Dimethylallyltranstransferase: Difference between revisions
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'''Dimethylallyltranstransferase''' ('''DMATT'''), also known as '''farnesylpyrophosphate synthase''' ('''FPPS''') or as '''farnesyldiphosphate synthase''' ('''FDPS'''), is an [[enzyme]] that [[catalysis|catalyze]]s the [[biotransformation|transformation]] of [[dimethylallylpyrophosphate]] (DMAPP) and [[isopentenyl pyrophosphate]] (IPP) into [[farnesylpyrophosphate]] (FPP).<ref>{{cite journal | title = Biosynthesis of geraniol and nerol in cell-free extracts of ''Tanacetum vulgare'' | | '''Dimethylallyltranstransferase''' ('''DMATT'''), also known as '''farnesylpyrophosphate synthase''' ('''FPPS''') or as '''farnesyldiphosphate synthase''' ('''FDPS'''), is an [[enzyme]] that [[catalysis|catalyze]]s the [[biotransformation|transformation]] of [[dimethylallylpyrophosphate]] (DMAPP) and [[isopentenyl pyrophosphate]] (IPP) into [[farnesylpyrophosphate]] (FPP).<ref>{{cite journal | title = Biosynthesis of geraniol and nerol in cell-free extracts of ''Tanacetum vulgare'' | vauthors = Banthorpe DV, Bucknall GA, Doonan HJ, Doonan S, Rowan MG | journal = Phytochemistry |date = 1976 |volume = 15 |pages = 91–100 |pmid = |doi=10.1016/s0031-9422(00)89061-5}}</ref><ref>{{cite journal | vauthors = Sagami H, Ogura K, Seto S, Kurokawa T | title = A new prenyltransferase from Micrococcus lysodeikticus | journal = Biochemical and Biophysical Research Communications | volume = 85 | issue = 2 | pages = 572-8 | date = November 1978 | pmid = 736921 | doi = 10.1016/0006-291X(78)91201-9 }}</ref> | ||
[[Pyrophosphate]] is also involved, as both a [[reactant]] and a [[product (chemistry)|product]]. [[Geranylpyrophosphate]] is created in an intermediate step. | [[Pyrophosphate]] is also involved, as both a [[reactant]] and a [[product (chemistry)|product]]. [[Geranylpyrophosphate]] is created in an intermediate step. | ||
==See also== | == See also == | ||
* [[Geranyltranstransferase]] | * [[Geranyltranstransferase]] | ||
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{{reflist}} | {{reflist}} | ||
==External links== | == External links == | ||
* {{MeshName|Dimethylallyltranstransferase}} | * {{MeshName|Dimethylallyltranstransferase}} | ||
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[[Category:EC 2.5.1]] | [[Category:EC 2.5.1]] | ||
{{2.5-enzyme-stub}} | {{2.5-enzyme-stub}} | ||
Latest revision as of 08:33, 17 February 2018
| Dimethylallyltranstransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| File:2f8z.jpg | |||||||||
| Identifiers | |||||||||
| EC number | 2.5.1.1 | ||||||||
| CAS number | 9032-79-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
| Farnesyldiphosphate synthase (farnesylpyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) | |
|---|---|
| Identifiers | |
| Symbol | FDPS |
| Entrez | 2224 |
| HUGO | 3631 |
| OMIM | 134629 |
| RefSeq | NM_002004 |
| UniProt | P14324 |
| Other data | |
| EC number | 2.5.1.1 |
| Locus | Chr. 1 q22 |
Dimethylallyltranstransferase (DMATT), also known as farnesylpyrophosphate synthase (FPPS) or as farnesyldiphosphate synthase (FDPS), is an enzyme that catalyzes the transformation of dimethylallylpyrophosphate (DMAPP) and isopentenyl pyrophosphate (IPP) into farnesylpyrophosphate (FPP).[1][2]
Pyrophosphate is also involved, as both a reactant and a product. Geranylpyrophosphate is created in an intermediate step.
See also
References
- ↑ Banthorpe DV, Bucknall GA, Doonan HJ, Doonan S, Rowan MG (1976). "Biosynthesis of geraniol and nerol in cell-free extracts of Tanacetum vulgare". Phytochemistry. 15: 91–100. doi:10.1016/s0031-9422(00)89061-5.
- ↑ Sagami H, Ogura K, Seto S, Kurokawa T (November 1978). "A new prenyltransferase from Micrococcus lysodeikticus". Biochemical and Biophysical Research Communications. 85 (2): 572–8. doi:10.1016/0006-291X(78)91201-9. PMID 736921.
External links
- Dimethylallyltranstransferase at the US National Library of Medicine Medical Subject Headings (MeSH)
| This EC 2.5 enzyme-related article is a stub. You can help Wikipedia by expanding it. |