Sideroblastic anemia epidemiology and demographics

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Nazia Fuad M.D.

Overview

Patients of all age groups may develop sideroblastic anemia. The incidence of acquired sideroblastic anemia increases with age; the median age at diagnosis is 74 years. Chronic sideroblastic anemia is usually first diagnosed among middle and older age group. There is no racial predilection to sideroblastic anemia. Males are more commonly affected than females in X-linked recessive types of sideroblastic anemia.

Epidemiology and Demographics

Age

  • Patients of all age groups may develop sideroblastic anemia.
  • Congenital X-linked sideroblastic anemia due to ALAS mutation can remain undiagnosed and then present late in the fourth to eighth decades of life.
  • The incidence of acquired sideroblastic anemia increases with age; the median age at diagnosis is 74 years.
  • Chronic sideroblastic anemia is usually first diagnosed among middle and older age group.[1]

Race

  • There is no racial predilection to sideroblastic anemia.

Gender

  • Males are more commonly affected than females in X-linked recessive types of sideroblastic anemia.
  • A female would have to inherit 1 abnormal chromosome from each parent to acquire the sideroblastic anemia.
  • Primary acquired sideroblastic anemia was found in 60.4% male and 39.6% female.[1]

Region

  • Sideroblastic anemia is more prevalent in European countries,in peadiatric population.

References

  1. 1.0 1.1 Hadnagy C (1991). "Primary acquired sideroblastic anemia and myelodysplastic syndrome from a geriatric point of view". Z Gerontol. 24 (2): 105–9. PMID 1877285.

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