew PA |title=Structure of the human natural killer cell receptor 2B4 gene and identification of a novel alternative transcript. |journal=Immunogenetics |volume=51 |issue= 11 |pages= 987-92 |year= 2000 |pmid= 11003394 |doi=  }}
*{{cite journal  | vauthors=Kumaresan PR, Mathew PA |title=Structure of the human natural killer cell receptor 2B4 gene and identification of a novel alternative transcript |journal=Immunogenetics |volume=51 |issue= 11 |pages= 987–92 |year= 2000 |pmid= 11003394 |doi=10.1007/s002510000237 }}
*{{cite journal  | author=Watzl C, Stebbins CC, Long EO |title=NK cell inhibitory receptors prevent tyrosine phosphorylation of the activation receptor 2B4 (CD244). |journal=J. Immunol. |volume=165 |issue= 7 |pages= 3545-8 |year= 2000 |pmid= 11034353 |doi=  }}
*{{cite journal  | vauthors=Watzl C, Stebbins CC, Long EO |title=NK cell inhibitory receptors prevent tyrosine phosphorylation of the activation receptor 2B4 (CD244) |journal=J. Immunol. |volume=165 |issue= 7 |pages= 3545–8 |year= 2000 |pmid= 11034353 |doi=  10.4049/jimmunol.165.7.3545}}
*{{cite journal  | author=Tangye SG, Cherwinski H, Lanier LL, Phillips JH |title=2B4-mediated activation of human natural killer cells. |journal=Mol. Immunol. |volume=37 |issue= 9 |pages= 493-501 |year= 2001 |pmid= 11163399 |doi= }}
*{{cite journal  | vauthors=Tangye SG, Cherwinski H, Lanier LL, Phillips JH |title=2B4-mediated activation of human natural killer cells |journal=Mol. Immunol. |volume=37 |issue= 9 |pages= 493–501 |year= 2001 |pmid= 11163399 |doi=10.1016/S0161-5890(00)00076-6  }}
*{{cite journal  | author=Chuang SS, Pham HT, Kumaresan PR, Mathew PA |title=A prominent role for activator protein-1 in the transcription of the human 2B4 (CD244) gene in NK cells. |journal=J. Immunol. |volume=166 |issue= 10 |pages= 6188-95 |year= 2001 |pmid= 11342640 |doi=  }}
*{{cite journal  | vauthors=Chuang SS, Pham HT, Kumaresan PR, Mathew PA |title=A prominent role for activator protein-1 in the transcription of the human 2B4 (CD244) gene in NK cells |journal=J. Immunol. |volume=166 |issue= 10 |pages= 6188–95 |year= 2001 |pmid= 11342640 |doi=  10.4049/jimmunol.166.10.6188}}
*{{cite journal  | author=Morra M, Simarro-Grande M, Martin M, ''et al.'' |title=Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients. |journal=J. Biol. Chem. |volume=276 |issue= 39 |pages= 36809-16 |year= 2001 |pmid= 11477068 |doi= 10.1074/jbc.M101305200 }}
*{{cite journal  | vauthors=Morra M, Simarro-Grande M, Martin M |title=Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients |journal=J. Biol. Chem. |volume=276 |issue= 39 |pages= 36809–16 |year= 2001 |pmid= 11477068 |doi= 10.1074/jbc.M101305200 |display-authors=etal}}
*{{cite journal  | author=Morra M, Lu J, Poy F, ''et al.'' |title=Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells. |journal=EMBO J. |volume=20 |issue= 21 |pages= 5840-52 |year= 2001 |pmid= 11689425 |doi= 10.1093/emboj/20.21.5840 }}
*{{cite journal  | vauthors=Morra M, Lu J, Poy F |title=Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells |journal=EMBO J. |volume=20 |issue= 21 |pages= 5840–52 |year= 2001 |pmid= 11689425 |doi= 10.1093/emboj/20.21.5840 | pmc=125701 |display-authors=etal}}
*{{cite journal  | author=Speiser DE, Colonna M, Ayyoub M, ''et al.'' |title=The activatory receptor 2B4 is expressed in vivo by human CD8+ effector alpha beta T cells. |journal=J. Immunol. |volume=167 |issue= 11 |pages= 6165-70 |year= 2002 |pmid= 11714776 |doi=  }}
*{{cite journal  | vauthors=Speiser DE, Colonna M, Ayyoub M |title=The activatory receptor 2B4 is expressed in vivo by human CD8+ effector alpha beta T cells |journal=J. Immunol. |volume=167 |issue= 11 |pages= 6165–70 |year= 2002 |pmid= 11714776 |doi=  10.4049/jimmunol.167.11.6165|display-authors=etal}}
*{{cite journal  | author=Chuang SS, Kumaresan PR, Mathew PA |title=2B4 (CD244)-mediated activation of cytotoxicity and IFN-gamma release in human NK cells involves distinct pathways. |journal=J. Immunol. |volume=167 |issue= 11 |pages= 6210-6 |year= 2002 |pmid= 11714782 |doi=  }}
*{{cite journal  | vauthors=Chuang SS, Kumaresan PR, Mathew PA |title=2B4 (CD244)-mediated activation of cytotoxicity and IFN-gamma release in human NK cells involves distinct pathways |journal=J. Immunol. |volume=167 |issue= 11 |pages= 6210–6 |year= 2002 |pmid= 11714782 |doi=  10.4049/jimmunol.167.11.6210}}
*{{cite journal  | author=Bottino C, Parolini S, Biassoni R, ''et al.'' |title=X-linked lymphoproliferative disease: the dark side of 2b4 function. |journal=Adv. Exp. Med. Biol. |volume=495 |issue=  |pages= 63-7 |year= 2002 |pmid= 11774610 |doi=  }}
*{{cite journal  | vauthors=Bottino C, Parolini S, Biassoni R |title=X-linked lymphoproliferative disease: the dark side of 2b4 function |journal=Adv. Exp. Med. Biol. |volume=495 |issue=  |pages= 63–7 |year= 2002 |pmid= 11774610 |doi=  10.1007/978-1-4615-0685-0_9|display-authors=etal}}
*{{cite journal  | author=Aoukaty A, Tan R |title=Association of the X-linked lymphoproliferative disease gene product SAP/SH2D1A with 2B4, a natural killer cell-activating molecule, is dependent on phosphoinositide 3-kinase. |journal=J. Biol. Chem. |volume=277 |issue= 15 |pages= 13331-7 |year= 2002 |pmid= 11815622 |doi= 10.1074/jbc.M112029200 }}
*{{cite journal  | vauthors=Aoukaty A, Tan R |title=Association of the X-linked lymphoproliferative disease gene product SAP/SH2D1A with 2B4, a natural killer cell-activating molecule, is dependent on phosphoinositide 3-kinase |journal=J. Biol. Chem. |volume=277 |issue= 15 |pages= 13331–7 |year= 2002 |pmid= 11815622 |doi= 10.1074/jbc.M112029200 }}
*{{cite journal  | author=Sivori S, Falco M, Marcenaro E, ''et al.'' |title=Early expression of triggering receptors and regulatory role of 2B4 in human natural killer cell precursors undergoing in vitro differentiation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 7 |pages= 4526-31 |year= 2002 |pmid= 11917118 |doi= 10.1073/pnas.072065999 }}
*{{cite journal  | vauthors=Sivori S, Falco M, Marcenaro E |title=Early expression of triggering receptors and regulatory role of 2B4 in human natural killer cell precursors undergoing in vitro differentiation |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 7 |pages= 4526–31 |year= 2002 |pmid= 11917118 |doi= 10.1073/pnas.072065999 | pmc=123681 |display-authors=etal}}
*{{cite journal  | vauthors=Assarsson E, Kambayshi T, Persson C |title=2B4 co-stimulation: NK cells and their control of adaptive immune responses |journal=Mol.Immunol. |volume=42 |issue= 4 |pages= 419–23 |year= 2005 |pmid= 15607793 |doi= 10.1016/j.molimm.2004.07.021|display-authors=etal}}
}}
}}
{{refend}}
{{refend}}
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==External links==
==External links==
* {{MeshName|CD244+protein,+human}}
* {{MeshName|CD244+protein,+human}}
* {{UCSC gene info|CD244}}


{{membrane-protein-stub}}
{{Clusters of differentiation}}
{{Clusters of differentiation}}
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[[Category:Clusters of differentiation]]
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Revision as of 09:21, 30 August 2017

Not to be confused with KIR2DL4.
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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Wikidata
View/Edit Human

CD244 (Cluster of Differentiation 244) is a human protein encoded by the CD244 gene.[1] It is also known as Natural Killer Cell Receptor 2B4[2]

This gene encodes a cell surface receptor expressed on natural killer cells (NK cells) (and some T cells) mediating non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via this receptor is thought to modulate NK-cell cytolytic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[3] CD244 can also be expressed on non-lymphocytes such as eosinophils, mast cells and dendritic cells.[4]


See also

References

  1. ↑ "Entrez Gene: CD244 CD244 molecule, natural killer cell receptor 2B4".
  2. ↑ Online Mendelian Inheritance in Man (OMIM) 605554
  3. ↑ "CD244 molecule, natural killer cell receptor 2B4 ( Homo sapiens (human) )".
  4. ↑ PMID 25643613

Further reading

External links


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