Protein Wnt-10b (formerly Wnt12[1]) is a protein that in humans is encoded by the WNT10Bgene.[2][3][4][5]
The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It may be involved in breast cancer, and its protein signaling is, it is presumed, a molecular switch that governs adipogenesis. Gain-of-function of Wnt10b in mouse hearts has shown to improve cardiac tissue repair after myocardial injury, by promoting coronary vessel formation and attenuating pathological fibrosis.[6] This protein is 96% identical to the mouse Wnt10b protein at the amino acid level. This gene is clustered with another family member, WNT1, in the chromosome 12q13 region.[5]
References
↑Schubert M, Holland LZ, Holland ND, Jacobs DK (2000). "A phylogenetic tree of the Wnt genes based on all available full-length sequences, including five from the cephalochordate amphioxus". Molecular Biology and Evolution. 17 (12): 1896–903. doi:10.1093/oxfordjournals.molbev.a026291. PMID11110906.
↑Bui TD, Rankin J, Smith K, Huguet EL, Ruben S, Strachan T, Harris AL, Lindsay S (Apr 1997). "A novel human Wnt gene, WNT10B, maps to 12q13 and is expressed in human breast carcinomas". Oncogene. 14 (10): 1249–53. doi:10.1038/sj.onc.1200936. PMID9121776.
↑Hardiman G, Kastelein RA, Bazan JF (Sep 1997). "Isolation, characterization and chromosomal localization of human WNT10B". Cytogenet Cell Genet. 77 (3–4): 278–82. doi:10.1159/000134597. PMID9284937.
↑Ugur SA, Tolun A (Aug 2008). "Homozygous WNT10b mutation and complex inheritance in Split-Hand/Foot Malformation". Hum Mol Genet. 17 (17): 2644–53. doi:10.1093/hmg/ddn164. PMID18515319.
↑Paik DT, Rai M, Ryzhov S, Sanders LN, Aisagbonhi O, Funke MJ, Feoktistov I, Hatzopoulos AK. Wnt10b gain-of-function improves cardiac repair by arteriole formation and attenuation of fibrosis. Circ Res. 2015; 117:804-816.
Bergstein I, Eisenberg LM, Bhalerao J, et al. (1998). "Isolation of two novel WNT genes, WNT14 and WNT15, one of which (WNT15) is closely linked to WNT3 on human chromosome 17q21". Genomics. 46 (3): 450–8. doi:10.1006/geno.1997.5041. PMID9441749.
Kirikoshi H, Sekihara H, Katoh M (2001). "WNT10A and WNT6, clustered in human chromosome 2q35 region with head-to-tail manner, are strongly coexpressed in SW480 cells". Biochem. Biophys. Res. Commun. 283 (4): 798–805. doi:10.1006/bbrc.2001.4855. PMID11350055.
Saitoh T, Kirikoshi H, Mine T, Katoh M (2002). "Proto-oncogene WNT10B is up-regulated by tumor necrosis factor alpha in human gastric cancer cell line MKN45". Int. J. Oncol. 19 (6): 1187–92. doi:10.3892/ijo.19.6.1187. PMID11713588.
Kasat K, Go V, Pogo BG (2003). "Effects of pyrethroid insecticides and estrogen on WNT10B proto-oncogene expression". Environment International. 28 (5): 429–32. doi:10.1016/S0160-4120(02)00072-7. PMID12437293.
