Protein Wnt-9a (formerly Wnt14[1]) is a protein that in humans is encoded by the WNT9Agene.[2][3]
The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is expressed in gastric cancer cell lines. The protein encoded by this gene shows 75% amino acid identity to chicken Wnt14, which has been shown to play a central role in initiating synovial joint formation in the chick limb. This gene is clustered with another family member, WNT3A, in the chromosome 1q42 region.[3]
References
↑Person AD, Garriock RJ, Krieg PA, Runyan RB, Klewer SE (2005). "Frzb modulates Wnt-9a-mediated beta-catenin signaling during avian atrioventricular cardiac cushion development". Developmental Biology. 278 (1): 35–48. doi:10.1016/j.ydbio.2004.10.013. PMID15649459.
↑Bergstein I, Eisenberg LM, Bhalerao J, Jenkins NA, Copeland NG, Osborne MP, Bowcock AM, Brown AM (Mar 1998). "Isolation of two novel WNT genes, WNT14 and WNT15, one of which (WNT15) is closely linked to WNT3 on human chromosome 17q21". Genomics. 46 (3): 450–8. doi:10.1006/geno.1997.5041. PMID9441749.
Hartmann C, Tabin CJ (2001). "Wnt-14 plays a pivotal role in inducing synovial joint formation in the developing appendicular skeleton". Cell. 104 (3): 341–51. doi:10.1016/S0092-8674(01)00222-7. PMID11239392.
Saitoh T, Hirai M, Katoh M (2001). "Molecular cloning and characterization of WNT3A and WNT14 clustered in human chromosome 1q42 region". Biochem. Biophys. Res. Commun. 284 (5): 1168–75. doi:10.1006/bbrc.2001.5105. PMID11414706.
Katoh M (2002). "Molecular cloning and expression of mouse Wnt14, and structural comparison between mouse Wnt14-Wnt3a gene cluster and human WNT14-WNT3A gene cluster". Int. J. Mol. Med. 9 (3): 221–7. doi:10.3892/ijmm.9.3.221. PMID11836627.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID16710414.
Bhattacharyya S, Borthakur A, Dudeja PK, Tobacman JK (2007). "Carrageenan reduces bone morphogenetic protein-4 (BMP4) and activates the Wnt/beta-catenin pathway in normal human colonocytes". Dig. Dis. Sci. 52 (10): 2766–74. doi:10.1007/s10620-006-9531-4. PMID17429723.
