Small intestinal bacterial overgrowth syndrome: Difference between revisions
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==Historical Perspective== | ==Historical Perspective== | ||
*Small intestinal bacterial overgrowth (SIBO) was first discovered by Barber and Hummel in 1939. | *Small intestinal bacterial overgrowth (SIBO) was first discovered by Barber and Hummel in 1939.<ref name="pmid15156063">{{cite journal |vauthors=Hao WL, Lee YK |title=Microflora of the gastrointestinal tract: a review |journal=Methods Mol. Biol. |volume=268 |issue= |pages=491–502 |year=2004 |pmid=15156063 |doi=10.1385/1-59259-766-1:491 |url=}}</ref><ref name="pmid23997926">{{cite journal |vauthors=Sachdev AH, Pimentel M |title=Gastrointestinal bacterial overgrowth: pathogenesis and clinical significance |journal=Ther Adv Chronic Dis |volume=4 |issue=5 |pages=223–31 |year=2013 |pmid=23997926 |pmc=3752184 |doi=10.1177/2040622313496126 |url=}}</ref> | ||
*In 2000, Pimentel et all at Cedars-Sinai Medical Center first identified that SIBO was present in 78% of patients with [[Irritable bowel syndrome|irritable bowel syndrome (IBS)]], and that [[Treatment IND|treatment]] with [[antibiotics]] improved [[symptoms]]. | *In 2000, Pimentel et all at Cedars-Sinai Medical Center first identified that SIBO was present in 78% of patients with [[Irritable bowel syndrome|irritable bowel syndrome (IBS)]], and that [[Treatment IND|treatment]] with [[antibiotics]] improved [[symptoms]]. | ||
*In May 2015, U.S. [[Food and Drug Administration|Food and Drug Administration (FDA)]] approved [[rifaximin]] to treat SIBO. | *In May 2015, U.S. [[Food and Drug Administration|Food and Drug Administration (FDA)]] approved [[rifaximin]] to treat SIBO. | ||
| Line 28: | Line 28: | ||
==Pathophysiology== | ==Pathophysiology== | ||
*The [[pathogenesis]] of small intestinal bacterial overgrowth (SIBO) is characterized by an increased [[microbial]] load in the [[small intestine]]. | *The [[pathogenesis]] of small intestinal bacterial overgrowth (SIBO) is characterized by an increased [[microbial]] load in the [[small intestine]].<ref name="pmid3890541">{{cite journal |vauthors=Mathias JR, Clench MH |title=Review: pathophysiology of diarrhea caused by bacterial overgrowth of the small intestine |journal=Am. J. Med. Sci. |volume=289 |issue=6 |pages=243–8 |year=1985 |pmid=3890541 |doi= |url=}}</ref><ref name="pmid15156063">{{cite journal |vauthors=Hao WL, Lee YK |title=Microflora of the gastrointestinal tract: a review |journal=Methods Mol. Biol. |volume=268 |issue= |pages=491–502 |year=2004 |pmid=15156063 |doi=10.1385/1-59259-766-1:491 |url=}}</ref><ref name="pmid20572300">{{cite journal |vauthors=Bures J, Cyrany J, Kohoutova D, Förstl M, Rejchrt S, Kvetina J, Vorisek V, Kopacova M |title=Small intestinal bacterial overgrowth syndrome |journal=World J. Gastroenterol. |volume=16 |issue=24 |pages=2978–90 |year=2010 |pmid=20572300 |pmc=2890937 |doi= |url=}}</ref> | ||
*A [[healthy]] individual has less than 103 organisms/mL in the upper [[small intestine]] and the majority of these [[organisms]] are [[gram-positive bacteria]]. | *A [[healthy]] individual has less than 103 organisms/mL in the upper [[small intestine]] and the majority of these [[organisms]] are [[gram-positive bacteria]]. | ||
*[[Human body|Human body's]] [[Homeostatic|homeostatic mechanisms]] that protect against excessive [[small intestinal]] colonization by [[Bacterial|bacteria]] include : | *[[Human body|Human body's]] [[Homeostatic|homeostatic mechanisms]] that protect against excessive [[small intestinal]] colonization by [[Bacterial|bacteria]] include : | ||
| Line 45: | Line 45: | ||
**Increased [[Intraepithelial lymphocyte|intraepithelial lymphocytes]] | **Increased [[Intraepithelial lymphocyte|intraepithelial lymphocytes]] | ||
==Causes== | ==Causes== | ||
*Small intestinal bacterial overgrowth (SIBO) may be caused by disruption of the [[Protective group|protective]] [[homeostatic]] [[Mechanisms of action|mechanisms]] that control [[enteric]] [[Bacterial|bacteria]] [[population]]. | *Small intestinal bacterial overgrowth (SIBO) may be caused by disruption of the [[Protective group|protective]] [[homeostatic]] [[Mechanisms of action|mechanisms]] that control [[enteric]] [[Bacterial|bacteria]] [[population]].<ref name="pmid27123301">{{cite journal |vauthors=Deng L, Liu Y, Zhang D, Li Y, Xu L |title=Prevalence and treatment of small intestinal bacterial overgrowth in postoperative patients with colorectal cancer |journal=Mol Clin Oncol |volume=4 |issue=5 |pages=883–887 |year=2016 |pmid=27123301 |pmc=4840787 |doi=10.3892/mco.2016.807 |url=}}</ref><ref name="pmid20572300">{{cite journal |vauthors=Bures J, Cyrany J, Kohoutova D, Förstl M, Rejchrt S, Kvetina J, Vorisek V, Kopacova M |title=Small intestinal bacterial overgrowth syndrome |journal=World J. Gastroenterol. |volume=16 |issue=24 |pages=2978–90 |year=2010 |pmid=20572300 |pmc=2890937 |doi= |url=}}</ref><ref name="pmid6412829">{{cite journal |vauthors=McEvoy A, Dutton J, James OF |title=Bacterial contamination of the small intestine is an important cause of occult malabsorption in the elderly |journal=Br Med J (Clin Res Ed) |volume=287 |issue=6395 |pages=789–93 |year=1983 |pmid=6412829 |pmc=1549133 |doi= |url=}}</ref> | ||
*Causes of small intestinal bacterial overgrowth (SIBO) include: | *Causes of small intestinal bacterial overgrowth (SIBO) include: | ||
**'''Irregular [[small intestinal]] [[motility]]:''' | **'''Irregular [[small intestinal]] [[motility]]:''' | ||
| Line 79: | Line 79: | ||
*Small intestinal bacterial overgrowth (SIBO) must be differentiated from other diseases that cause chronic diarrhea. For differential diagnosis of chronic diarrhoea, click '''[[Chronic diarrhea differential diagnosis|here]].''' | *Small intestinal bacterial overgrowth (SIBO) must be differentiated from other diseases that cause chronic diarrhea. For differential diagnosis of chronic diarrhoea, click '''[[Chronic diarrhea differential diagnosis|here]].''' | ||
==Epidemiology and Demographics== | ==Epidemiology and Demographics== | ||
Epidemiology and demographics of small intestinal bacterial overgrowth is as follows: <ref name="pmid437407">{{cite journal |vauthors=King CE, Toskes PP |title=Small intestine bacterial overgrowth |journal=Gastroenterology |volume=76 |issue=5 Pt 1 |pages=1035–55 |year=1979 |pmid=437407 |doi= |url=}}</ref> | |||
===Age=== | ===Age=== | ||
*Small intestinal bacterial overgrowth is more commonly observed among [[elderly]] [[patients]]. | *Small intestinal bacterial overgrowth is more commonly observed among [[elderly]] [[patients]]. | ||
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==Risk Factors== | ==Risk Factors== | ||
*Common [[risk factors]] in the development of small intestinal bacterial overgrowth (SIBO) are : | *Common [[risk factors]] in the development of small intestinal bacterial overgrowth (SIBO) are :<ref name="pmid6412829">{{cite journal |vauthors=McEvoy A, Dutton J, James OF |title=Bacterial contamination of the small intestine is an important cause of occult malabsorption in the elderly |journal=Br Med J (Clin Res Ed) |volume=287 |issue=6395 |pages=789–93 |year=1983 |pmid=6412829 |pmc=1549133 |doi= |url=}}</ref><ref name="pmid20572300">{{cite journal |vauthors=Bures J, Cyrany J, Kohoutova D, Förstl M, Rejchrt S, Kvetina J, Vorisek V, Kopacova M |title=Small intestinal bacterial overgrowth syndrome |journal=World J. Gastroenterol. |volume=16 |issue=24 |pages=2978–90 |year=2010 |pmid=20572300 |pmc=2890937 |doi= |url=}}</ref> | ||
**[[Intestinal tract]] [[surgery]] | **[[Intestinal tract]] [[surgery]] | ||
**[[Irritable bowel syndrome]] | **[[Irritable bowel syndrome]] | ||
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*Early [[clinical]] [[Features (pattern recognition)|features]] include [[bloating]], [[flatulence]], [[abdominal pain]]. | *Early [[clinical]] [[Features (pattern recognition)|features]] include [[bloating]], [[flatulence]], [[abdominal pain]]. | ||
*If left untreated, [[patients]] with small intestinal bacterial overgrowth (SIBO) may progress to develop [[diarrhea]], [[dyspepsia]] and [[weight loss]]. | *If left untreated, [[patients]] with small intestinal bacterial overgrowth (SIBO) may progress to develop [[diarrhea]], [[dyspepsia]] and [[weight loss]]. | ||
*Common [[complications]] of small intestinal bacterial overgrowth (SIBO) include: | *Common [[complications]] of small intestinal bacterial overgrowth (SIBO) include:<ref name="pmid7805370">{{cite journal |vauthors=Saltzman JR, Russell RM |title=Nutritional consequences of intestinal bacterial overgrowth |journal=Compr Ther |volume=20 |issue=9 |pages=523–30 |year=1994 |pmid=7805370 |doi= |url=}}</ref> | ||
**[[Iron]] [[deficiency]] resulting in [[microcytic]] [[anemia]] | **[[Iron]] [[deficiency]] resulting in [[microcytic]] [[anemia]] | ||
**[[Vitamin B-12]] or [[folate deficiency]] resulting in [[macrocytic anemia]] | **[[Vitamin B-12]] or [[folate deficiency]] resulting in [[macrocytic anemia]] | ||
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== Diagnosis == | == Diagnosis == | ||
===Diagnostic Criteria=== | ===Diagnostic Criteria=== | ||
*The [[diagnosis]] of small intestinal bacterial overgrowth (SIBO) is made when at least one of the following [[diagnostic]] [[criteria]] are met: | *The [[diagnosis]] of small intestinal bacterial overgrowth (SIBO) is made when at least one of the following [[diagnostic]] [[criteria]] are met:<ref name="pmid1607585">{{cite journal |vauthors=Donald IP, Kitchingmam G, Donald F, Kupfer RM |title=The diagnosis of small bowel bacterial overgrowth in elderly patients |journal=J Am Geriatr Soc |volume=40 |issue=7 |pages=692–6 |year=1992 |pmid=1607585 |doi= |url=}}</ref> | ||
:*A [[positive]] [[carbohydrate]] [[breath]] [[test]] | :*A [[positive]] [[carbohydrate]] [[breath]] [[test]] | ||
:*[[Bacterial]] [[Concentrations|concentration]] of >103 units/mL in a [[Jejunum|jejunal]] [[aspirate]] [[Culture media|culture]] | :*[[Bacterial]] [[Concentrations|concentration]] of >103 units/mL in a [[Jejunum|jejunal]] [[aspirate]] [[Culture media|culture]] | ||
=== Symptoms === | === Symptoms === | ||
*[[Symptoms]] of small intestinal bacterial overdose (SIBO) may include the following: | *[[Symptoms]] of small intestinal bacterial overdose (SIBO) may include the following:<ref name="pmid7805370">{{cite journal |vauthors=Saltzman JR, Russell RM |title=Nutritional consequences of intestinal bacterial overgrowth |journal=Compr Ther |volume=20 |issue=9 |pages=523–30 |year=1994 |pmid=7805370 |doi= |url=}}</ref> | ||
:*[[Bloating]] | :*[[Bloating]] | ||
:*[[Flatulence]] | :*[[Flatulence]] | ||
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=== Laboratory Findings === | === Laboratory Findings === | ||
*A [[positive]] [[carbohydrate]] [[breath]] [[test]] is [[diagnostic]] of small intestinal bacterial overgrowth (SIBO). | *A [[positive]] [[carbohydrate]] [[breath]] [[test]] is [[diagnostic]] of small intestinal bacterial overgrowth (SIBO).<ref name="pmid437407">{{cite journal |vauthors=King CE, Toskes PP |title=Small intestine bacterial overgrowth |journal=Gastroenterology |volume=76 |issue=5 Pt 1 |pages=1035–55 |year=1979 |pmid=437407 |doi= |url=}}</ref><ref name="pmid7805370">{{cite journal |vauthors=Saltzman JR, Russell RM |title=Nutritional consequences of intestinal bacterial overgrowth |journal=Compr Ther |volume=20 |issue=9 |pages=523–30 |year=1994 |pmid=7805370 |doi= |url=}}</ref><ref name="pmid1607585">{{cite journal |vauthors=Donald IP, Kitchingmam G, Donald F, Kupfer RM |title=The diagnosis of small bowel bacterial overgrowth in elderly patients |journal=J Am Geriatr Soc |volume=40 |issue=7 |pages=692–6 |year=1992 |pmid=1607585 |doi= |url=}}</ref> | ||
*An elevated concentration of [[bacterial]] [[Colony Forming Units (CFU)|colony forming units]] >103/mL in [[Jejunum|jejunal]] [[aspirate]] culture is [[diagnostic]] of small intestinal bacterial overgrowth (SIBO). | *An elevated concentration of [[bacterial]] [[Colony Forming Units (CFU)|colony forming units]] >103/mL in [[Jejunum|jejunal]] [[aspirate]] culture is [[diagnostic]] of small intestinal bacterial overgrowth (SIBO). | ||
*Other [[laboratory]] findings consistent with the [[diagnosis]] of small intestinal bacterial overgrowth (SIBO) include: | *Other [[laboratory]] findings consistent with the [[diagnosis]] of small intestinal bacterial overgrowth (SIBO) include: | ||
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===Other Diagnostic Studies=== | ===Other Diagnostic Studies=== | ||
====Breath Tests==== | ====Breath Tests==== | ||
*Small intestinal bacterial obstruction (SIBO) may also be [[Diagnose|diagnosed]] using [[breath]] [[Test|tests]]. | *Small intestinal bacterial obstruction (SIBO) may also be [[Diagnose|diagnosed]] using [[breath]] [[Test|tests]].<ref name="pmid10773721">{{cite journal |vauthors=Stotzer PO, Kilander AF |title=Comparison of the 1-gram (14)C-D-xylose breath test and the 50-gram hydrogen glucose breath test for diagnosis of small intestinal bacterial overgrowth |journal=Digestion |volume=61 |issue=3 |pages=165–71 |year=2000 |pmid=10773721 |doi=10.1159/000007753 |url=}}</ref><ref name="pmid24095975">{{cite journal |vauthors=Saad RJ, Chey WD |title=Breath testing for small intestinal bacterial overgrowth: maximizing test accuracy |journal=Clin. Gastroenterol. Hepatol. |volume=12 |issue=12 |pages=1964–72; quiz e119–20 |year=2014 |pmid=24095975 |doi=10.1016/j.cgh.2013.09.055 |url=}}</ref><ref name="pmid437407">{{cite journal |vauthors=King CE, Toskes PP |title=Small intestine bacterial overgrowth |journal=Gastroenterology |volume=76 |issue=5 Pt 1 |pages=1035–55 |year=1979 |pmid=437407 |doi= |url=}}</ref> | ||
*[[Breath]] [[Test|tests]] have the advantage of being easy to perform, noninvasive, and inexpensive. [[Breath]] [[Test|tests]] are based on the principle that [[carbohydrates]] are [[metabolized]] by [[bacteria]] in the [[gut]] to produce [[hydrogen]] or [[methane]] that is [[Absorbed dose|absorbed]] and [[excreted]] in [[breath]]. | *[[Breath]] [[Test|tests]] have the advantage of being easy to perform, noninvasive, and inexpensive. [[Breath]] [[Test|tests]] are based on the principle that [[carbohydrates]] are [[metabolized]] by [[bacteria]] in the [[gut]] to produce [[hydrogen]] or [[methane]] that is [[Absorbed dose|absorbed]] and [[excreted]] in [[breath]]. | ||
*The findings on [[carbohydrate]] [[breath]] [[test]] [[diagnostic]] of small intestinal bacterial obstruction (SIBO) include: | *The findings on [[carbohydrate]] [[breath]] [[test]] [[diagnostic]] of small intestinal bacterial obstruction (SIBO) include: | ||
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== Treatment == | == Treatment == | ||
Treatment options available for small intestinal bacterial overgrowth syndrome are as follows: <ref name="pmid19243285">{{cite journal |vauthors=Pimentel M |title=Review of rifaximin as treatment for SIBO and IBS |journal=Expert Opin Investig Drugs |volume=18 |issue=3 |pages=349–58 |year=2009 |pmid=19243285 |doi=10.1517/13543780902780175 |url=}}</ref><ref name="pmid437407">{{cite journal |vauthors=King CE, Toskes PP |title=Small intestine bacterial overgrowth |journal=Gastroenterology |volume=76 |issue=5 Pt 1 |pages=1035–55 |year=1979 |pmid=437407 |doi= |url=}}</ref> | |||
===Medical Therapy=== | ===Medical Therapy=== | ||
*The mainstay of [[therapy]] for small intestinal bacterial overgrowth (SIBO) is [[antibiotic therapy]]. | *The mainstay of [[therapy]] for small intestinal bacterial overgrowth (SIBO) is [[antibiotic therapy]].<ref name="pmid19496193">{{cite journal |vauthors=Peralta S, Cottone C, Doveri T, Almasio PL, Craxi A |title=Small intestine bacterial overgrowth and irritable bowel syndrome-related symptoms: experience with Rifaximin |journal=World J. Gastroenterol. |volume=15 |issue=21 |pages=2628–31 |year=2009 |pmid=19496193 |pmc=2691494 |doi= |url=}}</ref> | ||
*[[Antibiotics]] acts by eliminating the [[bacterial]] [[Overgrowth syndrome|overgrowth]]. | *[[Antibiotics]] acts by eliminating the [[bacterial]] [[Overgrowth syndrome|overgrowth]]. | ||
* [[Rifaximin]] is the [[antibiotic]] of choice for the [[Treatments|treatment]] of small intestinal bacterial overgrowth (SIBO). | * [[Rifaximin]] is the [[antibiotic]] of choice for the [[Treatments|treatment]] of small intestinal bacterial overgrowth (SIBO). | ||
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=== Prevention === | === Prevention === | ||
*Effective measures for the [[prevention]] of small bowel bacterial overgrowth syndrome include: | *Effective measures for the [[prevention]] of small bowel bacterial overgrowth syndrome include:<ref name="pmid437407">{{cite journal |vauthors=King CE, Toskes PP |title=Small intestine bacterial overgrowth |journal=Gastroenterology |volume=76 |issue=5 Pt 1 |pages=1035–55 |year=1979 |pmid=437407 |doi= |url=}}</ref> | ||
**Avoiding [[medications]] like [[narcotics]] and [[benzodiazepines]] that decrease [[intestinal]] [[motility]]. | **Avoiding [[medications]] like [[narcotics]] and [[benzodiazepines]] that decrease [[intestinal]] [[motility]]. | ||
**Avoid [[achlorhydria]] in high-risk [[patients]]. | **Avoid [[achlorhydria]] in high-risk [[patients]]. | ||
Revision as of 01:08, 4 February 2018
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Mazia Fatima, MBBS [2]
| Small intestinal bacterial overgrowth syndrome | |
| ICD-10 | K63 |
|---|---|
| ICD-9 | 579.9 |
| DiseasesDB | 29209 |
| MedlinePlus | 000222 |
| eMedicine | med/198 |
Synonyms and keywords:SIBO; small bowel bacterial overgrowth.
Overview
Small intestinal bacterial overgrowth (SIBO) was first discovered by Barber and Hummel in 1939. There is no established system for the classification of small intestinal bacterial overgrowth (SIBO).The pathogenesis of small intestinal bacterial overgrowth (SIBO) is characterized by an increased microbial load in the small intestine. Disruption of protective homeostatic mechanisms can increase the risk of SIBO. Bacterial colonization causes an inflammatory response in the intestinal mucosa. Damage to the intestinal mucosa leads to malabsorption of bile acids, carbohydrates, proteins and vitamins resulting in symptoms of diarrhea and weight loss. On gross pathology, mucosal edema, loss of normal vascular pattern, patchy erythema, friability and ulceration of the small intestinal wall is associated with small intestinal bacterial overgrowth (SIBO). On microscopic histopathological analysis small intestine and colon are normal in most patients with SIBO. Findings include blunting of the intestinal villi, thinning of the mucosa and crypts, increased intraepithelial lymphocytes. Small intestinal bacterial overgrowth (SIBO) must be differentiated from other diseases that cause chronic diarrhea. Small intestinal bacterial overgrowth is more commonly observed among elderly patients. Small intestinal bacterial overgrowth (SIBO) affects men and women equally.There is no racial predilection for small intestinal bacterial overgrowth (SIBO). Early clinical features include bloating, flatulence, abdominal pain. If left untreated, patients with small intestinal bacterial overgrowth (SIBO) may progress to develop diarrhea, dyspepsia and weight loss. Prognosis is generally good and associated with frequent relapses and symptom-free periods. The diagnosis of small intestinal bacterial overgrowth (SIBO) is made when at least one of the following diagnostic criteria are met: a positive carbohydrate breath test or bacterial concentration of >103 units/mL in a jejunal aspirate culture. Physical examination may be remarkable for distended abdomen with positive succussion splash as a result of distended bowel loops and peripheral edema due to malabsorption. Small intestinal bacterial obstruction(SIBO) may also be diagnosed using breath tests. The mainstay of therapy for small intestinal bacterial overgrowth (SIBO) is antibiotic therapy. Surgical approach can only be performed for patients with strictures, fistulae, and diverticula or any other structural abnormality resulting in obstruction and resultant bacterial overgrowth. Effective measures for the prevention of small bowel bacterial overgrowth syndrome include avoiding medications like narcotics and benzodiazepines that decrease intestinal motility and avoid achlorhydria in high-risk patients. Consider antibiotic prophylaxis for patients with four or more episodes of recurrent small bowel bacterial overgrowth syndrome within one year.
Historical Perspective
- Small intestinal bacterial overgrowth (SIBO) was first discovered by Barber and Hummel in 1939.[1][2]
- In 2000, Pimentel et all at Cedars-Sinai Medical Center first identified that SIBO was present in 78% of patients with irritable bowel syndrome (IBS), and that treatment with antibiotics improved symptoms.
- In May 2015, U.S. Food and Drug Administration (FDA) approved rifaximin to treat SIBO.
Classification
- There is no established system for the classification of small intestinal bacterial overgrowth (SIBO).
Pathophysiology
- The pathogenesis of small intestinal bacterial overgrowth (SIBO) is characterized by an increased microbial load in the small intestine.[3][1][4]
- A healthy individual has less than 103 organisms/mL in the upper small intestine and the majority of these organisms are gram-positive bacteria.
- Human body's homeostatic mechanisms that protect against excessive small intestinal colonization by bacteria include :
- Gastric acid and bile eradicate micro-organisms before they leave the stomach.
- Migrating motor complex clears the excess bacteria of upper intestine.
- Intestinal mucosa serves as a protective layer for the gut wall.
- Normal intestinal flora (eg, Lactobacillus) maintains a low pH that prevents bacterial overgrowth.
- Physical barrier of the ileocecal valve that prevents retrograde translocation of bacteria from colon to the small intestine.
- Disruption of these protective homeostatic mechanisms can increase the risk of SIBO.
- Bacterial colonization causes an inflammatory response in the intestinal mucosa.
- Damage to the intestinal mucosa leads to malabsorption of bile acids, carbohydrates, proteins, and vitamins resulting in symptoms of diarrhea and weight loss.
- On gross pathology, mucosal edema, loss of normal vascular pattern, patchy erythema, friability and ulceration of the small intestinal wall is associated with small intestinal bacterial overgrowth (SIBO).
- On microscopic histopathological analysis small intestine and colon is normal in most patients with SIBO. However, in some patients, findings may include:
- Blunting of the intestinal villi
- Thinning of the mucosa and crypts
- Increased intraepithelial lymphocytes
Causes
- Small intestinal bacterial overgrowth (SIBO) may be caused by disruption of the protective homeostatic mechanisms that control enteric bacteria population.[5][4][6]
- Causes of small intestinal bacterial overgrowth (SIBO) include:
- Irregular small intestinal motility:
- Blind pouches in the gastrointestinal tract:
- Side-to-side or end-to-side anastomoses
- Duodenal or jejunal diverticula
- Segmental dilatation of the ileum
- Blind loop syndrome
- Biliopancreatic diversion
- Chagasic megacolon
- Fistula:
- Partial Obstruction:
- Decreased gastric acid secretion:
- Achlorhydria
- Vagotomy
- Long-term proton pump inhibitor therapy
Differentiating Small Intestinal Bacterial Overgrowth from other Diseases
- Small intestinal bacterial overgrowth (SIBO) must be differentiated from other diseases that cause chronic diarrhea. For differential diagnosis of chronic diarrhoea, click here.
Epidemiology and Demographics
Epidemiology and demographics of small intestinal bacterial overgrowth is as follows: [7]
Age
Gender
Race
- There is no racial predilection for small intestinal bacterial overgrowth (SIBO).
Risk Factors
- Common risk factors in the development of small intestinal bacterial overgrowth (SIBO) are :[6][4]
- Intestinal tract surgery
- Irritable bowel syndrome
- Liver cirrhosis
- Celiac disease
- Immune deficiency (eg, AIDS, IgA deficiency, severe malnutrition)
- Short bowel syndrome
- End-stage renal disease
- Gastrojejunal anastomosis
- Antral resection
- Pancreatic exocrine insufficiency
Natural History, Complications and Prognosis
- Early clinical features include bloating, flatulence, abdominal pain.
- If left untreated, patients with small intestinal bacterial overgrowth (SIBO) may progress to develop diarrhea, dyspepsia and weight loss.
- Common complications of small intestinal bacterial overgrowth (SIBO) include:[8]
- Iron deficiency resulting in microcytic anemia
- Vitamin B-12 or folate deficiency resulting in macrocytic anemia
- Vitamin B-12 deficiency associated polyneuropathy
- Steatorrhea
- Hypocalcemia
- Vitamin A deficiency resulting in night blindness
- Selenium deficiency causing dermatitis
- Rosacea
- Cachexia as a result of protein-energy malnutrition
- Prognosis is generally good and associated with frequent relapses and symptom-free periods.
Diagnosis
Diagnostic Criteria
- The diagnosis of small intestinal bacterial overgrowth (SIBO) is made when at least one of the following diagnostic criteria are met:[9]
- A positive carbohydrate breath test
- Bacterial concentration of >103 units/mL in a jejunal aspirate culture
Symptoms
Physical Examination
- Patients with small intestinal bacterial overgrowth (SIBO) usually appear normal.
- Physical examination may be remarkable for:
- Distended abdomen with positive succussion splash as a result of distended bowel loops
- Peripheral edema due to malabsorption
Laboratory Findings
- A positive carbohydrate breath test is diagnostic of small intestinal bacterial overgrowth (SIBO).[7][8][9]
- An elevated concentration of bacterial colony forming units >103/mL in jejunal aspirate culture is diagnostic of small intestinal bacterial overgrowth (SIBO).
- Other laboratory findings consistent with the diagnosis of small intestinal bacterial overgrowth (SIBO) include:
- Macrocytic anemia
- B12 deficiency
- Presence of fecal fat on stool examination.
- Low levels of thiamine and niacin
- Elevated serum folate and vitamin K levels
Imaging Findings
- The CT abdomen or MRI may demonstrate associated strictures, malrotation, fistulae.
- Small intestinal bacterial overgrowth can result in small bowel obstruction that presents as small bowel feces sign on abdominal CT.
- Small bowel feces sign is the presence of particulate feculent material mingled with gas bubbles in the lumen of the small intestine, it is believed to be the result of delayed intestinal transit.
Other Diagnostic Studies
Breath Tests
- Small intestinal bacterial obstruction (SIBO) may also be diagnosed using breath tests.[10][11][7]
- Breath tests have the advantage of being easy to perform, noninvasive, and inexpensive. Breath tests are based on the principle that carbohydrates are metabolized by bacteria in the gut to produce hydrogen or methane that is absorbed and excreted in breath.
- The findings on carbohydrate breath test diagnostic of small intestinal bacterial obstruction (SIBO) include:
Treatment
Treatment options available for small intestinal bacterial overgrowth syndrome are as follows: [12][7]
Medical Therapy
- The mainstay of therapy for small intestinal bacterial overgrowth (SIBO) is antibiotic therapy.[13]
- Antibiotics acts by eliminating the bacterial overgrowth.
- Rifaximin is the antibiotic of choice for the treatment of small intestinal bacterial overgrowth (SIBO).
- Preferred regimen: Rifaximin 550 mg PO q8h for 14 days.
- Response to antibiotics can be assessed by the symptomatic improvement. In case of recurrent symptoms, the antibiotic dose is repeated.
Surgery
- Surgical approach can only be performed for patients with strictures, fistulae, and diverticula or any other structural abnormality resulting in obstruction and resultant bacterial overgrowth.
Prevention
- Effective measures for the prevention of small bowel bacterial overgrowth syndrome include:[7]
- Avoiding medications like narcotics and benzodiazepines that decrease intestinal motility.
- Avoid achlorhydria in high-risk patients.
- Consider antibiotic prophylaxis for patients with four or more episodes of recurrent small bowel bacterial overgrowth syndrome within one year.
References
- ↑ 1.0 1.1 Hao WL, Lee YK (2004). "Microflora of the gastrointestinal tract: a review". Methods Mol. Biol. 268: 491–502. doi:10.1385/1-59259-766-1:491. PMID 15156063.
- ↑ Sachdev AH, Pimentel M (2013). "Gastrointestinal bacterial overgrowth: pathogenesis and clinical significance". Ther Adv Chronic Dis. 4 (5): 223–31. doi:10.1177/2040622313496126. PMC 3752184. PMID 23997926.
- ↑ Mathias JR, Clench MH (1985). "Review: pathophysiology of diarrhea caused by bacterial overgrowth of the small intestine". Am. J. Med. Sci. 289 (6): 243–8. PMID 3890541.
- ↑ 4.0 4.1 4.2 Bures J, Cyrany J, Kohoutova D, Förstl M, Rejchrt S, Kvetina J, Vorisek V, Kopacova M (2010). "Small intestinal bacterial overgrowth syndrome". World J. Gastroenterol. 16 (24): 2978–90. PMC 2890937. PMID 20572300.
- ↑ Deng L, Liu Y, Zhang D, Li Y, Xu L (2016). "Prevalence and treatment of small intestinal bacterial overgrowth in postoperative patients with colorectal cancer". Mol Clin Oncol. 4 (5): 883–887. doi:10.3892/mco.2016.807. PMC 4840787. PMID 27123301.
- ↑ 6.0 6.1 McEvoy A, Dutton J, James OF (1983). "Bacterial contamination of the small intestine is an important cause of occult malabsorption in the elderly". Br Med J (Clin Res Ed). 287 (6395): 789–93. PMC 1549133. PMID 6412829.
- ↑ 7.0 7.1 7.2 7.3 7.4 King CE, Toskes PP (1979). "Small intestine bacterial overgrowth". Gastroenterology. 76 (5 Pt 1): 1035–55. PMID 437407.
- ↑ 8.0 8.1 8.2 Saltzman JR, Russell RM (1994). "Nutritional consequences of intestinal bacterial overgrowth". Compr Ther. 20 (9): 523–30. PMID 7805370.
- ↑ 9.0 9.1 Donald IP, Kitchingmam G, Donald F, Kupfer RM (1992). "The diagnosis of small bowel bacterial overgrowth in elderly patients". J Am Geriatr Soc. 40 (7): 692–6. PMID 1607585.
- ↑ Stotzer PO, Kilander AF (2000). "Comparison of the 1-gram (14)C-D-xylose breath test and the 50-gram hydrogen glucose breath test for diagnosis of small intestinal bacterial overgrowth". Digestion. 61 (3): 165–71. doi:10.1159/000007753. PMID 10773721.
- ↑ Saad RJ, Chey WD (2014). "Breath testing for small intestinal bacterial overgrowth: maximizing test accuracy". Clin. Gastroenterol. Hepatol. 12 (12): 1964–72, quiz e119–20. doi:10.1016/j.cgh.2013.09.055. PMID 24095975.
- ↑ Pimentel M (2009). "Review of rifaximin as treatment for SIBO and IBS". Expert Opin Investig Drugs. 18 (3): 349–58. doi:10.1517/13543780902780175. PMID 19243285.
- ↑ Peralta S, Cottone C, Doveri T, Almasio PL, Craxi A (2009). "Small intestine bacterial overgrowth and irritable bowel syndrome-related symptoms: experience with Rifaximin". World J. Gastroenterol. 15 (21): 2628–31. PMC 2691494. PMID 19496193.