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'''For patient information click [[Autoimmune hemolytic anemia (patient information)|here]]'''
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{{Infobox_Disease |
{{Infobox_Disease |
   Name          = Autoimmune hemolytic anemia |
   Name          = Autoimmune hemolytic anemia |
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   MeshID        = D000744 |
   MeshID        = D000744 |
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{{SI}}
{{Autoimmune hemolytic anemia}}
{{CMG}}
 
__NOTOC__
'''For patient information click [[Autoimmune hemolytic anemia (patient information)|here]]'''
{{Editor Help}}
 
{{CMG}} '''Assosciate Editor(s)-In-Chief:''' [[User: Prashanthsaddala|Prashanth Saddala M.B.B.S]]; {{shyam}}, [[User:Irfan Dotani|Irfan Dotani]] [3]
 
{{SK}} AIHA; hemolytic anemia with autoimmune cause.
==[[Autoimmune hemolytic anemia overview|Overview]]==
 
==[[Autoimmune hemolytic anemia historical perspective|Historical Perspective]]==
 
==[[Autoimmune hemolytic anemia classification|Classification]]==
 
==[[Autoimmune hemolytic anemia pathophysiology|Pathophysiology]]==
 
==[[Autoimmune hemolytic anemia causes|Causes]]==


==Overview==
==[[Autoimmune hemolytic anemia differential diagnosis|Differentiating Autoimmune hemolytic anemia from other Diseases]]==


'''Autoimmune hemolytic anemia''' (AIHA) is a type of [[hemolytic anemia]] where the body's immune system attacks its own [[red blood cells]] (RBCs), leading to their destruction ([[hemolysis]]).  [[Antibodies]] and associated [[complement system]] components become fixed onto the [[Red blood cell|RBC]] surface.    These [[antibodies]] can be detected with the [[Coombs test#Direct Coombs test|direct antiglobulin test]], also known as the direct [[Coombs test]].  AIHA can also be induced by several drugs including methyl-dopa and fluarabine.
==[[Autoimmune hemolytic anemia epidemiology and demographics|Epidemiology and Demographics]]==


[[Autoimmunity]] must not be confused with [[alloimmunity]].
==[[Autoimmune hemolytic anemia risk factors|Risk Factors]]==


==Classification==
==[[Autoimmune hemolytic anemia screening|Screening]]==
Haemolysis can be intravascular or extravascular.


'''Intravascular haemolysis'''<br>
==[[Autoimmune hemolytic anemia natural history, complications and prognosis|Natural History, Complications and Prognosis]]==
Red blood cell lysis occurs in the circulation as a result of activation of the [[complement system]] cascade.
'''Extravascular haemolysis'''<br>
Red Blood Cells that are coated with antibodies are specifically recognised in the [[reticuloendothelial system]] and destroyed by [[macrophages]].


==Subtypes==
==Diagnosis==


*'''[[Warm antibody autoimmune hemolytic anemia]]'''
[[Autoimmune hemolytic anemia diagnostic study of choice|Diagnostic Study of Choice]] | [[Autoimmune hemolytic anemia history and symptoms|History and Symptoms ]] | [[Autoimmune hemolytic anemia physical examination|Physical Examination]] | [[Autoimmune hemolytic anemia laboratory findings|Laboratory Findings]] | [[Autoimmune hemolytic anemia electrocardiogram|Electrocardiogram]] | [[Autoimmune hemolytic anemia chest x-ray|X-ray]] | [[Autoimmune hemolytic anemia echocardiography and ultrasound|Echocardiography and Ultrasound]] | [[Autoimmune hemolytic anemia CT|CT]] | [[Autoimmune hemolytic anemia MRI|MRI]] | [[Autoimmune hemolytic anemia other imaging findings|Other Imaging Findings]] | [[Autoimmune hemolytic anemia other diagnostic studies|Other Diagnostic Studies]]
:*Idiopathic
:*[[Systemic lupus erythematosus]]
:*[[Evans' syndrome]] (antiplatelet antibodies and haemolytic antibodies)
:*[[Chronic lymphocytic leukemia]]
:*Drugs ([[methyldopa]])


*'''Cold antibody autoimmune hemolytic anemia'''
==Treatment==
:*[[Idiopathic cold hemagglutinin syndrome]]
[[Autoimmune hemolytic anemia medical therapy|Medical Therapy]] | [[Autoimmune hemolytic anemia surgery |Surgery]] | [[Autoimmune hemolytic anemia primary prevention|Primary Prevention]] | [[Autoimmune hemolytic anemia secondary prevention|Secondary Prevention]] | [[Autoimmune hemolytic anemia cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] |  [[Autoimmune hemolytic anemia future or investigational therapies|Future or Investigational Therapies]]
:*[[Infectious mononucleosis]]
:*[[Paroxysmal cold hemoglobinuria]] (rare)
:*[[Lymphoma]]


*'''Mixed-type autoimmune hemolytic anemia'''
==Case Studies==


==Laboratory findings==
[[Autoimmune hemolytic anemia case study one|Case #1]]
*Positive direct [[Coombs test]]
*[[Anaemia]]


==See also==
==Related Chapters==
*[[Haematology]]
*[[Haematology]]
*[[Haemolytic anaemia]]
*[[Haemolytic anaemia]]
{{WH}}
{{WS}}


{{Hematology}}
{{Hematology}}
{{SIB}}
 
 
[[de:Autoimmunhämolytische Anämie]]
[[de:Autoimmunhämolytische Anämie]]
[[es:Anemia inmunohemolítica]]
[[es:Anemia inmunohemolítica]]
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{{WikiDoc Sources}}
{{WikiDoc Sources}}


[[Category:Mature chapter]]
[[Category:Disease]]
[[Category:Disease]]
[[Category:Autoimmune diseases]]
[[Category:Coagulation system]]
[[Category:Blood disorders]]
[[Category:Hematology]]
[[Category:Hematology]]

Latest revision as of 11:52, 20 September 2018

Autoimmune hemolytic anemia
ICD-10 D59.0-D59.1
ICD-9 283.0
MedlinePlus 000579
MeSH D000744

Autoimmune hemolytic anemia Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Autoimmune hemolytic anemia from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X-ray

Echocardiography and Ultrasound

CT

MRI

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Autoimmune hemolytic anemia On the Web

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Review articles

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Echo & Ultrasound
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MRI

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NICE Guidance

FDA on Autoimmune hemolytic anemia

CDC on Autoimmune hemolytic anemia

Autoimmune hemolytic anemia in the news

Blogs on Autoimmune hemolytic anemia

Directions to Hospitals Treating Autoimmune hemolytic anemia

Risk calculators and risk factors for Autoimmune hemolytic anemia

For patient information click here

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Assosciate Editor(s)-In-Chief: Prashanth Saddala M.B.B.S; Shyam Patel [2], Irfan Dotani [3]

Synonyms and keywords: AIHA; hemolytic anemia with autoimmune cause.

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Autoimmune hemolytic anemia from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice | History and Symptoms | Physical Examination | Laboratory Findings | Electrocardiogram | X-ray | Echocardiography and Ultrasound | CT | MRI | Other Imaging Findings | Other Diagnostic Studies

Treatment

Medical Therapy | Surgery | Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies

Case Studies

Case #1

Related Chapters

Template:WH Template:WS

Template:Hematology


de:Autoimmunhämolytische Anämie


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