AM-906

AM-906
	File:AM-906.png
Identifiers
	IUPAC name (6aR,9R,10aR)-3-[(Z)-hept-1-enyl]-9-(hydroxymethyl)-6,6-dimethyl-6a,7,8,9,10,10a-hexahydrobenzo[c]chromen-1-ol;
PubChem CID	10089808;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C23H34O3
Molar mass	358.513 g/mol
3D model (JSmol)	Interactive image;
	SMILES CCCCCC=Cc(cc1O)cc(OC(C)(C)C2CC3)c1C2CC3CO;

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AM-906 is an analgesic drug which is a cannabinoid agonist with a conformationally restricted side chain. It is a potent and selective agonist for the CB₁ cannabinoid receptor, with a Ki of 0.8nM at CB₁ vs 9.5nM at CB₂, a selectivity of almost 12x.^[1]

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References

↑ Papahatjis DP, Kourouli T, Abadji V, Goutopoulos A, Makriyannis A. Pharmacophoric requirements for cannabinoid side chains: multiple bond and C1'-substituted delta 8-tetrahydrocannabinols. Journal of Medicinal Chemistry. 1998 Mar 26;41(7):1195-200. PMID 9544219

Template:WikiDoc Sources

[1] Papahatjis DP, Kourouli T, Abadji V, Goutopoulos A, Makriyannis A. Pharmacophoric requirements for cannabinoid side chains: multiple bond and C1'-substituted delta 8-tetrahydrocannabinols. Journal of Medicinal Chemistry. 1998 Mar 26;41(7):1195-200. PMID 9544219

[1]

Identifiers
File:AM-906.png
IUPAC name (6aR,9R,10aR)-3-[(Z)-hept-1-enyl]-9-(hydroxymethyl)-6,6-dimethyl-6a,7,8,9,10,10a-hexahydrobenzo[c]chromen-1-ol
PubChem CID	10089808
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C₂₃H₃₄O₃
Molar mass	358.513 g/mol
3D model (JSmol)	Interactive image
SMILES CCCCCC=Cc(cc1O)cc(OC(C)(C)C2CC3)c1C2CC3CO

AM-906

References

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