CD200: Difference between revisions

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{{for|the vehicle|Honda CD200 RoadMaster}}
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{{Infobox_gene}}
| update_page = yes
'''OX-2 membrane glycoprotein''', also named CD200 ([[Cluster of Differentiation]] 200)<ref name=UniprotP41217>{{cite web|title=P41217 (OX2G_HUMAN)|url=http://www.uniprot.org/uniprot/P41217|publisher=Uniprot|accessdate=16 May 2013}}</ref>  is a human [[protein]] encoded by the {{gene|CD200}} [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CD200 CD200 molecule| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4345| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = CD200 molecule
| HGNCid = 7203
| Symbol = CD200
| AltSymbols =; MOX1; MOX2; MRC; OX-2
| OMIM = 155970
| ECnumber = 
| Homologene = 4344
| MGIid = 1196990
| GeneAtlas_image1 = PBB_GE_CD200_209582_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_CD200_209583_s_at_tn.png
| Function =
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4345
    | Hs_Ensembl = ENSG00000091972
    | Hs_RefseqProtein = NP_001004196
    | Hs_RefseqmRNA = NM_001004196
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 113522943
    | Hs_GenLoc_end = 113564346
    | Hs_Uniprot = P41217
    | Mm_EntrezGene = 17470
    | Mm_Ensembl = ENSMUSG00000022661
    | Mm_RefseqmRNA = NM_010818
    | Mm_RefseqProtein = NP_034948
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 16
    | Mm_GenLoc_start = 45311578
    | Mm_GenLoc_end = 45319635
    | Mm_Uniprot = Q05D16
  }}
}}
'''CD200''' (Cluster of Differentiation 200) is a human [[protein]] encoded by the {{gene|CD200}} [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CD200 CD200 molecule| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4345| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene is a type-1 membrane glycoprotein, which contains two immunoglobulin domains, and thus belongs to the immunoglobulin superfamily. Studies of the related genes in mouse and rat suggest that this gene may regulate myeloid cell activity and delivers an inhibitory signal for the macrophage lineage in diverse tissues. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: CD200 CD200 molecule| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4345| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is a type-1 membrane glycoprotein, which contains two immunoglobulin domains, and thus belongs to the immunoglobulin superfamily. Studies of the related genes in mouse and rat suggest that this gene may regulate myeloid cell activity and delivers an inhibitory signal for the macrophage lineage in diverse tissues. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene.<ref name="entrez" />
}}
}}


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==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
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{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Gorczynski RM |title=Evidence for an immunoregulatory role of OX2 with its counter ligand (OX2L) in the regulation of transplant rejection, fetal loss, autoimmunity and tumor growth. |journal=Arch. Immunol. Ther. Exp. (Warsz.) |volume=49 |issue= 4 |pages= 303-9 |year= 2002 |pmid= 11726033 |doi=  }}
*{{cite journal  | author=Gorczynski RM |title=Evidence for an immunoregulatory role of OX2 with its counter ligand (OX2L) in the regulation of transplant rejection, fetal loss, autoimmunity and tumor growth |journal=Arch. Immunol. Ther. Exp. (Warsz.) |volume=49 |issue= 4 |pages= 303–9 |year= 2002 |pmid= 11726033 |doi=  }}
*{{cite journal  | author=Douglas J, Albertson DG, Barclay AN, ''et al.'' |title=RFLP and mapping of human MOX-1 gene on chromosome 3. |journal=Nucleic Acids Res. |volume=16 |issue= 18 |pages= 9067 |year= 1988 |pmid= 2902568 |doi=  }}
*{{cite journal  | vauthors=Douglas J, Albertson DG, Barclay AN |title=RFLP and mapping of human MOX-1 gene on chromosome 3 |journal=Nucleic Acids Res. |volume=16 |issue= 18 |pages= 9067 |year= 1988 |pmid= 2902568 |doi=10.1093/nar/16.18.9067  | pmc=338677 |display-authors=etal}}
*{{cite journal  | author=McCaughan GW, Clark MJ, Barclay AN |title=Characterization of the human homolog of the rat MRC OX-2 membrane glycoprotein. |journal=Immunogenetics |volume=25 |issue= 5 |pages= 329-35 |year= 1987 |pmid= 3032785 |doi=  }}
*{{cite journal  | vauthors=McCaughan GW, Clark MJ, Barclay AN |title=Characterization of the human homolog of the rat MRC OX-2 membrane glycoprotein |journal=Immunogenetics |volume=25 |issue= 5 |pages= 329–35 |year= 1987 |pmid= 3032785 |doi=10.1007/BF00404426 }}
*{{cite journal  | author=Wright GJ, Puklavec MJ, Willis AC, ''et al.'' |title=Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function. |journal=Immunity |volume=13 |issue= 2 |pages= 233-42 |year= 2000 |pmid= 10981966 |doi=  }}
*{{cite journal  | vauthors=Wright GJ, Puklavec MJ, Willis AC |title=Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function |journal=Immunity |volume=13 |issue= 2 |pages= 233–42 |year= 2000 |pmid= 10981966 |doi=10.1016/S1074-7613(00)00023-6 |display-authors=etal}}
*{{cite journal  | author=Hoek RM, Ruuls SR, Murphy CA, ''et al.'' |title=Down-regulation of the macrophage lineage through interaction with OX2 (CD200). |journal=Science |volume=290 |issue= 5497 |pages= 1768-71 |year= 2000 |pmid= 11099416 |doi=  }}
*{{cite journal  | vauthors=Hoek RM, Ruuls SR, Murphy CA |title=Down-regulation of the macrophage lineage through interaction with OX2 (CD200) |journal=Science |volume=290 |issue= 5497 |pages= 1768–71 |year= 2000 |pmid= 11099416 |doi=10.1126/science.290.5497.1768 |display-authors=etal}}
*{{cite journal  | author=Wright GJ, Jones M, Puklavec MJ, ''et al.'' |title=The unusual distribution of the neuronal/lymphoid cell surface CD200 (OX2) glycoprotein is conserved in humans. |journal=Immunology |volume=102 |issue= 2 |pages= 173-9 |year= 2001 |pmid= 11260322 |doi=  }}
*{{cite journal  | vauthors=Wright GJ, Jones M, Puklavec MJ |title=The unusual distribution of the neuronal/lymphoid cell surface CD200 (OX2) glycoprotein is conserved in humans |journal=Immunology |volume=102 |issue= 2 |pages= 173–9 |year= 2001 |pmid= 11260322 |doi=10.1046/j.1365-2567.2001.01163.x  | pmc=1783166 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Wright GJ, Cherwinski H, Foster-Cuevas M, ''et al.'' |title=Characterization of the CD200 receptor family in mice and humans and their interactions with CD200. |journal=J. Immunol. |volume=171 |issue= 6 |pages= 3034-46 |year= 2003 |pmid= 12960329 |doi=  }}
*{{cite journal  | vauthors=Wright GJ, Cherwinski H, Foster-Cuevas M |title=Characterization of the CD200 receptor family in mice and humans and their interactions with CD200 |journal=J. Immunol. |volume=171 |issue= 6 |pages= 3034–46 |year= 2003 |pmid= 12960329 |doi=  10.4049/jimmunol.171.6.3034|display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Chen DX, Gorczynski RM |title=Discrete monoclonal antibodies define functionally important epitopes in the CD200 molecule responsible for immunosuppression function. |journal=Transplantation |volume=79 |issue= 3 |pages= 282-8 |year= 2005 |pmid= 15699757 |doi=  }}
*{{cite journal  | vauthors=Chen DX, Gorczynski RM |title=Discrete monoclonal antibodies define functionally important epitopes in the CD200 molecule responsible for immunosuppression function |journal=Transplantation |volume=79 |issue= 3 |pages= 282–8 |year= 2005 |pmid= 15699757 |doi=10.1097/01.TP.0000149506.61000.86 }}
*{{cite journal  | author=Chen Z, Marsden PA, Gorczynski RM |title=Cloning and characterization of the human CD200 promoter region. |journal=Mol. Immunol. |volume=43 |issue= 6 |pages= 579-87 |year= 2006 |pmid= 15955564 |doi= 10.1016/j.molimm.2005.04.014 }}
*{{cite journal  | vauthors=Chen Z, Marsden PA, Gorczynski RM |title=Cloning and characterization of the human CD200 promoter region |journal=Mol. Immunol. |volume=43 |issue= 6 |pages= 579–87 |year= 2006 |pmid= 15955564 |doi= 10.1016/j.molimm.2005.04.014 }}
*{{cite journal  | author=Shiratori I, Yamaguchi M, Suzukawa M, ''et al.'' |title=Down-regulation of basophil function by human CD200 and human herpesvirus-8 CD200. |journal=J. Immunol. |volume=175 |issue= 7 |pages= 4441-9 |year= 2005 |pmid= 16177086 |doi=  }}
*{{cite journal  | vauthors=Shiratori I, Yamaguchi M, Suzukawa M |title=Down-regulation of basophil function by human CD200 and human herpesvirus-8 CD200 |journal=J. Immunol. |volume=175 |issue= 7 |pages= 4441–9 |year= 2005 |pmid= 16177086 |doi=  10.4049/jimmunol.175.7.4441|display-authors=etal}}
*{{cite journal  | author=Otsuki T, Ota T, Nishikawa T, ''et al.'' |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. |journal=DNA Res. |volume=12 |issue= 2 |pages= 117-26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 }}
*{{cite journal  | vauthors=Otsuki T, Ota T, Nishikawa T |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries |journal=DNA Res. |volume=12 |issue= 2 |pages= 117–26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 |display-authors=etal}}
*{{cite journal  | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal  | vauthors=Kimura K, Wakamatsu A, Suzuki Y |title=Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 |display-authors=etal}}
*{{cite journal  | author=Matsue H |title=CD 200-mediated regulation of skin immunity. |journal=J. Invest. Dermatol. |volume=125 |issue= 6 |pages= x-xi |year= 2006 |pmid= 16354172 |doi= 10.1111/j.0022-202X.2005.23978.x }}
*{{cite journal  | author=Matsue H |title=CD 200-mediated regulation of skin immunity |journal=J. Invest. Dermatol. |volume=125 |issue= 6 |pages= x–xi |year= 2006 |pmid= 16354172 |doi= 10.1111/j.0022-202X.2005.23978.x }}
}}
}}
{{refend}}
{{refend}}
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==External links==
==External links==
* {{MeshName|CD200+Antigen}}
* {{MeshName|CD200+Antigen}}
* {{UCSC gene info|CD200}}


{{membrane-protein-stub}}
{{NLM content}}
{{NLM content}}
{{Clusters of differentiation}}
{{Clusters of differentiation}}
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[[Category:Clusters of differentiation]]
[[Category:Clusters of differentiation]]
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{{membrane-protein-stub}}

Revision as of 09:21, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

OX-2 membrane glycoprotein, also named CD200 (Cluster of Differentiation 200)[1] is a human protein encoded by the CD200 gene.[2]

The protein encoded by this gene is a type-1 membrane glycoprotein, which contains two immunoglobulin domains, and thus belongs to the immunoglobulin superfamily. Studies of the related genes in mouse and rat suggest that this gene may regulate myeloid cell activity and delivers an inhibitory signal for the macrophage lineage in diverse tissues. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene.[2]

See also

References

  1. "P41217 (OX2G_HUMAN)". Uniprot. Retrieved 16 May 2013.
  2. 2.0 2.1 "Entrez Gene: CD200 CD200 molecule".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.